Abstract: Compounds of the formula: ##STR1## and pharmaceutically acceptable salts thereof are inhibitors of angiotensin I converting enzyme and are useful as antihypertensive agents and are also useful as cholecystokinin antagonists.
Abstract: The invention relates to the treatment of gray matter edema in the brain or spinal cord by the administration of (indanyloxy)acetic acids, and analogs and salts thereof.
Type:
Grant
Filed:
March 11, 1983
Date of Patent:
July 31, 1984
Assignee:
Merck & Co., Inc.
Inventors:
Edward J. Cragoe, Jr., Robert S. Bourke
Abstract: A method and drug form enhancing the rate of absorption of a rectally administered drug from the rectal compartment into the blood stream of a warm blooded animal. The method includes the steps of preparing a drug form capable of being rectally administered. The drug form comprises a therapeutically effective unit dosage amount of a selected drug of the type which is capable of being absorbed into the blood stream from the rectal compartment and phenothiazines or salts thereof being present in the drug form in a sufficient amount to be effective in enhancing the drug absorption rate, when rectally administering the drug form to warm blooded animals.
Abstract: A method and drug form for enhancing the rate of absorption of a rectally administered drug from the rectal compartment into the blood stream of a warm blooded animal. The method includes the steps of preparing a .beta.-lactam drug form capable of being rectally administered. The drug form comprises a therapeutically effective unit dosage amount of a selected drug of the type which is capable of being absorbed into the blood stream from the rectal compartment and hydroxy aryl or hydroxy aralkyl acids or salts, amides or esters thereof, the hydroxy aryl or hydroxy aralkyl acids or salts, amides or esters thereof being present in the drug form in a sufficient amount to be effective in enhancing the drug absorption rate, when rectally administering the drug form to warm blooded animals.
Type:
Grant
Filed:
June 25, 1981
Date of Patent:
September 27, 1983
Assignee:
Merck & Co., Inc.
Inventors:
Takeru Higuchi, Toshiaki Nishihata, Howard J. Rytting