Abstract: A method of preventing, treating and/or controlling diseases caused by dysregulation and/or dysfunction of various portions of the nervous system which comprises administering to a patient, an effective amount of a compound of the avermectin family, e.g. ivermectin, in single or multiple doses of up to 1.6 mg/kg at intervals of from 3 days to 4 months.
Type:
Grant
Filed:
November 23, 1992
Date of Patent:
April 12, 1994
Assignee:
Fractal Laboratories, Inc.
Inventors:
Jonathan L. Costa, Jesus A. Diazgranados
Abstract: A method of treating comatose patients or near-comatose patients to increase their arousal and alertness as measured by the Glascow Coma Score by administering effective amounts of an adenosine receptor antagonist and a GABA agonist, either concomitantly in any order including simultaneously, or by administering an adenosine receptor antagonist as the sole active agent. The methods of administration are intravenous bolus or drip injection, subcutaneous injection or orally.
Type:
Grant
Filed:
June 30, 1992
Date of Patent:
September 28, 1993
Assignee:
Fractal Laboratories, Inc.
Inventors:
Jonathan L. Costa, Hernan V. Salazar, Jesus A. Diazgranados
Abstract: A method of preventing, treating and/or controlling diseases caused by dysregulation and/or dysfunction of various portions of the nervous system which comprises administering to a patient, an effective amount of a compound of the avermectin family, e.g. ivermectin, in single or multiple doses of up to 1.6 mg/kg at intervals of from 3 days to 4 months.
Type:
Grant
Filed:
June 7, 1991
Date of Patent:
February 23, 1993
Assignee:
Fractal Laboratories, Inc.
Inventors:
Jonathan L. Costa, Jesus A. Diazgranados