Abstract: The invention provides an intermediate form for use in forming a business type mailer, such as a Z-fold or an eccentric Z-fold mailer. The intermediate form is configured as an individual intermediate that is supplied as a single sheet where a multiple of intermediates is provided in stacked form. Alternatively, the intermediate form is configured such that a multiple of intermediates can be provided as a continuous web or sheet and can be supplied in a roll form. The single sheet intermediate and the web or roll form intermediate are defined with pluralities of patterns of cohesive disposed at certain locations along first and second, or front and back, surfaces of the intermediates such that when provided in a stacked form or a roll form the cohesive patterns do not touch or overlap one another.

Abstract: A cannula having a proximal end, a distal end, and a lumen extending between the proximal and distal ends is provided. The diameter of the lumen of the cannula can be varied to take into account differences in the diameter of access and target vessels during cannulation. The cannula is further characterized by at least one mechanism that, upon actuation, serves to alter the conformation of the cannula between a normal profile conformation and a low profile conformation. The normal profile conformation is characterized by the cannula having a lumen diameter at the point of insertion, which is smaller than the lumen diameter both proximal and distal to the point of insertion, with the lumen diameter distal to the point of insertion also expandable to the diameter of the cannulated vessel of the patient. The low profile conformation is characterized by the cannula having a lumen diameter at the point of insertion that is greater than the lumen diameter distal to the point of insertion.

Abstract: An information management system for operation over a network includes a first mobile device having a first application module, the first mobile device operating over the network and in communication with a second mobile device having a second application module, a first operating system residing on the first mobile device configured to detect a communication event between the first mobile device and the second mobile device, and an address book module residing on the second mobile device. The first application module is configured to send information associated with the first mobile device to the second mobile device in association with a detection of the communication event.

Abstract: The delivery system of the present invention is comprised of at least two chambers which store, individually, an activated blood component and an inactivated blood component. The first chamber comprises an activating agent and a filter which may be one in the same thus allowing the formed clot to be triturated thereby isolating the thrombin from the clot. The second chamber stores the inactivated blood component that when mixed with thrombin will produce a gel. The first or second chamber may further contain agents which are desired to be delivered to a specific site. The unique design of the delivery system allows for ease in operation of combining two agents at a specific time and place.

Abstract: Methods and apparatus, including computer program products, for generic archiving of enterprise service oriented architecture data. In general, an identification of an instance of a business object to archive is received. Information defining the business object is retrieved. A schema for the type definition and a definition of the instances of the business object in accordance with the schema is generated. The schema may be in accordance with a platform-independent file format including information reflecting the hierarchy of the business object. The schema may include hierarchy levels that reflect each hierarchy level of the business object. Each hierarchy level, with the exception of hierarchy levels including references to stand-alone business objects, may have the respective attributes of the hierarchy level of the business object. Instance data may be generated to reflect the instance of the business object, the instance data being in accordance with the schema.

Abstract: Prostaglandin-endoperoxide H synthase (PGHS-2) converts arachidonic acid to prostaglandin H2. PGHS-2 is an inducible gene product undetectable in most normal human tissues, but abundant in cancer cells. The present invention exploits a previously undisclosed transcriptional function of PGHS-2 distinct from its well-established enzymatic role to identify potential therapeutic agents useful in treating cancer. The method comprises a DNA binding assay in which PGHS-2 protein binding to the C/EBP, CRE and NF-?B regions of the PGHS-2 promoter in the presence and absence of test compounds is evaluated to identify inhibitors of PGHS-2 transactivation activity.

Abstract: A system, article and method of indexing web content is presented. An attribute is generated for a rendered web page rendered by a display component. The attribute includes a uniform resource locator to the rendered web page, and the rendered web page is associated with a complex resource structure that defines content of a design time version of the rendered web page. The attribute is added to the complex resource structure, and the uniform resource locator from the attribute is indexed in a search engine index.

Abstract: A flexible, disposable centrifuge bag for receiving and holding a fluid sample, comprising one or more tubes and upper and lower flexible sheets having doughnut shaped configurations. The upper and lower sheets are superimposed and completely sealed together at their outer perimeters to define an outer perimeter of the centrifuge bag. The inner perimeter of the bag defines a central core. The tubes are sandwiched between the upper and lower sheets and extend from the central core of the centrifuge bag. The upper and lower sheets are sealed together at their inner perimeters such that the tubes are sealed between said upper and lower sheets at the inner perimeter. The bag may be used to harvest platelet rich plasma from whole blood in either a batch method or while simultaneously infusing additional aliquots of whole blood into the bag during centrifugation.

Abstract: The present invention provides novel methods and kits for diagnosing the presence of cancer within a patient, and for determining whether a subject who has cancer is susceptible to different types of treatment regimens. The cancers to be tested include, but are not limited to, prostate, breast, lung, gastric, ovarian, bladder, lymphoma, mesothelioma, medulloblastoma, glioma, and AML. Identification of therapy-resistant patients early in their treatment regimen can lead to a change in therapy in order to achieve a more successful outcome. One embodiment of the present invention is directed to a method for diagnosing cancer or predicting cancer-therapy outcome by detecting the expression levels of multiple markers in the same cell at the same time, and scoring their expression as being above a certain threshold, wherein the markers are from a particular pathway related to cancer, with the score being indicative or a cancer diagnosis or a prognosis for cancer-therapy failure.

