Abstract: This invention relates to a liquid pharmaceutical preparation for topical use on the skin of patients, said preparation containing indomethacin as active ingredient and dimethylisosorbide and isopropanol as excipients.The preparation according to the invention allows an easy and precise local administration by external application on the skin of a solution of indomethacin in the excipients.
Type:
Grant
Filed:
October 5, 1989
Date of Patent:
July 30, 1991
Assignee:
Pharlyse S.A. Societe Anonyme
Inventors:
Arthur M. Deboeck, Philippe R. Baudier, Jacques J. Fossion, Paul J. Maes
Abstract: The invention relates to a novel galenic form of verapamil which show an excellent bioavailability. The novel galenic form comprises microgranules containing a verapamil addition salt with an acid, associated to at least one wetting agent. The microgranules are coated with a porous membrane constituted of a synthetic polymer associated to an adjuvant.
Type:
Grant
Filed:
September 18, 1986
Date of Patent:
August 22, 1989
Assignee:
Pharlyse Societe Anonyme
Inventors:
Philippe Baudier, Arthur De Boeck, Jacques Fossion
Abstract: The new galenic forms of prolonged release verapamil consist of microgranules containing a pharmacologically acceptable acid-addition salt or verapamil as active substance combined with at least one wetting agent, said microgranules being coated with a microporous membrane consisting of at least one pharmacologically acceptable adjuvant (such as plasticizer, filler, lubricant, etc) and of at least one film forming mixture composed of (1) at least one insoluble acrylic or methacrylic polymer and (2) a substance which is insoluble in the acid gastric medium, but soluble in the intestine.
Type:
Grant
Filed:
September 30, 1986
Date of Patent:
May 23, 1989
Assignee:
Pharlyse Societe Anonyme
Inventors:
Philippe Baudier, Arthur De Boeck, Jacques Fossion
Abstract: Water-soluble valproic acid salts, consisting of reaction products of valproic acid with at least one basic amino-acid, the latter being preferably selected from the group comprising arginine, lysine, histidine, ornithine and glycine.