Abstract: Enteric compositions comprising one or more tight junction agonists and/or one or more tight junction antagonists are provided. Compositions of the invention may comprise a delayed-release coating disposed over a tight junction agonist and/or tight junction antagonist layer which may be disposed over an inert core. Delayed-release coatings may be substantially stable in gastric fluid and substantially unstable in intestinal fluid, thus providing for substantial release of the tight junction agonist and/or antagonist from the composition in the duodenum or jejunum of the small intestine.
Abstract: The present invention provides materials and methods for the treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis). Materials of the invention may include compositions comprising one or more tight junction antagonists and optionally one or more therapeutic agents. Methods of the invention may comprise treating a subject in need thereof with a composition comprising one or more tight junction antagonists and, optionally one or more therapeutic agents.
Type:
Application
Filed:
September 24, 2012
Publication date:
April 25, 2013
Applicant:
Alba Therapeutics Corp.
Inventors:
Blake Paterson, Amir Tamiz, Niranjan Pandey
Abstract: The present invention provides materials and methods for the treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis). Materials of the invention may include compositions comprising one or more tight junction antagonists and optionally one or more therapeutic agents. Methods of the invention may comprise treating a subject in need thereof with a composition comprising one or more tight junction antagonists and, optionally one or more therapeutic agents.
Type:
Grant
Filed:
May 27, 2010
Date of Patent:
October 30, 2012
Assignee:
Alba Therapeutics Corp.
Inventors:
Blake Paterson, Amir Tamiz, Niranjan Pandey
Abstract: The present invention provides materials and methods to diagnose celiac disease. In some embodiments, the present invention provides a method of diagnosing celiac disease by measuring the serum zonulin level of a subject.
Type:
Application
Filed:
August 7, 2007
Publication date:
February 14, 2008
Applicants:
University of Maryland - Baltimore, ALBA Therapeutics Corp.
Inventors:
Alessio Fasano, Deborah Kryszak, Julio Bai
Abstract: The present invention provides materials and methods to facilitate the pulmonary delivery of therapeutic agents. In some embodiments, agonists of tight junctions (e.g., zonulin agonists) are used in compositions to facilitate the uptake of therapeutic agents from the pulmonary mucosa.
Abstract: Enteric compositions comprising one or more tight junction agonists and/or one or more tight junction antagonists are provided. Compositions of the invention may comprise a delayed-release coating disposed over a tight junction agonist and/or tight junction antagonist layer which may be disposed over an inert core. Delayed-release coatings may be substantially stable in gastric fluid and substantially unstable in intestinal fluid, thus providing for substantial release of the tight junction agonist and/or antagonist from the composition in the duodenum or jejunum of the small intestine.