Abstract: Inducing tolerance in a primate by use of a compound, or a combination of at least two compounds, that has certain characteristics when tested in vitro. The compound, alone or in combination, is preferably TRX1 antibody and the compound or combination is preferably used in accordance with a specified dosing regimen.

Abstract: For repair of cartilage damaged as part of the degenerative effects of osteoarthritis, the inventors have found that the human mesenchymal stem cell approach makes it possible to: (1) regenerate both shallow cartilage chondral defects and full thickness cartilage defects (osteochondral lesions); (2) broaden the suitable clinical population to routinely include middle-aged patients; (3) eliminate the use of autologous tissue grafts (mature cartilage and the periosteal covering) to repair an articular cartilage injury; (4) regenerate other types of injured cartilage such as patellar and spinal disk cartilage; (5) regenerate articular joint cartilage in older patients with osteoarthritis; and (6) form new cartilage and subchondral bone which fully integrate into the adjacent normal tissue.

Abstract: Methods of treating tumors, preventing restenosis, and treating hyperplasias, corneal haze, and cataracts by administering to an animal a mutated cyclin G1 protein. The mutated cyclin G1 protein may be administered to an animal by administering to an animal an expression vehicle, such as a retroviral vector comprising a gene construct encoding a mutated cyclin G1 protein.

Abstract: Bimodal inorganic material that in a pore size distribution plot has distinct mesopore and micropore peaks. A process for producing a bimodal material or a material that contains essentially only mesopores involves heating an inorganic oxide in the presence of material that bonds to the inorganic oxide by hydrogen bonding. The micropores may or may not include a crystalline structure.

Abstract: An improved zeolite having a high number of strong acid sites wherein said zeolite has an AAI of at least 1.0. In a preferred embodiment, such zeolite is produced by controlling conditions after production of the crystalline structure such that loss of tetrahedral aluminum is minimized to thereby provide a zeolite with the above defined AAI.

Abstract: The present invention provides a method to modulate immune responses using antigen presenting human mesenchymal stem cells to induce specific T cell anergy. The present invention also provides a method to modulate immune responses using human mesenchymal stem cells as a platform to express molecules which will induce T cell anergy.

Abstract: Disclosed are a composition of chemically defined components which support in vitro and in vivo chondrogenesis of mesenchymal stem cells, a method for in vitro and in vivo chondrogenic induction of such stem cells, and a method of forming human chondrocytes in vitro and in vivo from such stem cells.

Abstract: A vector, in particular a retroviral vector, which includes a heterologous or foreign gene and a gene encoding a negative selective marker. The negative selective marker enables one to kill cells which contain the gene encoding the negative selective marker, when a particular agent is administered to such cells.

Abstract: Ethylene and hexene-1 are produced from butene-1 by metathesis of butene-1 and isomerization of the hexene-3 produced therein to hexene-1. The initial starting material is a mixed butene stream wherein butene-1 is isomerized to butene-2 with isobutylene being separated therefrom, followed by isomerization of butene-2 to butene-1, with the butene-1 being the feed to the metathesis.

Abstract: A composition which comprises human mesenchymal stem cells which have the potential to differentiate into cells of more than one connective tissue type and a composition which induces cells from the mesenchymal stem cell population to differentiate into the adipogenic lineage, and a process for inducing such differentiation. The composition for inducing such differentiation comprises a glucocorticoid, a compound which stimulates cAMP production or inhibits cAMP degradation (such as a phosphodiesterase inhibitor), and/or a compound which upregulates peroxisome proliferator activated receptor &ggr; (PPAR &ggr;) expression and/or increases its binding affinity to its DNA binding site. The process can further include isolating the adipocytes from remaining hMSCs.

Abstract: This invention provides a method of using a porcine stem cell factor (PSCF), which may also be termed porcine “steel” factor, which is preferably membrane-bound PSCF on transfected murine STO feeder cells, for establishing pluripotent or totipotent porcine cell lines, especially for the culture of porcine primordial germ cells (PGCs).

Abstract: Described is an apparatus for adjusting the inclination of a seat squab (12) of a vehicle seat (10), wherein the device (18) has a rocker (20) with an upper and a lower rocker element (22, 24) which are pivotably movably connected together by lateral bearing bushes (36). Fixed to the upper rocker element (22) is a toothed bridge (38) with mutually oppositely disposed bridge tooth arrangements (40) which are concentric with respect to the bearing bushes (36). Provided between the two bridge tooth arrangements (40) of the toothed bridge (38) are two toothed sliders (64) with slider tooth arrangements (66). Provided between the two toothed sliders (64) is a locking member (48) rotatable about a rotary axis (26) extending through the bearing bushes (36). The two toothed sliders (64) are linearly movably guided on the lower rocker element (24) between a locking position and a release and adjusting position.