Abstract: An embodiment of a method for detecting low frequency occurrence of one or more HIV sequence variants associated with drug resistance is described that comprises the steps of: generating cDNA species from each RNA molecule in an HIV sample population; amplifying at least one first amplicon from the cDNA species, wherein each first amplicon comprises a plurality of amplified copies and is amplified with a pair of nucleic acid primers that define a locus of the first amplicon; clonally amplifying the amplified copies of the first amplicons to produce a plurality of second amplicons wherein a plurality of the second amplicons comprise an immobilized population of substantially identical copies from one of the amplified copies of first amplicons; determining a nucleic acid sequence composition of the substantially identical copies from at least 100 of the immobilized populations in parallel on a single substrate; and detecting one or more sequence variants that occur at a frequency of 5% or less in the nucleic ac

Abstract: A double syringe delivery system is disclosed for holding a pair of syringes in a manner so as to accommodate the simultaneous activation of the plunger of each syringe in order to effect simultaneous delivery of the contents of each syringe. The delivery system includes a delivery mechanism for delivering the contents of both syringes to a site of application. The delivery system further includes a support member that is positioned between the two syringe bodies. The elongated support member has resilient, C-shaped clamps on one end of the support member. The clamps are designed to be removably clamped onto the applicator so that the syringe barrels will be held together in a parallel manner. The elongated support member further comprises finger grips. A plunger connects the two syringe plungers so that they can also be simultaneously activated.

Abstract: An apparatus for use with communication devices, the communication devices being configured to send and receive SMS messages, the apparatus includes a memory configured to store information indicative of the communication devices that are configured to process an SMS message of a first type, a processor configured to receive an SMS message of the first type from a first communication device, wherein the received SMS message includes contact information related to a user of the first communication device, analyze the received SMS message to determine information indicative of a destination address of the SMS message, the destination address corresponding to a second communication device, determine whether the second communication device is configured to receive SMS messages of the first type using the information indicative of the destination address and the information stored in the memory, send an outgoing SMS message to the second communication device wherein the outgoing SMS message is of the first type if

Abstract: A machine for molding containers, comprising a unit for extruding plastic tubes, a blow-molding unit, a mold for containing containers which is formed by two half-molds movable, upon operation of associated first actuator, in a longitudinal direction (X-X) and symmetrically with respect to a fixed axis (Z-Z) perpendicular to said longitudinal direction, the unit formed by the mold and by the associated first actuator being movable, upon operation of second actuator, in a transverse direction (Y-Y) from a first position where it is substantially aligned with the extrusion unit into a second position where it is substantially aligned with the blow-molding unit and vice versa, said first actuator for operating the half-molds in the longitudinal direction comprising at least one motor, the shaft of which has, keyed thereon, a cam for actuating a pair of connecting rods which are arranged in-line and are respectively connected to the first half-mold and to the second half-mold.

Abstract: A system and technique for generating reports dealing with control objects utilizing a central class, such as a control factory class, without redundant use of container and control classes. The central class creates the entire graphical user interface needed in a particular report during the report's initialization. By calling the central class, the programmer does not have to initialize the class and use a special object within the program and simply may provide the central class with two tables: a container table and a control table. The programmer need not provide the actual control and container classes to the central class through the tables. The programmer need only provide the description of the construction of the graphical user interface through the tables.

Abstract: A centrifugal method, and corresponding system, for processing blood to collect platelet rich plasma. A separation chamber is filled with blood from a fill syringe by rotating the separation chamber at a fill rotation rate and pumping the blood from the fill syringe. A soft spin is used to initially separate red blood cells from platelets by spinning the separation chamber at a soft spin rate. A percentage of the blood is drawn from the separation chamber back into the fill syringe to remove separated red blood cells. A second portion of the separated blood is drawn from the separation chamber until a red blood cell/platelet interface is detected. A hard spin is performed by spinning the separation chamber at a higher rate and connecting tubing is cleared of red blood cells by drawing a predetermined clearing volume. The platelet rich plasma is then collected in the collection syringe.

Abstract: A system and method for providing randomly-generated test cases for a set of interfaces of a piece of software are disclosed. A test case generator is initialized with parameter arrays Sp with cardinality mp and a prime number qp. For each independent parameter p of each of the set of interfaces, a test case number t is generated. A test case is then generated based on the values for each independent parameter p and based on t and Sp, mp, and qp.

Abstract: A method and an apparatus for receiving an error notification associated with a runtime error of a software application to generate a plurality of context attributes from a runtime state of the software application associated with an instant of time of the runtime error are described. One or more potential solutions are searched from a data storage including a solution repository based on the plurality of context attributes at substantially the same instant of time. An acceptable solution for the runtime error is determined based on the one or more potential solutions. The solution repository is updated with a new solution if the acceptable solution cannot be determined.

Abstract: Amphoteric liposomes are proposed, which comprise positive and negative membrane-based or membrane-forming charge carriers as well as the use of these liposomes.

Abstract: Disclosed are methods for nucleic acid amplification wherein nucleic acid templates, beads, and amplification reaction solution are emulsified and the nucleic acid templates are amplified to provide clonal copies of the nucleic acid templates attached to the beads. Also disclosed are kits and apparatuses for performing the methods of the invention.

Abstract: Provided are methods of applying biological compositions, that is, autologous bioadhesive sealant compositions containing one or more biological agents, to an individual, wherein all the blood components used in preparing the composition are derived from the patient who is to receive the biological composition. In one embodiment, the method comprises obtaining a whole blood sample from an individual; forming an inactive platelet rich plasma from the whole blood sample; mixing a biological agent into the inactive platelet rich plasma; obtaining thrombin from the whole blood sample; mixing the thrombin into the inactive platelet rich plasma to form a biological composition; and applying the biological composition to the individual.