Patents Assigned to Hoffmann-La Roche Inc.
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Patent number: 11993630Abstract: Herein is reported a method for the purification of a protein comprising erythropoietin and a single poly (ethylene glycol) residue from reaction by-products or not reacted starting material by a cation exchange chromatography method. It has been found that by employing a cation exchange Toyopearl® SP-650 chromatography material and employing a second wash step with an increased pH value compared to the first wash step a fusion protein of erythropoietin and a single poly (ethylene glycol) residue can be obtained in a single step with high purity and yield and suitability for large scale applications.Type: GrantFiled: January 11, 2021Date of Patent: May 28, 2024Assignee: HOFFMANN-LA ROCHE INCInventors: Roberto Falkenstein, Bernhard Spensberger
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Patent number: 11993642Abstract: The present invention relates to trivalent, bispecific antibodies, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.Type: GrantFiled: May 15, 2019Date of Patent: May 28, 2024Assignee: Hoffmann-La Roche Inc.Inventors: Ulrich Brinkmann, Rebecca Croasdale, Eike Hoffmann, Christian Klein, Ekkehard Moessner, Juergen Michael Schanzer, Claudio Sustmann, Pablo Umana
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Patent number: 11993591Abstract: The present invention provides novel compounds having the general formula (I) wherein R1 to R6, and m are as described herein, compositions including the compounds and methods of using the compounds.Type: GrantFiled: October 17, 2019Date of Patent: May 28, 2024Assignee: Hoffmann-La Roche Inc.Inventors: Song Feng, Chungen Liang, Yongfu Liu, Xuefei Tan, Jun Wu, Jianping Wang
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Publication number: 20240166771Abstract: Herein is reported a circular fusion polypeptide comprising a first part of a binding domain, a second part of a binding domain and a spacer domain, wherein the spacer domain is a polypeptide and comprises at least 25 amino acid residues, the first part of the binding domain is a polypeptide and is fused via a first linker to the N-terminus of the spacer domain, the second part of the binding domain is a polypeptide and is fused via a second linker to the C-terminus of the spacer domain, the first part of the binding domain and the second part of the binding domain are associated with each other and form a binding site that specifically binds to a target.Type: ApplicationFiled: August 25, 2023Publication date: May 23, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Stefan Dengl, Guy Georges, Friederike Hesse, Sabine Imhof-Jung, Josef Platzer
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Publication number: 20240168015Abstract: The present invention provides a method for the detection of organ derived extracellular vesicles expressing PD-L1 in a biological sampleType: ApplicationFiled: January 26, 2024Publication date: May 23, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Priscila CAMILLO TEIXEIRA, Axel DUCRET, Souphalone LUANGSAY, Johanna Marie WALTHER
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Patent number: 11987632Abstract: The present invention generally relates to antibodies that bind to HLA-A2/MAGE-A4, including multispecific antibodies e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.Type: GrantFiled: December 17, 2020Date of Patent: May 21, 2024Assignee: Hoffmann-La Roche Inc.Inventors: Tina Weinzierl, Lydia Jasmin Hanisch, Alexander Bujotzek, Alejandro Carpy Gutierrez Cirlos, Stefan Klostermann, Christian Klein, Simon Patrick Keiser, Tanja Fauti, Estelle Marrer-Berger, Pablo Umaña
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Publication number: 20240158520Abstract: The present application concerns methods for treating an IL-6-mediated disorder such as rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), systemic JIA (sJIA), polyarticular course JIA (pcJIA), systemic sclerosis, or giant cell arteritis (GCA), with subcutaneously administered antibody that binds interleukin-6 receptor (anti-IL-6R antibody). In particular, it relates to identification of a fixed dose of anti-IL-6R antibody, e.g. tocilizumab, which is safe and effective for subcutaneous administration in patients with IL-6-mediated disorders. In addition, formulations and devices useful for subcutaneous administration of an anti-IL-6R antibody are disclosed.Type: ApplicationFiled: August 31, 2023Publication date: May 16, 2024Applicants: Hoffmann-La Roche Inc., Chugai Seiyaku Kabushiki KaishaInventors: Xiaoping Zhang, Kimio Terao
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Publication number: 20240158533Abstract: Herein is reported a multispecific antibody comprising two circular fusion polypeptides each of them comprising a VH/VL-pair and thereby a first and a second binding site, whereby a third VH/VL-pair and thereby a third binding site is formed by the associated of the two circular fusion polypeptides.Type: ApplicationFiled: November 1, 2023Publication date: May 16, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Ulrich BRINKMANN, Steffen DICKOPF, Guy GEORGES, Irmgard THOREY
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Patent number: 11981661Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein B, C, L, X, Y, RL and R3 to R5 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: GrantFiled: September 2, 2021Date of Patent: May 14, 2024Assignee: Hoffmann-La Roche Inc.Inventors: Joerg Benz, Uwe Grether, Benoit Hornsperger, Carsten Kroll, Bernd Kuhn, Rainer E. Martin, Fionn O'Hara, Bernd Puellmann, Hans Richter, Martin Ritter
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Patent number: 11981737Abstract: The present invention relates to anti-HLA-G antibodies and methods of using the same.Type: GrantFiled: May 17, 2019Date of Patent: May 14, 2024Assignee: Hoffmann-La Roche Inc.Inventors: Jens Fischer, Meher Majety, Stefan Dengl, Georg Tiefenthaler, Stefan Klostermann, Claudia Kirstenpfad, Esther Koenigsberger, Francesca Ros
