Patents Represented by Attorney Jean B. Barish
  • Patent number: 5981606
    Abstract: This invention pertains to therapeutic wound healing compositions for protecting and resuscitating mammalian cells (Embodiment One (I)). This invention also pertains to therapeutic TGF-beta-wound healing compositions for reducing the formation of scar tissue and increasing the proliferation and resuscitation rate of mammalian cells (Embodiment Two (II)). In a first aspect of Embodiment One (I.A), the therapeutic wound healing composition comprises (a) pyruvate, (b) an antioxidant, and (c) a mixture of saturated and unsaturated fatty acids. In a second aspect of Embodiment One (I.B), the therapeutic wound healing composition comprises (a) pyruvate, (b) lactate, and (c) a mixture of saturated and unsaturated fatty acids. In a third aspect of Embodiment One (I.C), the therapeutic wound healing composition comprises (a) an antioxidant and (b) a mixture of saturated and unsaturated fatty acids. In a fourth aspect of Embodiment One (I.
    Type: Grant
    Filed: February 5, 1998
    Date of Patent: November 9, 1999
    Assignee: Warner-Lambert Company
    Inventor: Alain Martin
  • Patent number: 5942211
    Abstract: An improved stable acidic antiseptic dentifrice composition with therapeutically effective amounts of essential oils formulated at a pH of between 3.0 and 5.5 is disclosed. Also disclosed is an improved stable acidic antiseptic and anticaries dentifrice composition with essential oils and one or more fluorine-releasing compounds, formulated at a pH of between 3.0 and 5.5.
    Type: Grant
    Filed: December 27, 1996
    Date of Patent: August 24, 1999
    Assignee: Warner-Lambert Company
    Inventors: D. Scott Harper, Rita M. Parikh, Dhananjaya Alli, Anil Talwar
  • Patent number: 5891422
    Abstract: An antimicrobial composition containing an alcohol having 3 to 6 carbon atoms which effectively increases antimicrobial activity and particularly a mouthwash composition that is useful in the prevention and reduction of bad breath, plaque and related gum diseases having an antimicrobially effective amount of one or more active essential oils; from about 0.01% to about 30.0% v/v of an alcohol having 3 to 6 carbon atoms; optionally, ethanol; at least one surfactant; and water. The actives not only provide enhanced efficacy but are completely solubilized, thus providing an aesthetically appealing product.
    Type: Grant
    Filed: October 10, 1996
    Date of Patent: April 6, 1999
    Assignee: Warner-Lambert Company
    Inventors: Pauline Pan, Edward Carlin, R. Michael Buch, Frank Volpe, Alain Martin
  • Patent number: 5874479
    Abstract: This invention pertains to therapeutic wound healing compositions for protecting and resuscitating mammalian cells (Embodiment One (I)). This invention also pertains to therapeutic permeation enhanced-wound healing compositions for enhancing the penetration of actives into membranes and increasing the proliferation and resuscitation rate of mammalian cells (Embodiment Two (II)). In a first aspect of Embodiment One (I.A), the therapeutic wound healing composition comprises (a) pyruvate, (b) an antioxidant, and (c) a mixture of saturated and unsaturated fatty acids. In a second aspect of Embodiment One (I.B), the therapeutic wound healing composition comprises (a) pyruvate, (b) lactate, and (c) a mixture of saturated and unsaturated fatty acids. In a third aspect of Embodiment One (I.C), the therapeutic wound healing composition comprises (a) an antioxidant and (b) a mixture of saturated and unsaturated fatty acids. In a fourth aspect of Embodiment One (I.
    Type: Grant
    Filed: February 5, 1998
    Date of Patent: February 23, 1999
    Assignee: Warner-Lambert Company
    Inventor: Alain Martin
  • Patent number: 5863938
    Abstract: This invention pertains to therapeutic antibacterial-wound healing compositions. The compositions comprise a therapeutically effective amount of an antibacterial agent and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic antibacterial-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic antibacterial-wound healing compositions and the pharmaceutical products in which the therapeutic compositions may be used.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: January 26, 1999
    Assignee: Warner Lambert Company
    Inventor: Alain Martin
  • Patent number: 5856364
    Abstract: This invention pertains to therapeutic wound healing compositions for protecting and resuscitating mammalian cells (Embodiment One (I)). This invention also pertains to therapeutic antiviral-wound healing compositions for reducing viral titers and increasing the proliferation and resuscitation rate of mammalian cells (Embodiment Two (II)). In a first aspect of Embodiment One (I.A), the therapeutic wound healing composition comprises (a) pyruvate, (b) an antioxidant, and (c) a mixture of saturated and unsaturated fatty acids. In a second aspect of Embodiment One (I.B), the therapeutic wound healing composition comprises (a) pyruvate, (b) lactate, and (c) a mixture of saturated and unsaturated fatty acids. In a third aspect of Embodiment One (I.C), the therapeutic wound healing composition comprises (a) an antioxidant and (b) a mixture of saturated and unsaturated fatty acids. In a fourth aspect of Embodiment One (I.
