Abstract: The present invention relates to an anti-inflammatory composition comprising a graphene nano-structure as an active ingredient. Specifically, the present invention relates to a pharmaceutical composition for preventing or treating an inflammatory disease, and a cosmetic composition or feed composition for preventing or improving an inflammatory disease, which include the anti-inflammatory composition, and a method of treating an inflammatory disease, including administering the composition to a subject in need thereof.
Type:
Grant
Filed:
November 23, 2018
Date of Patent:
October 17, 2023
Assignees:
SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, BIOGRAPHENE INC.
Inventors:
Kyung-Sun Kang, Byung-Chul Lee, Jin Young Lee, Jong Bo Park
Abstract: Provided is a method for preparing a carbon-13-containing graphene quantum dot available as an MRI contrast medium, a carbon-13-containing graphene quantum dot prepared by the method, and an MRI contrast medium comprising the carbon-13 graphene quantum dot.
Type:
Application
Filed:
August 25, 2021
Publication date:
September 28, 2023
Applicants:
BIOGRAPHENE INC., SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION
Inventors:
Byung Hee HONG, Young Jin JUNG, Jong Bo PARK
Abstract: Provided is a method for prevention or treatment of a lysosomal storage disorder, and more particularly, to a method that may exhibit excellent efficacy against various lysosomal storage disorders including Niemann-Pick disease by including graphene quantum dots.
Type:
Application
Filed:
January 23, 2020
Publication date:
March 31, 2022
Applicants:
BIOGRAPHENE INC., SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION
Inventors:
Kyung-Sun KANG, Byung Hee HONG, Insung KANG, Je Min YOO, Donghoon KIM
Abstract: Provided is a graphene quantum dot as a therapeutic agent for diseases associated with abnormal fibrillation or aggregation of neuroproteins. The graphene quantum dot according to the presently claimed subject matter suppresses ?-syn fibrillation or disaggregates already formed ?-syn fibrils, and shows the working effect of passing through the blood brain barrier (BBB). Therefore, the graphene quantum dot according to the presently claimed subject matter can be advantageously used as a therapeutic agent for diseases associated with abnormal fibrillation and aggregation of neuroproteins, such as neurodegenerative diseases, inflammatory diseases, and metabolic diseases.
Type:
Application
Filed:
July 8, 2019
Publication date:
August 19, 2021
Applicants:
BIOGRAPHENE INC., SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION
Abstract: Provided is a composition capable of promoting osteogenic differentiation of stem cells, comprising, as active ingredients, a bone and cartilage progenitor cell culture solution and a multilayer graphene film, which promotes the differentiation of stem cells into specific cells, and thus is expected to be variously applicable in the in vivo/in vitro stem cell application fields.
Type:
Application
Filed:
May 14, 2019
Publication date:
June 17, 2021
Applicants:
SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION, BIOGRAPHENE INC.
Inventors:
Jeong Mook LIM, Ji Yeon AHN, Jong Bo PARK, Byung Hee HONG, Woo Sub YANG
Abstract: Provided are a culture scaffold for promoting stem cell differentiation comprising a multilayer graphene film, a method of regulating growth and differentiation of a stem cell using the culture scaffold, and a method of preparing the culture scaffold, where the culture scaffold is capable of promoting the osteogenic differentiation of stem cells as a result of laminating a graphene film without comprising an additional substance, and it may be variously applicable to application fields of stem cells in/outside the body.
Type:
Application
Filed:
April 5, 2019
Publication date:
February 4, 2021
Applicants:
Seoul National University R & DB Foundation, BIOGRAPHENE INC.
Inventors:
Byung Hee HONG, Ji Yeon AHN, Jong Bo PARK, Jeong Mook LIM, Woo Sub YANG
Abstract: The present invention relates to an anti-inflammatory composition comprising a graphene nano-structure as an active ingredient. Specifically, the present invention relates to a pharmaceutical composition for preventing or treating an inflammatory disease, and a cosmetic composition or feed composition for preventing or improving an inflammatory disease, which include the anti-inflammatory composition, and a method of treating an inflammatory disease, including administering the composition to a subject in need thereof.
Type:
Application
Filed:
November 23, 2018
Publication date:
November 19, 2020
Applicants:
SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, BIOGRAPHENE INC.
Inventors:
Kyung-Sun KANG, Byung-Chul LEE, Jin Young LEE, Jong Bo PARK