Abstract: Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin dependent diabetes mellitus, and ischemia in a mammal are disclosed.
Type:
Application
Filed:
November 19, 2009
Publication date:
July 1, 2010
Applicant:
Beth Israel Deaconess Medical Center , Inc. And Trustees of Boston University
Inventors:
Chen-Yu Zhang, Bradford B. Lowell, John A. Porco, JR., Ruichao Shen, Cheng T. Lin, Stefan Krauss