Patents Represented by Attorney Jean B. Barish
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Patent number: 5981606Abstract: This invention pertains to therapeutic wound healing compositions for protecting and resuscitating mammalian cells (Embodiment One (I)). This invention also pertains to therapeutic TGF-beta-wound healing compositions for reducing the formation of scar tissue and increasing the proliferation and resuscitation rate of mammalian cells (Embodiment Two (II)). In a first aspect of Embodiment One (I.A), the therapeutic wound healing composition comprises (a) pyruvate, (b) an antioxidant, and (c) a mixture of saturated and unsaturated fatty acids. In a second aspect of Embodiment One (I.B), the therapeutic wound healing composition comprises (a) pyruvate, (b) lactate, and (c) a mixture of saturated and unsaturated fatty acids. In a third aspect of Embodiment One (I.C), the therapeutic wound healing composition comprises (a) an antioxidant and (b) a mixture of saturated and unsaturated fatty acids. In a fourth aspect of Embodiment One (I.Type: GrantFiled: February 5, 1998Date of Patent: November 9, 1999Assignee: Warner-Lambert CompanyInventor: Alain Martin
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Patent number: 5942211Abstract: An improved stable acidic antiseptic dentifrice composition with therapeutically effective amounts of essential oils formulated at a pH of between 3.0 and 5.5 is disclosed. Also disclosed is an improved stable acidic antiseptic and anticaries dentifrice composition with essential oils and one or more fluorine-releasing compounds, formulated at a pH of between 3.0 and 5.5.Type: GrantFiled: December 27, 1996Date of Patent: August 24, 1999Assignee: Warner-Lambert CompanyInventors: D. Scott Harper, Rita M. Parikh, Dhananjaya Alli, Anil Talwar
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Patent number: 5891422Abstract: An antimicrobial composition containing an alcohol having 3 to 6 carbon atoms which effectively increases antimicrobial activity and particularly a mouthwash composition that is useful in the prevention and reduction of bad breath, plaque and related gum diseases having an antimicrobially effective amount of one or more active essential oils; from about 0.01% to about 30.0% v/v of an alcohol having 3 to 6 carbon atoms; optionally, ethanol; at least one surfactant; and water. The actives not only provide enhanced efficacy but are completely solubilized, thus providing an aesthetically appealing product.Type: GrantFiled: October 10, 1996Date of Patent: April 6, 1999Assignee: Warner-Lambert CompanyInventors: Pauline Pan, Edward Carlin, R. Michael Buch, Frank Volpe, Alain Martin
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Patent number: 5874479Abstract: This invention pertains to therapeutic wound healing compositions for protecting and resuscitating mammalian cells (Embodiment One (I)). This invention also pertains to therapeutic permeation enhanced-wound healing compositions for enhancing the penetration of actives into membranes and increasing the proliferation and resuscitation rate of mammalian cells (Embodiment Two (II)). In a first aspect of Embodiment One (I.A), the therapeutic wound healing composition comprises (a) pyruvate, (b) an antioxidant, and (c) a mixture of saturated and unsaturated fatty acids. In a second aspect of Embodiment One (I.B), the therapeutic wound healing composition comprises (a) pyruvate, (b) lactate, and (c) a mixture of saturated and unsaturated fatty acids. In a third aspect of Embodiment One (I.C), the therapeutic wound healing composition comprises (a) an antioxidant and (b) a mixture of saturated and unsaturated fatty acids. In a fourth aspect of Embodiment One (I.Type: GrantFiled: February 5, 1998Date of Patent: February 23, 1999Assignee: Warner-Lambert CompanyInventor: Alain Martin
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Patent number: 5863938Abstract: This invention pertains to therapeutic antibacterial-wound healing compositions. The compositions comprise a therapeutically effective amount of an antibacterial agent and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic antibacterial-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic antibacterial-wound healing compositions and the pharmaceutical products in which the therapeutic compositions may be used.Type: GrantFiled: May 22, 1995Date of Patent: January 26, 1999Assignee: Warner Lambert CompanyInventor: Alain Martin
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Patent number: 5856364Abstract: This invention pertains to therapeutic wound healing compositions for protecting and resuscitating mammalian cells (Embodiment One (I)). This invention also pertains to therapeutic antiviral-wound healing compositions for reducing viral titers and increasing the proliferation and resuscitation rate of mammalian cells (Embodiment Two (II)). In a first aspect of Embodiment One (I.A), the therapeutic wound healing composition comprises (a) pyruvate, (b) an antioxidant, and (c) a mixture of saturated and unsaturated fatty acids. In a second aspect of Embodiment One (I.B), the therapeutic wound healing composition comprises (a) pyruvate, (b) lactate, and (c) a mixture of saturated and unsaturated fatty acids. In a third aspect of Embodiment One (I.C), the therapeutic wound healing composition comprises (a) an antioxidant and (b) a mixture of saturated and unsaturated fatty acids. In a fourth aspect of Embodiment One (I.Type: GrantFiled: March 29, 1995Date of Patent: January 5, 1999Assignee: Warner Lambert CompanyInventor: Alain Martin
