Patents Assigned to Cephalon France
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Publication number: 20130123499Abstract: The present invention relates a method for purifying a fused pyrrolocarbazole compound known as 11-isobutyl-2-methyl-8-(2-pyrimidinylamino)-2,5,6,11,12,13-hexahydro-4Hindazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one using an acid complex thereof. The present invention also relates to a crystalline form of the acid complex.Type: ApplicationFiled: November 16, 2012Publication date: May 16, 2013Applicants: CEPHALON FRANCE, CEPHALON, INC.Inventors: Cephalon, Inc., Cephalon France
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Publication number: 20130066111Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein n, Y, R1, R1a, R2 and R2a are as defined in claim 1.Type: ApplicationFiled: November 1, 2012Publication date: March 14, 2013Applicant: CEPHALON FRANCEInventors: Cephalon France, Veronique Courvoisier
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Patent number: 8318979Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein n, Y, R1, R1a, R2 and R2a are as defined in claim 1.Type: GrantFiled: March 24, 2011Date of Patent: November 27, 2012Assignee: Cephalon FranceInventors: Laurent Courvoisier, Veronique Courvoisier, legal representative, Gerard Duret, Stephanie Graf, Laurence Prat-Lacondemine, Francois Rebiere, Nicolas Sabourault
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Patent number: 8314155Abstract: The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith.Type: GrantFiled: June 20, 2008Date of Patent: November 20, 2012Assignees: Cephalon, Inc, Cephalon FranceInventors: Edward R. Bacon, Sankar Chatterjee, Mohamed Iqbal, Brigitte Lesur, Philippe Louvet
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Publication number: 20120252795Abstract: The present invention relates to novel oral pharmaceutical compositions in lyophilized form, in which the dissolution and the bioavailability of the active ingredient that they contain are improved. The compositions according to the invention comprise in particular a polyvinyl acetate/polyvinylpyrrolidone copolymer. The oral lyophilisates according to the invention are particularly suitable for the production of medicaments based on active ingredients which have low solubility or very low solubility in water or which are virtually insoluble in water.Type: ApplicationFiled: June 4, 2012Publication date: October 4, 2012Applicant: CEPHALON FRANCEInventor: Thanh-Tam Nguyen
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Publication number: 20120245156Abstract: The present invention relates to a method for preparing an oral lyophilizate composition comprising: a) forming a liquid phase by using at least one homogenising agent having tensioactive properties, said liquid phase comprising at least an active pharmaceutical ingredient, a filler and/or a binding agent and a solvent, b) lyophilizing said liquid phase to form the oral lyophilizate composition.Type: ApplicationFiled: June 4, 2012Publication date: September 27, 2012Applicant: CEPHALON FRANCEInventor: Thanh-Tam Nguyen
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Publication number: 20120238551Abstract: The present invention provides compounds of formula I: their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceutical compositions thereof.Type: ApplicationFiled: December 22, 2011Publication date: September 20, 2012Applicants: Cephalon France, Cephalon, Inc.Inventors: Edward R. Bacon, Thomas R. Bailey, Sankar Chatterjee, Derek D. Dunn, Greg A. Hostetler, Robert L. Hudkins, Brigitte Lesur, Babu G. Sundar, Allizon L. Zulli, Christophe Yue
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Publication number: 20120123161Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein n, Y, R1, R1a, R2 and R2a are as defined in claim 1.Type: ApplicationFiled: March 24, 2011Publication date: May 17, 2012Applicant: CEPHALON FRANCEInventors: Laurent Courvoisier, Veronique Courvoisier, Gerard Duret, Stephanie Graf, Laurence Prat-Lacondemine, Francois Rebiere, Nicolas Sabourault
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Publication number: 20120035133Abstract: Lyophilized cakes of proteasome inhibitors are described, as well as methods for their production and use.Type: ApplicationFiled: September 29, 2011Publication date: February 9, 2012Applicants: CEPHALON FRANCE, CEPHALON, INC.Inventors: Denis Bricout, Helene Cambourieux, Michael L. Cappola, Nicole Frati, Piyush R. Patel
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Patent number: 8071604Abstract: The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein Ar, X, Y, R1, R2, R3, and q are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness, promotion of wakefulness, treatment of Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, treatment of attention deficit hyperactivity disorder (“ADHD”), enhancing function in disorders associated with hypofunctionality of the cerebral cortex, including, but not limited to, depression, schizophrenia, fatigue, in particular, fatigue associated with neurologic disease, such as multiple sclerosis, chronic fatigue syndrome, and improvement of cognitive dysfunction.Type: GrantFiled: November 8, 2007Date of Patent: December 6, 2011Assignees: Cephalon France, Cephalon, Inc.Inventors: Brigitte Lesur, Philippe Louvet, Rabindranath Tripathy