Abstract: Although the mechanism of induction of apoptosis through antibody dependent cellular cytotoxicity (ADCC) mediated by NK cells is well understood, little is known about the fate of the reactive NK cells. Nevertheless, it has been shown that NK cells previously activated by IL-2, but not naive NK cells, died by apoptosis after Fc&ggr;RIIIa crosslinking, or after engagement in cytolytic functions. It is demonstrated that apoptosis of naive NK cells is also observed after stimulation with a rat IgG2b anti CD2 mAb (LO-CD2a/BTI-322) or anti HLAI (LO-HLA-1)mAb. The NK apoptosis is rapid (within minutes), Fas-ligand and mRNA synthesis independent and does not require a cell contact. The intracellular mechanism of NK cell apoptosis is calcium, PKC and PLA2 dependent but calcineurin and P13 kinase independent. We suggest that NK cell apoptosis results from the crosslinking on the same cell surface of CD2 or HLA-I molecules and Fc&ggr;RIIIa that exhibits a high affinity for the rat IgG2b isotype.

Abstract: A method of reducing an immune response to a transplant in a recipient by treating said recipient with an amount of suppressor T cells effective to reduce or inhibit host rejection of the transplant. The suppressor T cells can be administered before, at the same time as, or after the transplant. Also disclosed is a method of inducing a reduced immune response against a host by foreign tissue, i.e., graft versus host disease, by treatment with suppressor T cells.

Abstract: A vehicle seat comprises a seat squab supported on a base structure, and a spring arrangement for weight adjustment, the spring arrangement being connected to a weight adjustment actuating device. Associated with the actuating device is a level indicator device for indicating adjustment of the seat squab to the seat squab level which optimally corresponds to the weight of the respective seat occupant, in relation to the spring travel of the seat squab. The level indicator device and the actuating device are provided at least substantially centrally at the front edge of the seat squab for optimum actuability and adjustability.

Abstract: A product comprised of a three dimensional network of material is coated with a particulate support. The coating may be applied by an electrophoretic coating procedure to apply a particulate coating on the surface or into the interior portions of such three dimensional network of material. In one embodiment, the particles are a catalyst or a catalyst precursor or a catalyst support to thereby provide a catalyst structure in which catalyst may be supported as a coating in the interior and on the exterior of a three-dimensional network of material having a high void volume. Edge effects may be reduced by control or disruption of field lines during the coating. In addition, larger particles may be electrophoretically coated onto a product by the use of smaller particles which function as a “glue”.

Abstract: A liquid pharmaceutical for oral delivery wherein at the time of use, a solid unit dosage form is added to the liquid wherein the unit dosage form is comprised of a substrate soluble in the liquid and a particulate pharmaceutically active material in a pharmaceutically effective amount. At the time of use, the unit dosage form is added to the liquid, without requiring measurement of the liquid, and the entire liquid is consumed to provide for oral delivery of the pharmaceutically effective amount of material.

Abstract: A vehicle seat includes a backrest with a forearm support carried thereon at the rear side thereof, the aim being to improve the level of comfort for the user of the seat in a position of facing rearwardly.

Abstract: An integrated child's seat (10) is provided for a motor vehicle seat. The child's seat (10) is displaceable between a low and an unfolded raised position. It has a base portion (12) and a support portion (14) which are pivotably connected by front and rear parallelogram arm devices (16, 18). A diagonal strut device (40) is linearly movably guided with a guide end portion (42) along a guide device (44) provided on the support portion (14) or on the front parallelogram arm device (16). The diagonal strut device (40) is pivotably connected with its second end portion (52) to the rear parallelogram arm device (18) by a pivotal connection (58). The rear parallelogram arm device (18) has a weak crash location (38) so that in the unfolded condition of the child's seat (10) with a corresponding weight on the support portion (14), the rear parallelogram arm device (18) buckles at the weak crash location (38) and the support portion (14) dips downwardly with its rear end part.

Abstract: Described is a seat (10) comprising a seat squab (12) and a backrest (14) which is displaceable in respect of its inclination. In order to achieve a load relief for the intervertebral disc of a user of the seat and thus optimum seating comfort, the seat (10) provides that the backrest (14) is displaceable between convex lordosis positions and concave kyphosis positions in dependence on the respective backrest inclination.