Patents Assigned to Centre Europeen de Recherches Mauvernay
  • Patent number: 4430332
    Abstract: The invention is dealing with compounds of the formula: ##STR1## and pharmaceutically acceptable salts thereof, in which R.sub.1 and R.sub.2 each represent a lower alkyl radical or a phenyl radical, or, together with the carbon atom to which they are bound, a cycloalkyl radical having at the most 7 carbon atoms; R.sub.3 represents hydrogen, a lower alkyl radical, or the phenyl radical; R.sub.4 and R.sub.5 each represent a lower alkyl radical, or, together with the nitrogen atom to which they are bound, a heterocyclic amino radical such as the pyrrolidinyl or morpholino radicals; and R.sub.6 represents a lower alkyl radical, a phenyl radical, a benzyl radical, or the 1-ethynyl-cyclohexyl radical, which compounds can be used in the treatment of angina pectoris.
    Type: Grant
    Filed: December 19, 1980
    Date of Patent: February 7, 1984
    Assignee: Centre Europeen de Recherches Mauvernay
    Inventors: Patrick Carlier, Andre J. C. Monteil, Jacques A. L. Simond
  • Patent number: 4218473
    Abstract: The present invention relates to derivatives of 4-cyclohexyl-1-naphthalene-acetic acid of formula ##STR1## wherein R is a lower alkyl group and pharmaceutically acceptable salts and derivatives thereof the invention also relates to pharmaceutic compositions containing such derivatives.These derivatives are useful as drugs, notably for the treatment of inflammatory syndromes.
    Type: Grant
    Filed: September 26, 1978
    Date of Patent: August 19, 1980
    Assignee: Centre Europeen de Recherches Mauvernay
    Inventors: Jean-Jacques Godfroid, Efroim Steiner
  • Patent number: 4105785
    Abstract: Substituted methyl-2-[(dimethylamino-3')propylidene]-4-dihydro-9,10-benzo-[4,5]cyclohe pta[1,2-b]-furan compounds are described which are useful in the treatment of depressive syndromes and which may be obtained by cyclization from substituted derivatives of furan.
    Type: Grant
    Filed: March 16, 1977
    Date of Patent: August 8, 1978
    Assignee: Centre Europeen de Recherches Mauvernay
    Inventors: Roland Y. Mauvernay, Norbert Busch, Jacques Moleyre
  • Patent number: 4086352
    Abstract: The invention relates to novel 6-aryloxy-2-oxo-1-aza-4-(or thia)-spiro[4,5]decane compounds. These compounds are represented by the formula: ##STR1## in which A stands for an oxygen or sulfur heteroatom; R.sub.1 and R.sub.2 are each H, lower alkyl or aryl such as phenyl; X is H, a halogen atom such as chlorine or fluorine or a lower alkyl.Compounds according to the invention are useful as stimulating agents for vigilance, as psycho-stimulators and genesic stimulators.
    Type: Grant
    Filed: August 25, 1970
    Date of Patent: April 25, 1978
    Assignee: Centre Europeen de Recherches Mauvernay
    Inventors: Roland Yves Mauvernay, Norbert Busch, Jacques Moleyre, Jacques Simond, Andre Monteil
  • Patent number: 4086216
    Abstract: A process for obtaining an anti-viral substance, useful in herpetiform diseases, from Psalliota Xanthoderma is described.
    Type: Grant
    Filed: December 2, 1975
    Date of Patent: April 25, 1978
    Assignee: Centre Europeen de Recherches Mauvernay "C.E.R.M."
    Inventors: Roland-Yves Mauvernay, Henri-Jean Pourrat, Jean-Louis Lamaison
  • Patent number: 4062956
    Abstract: 2-(2-Hydroxyethyl)tetrahydro-1,4-oxazines and quaternary salts thereof having the formula: ##STR1## WHEREIN Ar and Ar.sub.1 are the same or different and are unsubstituted and substituted aryl, said substituent being a halogen atom, R represents a lower alkyl group having from 1 to 4 carbon atoms, R.sub.1 is zero when X.sup.(-) is zero or is an alkyl group of from 1 to 4 carbon atoms which is the same or different from R, as defined above, and X.sup.(-) is zero when R.sub.1 is zero or is selected from the group consisting of Cl.sup.(-), Br.sup.(-), I.sup.(-) and CH.sub.3 SO.sub.4.sup.(-) when R.sub.1 is lower alkyl, as defined above, is described. These compounds are useful for treating spasmodic syndromes.
