Abstract: An NSAID formulation for encapsulation into a soft gel capsule with increased stability, concentration and bioavailability of the NSAID. The preferred NSAIDS are naproxen, ibprofen, indomethacin and diclofenac, which are provided in both an acidic and basic form in the fill formulation. The pH values of fill formulations may be adjusted without additional process steps. A process for increasing the achievable concentration of an NASAID pharmaceutical ingredient in a fill composition for dosage units is also provided. The highly concentrated NASAID formulation permits a reduction in the fill volume or dosage unit size or an increase in concentration of the NSAID in each dosage it.
Type:
Grant
Filed:
January 19, 2011
Date of Patent:
November 1, 2016
Assignee:
ACCUCAPS INDUSTRIES LIMITED
Inventors:
John Lopez, Peter Draper, Sankalp Vashishtha, Nancy Klassen, Christina Armstrong
Abstract: A multi phase soft gelatin dosage form comprising at least one preformed solid dosage form and at least one liquid fill phase. The multi phase soft gelatin dosage forms of the present invention are especially useful to combine at least one solid dosage form and at least one liquid phase for single ingestion. Method and apparatus for manufacturing the multiphase soft gelatin dosage forms are also described. The solid phase, liquid phase or coatings may comprise active pharmaceutical ingredients, nutraceuticals, nutritional supplements, therapeutic substances, functional excipients or combinations thereof.
Type:
Application
Filed:
June 3, 2011
Publication date:
May 30, 2013
Applicant:
ACCUCAPS INDUSTRIES LIMITED
Inventors:
Peter Draper, James Edward Draper, Beth Marie Okutan
Abstract: A multi phase soft gelatin dosage form comprising at least one preformed solid dosage form comprising a statin compound and at least one liquid fill phase comprising Omega-3 fatty acids. The multi phase soft gelatin dosage forms of the present invention are especially useful to combine at least one solid dosage form and at least one liquid phase for single ingestion. The solid phase, liquid phase or coatings may further comprise active pharmaceutical ingredients, nutraceuticals, nutritional supplements, or therapeutic substances, functional excipients or combinations thereof.
Type:
Application
Filed:
June 3, 2011
Publication date:
May 9, 2013
Applicant:
ACCUCAPS INDUSTRIES LIMITED
Inventors:
Peter Draper, James Draper, Beth Marie Okutan
Abstract: An NSAID formulation for encapsulation into a soft gel capsule with increased stability, concentration and bioavailability of the NSAID. The preferred NSAIDS are naproxen, ibprofen, indomethacin and diclofenac, which are provided in both an acidic and basic form in the fill formulation. The pH values of fill formulations may be adjusted without additional process steps. A process for increasing the achievable concentration of an NASAID pharmaceutical ingredient in a fill composition for dosage units is also provided. The highly concentrated NASAID formulation permits a reduction in the fill volume or dosage unit size or an increase in concentration of the NSAID in each dosage it.
Type:
Application
Filed:
January 19, 2011
Publication date:
January 10, 2013
Applicant:
ACCUCAPS INDUSTRIES LIMITED
Inventors:
John Lopez, Peter Draper, Sankalp Vashishtha, Nancy Klassen, Christina Armstrong
Abstract: This invention relates to a loratadine formulation suitable for encapsulation into a soft gel capsule or suitable dosage unit improved functionality providing enhanced in vitro dissolution and bioavailability of loratadine. The invention also provides a formulation with improved functionality as a highly concentrated solution within a given fill volume in order to manufacture as small a capsule as possible to facilitate consumer acceptance and acceptable manufacturing costs. The invention also relates to a formulation of optimal stability for supporting fill composition compatible with the soft gel capsule dosage unit.
Type:
Application
Filed:
January 18, 2011
Publication date:
November 29, 2012
Applicant:
ACCUCAPS INDUSTRIES LIMITED
Inventors:
Beth Okutan, Peter Draper, James Draper