Abstract: A transdermal nicotine salt delivery system to an individual. The system has a high nicotine salt loading to effect therapeutic flux rate. Acrylate polymeric drug reservoir with the high nicotine salt dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties.
Type:
Application
Filed:
May 18, 2015
Publication date:
September 3, 2015
Applicant:
ALZA Corporation
Inventors:
Robert M. Gale, Jay Audett, Rama V. Padmanabhan, Michel J.N. Cormier, Allison Luciano, Eric N. Silverberg, Paul B. Foreman
Abstract: Electrotransport drug delivery devices, system and methods of using configured to determine if a current is present between the anode and cathode when drug is not intended to be delivered by the device. These devices/systems may include an off-current module to determine that any current (e.g., which may be inferred by measuring potential difference between the anode and cathode of the device) flowing between the anode and cathode is below a threshold value when the device is not supposed to be delivering drug, thereby preventing unintended delivery of drug and/or alerting a user that unintended delivery of drug may occur.
Abstract: Devices, systems and methods for controlling the application of current and/or voltage to deliver drug from patient contacts of an electrotransport drug delivery device by indirectly controlling and/or monitoring the applied current without directly measuring from the cathode of the patient terminal. In particular, described herein are electrotransport drug delivery systems including constant current delivery systems having a feedback current and/or voltage control module that is isolated from the patient contacts (e.g., anodes and cathodes). The feedback module may be isolated by a transistor from the patient contacts; feedback current and/or voltage control measurements may be performed at the transistor rather than at the patient contact (e.g., cathode).
Type:
Application
Filed:
March 5, 2013
Publication date:
July 16, 2015
Applicants:
ALZA CORPORATION, INCLINE THERAPEUTICS, INC.
Inventors:
Bradley E. White, Paul Hayter, John Lemke, Scot Satre, Corinna X. Chen, Brian W. Read, Jason E. Dougherty
Abstract: A novel backing construction for a transdermal drug delivery system is disclosed. In particular, the invention relates to a system and method for labeling a transdermal drug delivery system, wherein the backing layer contains a writable medium capable of inkless printing.
Abstract: A transdermal nicotine salt delivery system to an individual. The system has a high nicotine salt loading to effect therapeutic flux rate. Acrylate polymeric drug reservoir with the high nicotine salt dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties.
Type:
Grant
Filed:
September 22, 2006
Date of Patent:
June 16, 2015
Assignee:
ALZA Corporation
Inventors:
Robert M. Gale, Jay Audett, Rama V. Padmanabhan, Michel J. N. Cormier, Allison Luciano, Eric N. Silverberg, Paul B. Foreman
Abstract: Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.
Type:
Grant
Filed:
August 12, 2003
Date of Patent:
May 12, 2015
Assignee:
Alza Corporation
Inventors:
Andrew C. Lam, Padmaja Shivanand, Atul D. Ayer, Zahedeh Hatamkhany, Suneel K. Gupta, Diane R. Guinta, Carol A. Christopher, Samuel R. Saks, Lawrence G. Hamel, Jeri D. Wright, Richard G. Weyers
Abstract: Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.
Type:
Application
Filed:
March 13, 2013
Publication date:
May 7, 2015
Applicant:
ALZA CORPORATION
Inventors:
SUNEEL K. GUPTA, DIANE R. GUINTA, CAROL A. CHRISTOPHER, SAMUEL R. SAKS, LAWRENCE G. HAMEL
Abstract: A method for delivering a drug into tissue includes the steps of: providing a drug delivery device having at least one nozzle and a drug contained in a portion of the device; identifying a site for delivery of the drug in or on tissue; placing a portion of the device on or near the site; and delivering the drug into the tissue at the site through at least one nozzle of the device under microjet propulsion.
Abstract: Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.
Type:
Grant
Filed:
March 13, 2013
Date of Patent:
April 7, 2015
Assignee:
ALZA Corporation
Inventors:
Andrew C. Lam, Padmaja Shivanand, Atul D Ayer, Zahedeh Hatamkhany, Richard G Weyers, Suneel K. Gupta, Diane R Guinta, Carol A. Christopher, Samuel R. Saks, Lawrence G. Hamel, Jeri D. Wright
Abstract: Rapid and accurate determination of the formulation orientation of multi-layer capsule-shaped tablets with respect to different internal formulation layers proximate to the opposite narrow and rounded ends of the tablets is required. By including an appropriate color scheme in multi-layer osmotic tablets, detection of the formulation orientation is achieved by detecting the color at a spot location on a side of the tablet corresponding to one or another formulation layer or to one or another interface of two formulation layers depending on the formulation orientation of the tablet.
