Patents Assigned to Joslin Diabetes Center
  • Systems and methods for detecting retinal abnormalities
    Patent number: 8737703
    Abstract: The systems and methods described herein relate generally to the detection of retinal abnormalities. More particularly, the systems and methods are used to analyze a fundus or other image of the retina. In some implementations, the image is analyzed by interdependently smoothing and segmenting the image. Using the smoothed and segmented image, retinal features can be identifying in the image. The systems and methods can then analyze the detected retinal features to identify retinal abnormalities.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: May 27, 2014
    Assignees: The Charles Stark Draper Laboratory, Inc., Joslin Diabetes Center, Inc.
    Inventors: Rami Mangoubi, Mukund Desai, Joseph Danko, Lloyd Paul Aiello
  • Methods for treatment of kallikrein-related disorders
    Patent number: 8658685
    Abstract: We have identified classes of kallikrein inhibitors as compounds that are useful in the reduction of vascular permeability (e.g., retinal vascular permeability and cerebral vascular permeability) and astrocyte activation. Diseases and conditions associated with increased vascular permeability include diabetic retinopathy, hemorrhagic stroke, and macular edema. Diseases and conditions associated with astrocyte activation include Alzheimer's disease, multiple sclerosis, Parkinson's disease, amyotrophic lateral sclerosis, Creutzfeldt-Jakob disease, stroke, epilepsy, and brain trauma.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: February 25, 2014
    Assignees: Activesite Pharmaceuticals, Inc., Joslin Diabetes Center
    Inventors: Lloyd P. Aiello, Tamie Jo Chilcote, Sukanto Sinha, Edward P. Feener
  • Insulin B chain autoantigen composition
    Patent number: 8652488
    Abstract: The invention features methods for the prevention or treatment of autoimmune disorders in humans. The methods include administering an autoantigen in combination with an oil-based carrier. Included are methods for the prevention and treatment of diabetes mellitus which include treating a patient with a diabetes type 1 autoantigen, e.g., human insulin B-chain or GAD65, and an oil-based carrier approved for human use. Also included are vaccines and kits for the treatment of diabetes mellitus.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: February 18, 2014
    Assignee: Joslin Diabetes Center, Inc.
    Inventor: Tihamer Orban
  • Inhibiting serum response factor (SRF) to improve glycemic control
    Patent number: 8524661
    Abstract: Described are methods of improving glycemic control/improving insulin sensitivity by administering an inhibitor of serum response factor (SRF) activity, and methods of identifying new compounds for use in the described methods of treatment.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: September 3, 2013
    Assignee: Joslin Diabetes Center, Inc.
    Inventors: Mary Elizabeth Patti, Wanzhu Jin, Allison B. Goldine
  • INHIBITING STRIATED MUSCLE ACTIVATOR OF RHO (STARS) TO IMPROVE GLYCEMIC CONTROL
    Publication number: 20130197058
    Abstract: Described are methods of improving glycemic control/improving insulin sensitivity by administering an inhibitor of Striated Muscle Activator of Rho Signaling (STARS) activity, and methods of identifying new compounds for use in the described methods of treatment.
    Type: Application
    Filed: June 3, 2011
    Publication date: August 1, 2013
    Applicant: JOSLIN DIABETES CENTER, INC.
    Inventors: Mary Elizabeth Patti, Wanzhu Jin, Allison B. Goldfine
  • Reducing risk of type 2 diabetes (T2D)
    Patent number: 8445467
    Abstract: This invention relates to methods for reducing chronic subacute inflammatory states associated with obesity and improve glycemia, thereby preventing or delaying the development of type 2 diabetes (T2D) in obese subjects, or subjects with the metabolic syndrome, using non-acetylated forms of salicylate, e.g., salsalate or trilisate.
    Type: Grant
    Filed: April 27, 2007
    Date of Patent: May 21, 2013
    Assignee: Joslin Diabetes Center, Inc.
    Inventors: Steven Shoelson, Allison B. Goldfine
  • Methods of modulating metabolic memory
    Patent number: 8372582
    Abstract: Described are methods of identifying modulators of metabolic memory, for the treatment of microvascular complications of diabetes, as well as methods of use thereof. Also described are methods of treating microvascular complications of diabetes by decreasing expression and/or activity of SHP-1.
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: February 12, 2013
    Assignee: Joslin Diabetes Center, Inc.
    Inventors: Pedro Geraldes, George Liang King
  • BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE
    Publication number: 20130023491
    Abstract: In the invention provides for a method of stimulating or increasing ?-cell replication or growth, by contacting a ?-cell with an inhibitor of adenosine kinase (ADK), an inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) or an activator of AMP activated protein kinase (AMPK).
    Type: Application
    Filed: December 17, 2010
    Publication date: January 24, 2013
    Applicants: President and Fellows of Harvard College, Joslin Diabetes Center, Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Justin P. Annes, Douglas A. Melton, Lee L. Rubin, Gordon Weir
  • Methods of modulating angiogenesis
    Patent number: 8343939
    Abstract: The present inventors discovered that PKC? is necessary for VEGF signaling through PI3K/Akt-dependent pathways and is involved in MAPK-dependent pathways, thus regulating eNOS activity and DNA synthesis, respectively. Thus differential manipulation of PKC? activity can be used to modify VEGF effects in conditions in which modulation of angiogenesis is desirable (e.g., for treatment of diabetic proliferative retinopathy or to enhance angiogenesis for treatment of peripheral and myocardial ischemia).
    Type: Grant
    Filed: July 27, 2009
    Date of Patent: January 1, 2013
    Assignee: Joslin Diabetes Center, Inc.
