Abstract: The present technology relates to depots for the treatment of postoperative pain via sustained, controlled release of a therapeutic agent. In some embodiments, the depot may comprise a therapeutic region comprising an analgesic, and a control region comprising a bioresorbable polymer and a releasing agent mixed with the polymer. The releasing agent may be configured to dissolve when the depot is placed in vivo to form diffusion openings in the control region. The depot may be configured to be implanted at a treatment site in vivo and, while implanted, release the therapeutic agent at the treatment site for no less than 3 days.
Type:
Grant
Filed:
November 10, 2021
Date of Patent:
April 30, 2024
Assignee:
Foundry Therapeutics, Inc.
Inventors:
Karun D. Naga, Hanson S. Gifford, III, Stephen W. Boyd, Patrick H. Ruane, Jackie Joe Hancock, Michael Feldstein, Koon Kiat Teu, Honglei Wang, Jingnan Luo, Daniel Boon Lim Seet
Abstract: There is provided a controlled-release antibiotic socket for securely holding an implantable medical device that is made from: at least one film having at least one polymer layer, where the at least one film is formed into the socket; at least one antibiotic agent; and at least one opening in the socket, where the at least one polymer layer comprises a biodegradable elastomeric polymeric material; and the at least one antibiotic agent is dispersed within at least one of the at least one polymer layers and/or, when the film comprises at least two polymer layers, the at least one antibiotic agent is disposed as a separate layer between two polymer layers. Also disclosed is the film used to make the socket and uses of both the socket and film.
Abstract: The present technology relates to depots for the treatment of postoperative pain via sustained, controlled release of a therapeutic agent. In some embodiments, the depot may comprise a therapeutic region comprising an analgesic, and a control region comprising a bioresorbable polymer and a releasing agent mixed with the polymer. The releasing agent may be configured to dissolve when the depot is placed in vivo to form diffusion openings in the control region. The depot may be configured to be implanted at a treatment site in vivo and, while implanted, release the therapeutic agent at the treatment site for no less than 3 days.
Type:
Grant
Filed:
February 15, 2021
Date of Patent:
January 18, 2022
Assignee:
Foundry Therapeutics, Inc.
Inventors:
Karun D. Naga, Hanson S. Gifford, III, Stephen W. Boyd, Patrick H. Ruane, Jackie Joe Hancock, Michael Feldstein, Koon Kiat Teu, Honglei Wang, Jingnan Luo, Daniel Boon Lim Seet
Abstract: The present technology relates to depots for the treatment of postoperative pain via sustained, controlled release of a therapeutic agent. In some embodiments, the depot may comprise a therapeutic region comprising an analgesic, and a control region comprising a bioresorbable polymer and a releasing agent mixed with the polymer. The releasing agent may be configured to dissolve when the depot is placed in vivo to form diffusion openings in the control region. The depot may be configured to be implanted at a treatment site in vivo and, while implanted, release the therapeutic agent at the treatment site for no less than 3 days.
Type:
Grant
Filed:
April 3, 2020
Date of Patent:
December 21, 2021
Assignee:
Foundry Therapeutics, Inc.
Inventors:
Karun D. Naga, Hanson S. Gifford, III, Stephen W. Boyd, Patrick H. Ruane, Jackie Joe Hancock, Michael Feldstein, Koon Kiat Teu, Honglei Wang, Jingnan Luo, Daniel Boon Lim Seet