Abstract: A composition, workout/exercise supplement, treatment method for conditions associated with vasoconstriction, and method of extracting galloylated procyanidins. The composition includes galloylated procyanidins having a preponderance of (?)-epicatechins. The treatment methods include administering a therapeutically effective amount of galloylated procyanidins having a preponderance of (?)-epicatechins. The extraction methods include isolating galloylated procyanidins having a preponderance of (?)-epicatechins from a sample that contains polyphenols, catechins, epicatechins, and galloylated epicatechins.
Type:
Application
Filed:
August 9, 2023
Publication date:
April 4, 2024
Applicants:
UNIVERSITY OF SOUTH FLORIDA, ENCORE IP MANAGEMENT, LLC
Inventors:
Michael Louis Sperduti, Matthew Cleary Nickerson, Jimmy Roy Huddleston, Leigh Anthony West
Abstract: The present disclosure is directed to compositions, methods of use, and methods of making, wherein the compositions contain one or more galloylated procyanidins having between two and five epicatechin monomers, wherein the one or more galloylated procyanidins include epicatechin-(4-8)-epicatechin-(4-8)-epicatechin-gallate, catechin trimer gallate, catechin dimer digallate, or combinations thereof.
Type:
Grant
Filed:
March 14, 2019
Date of Patent:
September 26, 2023
Assignees:
University of South Florida, Encore IP Management, LLC
Inventors:
Michael Louis Sperduti, Matthew Cleary Nickerson, Jimmy Roy Huddleston, Leigh Anthony West