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Patent number: 5817330Abstract: Paraffin oil and lactulose-based jellied clear laxative emulsion containing from 75 to 85 parts by weight of liquid paraffin oil and from 25 to 15 parts by weight of an edulcorated lactulose aqueous solution. The invention also concerns a method for the preparation of said emulsion.Type: GrantFiled: February 4, 1997Date of Patent: October 6, 1998Inventor: Bernard Doat
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Patent number: 5817295Abstract: A pleasant-tasting, substantially alcohol-free oral mouthwash composition is effective in eliminating the bacteria and other oral microflora responsible for the production of plaque, periodontitis, gingivitis, gum disease and bad breath. The composition consists of a unique blend of the essential oils thymol or eucalyptol, methyl salicylate, menthol and tripartite blend of peppermint flavor oils that are dissolved in solution using a non-ionic surfactant blend.Type: GrantFiled: January 28, 1997Date of Patent: October 6, 1998Assignee: Warner-Lambert CompanyInventors: Atma Chaudhari, Heinrich Scheurer, Pauline Pan, Frank Volpe
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Patent number: 5811079Abstract: An anticalculus dentifrice composition containing an antimicrobially effective amount of an antimicrobial agent selected from the group consisting of thymol, eucalyptol, methyl salicylate and mixtures thereof, and a pyrophosphate ion in an amount from about 0.1% to less than about 1.5% by weight of the composition, the pyrophosphate ion being derived from a highly soluble alkali metal pyrophosphate salt. The composition exhibits both antimicrobial and anticalculus efficacy at low levels of pyrophosphate ion even in the substantial absence of anticalculus enhancing agents.Type: GrantFiled: February 5, 1997Date of Patent: September 22, 1998Assignee: Warner-Lambert CompanyInventors: Dahsehn Yu, Anil K. Talwar, D. Scott Harper, Dhananjaya Alli
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Patent number: 5762962Abstract: Antacid pharmaceutical compositions provide optimal buffering profiles of from 3.0 to 5.0 for immediate and long lasting relief from the symptoms of acid indigestion, sour stomach, heartburn and gas. The composition may comprise a dual or tripartite combination of the actives calcium carbonate, calcium or magnesium citrate and/or calcium phosphate which, as a result of their different activities, neutralize the excess stomach acid both immediately and continuously over time. The formulations also provide the individual with alternative dosage forms which may provide greater levels of calcium, less sodium and less production of gastrointestinal gas.Type: GrantFiled: October 5, 1994Date of Patent: June 9, 1998Assignee: Warner-Lambert CompanyInventors: Constantine Georgiades, R. Michael Buch, E. Eric Engelman, Frank A. Volpe
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Patent number: 5723106Abstract: Reduced alcohol antiseptic mouthwash compositions are achieved which have the same oral antimicrobial efficacy, clarity and taste as higher alcohol level compositions. Availability of the active ingredients is best maintained by increasing the levels of surfactant employed in the composition together with the addition of two co-solvents, propylene glycol and glycerin. Propylene glycol with artificial sweetener(s), or propylene glycol alone with corresponding increases in the levels of surfactant are only marginally acceptable.Type: GrantFiled: January 21, 1997Date of Patent: March 3, 1998Assignee: Warner-Lambert CompanyInventors: R. Michael Buch, Thomas A. Biemer, Frank A. Volpe
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Patent number: 5692302Abstract: This invention pertains to therapeutic wound healing compositions useful for preventing and reducing injury to mammalian cells affixed to razor cartridges to form therapeutic razor cartridges with wound healing compositions. In one embodiment of this invention the therapeutic wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. This invention also pertains to methods for making and using the razor cartridges comprising therapeutic wound healing compositions.Type: GrantFiled: May 22, 1995Date of Patent: December 2, 1997Assignee: Warner-Lambert CompanyInventors: Alain Martin, William E. Vreeland, Anthony R. Booth
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Patent number: 5674912Abstract: The present invention pertains to therapeutic sunscreen-wound healing compositions useful to minimize and treat sunburn damage. The compositions comprise a therapeutically effective amount of (1) a sunscreen agent; (2) an anti-inflammatory; and, (3) a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic sunscreen-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic sunscreen-wound healing compositions and the pharmaceutical products in which the therapeutic compositions may be used.Type: GrantFiled: May 22, 1995Date of Patent: October 7, 1997Assignee: Warner-Lambert CompanyInventor: Alain Martin