    Inventors: Christian Rask Madsen, George Liang King
  • Enhancing stem cell mobilization
    Patent number: 8323967
    Abstract: This invention relates to methods and compositions for enhancing hematopoietic stem cell mobilization by inhibiting early growth response-1 (egr1) activity.
    Type: Grant
    Filed: April 5, 2007
    Date of Patent: December 4, 2012
    Assignee: Joslin Diabetes Center, Inc.
    Inventors: Amy Wagers, Irene Min
  • METHODS AND COMPOSITIONS FOR MODULATING ADIPOCYTE FUNCTION
    Publication number: 20120251457
    Abstract: Methods and compositions for treating obesity and related disorders. The methods include the use of BMP-2, -4, -6 and -7.
    Type: Application
    Filed: March 28, 2012
    Publication date: October 4, 2012
    Applicants: CHILDREN'S HOSPITAL BOSTON, JOSLIN DIABETES CENTER, INC.
    Inventors: C. Ronald Kahn, Yu-Hua Tseng, Atul Butte
  • USE OF PROTEIN KINASE C DELTA (PKCD) INHIBITORS TO TREAT DIABETES, OBESITY, AND HEPATIC STEATOSIS
    Publication number: 20120208750
    Abstract: Described are methods of improving insulin sensitivity, and treating fatty liver disease (including non-alcoholic steatohepatitis (NASH)), by administering specific inhibitors of PKC delta.
    Type: Application
    Filed: September 29, 2010
    Publication date: August 16, 2012
    Applicant: JOSLIN DIABETES CENTER, INC.
    Inventors: C. Ronald Kahn, Olivier Bezy
  • Methods of diagnosing cardiovascular disease
    Patent number: 8236497
    Abstract: Methods are disclosed for diagnosing increased risk of cardiovascular disease in a subject.
    Type: Grant
    Filed: September 20, 2006
    Date of Patent: August 7, 2012
    Assignees: Joslin Diabetes Center, Inc., Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Casa Sollievo Della
    Inventors: Alessandro Doria, Vincenzo Trischitta
  • COMPOSITIONS AND METHODS FOR PROMOTING BETA CELL MATURITY
    Publication number: 20120141436
    Abstract: Compositions and methods for providing an enriched population of mature, glucose-responsive insulin secreting cells, and for modulating insulin expression, activity and secretion in a subject.
    Type: Application
    Filed: May 21, 2010
    Publication date: June 7, 2012
    Applicant: JOSLIN DIABETES CENTER, INC.
    Inventors: Susan Bonner-Weir, Arun Sharma, Cristina Aguayo-Mazzucato
  • BONE MORPHOGENETIC PROTEINS FOR THE TREATMENT OF INSULIN RESISTANCE
    Publication number: 20120135927
    Abstract: The present disclosure relates to compositions and methods for treating insulin resistance and/or obesity in a cell and/or a subject.
    Type: Application
    Filed: May 21, 2010
    Publication date: May 31, 2012
    Applicant: JOSLIN DIABETES CENTER, INC.
    Inventors: Yu-Hua Tseng, C. Ronald Kahn
  • Methods and compositions for modulating adipocyte function
    Patent number: 8178492
    Abstract: Methods and compositions for treating obesity and related disorders. The methods include the use of BMP-2, -4, -6 and -7.
    Type: Grant
    Filed: July 14, 2009
    Date of Patent: May 15, 2012
    Assignees: Joslin Diabetes Center, Inc., Children's Hospital Boston
    Inventors: C. Ronald Kahn, Yu-Hua Tseng, Atul Butte
  • Inhibiting Serum Response Factor (SRF) to Improve Glycemic Control
    Publication number: 20120028895
    Abstract: Described are methods of improving glycemic control/improving insulin sensitivity by administering an inhibitor of serum response factor (SRF) activity, and methods of identifying new compounds for use in the described methods of treatment.
    Type: Application
    Filed: July 11, 2011
    Publication date: February 2, 2012
    Applicant: Joslin Diabetes Center, Inc.
    Inventors: Mary Elizabeth Patti, Wanzhu Jin, Allison B. Goldfine
  • Methods of diagnosing cardiovascular disease
    Patent number: 8080374
    Abstract: Described herein are methods for diagnosing increased risk of cardiovascular disease in a subject, based on the presence or absence of polymorphisms in the D36 gene.
    Type: Grant
    Filed: October 12, 2005
    Date of Patent: December 20, 2011
    Assignee: Joslin Diabetes Center, Inc.
    Inventors: Alessandro Doria, Xiaowei Ma
  • METHODS OF DIAGNOSING AND PREDICTING RENAL DISEASE
    Publication number: 20110281758
    Abstract: This disclosure relates to methods of diagnosing and predicting renal disease, using one, two, or more biomarkers, including sTNFR1, sTNFR2, sFAS, TNF, and IL-6.
    Type: Application
    Filed: December 9, 2009
    Publication date: November 17, 2011
    Applicant: JOSLIN DIABETES CENTER, INC.
    Inventors: Monika A. Niewczas, Andrzej S. Krolewski
  • Inhibiting serum response factor (SRF) to improve insulin sensitivity
    Patent number: 8003606
    Abstract: Described are methods of improving glycemic control/improving insulin sensitivity by administering an inhibitor of serum response factor (SRF) activity, and methods of identifying new compounds for use in the described methods of treatment.
    Type: Grant
    Filed: June 5, 2009
    Date of Patent: August 23, 2011
    Assignee: Joslin Diabetes Center, Inc.
    Inventors: Mary Elizabeth Patti, Wanzhu Jin, Allison B. Goldfine