Patents Assigned to Biotek, Inc.
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Patent number: 10188859Abstract: A portable one-piece therapeutical apparatus with dual heating and low-frequency treatment functions includes a main unit having an accommodating space and a patch portion; a control means installed in the accommodating space and including a printed circuit board assembly with an operating component for controlling low-frequency pulses and a heating operation, an electrical connector installed at the front of the printed circuit board assembly for charging a battery and reading, writing and transmitting data; at least one heating means installed at the main unit and electrically coupled to the printed circuit board assembly for producing a heating effect; at least one low-frequency electrode layer disposed under the patch portion and electrically coupled to the printed circuit board assembly for transmitting low-frequency pulses; and a battery installed in the accommodating space and directly and electrically coupled to the printed circuit board assembly for supplying power to the patch therapeutical apparatuType: GrantFiled: August 3, 2018Date of Patent: January 29, 2019Assignee: HIVOX BIOTEK INC.Inventor: Wei Tuan
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Patent number: 10076662Abstract: A portable one-piece therapeutical apparatus with dual heating and low-frequency treatment functions includes a main unit having an accommodating space and a patch portion; a control means installed in the accommodating space and including a printed circuit board assembly with an operating component for controlling low-frequency pulses and a heating operation, an electrical connector installed at the front of the printed circuit board assembly for charging a battery and reading, writing and transmitting data; at least one heating means installed at the main unit and electrically coupled to the printed circuit board assembly for producing a heating effect; at least one low-frequency electrode layer disposed under the patch portion and electrically coupled to the printed circuit board assembly for transmitting low-frequency pulses; and a battery installed in the accommodating space and directly and electrically coupled to the printed circuit board assembly for supplying power to the patch therapeutical apparatuType: GrantFiled: October 26, 2015Date of Patent: September 18, 2018Assignee: HIVOX BIOTEK INC.Inventor: Wei Tuan
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Patent number: 8463388Abstract: An electronic low-frequency pulse patch of a one-piece structure comprises a flexible top cover body, a hollow supporting enclosure, a circuit control unit, a power supply unit, a base and a coupling output conductive flexible film. Flexible top cover body is coupled to the coupling output conductive flexible film with hollow supporting enclosure located therebetween. Circuit control unit and the power supply unit are coupled to the base for providing respective low-frequency electric pulses. Electrical conduction is accomplished by electrically connecting the first and the second conductive ends of the base to respective conductive contact lugs of the coupling output conductive flexible film. At either side of which, first and second low-frequency pulse output regions are disposed, such that the electronic low-frequency pulse patch is bendable for conforming to curvature at different locations of the human body without using screw or other means.Type: GrantFiled: March 9, 2010Date of Patent: June 11, 2013Assignee: Hivox Biotek Inc.Inventor: Tuan Wei
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Publication number: 20110224754Abstract: An electronic low-frequency pulse patch of a one-piece structure is disclosed, which has a power supply and a circuit capable of outputting positive and negative current pulses concealed therein, and in which, without use of a flexible ribbon cable set and an additional fastener, a host unit and a coupling conductive patch unit assembly are joined together with the appearance to form a one-piece seamless water-proof structure for use as a self-adhesion patch device capable of generating a low-frequency pulse output.Type: ApplicationFiled: March 9, 2010Publication date: September 15, 2011Applicant: HIVOX BIOTEK INC.Inventor: Tuan WEI
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Patent number: 7157102Abstract: A multi-layered microcapsule containing one or more active ingredients and process for preparing the same is disclosed. The multi-layered microcapsule comprises an inner solid microparticle core, typically composed of a biodegradable polymer, and having one or more alternating layers of polymer, active ingredient or polymer/active ingredient mixtures to produce a multi-layered microcapsule wherein the polymer or active ingredient in each layer may be the same or different or have the same or different concentration of the polymer or active ingredient in other layers.Type: GrantFiled: May 31, 2002Date of Patent: January 2, 2007Assignee: Biotek, Inc.Inventor: Elie S. Nuwayser
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Patent number: 7041320Abstract: Methods and compositions to induce opioid drug independence in opioid drug dependent individuals comprising administering opioid agonists and/or antagonists encapsulated in biodegradable polymer microspheres in a dosage formulation.Type: GrantFiled: May 31, 2002Date of Patent: May 9, 2006Assignee: Biotek, Inc.Inventor: Elie S. Nuwayser