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Patent number: 5663208Abstract: This invention pertains to therapeutic antifungal-wound healing compositions. The compositions comprise a therapeutically effective amount of an antifungal agent and a wound healing compositions. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic antifungal-wound healing compositions may be utilized in a wide variety of topical and ingestible pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic antifungal-wound healing compositions and the pharmaceutical products in which the compositions may be used.Type: GrantFiled: May 22, 1995Date of Patent: September 2, 1997Assignee: Warner-Lambert CompanyInventor: Alain Martin
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Patent number: 5658956Abstract: The present invention pertains to therapeutic bioadhesive-wound healing compositions useful for treating wounds and increasing the proliferation and resuscitation rate of mammalian cells. The compositions comprise a bioadhesive agent and a therapeutically effective amount of a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic bioadhesive-wound healing compositions may further comprise medicaments such as antiviral agents, antikeratolytic agents, anti-inflammatory agents, antifungal agents, antibacterial agents, immunostimulating agents, and the like. The bioadhesive-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the bioadhesive-wound healing compositions and the pharmaceutical products in which the compositions may be used.Type: GrantFiled: May 22, 1995Date of Patent: August 19, 1997Assignee: Warner-Lambert CompanyInventors: Alain Martin, Sau-Hung S. Leung
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Patent number: 5658957Abstract: This invention pertains to therapeutic immunostimulating-wound healing compositions. The compositions comprise a therapeutically effective amount of an immunostimulating agent and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic immunostimulating-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic immunostimulating-wound healing compositions and the pharmaceutical products in which the compositions may be used.Type: GrantFiled: May 22, 1995Date of Patent: August 19, 1997Assignee: Warner Lambert CompanyInventor: Alain Martin
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Patent number: 5652274Abstract: This invention pertains to therapeutic wound healing compositions for protecting and resuscitating mammalian cells. In one embodiment, the therapeutic wound healing composition comprises (a) pymvate, (b) an antioxidant, and (c) a mixture of saturated and unsaturated fatty acids. In another embodiment, the therapeutic wound healing composition comprises (a) pyruvate, (b) lactate, and (c) a mixture of saturated and unsaturated fatty acids. In yet another embodiment, the therapeutic wound healing composition comprises (a) an antioxidant and (b) a mixture of saturated and unsaturated fatty adds. In still yet another embodiment, the therapeutic wound healing composition comprises (a) lactate, (b) an antioxidant, and (c) a mixture of saturated and unsaturated fatty acids.Type: GrantFiled: May 22, 1995Date of Patent: July 29, 1997Inventor: Alain Martin
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Patent number: 5648380Abstract: This invention pertains to therapeutic anti-inflammatory-wound healing compositions. The compositions comprise a therapeutically effective amount of one or more anti-inflammatory agents and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic anti-inflammatory-wound healing compositions may be utilized in a wide variety of topical and ingestible pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic anti-inflammatory-wound healing compositions and the pharamceutical products in which the therapeutic compositions may be used.Type: GrantFiled: May 22, 1995Date of Patent: July 15, 1997Assignee: Warner-Lambert CompanyInventor: Alain Martin
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Patent number: 5646190Abstract: This invention pertains to therapeutic acne treating-wound healing compositions useful for the topical treatment of aene vulgaris. The compositions comprise a therapeutically effective amount of tretinoin and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixtrite of saturated and unsaturated fatty acids. The therapeutic acne treating-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic acne treating-wound healing compositions and the pharmaceutical products in which the therapeutic compositions may be used. This invention also relates to methods for employing the therapeutic ache treating-wound healing compositions to treat wrinkles.Type: GrantFiled: May 22, 1995Date of Patent: July 8, 1997Assignee: Warner-Lambert CompanyInventor: Alain Martin
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Patent number: 5641814Abstract: This invention pertains to therapeutic antikeratolytic-wound healing compositions. The compositions comprise a therapeutically effective amount of an antikeratolytic agent and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic antikeratolytic-wound healing compositions may be utilized in a wide variety of topical and ingestible pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic antikeratolytic-wound healing compositions and the pharmaceutical products in which the compositions may be used.Type: GrantFiled: May 22, 1995Date of Patent: June 24, 1997Assignee: Warner-Lambert CompanyInventor: Alain Martin