Patents Assigned to Aptapharma, Inc.
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Patent number: 11207317Abstract: Methylnaltrexone nasal formulations are disclosed which provide improved bioavailability over oral dosage forms and improved patient compliance over injectable dosage forms. Also disclosed are methods of making the nasal formulations and methods of using, specifically to treat the side effects of opioid drug use, such as constipation, and other indications.Type: GrantFiled: October 24, 2019Date of Patent: December 28, 2021Assignee: APTAPHARMA INC.Inventor: Siva Rama K. Nutalapati
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Patent number: 10485798Abstract: Methylnaltrexone nasal formulations are discloses which provide improved bioavailability over oral dosage forms and improved patient compliance over injectable dosage forms. Also disclosed are methods of making the nasal formulations and methods of using, specifically to treat the side effects of opioid drug use, such as constipation, and other indications.Type: GrantFiled: August 21, 2013Date of Patent: November 26, 2019Assignee: APTAPHARMA INC.Inventor: Siva Rama K. Nutalapati
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Patent number: 10485770Abstract: Multilayer functionally coated tablets for oral administration of one or more active pharmaceutical ingredients containing one or more quick release layers and one or more modified release layers separated by an inert layer are provided. Also provided are methods for formulation and use of these tablets.Type: GrantFiled: December 15, 2010Date of Patent: November 26, 2019Assignee: APTAPHARMA, INC.Inventor: Siva Rama Krishna Nutalapati
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Patent number: 10426724Abstract: Combinations of a first generation antihistamine for a quick onset with a maintenance dosage amount of a second or third generation antihistamine, along with an additional active agent such as a decongestant, a cough suppressant (an antitussive), a leukotriene receptor antagonist, a 5-lipoxygenase inhibitor, a bronchodilator, an expectorant, or a combination thereof, are disclosed. Methods of using such combinations by concomitant administration, either in the form of a single composition or multiple compositions, are further disclosed.Type: GrantFiled: August 2, 2018Date of Patent: October 1, 2019Assignee: APTAPHARMA INC.Inventors: Siva Rama K. Nutalapati, Prahlad Patel, Nisha Sureshbhai Patel
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Patent number: 10064820Abstract: Combinations of a first generation antihistamine for a quick onset with a maintenance dosage amount of a second or third generation antihistamine, along with an additional active agent such as a decongestant, a cough suppressant (an antitussive), a leukotriene receptor antagonist, a 5-lipoxygenase inhibitor, a bronchodilator, an expectorant, or a combination thereof, are disclosed. Methods of using such combinations by concomitant administration, either in the form of a single composition or multiple compositions, are further disclosed.Type: GrantFiled: September 30, 2016Date of Patent: September 4, 2018Assignee: APTAPHARMA INC.Inventors: Siva Rama K. Nutalapati, Prahlad Patel, Nisha Sureshbhai Patel
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Patent number: 9265757Abstract: Methods of using combinations of antihistamines by administering an attenuated dosage amount of a first generation antihistamine for a quick onset concomitantly with a maintenance dosage amount of a second or third generation antihistamine are disclosed.Type: GrantFiled: July 19, 2012Date of Patent: February 23, 2016Assignee: APTAPHARMA INC.Inventor: Siva Rama K. Nutalapati
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Patent number: 9011904Abstract: Self-breaking core tablets and functionally coated tablets and capsule formulations are provided. Methods for production of these tablet and capsule formulations and their administration are also provided.Type: GrantFiled: July 2, 2010Date of Patent: April 21, 2015Assignee: Aptapharma, Inc.Inventors: Ishwar Chauhan, Siva Rama Krishna Nutalapati
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Publication number: 20140057934Abstract: Methylnaltrexone nasal formulations are discloses which provide improved bioavailability over oral dosage forms and improved patient compliance over injectable dosage forms. Also disclosed are methods of making the nasal formulations and methods of using, specifically to treat the side effects of opioid drug use, such as constipation, and other indications.Type: ApplicationFiled: August 21, 2013Publication date: February 27, 2014Applicant: AptaPharma Inc.Inventor: Siva Rama K. Nutalapati