    Type: Grant
    Filed: March 29, 1995
    Date of Patent: January 5, 1999
    Assignee: Warner Lambert Company
    Inventor: Alain Martin
  • Patent number: 5817330
    Abstract: Paraffin oil and lactulose-based jellied clear laxative emulsion containing from 75 to 85 parts by weight of liquid paraffin oil and from 25 to 15 parts by weight of an edulcorated lactulose aqueous solution. The invention also concerns a method for the preparation of said emulsion.
    Type: Grant
    Filed: February 4, 1997
    Date of Patent: October 6, 1998
    Inventor: Bernard Doat
  • Patent number: 5817295
    Abstract: A pleasant-tasting, substantially alcohol-free oral mouthwash composition is effective in eliminating the bacteria and other oral microflora responsible for the production of plaque, periodontitis, gingivitis, gum disease and bad breath. The composition consists of a unique blend of the essential oils thymol or eucalyptol, methyl salicylate, menthol and tripartite blend of peppermint flavor oils that are dissolved in solution using a non-ionic surfactant blend.
    Type: Grant
    Filed: January 28, 1997
    Date of Patent: October 6, 1998
    Assignee: Warner-Lambert Company
    Inventors: Atma Chaudhari, Heinrich Scheurer, Pauline Pan, Frank Volpe
  • Patent number: 5811079
    Abstract: An anticalculus dentifrice composition containing an antimicrobially effective amount of an antimicrobial agent selected from the group consisting of thymol, eucalyptol, methyl salicylate and mixtures thereof, and a pyrophosphate ion in an amount from about 0.1% to less than about 1.5% by weight of the composition, the pyrophosphate ion being derived from a highly soluble alkali metal pyrophosphate salt. The composition exhibits both antimicrobial and anticalculus efficacy at low levels of pyrophosphate ion even in the substantial absence of anticalculus enhancing agents.
    Type: Grant
    Filed: February 5, 1997
    Date of Patent: September 22, 1998
    Assignee: Warner-Lambert Company
    Inventors: Dahsehn Yu, Anil K. Talwar, D. Scott Harper, Dhananjaya Alli
  • Patent number: 5762962
    Abstract: Antacid pharmaceutical compositions provide optimal buffering profiles of from 3.0 to 5.0 for immediate and long lasting relief from the symptoms of acid indigestion, sour stomach, heartburn and gas. The composition may comprise a dual or tripartite combination of the actives calcium carbonate, calcium or magnesium citrate and/or calcium phosphate which, as a result of their different activities, neutralize the excess stomach acid both immediately and continuously over time. The formulations also provide the individual with alternative dosage forms which may provide greater levels of calcium, less sodium and less production of gastrointestinal gas.
    Type: Grant
    Filed: October 5, 1994
    Date of Patent: June 9, 1998
    Assignee: Warner-Lambert Company
    Inventors: Constantine Georgiades, R. Michael Buch, E. Eric Engelman, Frank A. Volpe
  • Patent number: 5723106
    Abstract: Reduced alcohol antiseptic mouthwash compositions are achieved which have the same oral antimicrobial efficacy, clarity and taste as higher alcohol level compositions. Availability of the active ingredients is best maintained by increasing the levels of surfactant employed in the composition together with the addition of two co-solvents, propylene glycol and glycerin. Propylene glycol with artificial sweetener(s), or propylene glycol alone with corresponding increases in the levels of surfactant are only marginally acceptable.
