Abstract: 7-ethyl-10-hydroxy camptothecin (HECPT), an active metabolite of the camptothecin analog CPT-11 which is used as an anticancer drug, is poorly soluble in water. Because of its poor water solubility, HECPT has not been directly administered by parenteral or oral routes in human patients for the purpose of inhibiting the growth of cancer cells. There is also unpredictable interpatient variability in the metabolic production of HECPT from CPT-11 which limits the utility of CPT-11. This invention overcomes these limitations by teaching novel pharmaceutically acceptable lactone stable HECPT formulations for the direct administration of lactone stable HECPT formulations orally or parenterally to patients with various forms of cancer.

Abstract: The novel compounds 11-hydroxy-7-ethyl camptothecin and 11-hydroxy-7-methoxy camptothecin (11,7-HECPT and 11,7-HMCPT) are active anticancer compounds which are poorly soluble in water. Because of their novelty, 11,7-HECPT and 11,7-HMCPT derivatives have not been directly administered by parenteral or oral routes to human subjects as an antitumor composition for the purpose of inhibiting the growth of cancer cells. The claimed compositions are useful as compared to the water soluble camptothecin derivatives, such as CPT-11, in clinical trials. The unpredictable interpatient variability in the metabolic production of an active metabolite from CPT-11 limits the utility of CPT-11. This invention overcomes these limitations by claiming novel pharmaceutically acceptable lactone stable formulations of 11,7-HECPT or 11,7-HMCPT, to directly administer to patients.

Abstract: A method for photochemical cleavage of carbon-sulfur bonds in conjunction with solid-phase synthesis utilizing a deoxygenated solvent and light to cleave the carbon-sulfur bond from a heterogeneous support. Also disclosed are compounds for use with said photochemical cleavage and methods of preparing them.

Abstract: This invention relates to derivatives of Wortmannin and particularly to 11,17 substituted derivatives of Wortmannin. The invention also relates to a method of using these compounds as PI-3-kinase inhibitors and as anti-tumor agents.

Abstract: The present invention provides novel decahydroisoquinoline derivatives which are useful as excitatory amino acid antagonists. The invention also provides for methods of using these derivatives to treat various neurological disorders.

Abstract: A flip-up arm rest for a chair or other seating. The arm rest is rotatably connected to a control housing through a connecting rod. The control housing includes a central passage to accommodate a control pin which extends from the connecting rod. A stop pin is housed in a passage which communicates with the central passage and serves to limit rotation movement of the arm rest.

Abstract: A reclining chair which includes a base, frame supports, and pivotable seat and back supports. The seat and back supports are pivotally connected for correlative movement, and the seat support is operably connected to an inclined ramp which raises the vertical height of the seat support during reclining.

Abstract: A multiplexer for mixing multiple audio inputs into a plurality of summed audio outputs in which computer-controlled sensors are associated with the amplifier components of the multiplexer for specific monitoring the voice levels and in association with the volume controls maintains the voice levels within selected parameters.

Abstract: A reclining chair which includes a pivotal connection between the seat support, the arm support and the back support. The connection allows for the seat support to be raised during reclining operation to allow a user to maintain a consistent eye level at all times. The pivotal connection includes links which are pivotally connected at the sides of the chair to their corresponding supports and are actuated by the weight of the user.

Abstract: Disclosed herein is a washing machine which comprises a bubble generator operable to supply a predetermined amount of air bubbles into the washer tub in a batchwise manner at such a time interval as to allow said amount of air bubbles supplied in a preceding batch to be substantially collapsed before a next supply of said air bubbles commences.

Abstract: The present invention relates to novel benzopyran derivatives of formula(I) which have exellent effectiveness in the treatment of asthma as well as hypertension. ##STR1## wherein R.sub.1 is --CN, --NO.sub.2, --OCX.sub.1 X.sub.2 X.sub.3, --NH.sub.2, --NHSO.sub.2 R.sup.A, ##STR2## --SO.sub.2 R.sup.C or --SO.sub.2 NR.sup.C R.sup.D wherein X.sub.1, X.sub.2 and X.sub.3 are, each independently, F, Cl or H, except for that X.sub.1, X.sub.2 and X.sub.3 may not be hydrogen atom simulaneously; R.sup.A and R.sup.B are, each independently, a hydrogen atom, or a C.sub.1-6 alkyl group or an optionally substituted phenyl group with a halogen atom, or a straight or branched C.sub.1-3 alkyl group; and R.sup.C and R.sup.D are, each independently, a hydrogen atom or a C.sub.1-6 alkyl group or an optionally substituted phenyl group with a halogen atom, or a straight or branched C.sub.1-3 alkyl group;R.sub.2 is a C.sub.1-4 straight or branched alkyl group;R.sub.3 is a C.sub.

Abstract: A multiple baker for confectionery items such as waffles and pancakes having multiple baking irons vertically mounted between vertical heating partitions of a base and pivotally hinged to the base for rotation in a vertical plane, between a baking position and an offset position. Each baking iron has separatable shell members for receiving the food items and a flanged mouth positioned atop each baking iron when in the baking position. The position of the flange mouth allows steam to escape vertically during the baking process and distance the user from the steam.

Abstract: An apparatus for controlling the rotational speed of a motor.

Abstract: A machine for analyzing and displaying the concentration of a pressurized gas flowing through a delivery line in relationship to a reference gas. The machine includes a thermal conductivity detector which is connected to a microprocessor and a visual display. The microprocessor allows the machine operator to select any of a number of references and sample gas combinations for analysis.

Abstract: A crank mechanism for an internal combustion engine comprises a cylinder, a piston reciprocalable within the cylinder, and a rotatable shaft. The piston is in drivable in connection with the shaft via a connecting rod, a slipper, and a torque lob. The connecting rod is pivotally fixed to the piston, and the slipper is pivotally attached to the free end of the connecting rod. The torque lob is a circular plate eccentrically mounted on the shaft for rotation therewith about the axis thereof. The slipper is slidable along but restrained to the rim of the torque lob. The slipper is constrained to move around a close path, whereby rectilinear movement of the piston is converted to rotary movement of the torque lob or vice versa.

Abstract: An Almen type gage with an improved test strip support mechanism, which concentrates the holding force at the contact points. The support mechanism includes four paired contact balls and a permanent magnet engaged between the paired balls to magnetically hold the test strip against the contact balls. Each contact ball seated atop a set screw turned into a test platform with the magnetic flux of the permanent magnets passing through both the contact balls and the set screws.

Abstract: A painting rack for the mounting of a variety and multiplicity of vehicle parts, the sections of which are designed for ease in assembly and disassembly for storage and transport. The rack defines a hole portion to which can be inserted a plurality of rod-like supports extending outwardly therefrom which are rotatable in a given plane for spacing and counterbalance of the parts mounted thereon.

Abstract: Disclosed herein is a washing machine which comprises a bubble generator operable to supply a predetermined amount of air bubbles into the washer tub in a batchwise manner at such a time interval as to allow said amount of air bubbles supplied in a preceding batch to be substantially collapsed before a next supply of said air bubbles commences.

Abstract: An equalizer for passively controlling the movements of two or more sliding tubes. The equalizer includes a plurality of pulleys interconnected by cables. The cables are movably connected between the pulleys and the movable tubes to ensure the equalization of movement of one tube relative to the other.