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Patent number: 5648097Abstract: A novel method of producing biodegradable microparticles is disclosed. Inorganic calcium salts are mixed with water to form a slurry. The slurry is then added to an oil bath which is then mixed to form an emulsion. The mixing continues for a period of time sufficient to form hardened microparticles. The hardened microparticles are then retrieved and characterized. Biologically active agents may be added to the slurry prior to emulsification, or they may be added to the hardened microparticles after production. The microparticles may be injected into a human being whereby they act as controlled release drug delivery vehicles.Type: GrantFiled: October 4, 1995Date of Patent: July 15, 1997Assignee: Biotek, Inc.Inventor: Elie S. Nuwayser
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Patent number: 5556757Abstract: Peptides comprising a Meningitis Related Homologous Antigenic Sequence (MRHAS) are provided. The MRHAS is found in meningitis-causing organisms and chemokines involved in cell chemotaxis. The peptides are useful as antigens and vaccines for detection, diagnosis and treatment of meningitis.Type: GrantFiled: June 7, 1995Date of Patent: September 17, 1996Assignee: Insight Biotek, Inc.Inventors: Diane V. Alstyne, Lawrence R. Sharma
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Patent number: 4927687Abstract: A transdermal drug delivery system useful for the controlled, for example zero order release of one or more drugs to a selected skin area of a user, which system comprises an impervious backing sheet and a face membrane, the backing sheet and membrane secured together to form an intermediate reservoir. The face membrane is a macroporous membrane which has pores of sufficient size to avoid any rate control of the drug to be transdermally delivered to the user. The reservoir contains a viscous liquid base material selected to exude from the membrane to form a film and to occlude the skin of the user to force hydration of the stratum corneum with water from the lower layers of the epidermis of the user and a plurality of solid microparticles generally uniformly dispersed and suspended in the liquid base material. The microparticles containing an effective therapeutic amount of the drug for transdermal delivery, such as the contraceptive steroid.Type: GrantFiled: September 22, 1986Date of Patent: May 22, 1990Assignee: Biotek, Inc.Inventor: Elie S. Nuwayser
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Patent number: 4834978Abstract: A transdermal drug delivery system useful for the controlled, for example, zero order, release of one or more drugs to a selected skin area of a user, which system comprises a reservoir containing a transdermal delivery composition. The reservoir contains a composition which comprises a base material, which is a solid but which melts or liquefies upon contact with the skin of a user and selected to occlude the skin of the user to force hydration of the stratum corneum with water from the lower layers of the epidermis of the user and a plurality of solid microparticles, generally uniformly dispersed and suspended in the base material, the microparticles containing an effective, therapeutic amount of the drug for transdermal delivery, such as the contraceptive steroid.Type: GrantFiled: February 8, 1988Date of Patent: May 30, 1989Assignee: BIOTEK, Inc.Inventor: Elie S. Nuwayser
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Patent number: 4810499Abstract: A transdermal drug delivery system which system comprises an impervious backing sheet and face membrane, the backing sheet and membrane secured together to form an intermediate reservoir. The face membrane is a macroporous membrane which has pores of sufficient size to avoid any rate control of the drug to be transdermally delivered to the user. The reservoir contains a viscous liquid base material selected to exude from the membrane to form a film and to occlude the skin of the user to force hydration of the stratum corneum with water from the lower layers of the epidermis of the user. The liquid base material contains an effective, therapeutic amount of the drug for transdermal delivery, such as the contraceptive steroid, which drug is highly soluble in the liquid base material.Type: GrantFiled: February 5, 1988Date of Patent: March 7, 1989Assignee: Biotek, Inc.Inventor: Elie S. Nuwayser
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Patent number: 4707362Abstract: A vehicle which provides rapid release of a drug and prolonged release of a drug is disclosed.Type: GrantFiled: February 15, 1985Date of Patent: November 17, 1987Assignee: Biotek, Inc.Inventor: Elie S. Nuwayser
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Patent number: 4687481Abstract: A transdermal drug delivery system useful for the controlled, for example zero order release of one or more drugs to a selected skin area of a user, which system comprises an impervious backing sheet and a face membrane, the backing sheet and membrane secured together to form an intermediate reservoir. The face membrane is a macroporous membrane which has pores of sufficient size to avoid any rate control of the drug to be transdermally delivered to the user. The reservoir contains a viscous liquid base material selected to exude from the membrane to form a film and to occlude the skin of the user to force hydration of the stratum corneum with water from the lower layers of the epidermis of the user and a plurality of solid microparticles generally uniformly dispersed and suspended in the liquid base material. The microparticles containing an effective therapeutic amount of the drug for transdermal delivery, such as the contraceptive steroid.Type: GrantFiled: March 3, 1986Date of Patent: August 18, 1987Assignee: BIOTEK, Inc.Inventor: Elie S. Nuwayser