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Publication number: 20240150291Abstract: The present invention relates to intermediates and processes useful for preparing 1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide and salts thereof. The present invention further relates to 1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide and salts thereof when prepared by such processes and to associated pharmaceutical compositions and uses for the treatment and prevention of medical disorders and diseases, most especially by NLRP3 inhibition.Type: ApplicationFiled: December 19, 2023Publication date: May 9, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Paul FRASER, Jetta PALGUNA, Mallesh BHARATHA, Joséphine Eliette Françoise CINQUALBRE, Régis Jean Georges MONDIÈRE, Paolo TOSATTI
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Publication number: 20240151720Abstract: Herein is reported a novel, high throughput suitable method for the characterization and identification as well as selection of recombinant cell clones expressing a bispecific antibody with high titers and low levels of antibody-related side products. The method according to the current invention uses the binding signals of an immunoassay-based screening of recombinant cell clone cultivation supernatants for isolated as well as simultaneous binding to the respective targets of the antibody. This data allows for the selection of high producer cell clones with desired product profile.Type: ApplicationFiled: October 6, 2023Publication date: May 9, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Tobias Grosskopf, Xenia Wezler
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Publication number: 20240150373Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: ApplicationFiled: September 26, 2023Publication date: May 9, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Charles BELL, Joerg BENZ, Luca GOBBI, Uwe GRETHER, Katrin GROEBKE ZBINDEN, Benoit HORNSPERGER, Buelent KOCER, Carsten KROLL, Bernd KUHN, Marius Daniel Rinaldo LUTZ, Fionn O'HARA, Hans RICHTER, Martin RITTER, Didier ROMBACH, Martin KURATLI
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Publication number: 20240140933Abstract: The present invention relates to compounds of formula (I), wherein R1 to R3, A1 to A3 and n are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.Type: ApplicationFiled: November 20, 2023Publication date: May 2, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Fabian DEY, Dong DING, Xingchun HAN, Chungen LIANG, Hongtao XU, Ge ZOU
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Publication number: 20240139192Abstract: The present invention is directed to the combination therapy of cancer with a BRAF inhibitor and a MEK inhibitor, as well as uses and pharmaceutical compositions thereof.Type: ApplicationFiled: December 8, 2023Publication date: May 2, 2024Applicants: Hoffmann-La Roche Inc., Chugai Seiyaku Kabushiki KaishaInventors: Jan ECKMANN, Thomas FRIESS, Frank HERTING, Yusuke IDE, Hiroshi TANAKA, Piergiorgio Francesco Tommaso PETTAZZONI, Juergen WICHMANN
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Patent number: 11970550Abstract: The invention provides anti-variant Fc-region antibodies which specifically bind to an antibody that has the mutation P329G or the mutations P329G/L234A/L235A or the mutations 1253A/H310A/H435A in the Fc-region, and methods of using the same.Type: GrantFiled: December 7, 2020Date of Patent: April 30, 2024Assignee: Hoffmann-La Roche Inc.Inventors: Frank Kowalewsky, Mirko Ritter, Kay-Gunnar Stubenrauch, Uwe Wessels
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Publication number: 20240132508Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3?-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4?]bipyridinyl-2?-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided.Type: ApplicationFiled: November 3, 2023Publication date: April 25, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Stephan BACHMANN, Lukas CHYTIL, Serena Maria FANTASIA, Alec FETTES, Ursula HOFFMANN, Christian Oliver KAPPE, Rene LEBL, Kurt PUENTENER, Paolo TOSATTI, Jason Douglas WILLIAMS
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Publication number: 20240132574Abstract: Herein is reported a method for the final filtration of concentrated polypeptide solutions comprising the combination of two immediately consecutive filtration steps with a first filter of 3.0 ?m and 0.8 ?m pore size and a second filter of 0.45 ?m and 0.22 ?m pore size.Type: ApplicationFiled: December 20, 2023Publication date: April 25, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Roberto Falkenstein, Klaus Schwendner
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Publication number: 20240132471Abstract: The invention relates to novel compounds having the general formula Ib wherein R1, R2, R1, R4, R5 and Z are as described herein, composition including the compounds and methods of using the compounds.Type: ApplicationFiled: November 30, 2023Publication date: April 25, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Lea Aurelie BOUCHE, Wolfgang GUBA, Georg JAESCHKE, Stefanie Katharina MESCH, Angélique PATINY-ADAM, Christian SCHNIDER, Sandra STEINER, Andreas Michael TOSSTORFF
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Publication number: 20240122469Abstract: A virtual reality system for quantifying functional visual capabilities of a user at varying assessment conditions (e.g., varying light, contrast, color conditions), using a head-mountable display. In addition to the high relevance to users with optical conditions, the present embodiments can lead to rapid and simple measurements within the controlled and reproducible testing conditions that virtual reality can offer. The virtual environment system can obtain a selection of a task to be performed. During execution of the task, a virtual environment optical setting (e.g., a modified lighting setting in the virtual environment display) can be dynamically modified. The user can interact with the objects during execution of the task, which can provide an insight into functional visual capabilities of the user. After completion of the task, an output can be generated that quantifies a functional visual capability of the user during execution of the task.Type: ApplicationFiled: December 18, 2023Publication date: April 18, 2024Applicant: HOFFMANN-LA ROCHE INC.Inventors: Geraint Iwan DAVIES, Jonas Franz DORN, Bernhard FEHLMANN, Noémie HURST-FISCHER, Angelos KARATSIDIS, Joerg SPRENGEL