    Type: Grant
    Filed: September 16, 1976
    Date of Patent: December 13, 1977
    Assignee: Centre Europeen de Recherches Mauvernay
    Inventors: Roland Yves Mauvernay, Norbert Busch, Jacques Moleyre, Jacques Simond, Andre Monteil
  • Patent number: 4035498
    Abstract: Compounds of the formula: ##STR1## wherein R is a lower alkyl group, X is oxygen or the group --(CH.sub.2).sub.n -- where n is 0 or 1, having bronchospasmolytic activity, are described.
    Type: Grant
    Filed: September 29, 1975
    Date of Patent: July 12, 1977
    Assignee: Centre Europeen de Recherches Mauvernay
    Inventors: Roland Yves Mauvernay, Norbert Busch, Jacques Moleyre, Jacques Simond, Andre Monteil
  • Patent number: 4033818
    Abstract: The invention provides a process for the preparation of a complete extract of pilewort roots, used in cosmetological compositions, which consists of first subjecting the dried and ground roots to an extraction with 35.degree.-45.degree. C petroleum ether and then treating the insoluble powder by extraction with an aqueous lower alcohol. After having removed the insoluble impurities by filtration, the filtrate is treated with papaine and is concentrated to a solids content of 40 to 50%. Aqueous alcohol is then added to the concentrated extract and the deposit thus formed is removed by decantation when cold, leaving the desired extract.
    Type: Grant
    Filed: July 15, 1976
    Date of Patent: July 5, 1977
    Assignee: Centre Europeen de Recherches Mauvernay C.E.R.M.
    Inventors: Henri Pourrat, Aimee Pourat nee Gaillard
  • Patent number: 4011240
    Abstract: This invention relates to a new group of substituted cysteines having the general formula: ##STR1## in which: Ar is an aromatic or heteromonocyclic group, such as 2-thienyl or phenyl, which may be substituted by a halogen atom or by a lower alkyl or alkoxy group, and R is a hydrogen atom or a lower alkyl group.These compounds are of use in human therapeutics as liquifiers for bronchal secretions in complaints of the respiratory passage and, in particular, in chronic bronchitis.The invention also relates to a method of preparing these compounds and to the application of these compounds, particularly in human therapeutics.
    Type: Grant
    Filed: October 12, 1972
    Date of Patent: March 8, 1977
    Assignee: Centre Europeen de Recherches Mauvernay (CERM)
    Inventors: Roland-Yves Mauvernay, Andre Monteil, Jacques Simond, Jacques Moleyre, Norbert Busch
  • Patent number: 3962238
    Abstract: Ethers of n-propanolamine, preparation thereof and their use in treatment of cardiovascular conditions.
    Type: Grant
    Filed: February 27, 1973
    Date of Patent: June 8, 1976
    Assignee: Centre Europeen de Recherches Mauvernay "CERM"
    Inventors: Roland Yves Mauvernay, Norbert Busch, Jacques Moleyre, Andre Monteil, Jacques Simond
  • Patent number: 3936450
    Abstract: Tetra-substituted ethylenes having the general formula ##EQU1## in which R is selected from the group consisting of alkyl radicals containing 1 to 4 carbon atoms and ##SPC1## AND A is selected from the group consisting of ##EQU2## and salts thereof with pharmacologically acceptable acids are useful as anti-inflammatory agents.
    Type: Grant
    Filed: February 7, 1973
    Date of Patent: February 3, 1976
    Assignee: Centre Europeen de Recherches Mauvernay "C.E.R.M."
    Inventors: Roland Yves Mauvernay, Norbert Bush, Jacques Simond, Andre Monteil, Jacques Moleyre
  • Patent number: RE29902
    Abstract: 6-Aryloxy-2-oxo-1-aza-4-oxa (or thia)-spiro[ 4,5]decane compounds. These compounds are represented by the formula ##STR1## in which A stands for an oxygen or sulfur heteroatom; R.sub.1 and R.sub.2 are each H, lower alkyl or aryl such as phenyl; X is H, a halogen atom such as chlorine or fluorine or a lower alkyl. Compounds according to the invention are useful as stimulating agents for vigilance, as psycho-stimulators and genesic stimulators.
    Type: Grant
    Filed: October 17, 1977
    Date of Patent: February 6, 1979
    Assignee: Centre Europeen de Recherches Mauvernay
    Inventors: Roland Y. Mauvernay, Norbert Busch, Jacques Moleyre, Jacques Simond, Andre Monteil
  • Patent number: RE30577
    Abstract: .[.Ethers.]. .Iadd.An ether .Iaddend.of n-propanolamine, preparation thereof and .[.their.]. .Iadd.its .Iaddend.use in treatment of cardiovascular conditions.
    Type: Grant
    Filed: February 27, 1979
    Date of Patent: April 14, 1981
    Assignee: Centre Europeen de Recherches Mauvernay
    Inventors: Norbert Busch, Jacques Simond, Andre Monteil, Jacques Moleyre, Roland Y. Mauvernay