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Publication number: 20110229578Abstract: The invention concerns an oral lyophilizate comprising modafinil particles having a median diameter of about 10 to about 1000 ?m in association with an appropriate amount of at least one excipient selected from the group consisting of fatty acid esters of glycerol, cyclic oligosaccharides, sweeteners or mixtures thereof.Type: ApplicationFiled: April 26, 2011Publication date: September 22, 2011Applicant: CEPHALON FRANCEInventors: Thanh-Tam Nguyen, Joëolle Leyder
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Publication number: 20110224436Abstract: The present invention relates to a method for regioselectively reducing the maleimide compounds of formula (I). The invention also relates to C7 hydroxy lactam regioisomers of formula (II) obtainable by this method and their use for the preparation of lactams of formula (III) which are particularly useful as intermediate for the synthesis of fused pyrrolocarbazoles.Type: ApplicationFiled: May 11, 2011Publication date: September 15, 2011Applicant: CEPHALON FRANCEInventor: Laurence Prat-Lacondemine
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Patent number: 7981907Abstract: The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl-methanesulfinyl acetamides of Formula (I): wherein Ar, Y, R1, R2, R4, R5, q and x are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness associated with narcolepsy, obstructive sleep apnea, or shift work disorder; Parkinson's disease; Alzheimer's disease; attention deficit disorder; attention deficit hyperactivity disorder; depression; or fatigue associated with a neurological disease; as well as the promotion of wakefulness.Type: GrantFiled: August 27, 2008Date of Patent: July 19, 2011Assignees: Cephalon, Inc., Cephalon FranceInventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, Marie-Edith Gourdel, Greg Hostetler, Mohamed Iqbal, Brigitte Lesur, Philippe Louvet, Eric Riguet, Dominique Schweizer, Christophe Yue
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Publication number: 20110098505Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein Ar, Y, R1 are as defined in claim 1.Type: ApplicationFiled: January 4, 2011Publication date: April 28, 2011Applicant: CEPHALON FRANCEInventors: Laurence Prat, Olivier Neckebrock, Dominique Schweizer, Philippe Louvet
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Patent number: 7915449Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein n, Y, R1, R1a, R2 and R2a are as defined.Type: GrantFiled: March 18, 2008Date of Patent: March 29, 2011Assignee: Cephalon FranceInventors: François Rebiere, Gérard Duret, Laurence Prat
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Patent number: 7893111Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein Ar, Y, R1 are as defined in claim 1.Type: GrantFiled: March 13, 2006Date of Patent: February 22, 2011Assignee: Cephalon FranceInventors: Laurence Prat, Olivier Neckebrock
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Patent number: 7812193Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I); wherein n, Y, R1, R1a, R2 and R2a are as defined herein.Type: GrantFiled: October 30, 2007Date of Patent: October 12, 2010Assignee: Cephalon FranceInventors: Francois Rebiere, Gerard Duret, Laurence Prat
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Patent number: 7772237Abstract: The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein Ar, Y, R1 and q are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness, promotion of wakefulness, treatment of Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, treatment of attention deficit hyperactivity disorder (“ADHD”), enhancing function in disorders associated with hypofunctionality of the cerebral cortex, including, but not limited to, depression, schizophrenia, fatigue, in particular, fatigue associated with neurologic disease, such as multiple sclerosis, chronic fatigue syndrome, and improvement of cognitive dysfunction.Type: GrantFiled: December 12, 2008Date of Patent: August 10, 2010Assignee: Cephalon FranceInventors: Sophie Chasset, Brigitte Lesur, Olivier Renault, Christophe Yue
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Publication number: 20100080829Abstract: The present invention relates to a new lyophilized pharmaceutical composition capable of adhering to oral mucosal tissue for an extended period of time for delivering active pharmaceutical ingredient through the oral mucosal tissue using transmucosal absorption.Type: ApplicationFiled: October 1, 2009Publication date: April 1, 2010Applicants: CEPHALON FRANCE, CEPHALON, INC.Inventors: Claire Dulieu, Steve Durfee, Richard J. Holl, Tam Nguyen
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Publication number: 20100048719Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 12.31, 8.54, 7.27 and 3.62 ?, and a process for the preparation thereof.Type: ApplicationFiled: July 22, 2009Publication date: February 25, 2010Applicant: Cephalon FranceInventors: Olivier Neckebrock, Laurent Courvoisier, Stephanie Graf, Gilles Serrure, Gerard Francois Coquerel, Sebastien Rose, Christine Besselievre, Franck Patrick Mallet, Adriaan Jan Van Langevelde