Abstract: The invention provides for a formulation for coating one or more microprojections which reduces or minimizes the loss of counterions from the coating in order to achieve a pH-stabilized formulation.
Type:
Grant
Filed:
August 24, 2009
Date of Patent:
December 30, 2014
Assignee:
Alza Corporation
Inventors:
Mahmoud Ameri, Wei-Qi Lin, Michel J. N. Cormier, Yuh-Fun Maa
Abstract: A method and a non-rate controlled, monolithic, subsaturated patch for transdermally administering fentanyl and analogs thereof, for analgetic purposes, to a subject through skin over an extended period of time are disclosed.
Type:
Application
Filed:
June 2, 2014
Publication date:
September 18, 2014
Applicant:
ALZA Corporation
Inventors:
SUBRAMANIAN S. VENKATRAMAN, SHAOLING LI, ROBERT M. GALE, JANE STEPIC, WILLIAM W. VAN OSDOL
Abstract: Compositions of and methods for formulating and delivering biologically active agent formulations having enhanced physical stability, and wherein deterioration from the presence of oxygen and/or water is minimized and/or controlled, to yield a stable formulation. The compositions of and methods for formulating and delivering biologically active agents of the present invention further facilitate their incorporation into a biocompatible coating which can be employed to coat a stratum-corneum piercing microprojection, or a plurality of stratum-corneum piercing microprojections of a delivery device, for delivery of the biocompatible coating through the skin of a subject, thus providing an effective means of delivering the biologically active agents.
Type:
Application
Filed:
January 21, 2014
Publication date:
September 18, 2014
Applicant:
ALZA CORPORATION
Inventors:
Mahmoud Ameri, Michel J.N. Cormier, Scott Sellers, Yuh-Fun Maa
Abstract: Short oligopeptides are provide which are capable of binding to the epidermal growth factor receptor on the surface of human tumor cells. Methods for using the peptides as targeting moieties in more complex compositions, such as conjugates of cytoxins, and/or structures, such as liposomal structures, for the purposes of drug delivery are also provided.
Type:
Grant
Filed:
December 20, 2007
Date of Patent:
September 16, 2014
Assignee:
Alza Corporation
Inventors:
Ken Shi Kun Huang, Weiming Zhang, Guoyang Zhang, Francois Nicol, Anthony Huang
Abstract: A polyacrylate formulation suitable for delivery of drug to through a body surface of an individual. By loading the drug and permeation enhancers at a high concentration into a polyacrylate proadhesive that has inadequate adhesive properties for typical adhesive application on the skin, a formulation with desirable adhesive characteristics and effective therapeutic properties can be made. The proadhesive has higher glass transition temperature than typical pressure sensitive adhesives.
Type:
Application
Filed:
May 9, 2014
Publication date:
September 4, 2014
Applicant:
ALZA Corporation
Inventors:
Jay Audett, Jianye Wen, Eli J. Goldman, Robert M. Gale, Allison Luciano, Paul B. Foreman, Eric N. Silverberg
Abstract: A polyacrylate formulation suitable for delivery of drug to through a body surface of an individual. By loading the drug and permeation enhancers at a high concentration into a polyacrylate proadhesive that has inadequate adhesive properties for typical adhesive application on the skin, a formulation with desirable adhesive characteristics and effective therapeutic properties can be made. The proadhesive has higher glass transition temperature than typical pressure sensitive adhesives.
Type:
Grant
Filed:
February 25, 2013
Date of Patent:
June 24, 2014
Assignee:
ALZA Corporation
Inventors:
Jay Audett, Jianye Wen, Eli J. Goldman, Robert M. Gale, Allison Luciano, Paul B. Foreman, Eric N. Silverberg
Abstract: A retainer (34) is provided for holding a microprotrusion member (44) for application of the microprotrusion member (44) to the stratum corneum with an impact applicator (10). The microprotrusion member (44) includes a plurality of microprotrusions (90) which penetrate the stratum corneum to improve transport of an agent across the stratum corneum.