    Type: Grant
    Filed: January 21, 1997
    Date of Patent: March 3, 1998
    Assignee: Warner-Lambert Company
    Inventors: R. Michael Buch, Thomas A. Biemer, Frank A. Volpe
  • Patent number: 5692302
    Abstract: This invention pertains to therapeutic wound healing compositions useful for preventing and reducing injury to mammalian cells affixed to razor cartridges to form therapeutic razor cartridges with wound healing compositions. In one embodiment of this invention the therapeutic wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. This invention also pertains to methods for making and using the razor cartridges comprising therapeutic wound healing compositions.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: December 2, 1997
    Assignee: Warner-Lambert Company
    Inventors: Alain Martin, William E. Vreeland, Anthony R. Booth
  • Patent number: 5674912
    Abstract: The present invention pertains to therapeutic sunscreen-wound healing compositions useful to minimize and treat sunburn damage. The compositions comprise a therapeutically effective amount of (1) a sunscreen agent; (2) an anti-inflammatory; and, (3) a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic sunscreen-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic sunscreen-wound healing compositions and the pharmaceutical products in which the therapeutic compositions may be used.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: October 7, 1997
    Assignee: Warner-Lambert Company
    Inventor: Alain Martin
  • Patent number: 5663208
    Abstract: This invention pertains to therapeutic antifungal-wound healing compositions. The compositions comprise a therapeutically effective amount of an antifungal agent and a wound healing compositions. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic antifungal-wound healing compositions may be utilized in a wide variety of topical and ingestible pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic antifungal-wound healing compositions and the pharmaceutical products in which the compositions may be used.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: September 2, 1997
    Assignee: Warner-Lambert Company
    Inventor: Alain Martin
  • Patent number: 5658956
    Abstract: The present invention pertains to therapeutic bioadhesive-wound healing compositions useful for treating wounds and increasing the proliferation and resuscitation rate of mammalian cells. The compositions comprise a bioadhesive agent and a therapeutically effective amount of a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic bioadhesive-wound healing compositions may further comprise medicaments such as antiviral agents, antikeratolytic agents, anti-inflammatory agents, antifungal agents, antibacterial agents, immunostimulating agents, and the like. The bioadhesive-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the bioadhesive-wound healing compositions and the pharmaceutical products in which the compositions may be used.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: August 19, 1997
    Assignee: Warner-Lambert Company
    Inventors: Alain Martin, Sau-Hung S. Leung
  • Patent number: 5658957
    Abstract: This invention pertains to therapeutic immunostimulating-wound healing compositions. The compositions comprise a therapeutically effective amount of an immunostimulating agent and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic immunostimulating-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic immunostimulating-wound healing compositions and the pharmaceutical products in which the compositions may be used.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: August 19, 1997
    Assignee: Warner Lambert Company
    Inventor: Alain Martin
  • Patent number: 5652274
    Abstract: This invention pertains to therapeutic wound healing compositions for protecting and resuscitating mammalian cells. In one embodiment, the therapeutic wound healing composition comprises (a) pymvate, (b) an antioxidant, and (c) a mixture of saturated and unsaturated fatty acids. In another embodiment, the therapeutic wound healing composition comprises (a) pyruvate, (b) lactate, and (c) a mixture of saturated and unsaturated fatty acids. In yet another embodiment, the therapeutic wound healing composition comprises (a) an antioxidant and (b) a mixture of saturated and unsaturated fatty adds. In still yet another embodiment, the therapeutic wound healing composition comprises (a) lactate, (b) an antioxidant, and (c) a mixture of saturated and unsaturated fatty acids.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: July 29, 1997
    Inventor: Alain Martin
  • Patent number: 5648380
    Abstract: This invention pertains to therapeutic anti-inflammatory-wound healing compositions. The compositions comprise a therapeutically effective amount of one or more anti-inflammatory agents and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic anti-inflammatory-wound healing compositions may be utilized in a wide variety of topical and ingestible pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic anti-inflammatory-wound healing compositions and the pharamceutical products in which the therapeutic compositions may be used.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: July 15, 1997
    Assignee: Warner-Lambert Company
    Inventor: Alain Martin
  • Patent number: 5646190
    Abstract: This invention pertains to therapeutic acne treating-wound healing compositions useful for the topical treatment of aene vulgaris. The compositions comprise a therapeutically effective amount of tretinoin and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixtrite of saturated and unsaturated fatty acids. The therapeutic acne treating-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic acne treating-wound healing compositions and the pharmaceutical products in which the therapeutic compositions may be used. This invention also relates to methods for employing the therapeutic ache treating-wound healing compositions to treat wrinkles.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: July 8, 1997
    Assignee: Warner-Lambert Company
    Inventor: Alain Martin
  • Patent number: 5641814
    Abstract: This invention pertains to therapeutic antikeratolytic-wound healing compositions. The compositions comprise a therapeutically effective amount of an antikeratolytic agent and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic antikeratolytic-wound healing compositions may be utilized in a wide variety of topical and ingestible pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic antikeratolytic-wound healing compositions and the pharmaceutical products in which the compositions may be used.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: June 24, 1997
    Assignee: Warner-Lambert Company
    Inventor: Alain Martin