Abstract: Electronic devices and methods for reading an output signal and controlling a three-electrode electro-chemical amperometric sensor include an operational amplifier having a non-inverting input adapted to receive a biasing electric potential and an inverting input connectable to a reference electrode of the sensor. The devices further include one or more MOS transistors connected to the operational amplifier, with a first MOS transistor connectable to the collector electrode of the sensor to receive or supply a MOS transistor channel current representative of the cell current generated in the sensor, and a second MOS transistor connectable to a reference voltage by a conductor or a resistor. The resistance is lower than the cell impedance such that the current in the second MOS transistor channel depends on the current in the first MOS transistor channel through a nonlinear gain dependent on the resistor.

Abstract: Formulations are described, containing silibinin or other active ingredients incorporated in lipid nanoparticle systems of the SLN and NLC type, and based on calixarenes, possibly mucoadhesive, or in micellar and nanoparticle systems based on amphiphilic inulin copolymers for use in the treatment of neurodegenerative ocular diseases. The versatility of the calixarene compound is also described, capable of charging and releasing active ingredients characterized by low water solubility, easy chemical and enzymatic degradation, low bioavailability, either of natural origin or not, to be used in the treatment of ocular diseases.

Abstract: Described herein are loaded nanoparticles of Sorafenib (Sorafenib PBB) or Sorafenib derivatives (Sorafenib PBB derivatives), wherein the nanoparticles are polymeric PBB nanoparticles, (PHEA-BIB-pButMA, ?,?-poly(N-2-hydroxyethyl)-co-{N-2-ethylene-[2-(poly(butylmethacrylate)-isobutyrate]}-D, L-aspartamide, as well as a method for obtaining them. Also described herein are a controlled release formulation of Sorafenib or Sorafenib, derivatives that include Sorafenib PBB or Sorafenib PBB derivatives, and to the use of the formulation in the treatment of tumor diseases of the kidney, liver, thyroid, colon, breast, pancreas, lungs and/or recurrent glioblastoma.

Abstract: Formulations are described, containing silibinin or other active ingredients incorporated in lipid nanoparticle systems of the SLN and NLC type, and based on calixarenes, possibly mucoadhesive, or in micellar and nanoparticle systems based on amphiphilic inulin copolymers for use in the treatment of neurodegenerative ocular diseases. The versatility of the calixarene compound is also described, capable of charging and releasing active ingredients characterized by low water solubility, easy chemical and enzymatic degradation, low bioavailability, either of natural origin or not, to be used in the treatment of ocular diseases.

Abstract: Formulations are described, containing silibinin or other active ingredients incorporated in lipid nanoparticle systems of the SLN and NLC type, and based on calixarenes, possibly mucoadhesive, or in micellar and nanoparticle systems based on amphiphilic inulin copolymers for use in the treatment of neurodegenerative ocular diseases. The versatility of the calixarene compound is also described, capable of charging and releasing active ingredients characterized by low water solubility, easy chemical and enzymatic degradation, low bioavailability, either of natural origin or not, to be used in the treatment of ocular diseases.

Abstract: There is described an electronic interface device (1) for reading an output signal and controlling and conditioning a three-electrode amperometric sensor (S). The device (1) may be used with a sensor having an electro-chemical cell comprising a reference electrode (RE) configured to supply a constant cell electric potential to the electrochemical cell; a working electrode (WE) at which oxidation or reduction reactions occur, connectable to a first reference voltage; and a collector electrode (CE) configured to deliver or receive electric charge carriers. In the electro-chemical cell, a cell impedance (Zcw) is always present between the working electrode (WE) and the collector electrode (CE). The device (1) comprises an operational amplifier (U), having a non-inverting input (u1), adapted to receive a biasing electric potential (VBIAS) depending on the type of electrochemical reaction of the sensor, and an inverting input (u2) connectable to the reference electrode (RE) of the sensor.

Abstract: A microreactor includes: a substrate (2; 102; 202) made of semiconductor material; a plurality of wells (5; 105; 205) separated by walls (6; 106; 206) in the substrate (2; 102; 202); a dielectric structure (7; 107; 207a, 207b) coating at least the top of the walls (6; 106; 206); a cap (3; 103; 203), bonded to the substrate (2; 102; 202) and defining a chamber (10; 110; 210) above the wells (5; 105; 205); and a biasing structure (2, 8, 13; 102, 108, 113; 202, 208a, 208b, 213), configured for setting up a voltage (VB) between the substrate (2; 102; 202) and the chamber (10; 110; 210).