Abstract: Pharmaceutical formulations are disclosed, adapted for preparing solid oral dosage forms (tablets, capsules, lozenges, etc.) having a regular and sustained release after administration. Said formulations comprise one or more active substances and a retarding base or matrix consisting of a polysaccharide of natural origin, alone or mixed with one or more natural or synthetic polymers which may be used to modify the release pattern so as to obtain a therapeutically effective formulation.

Abstract: The invention relates to a method by which it is possible to prepare a formulation consisting of thickening or suspending agents and other excipients, having the property of dispersing and dissolving quickly in water or aqueous vehicles, without clot formation, with which it is possible to prepare an extermoraneous homogeneous suspension of solid particles and more particularly of micro-encapsulated drugs, which otherwise have the tendency to precipitate or float.

Abstract: The object of the present invention is a process which permits the increase of the bioavailability in the solid formulations of nifedipine and its derivatives. In consists in dissolving the active substance together with a polyethylene glycol, in a common solvent, then absorbing this solution on a micronized, inert excipient, soluble in the gastrointestinal juices, and finally, co-precipitating the active substance and the polyethylene glycol by evaporating the solvent.The very large surface of the excipient on which the solution is absorbed, and the presence of polyethylene glycol, which facilitate the homogeneous distribution of the solution on this surface, permit the active substance to precipitate and become very fine particles.

Abstract: The present invention relates to obtaining isosorbide-5-mononitrate tablets, being also of retard form, which are stable in time. Such embodiment is now possible after the discovery of the stabilizing activity of the with respect to the isosorbide-5-mononitrate with which it forms a solid solution. The use of PVP is essential so that the tablets can remain stable in time: the retard effect in turn can be obtained with the use of hydroxyalkylcelluloses.