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Publication number: 20130064889Abstract: Tablet-in tablet paliperidone formulations and processes for preparation and use thereof are provided.Type: ApplicationFiled: September 10, 2012Publication date: March 14, 2013Applicant: Aptapharma, Inc.Inventors: Siva Rama Krishna Nutalapati, Rakeshkumar Khushalbhai Lad
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Publication number: 20120258173Abstract: Multilayer functionally coated tablets for oral administration of one or more active pharmaceutical ingredients containing one or more quick release layers and one or more modified release layers separated by an inert layer are provided. Also provided are methods for formulation and use of these tablets.Type: ApplicationFiled: December 15, 2010Publication date: October 11, 2012Applicant: AptaPharma, Inc.Inventor: Siva Rama Krishna Nutalapati
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Publication number: 20120141584Abstract: Multilayer minitablets for oral administration of an active pharmaceutical ingredient which release the active pharmaceutical ingredient at different pH ranges and/or in different release profiles are described.Type: ApplicationFiled: August 13, 2010Publication date: June 7, 2012Applicant: Aptapharma, Inc.Inventors: Ishwar Chauhan, Siva Rama Krishna Nutalapati
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Publication number: 20120128766Abstract: Self-breaking core tablets and functionally coated tablets and capsule formulations are provided. Methods for production of these tablet and capsule formulations and their administration are also provided.Type: ApplicationFiled: July 2, 2010Publication date: May 24, 2012Applicant: Aptapharma, Inc.Inventors: Ishwar Chauhan, Siva Rama Krishna Nutalapati
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Publication number: 20120064159Abstract: Multilayer tablets of a non-steroidal anti-inflammatory drug (NSAID) and/or acetaminophen for oral administration containing an immediate release layer or layers containing a NSAID and/or acetaminophen and/or a second therapeutic agent and an extended release layer containing a NSAID and/or acetaminophen are provided. Multilayer tablets containing an additional immediate and/or extended release layer of a second therapeutic agent are also provided. Methods for production of these multi-layer tablets and methods for their use in treating a subject in need of a NSAID and/or acetaminophen are also provided.Type: ApplicationFiled: May 24, 2010Publication date: March 15, 2012Applicant: Aptapharma, Inc.Inventors: Ishwar Chauhan, Siva Rama Krishna Nutalapati
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Publication number: 20120041068Abstract: An extended release preparation of an active pharmaceutical ingredient with pH dependent solubility dissolved or dispersed in a semi-solid or liquid nonionic solubilizer and further containing a non-pH dependent sustained release agent as well as a process for the preparation thereof are provided.Type: ApplicationFiled: August 11, 2011Publication date: February 16, 2012Applicant: Aptapharma, Inc.Inventor: Siva Rama Krishna Nutalapati
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Publication number: 20120003312Abstract: Multilayer minitablets for oral administration of a combination of active pharmaceutical ingredients which release the active pharmaceutical ingredient at different release rates are described.Type: ApplicationFiled: June 22, 2011Publication date: January 5, 2012Applicant: Aptapharma, Inc.Inventors: Siva Rama Krishna Nutalapati, Rakeshkumar Khushalbhai Lad
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Publication number: 20110280936Abstract: Self-breaking tablet and capsule formulations with a similar in vitro drug release profile for whole tablet and when broken and/or a bioequivalent drug release profile when taken whole or when broken are provided. Methods for production of these formulations and tablets and their administration are also provided.Type: ApplicationFiled: May 10, 2011Publication date: November 17, 2011Applicant: Aptapharma, Inc.Inventors: Siva Rama Krishna Nutalapati, Rakeshkumar Khushalbhai Lad