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Patent number: 4624665Abstract: A transdermal drug delivery system useful for the controlled, for example zero order, release of one or more drugs to a selected skin area of a user, which system comprises an impervious backing sheet and a face membrane, the backing sheet and membrane secured together to form an intermediate reservoir. The face membrane is a macroporous membrane which has pores of sufficient size to avoid any rate control of the drug to be transdermally delivered to the user. The reservoir contains a viscous liquid base material selected to exude from the membrane to form a film and to occlude the skin of the user to force hydration of the stratum corneum with water from the lower layers of the epidermis of the user and a plurality of solid microparticles generally uniformly dispersed and suspended in the liquid base material. The microparticles containing an effective therapeutic amount of the drug for transdermal delivery, such as the contraceptive steroid.Type: GrantFiled: October 1, 1984Date of Patent: November 25, 1986Assignee: Biotek, Inc.Inventor: Elie S. Nuwayser
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Patent number: 4623588Abstract: A process for preparing coated microparticles, which process comprises preparing a solvent solution of an active ingredient to be encapsulated and a film-forming polymer, removing the solvent to provide a dry, composite, uniform admixture of the active ingredient and the polymer material, reducing the composite admixture to a defined smaller particle size distribution, coating the reduced composite core particles in a fluidized bed, with a uniform defined wall thickness of the same or substantially the same film-forming polymer material to provide composite core coated microparticles.Type: GrantFiled: December 2, 1985Date of Patent: November 18, 1986Assignee: Biotek, Inc.Inventors: Elie S. Nuwayser, William A. Nucefora
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Patent number: 4568559Abstract: A process for preparing coated microparticles, which process comprises preparing a solvent solution of an active ingredient to be encapsulated and a film-forming polymer, removing the solvent to provide a dry, composite, uniform admixture of the active ingredient and the polymer material, reducing the composite admixture to a defined smaller particle size distribution, coating the reduced composite core particles in a fluidized bed, with a uniform defined wall thickness of the same or substantially the same film-forming polymer material to provide composite core coated microparticles.Type: GrantFiled: February 6, 1984Date of Patent: February 4, 1986Assignee: Biotek, Inc.Inventors: Elie S. Nuwayser, William A. Nucefora
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Patent number: 4525164Abstract: A wearable medicator suitable for controlled subcutaneous dispensing of a liquid medication into a patient. The medicator utilizes a unique arcuate syringe means to provide a small compact medicator that can be easily worn by the patient. The medicator can provide controlled release of insulin for the treatment of diabetes.Type: GrantFiled: April 24, 1981Date of Patent: June 25, 1985Assignee: Biotek, Inc.Inventors: Marvin P. Loeb, Arne M. Olson
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Patent number: 4403984Abstract: A system is disclosed for demand-based administration of insulin which utilizes a change in a physical property of a patient's body fluid as an indicator that a change in the body fluid glucose level has occurred and that an appropriate amount of insulin should be supplied to the patient. Body fluid osmolality or one of its colligative properties are particularly suitable for this purpose. A second sensor for measuring such properties as electrical conductivity may be added to detect changes in osmolality caused by such factors as dehydration. Insulin can be delivered to the patient from an extracorporeal source by means of a dual lumen catheter. One lumen of the catheter provides a passageway for the insulin dose and the other lumen provides a passageway through which a replaceable sensors can be introduced into or removed from the patient's body. In the alternative, the entire insulin administration system can be implanted into the patient.Type: GrantFiled: December 22, 1980Date of Patent: September 13, 1983Assignee: Biotek, Inc.Inventors: Stephen R. Ash, Marvin P. Loeb
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Patent number: 4402694Abstract: A body cavity access device for supplying a hormone to a patient including an implantable housing placed in the body and having an impermeable extracorporeal segment and a semipermeable subcutaneous segment. A hormone source such as live, hormone-producing cells, e.g., pancreatic islet cells is then removably positioned in the housing to provide a hormone supply to the patient. A sensor can be located within the subcutaneous segment and operably associated with a dispenser to release medication into the housing and to the patient.Type: GrantFiled: July 16, 1981Date of Patent: September 6, 1983Assignee: Biotek, Inc.Inventors: Stephen R. Ash, Marvin P. Loeb
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Patent number: 4378016Abstract: An artifical endocrine gland for supplying a hormone to a patient including an implantable housing placed in the body and having an impermeable extracorpeal segment and a semipermeable subcutaneous segment. A replaceable envelope containing live hormone-producing cells such as pancreatic islet cells is then removably positioned in the housing to provide hormones to the patient.Type: GrantFiled: July 15, 1981Date of Patent: March 29, 1983Assignee: Biotek, Inc.Inventor: Marvin P. Loeb