Patents Assigned to QUEEN MARY UNIVERSITY OF LONDON
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Patent number: 11977077Abstract: The present invention relates to pancreatic cancers and the use of biomarkers in biological samples for the diagnosis of such conditions, in particular pancreatic ductal adenocarcinoma. The biomarker panel comprises LYVE1, REG1 and TFF1. Methods of treatment are also provided, as well as kits useful in the diagnosis and treatment of pancreatic ductal adenocarcinoma. The present invention is particularly useful in detecting early-stage PDAC.Type: GrantFiled: August 26, 2020Date of Patent: May 7, 2024Assignee: Queen Mary University of LondonInventors: Tatjana Crnogorac-Jurcevic, Tomasz Radon
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Biodegradable multilayer nanocapsules for the delivery of biologically active agents in target cells
Patent number: 11957794Abstract: The present invention relates to a biodegradable multilayer nanocapsule for the delivery of at least one biologically active agent into at least one target cell consisting of at least two layers of at least two biodegradable polymers which are laid one onto the other and whereby the biologically active agent is layered onto a layer of a biodegradable polymer and covered with a further layer of a biodegradable polymer, whereby one biologically active agent is a nucleic acid.Type: GrantFiled: January 13, 2022Date of Patent: April 16, 2024Assignees: Albert-Ludwigs-Universitaet Freiburg, Queen Mary University of LondonInventors: Gleb Sukhorukov, Irina Nazarenko, Yana Tarakanchikova, Toni Cathomen, Tatjana Cornu, Valentina Pennucci, Jamal Alzubi -
Publication number: 20240058232Abstract: A composition comprising a mixture of a calcium orthophosphate and a bioactive glass comprising fluorine is useful in a non-aqueous toothpaste.Type: ApplicationFiled: December 22, 2021Publication date: February 22, 2024Applicant: Queen Mary University of LondonInventors: Robert Hill, Melissa Tiskaya, David Geoffrey Gillam
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Patent number: 11891652Abstract: The invention relates to a method of assembling a biosensor device comprising two or more biosensor units, wherein each unit comprises one or more biosensors comprising one or more carbon nanotubes (CNTs) coated with nucleic acid and one or more sensor molecules coupled to the nucleic acid, wherein each one of the one or more sensor molecules is capable of binding to a target molecule in a sample. Each biosensor unit is capable of detecting a different target molecule in a sample, and each unit comprises one or more biosensors each capable of detecting the same target molecule. The invention further relates to biosensor devices and methods for detecting target molecules in a sample using the same.Type: GrantFiled: November 23, 2018Date of Patent: February 6, 2024Assignee: QUEEN MARY UNIVERSITY OF LONDONInventors: Matteo Palma, Xinzhao Xu, Pierrick Clement
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Publication number: 20240036048Abstract: The present invention pertains to the field of cancer diagnosis. Specifically, it relates to a method for diagnosing pancreas cancer in a subject comprising the steps of determining in a sample of a subject suspected to suffer from pancreas cancer the amount of at least one biomarker selected from the biomarkers shown in Table 1 and comparing the said amount of the at least one biomarker with a reference, whereby pancreas cancer is to be diagnosed. The present invention also contemplates a method for identifying whether a subject is in need of a pancreas cancer therapy comprising the steps of the aforementioned methods and the further step of identifying a subject in need of a pancreas cancer therapy if said subject is to be diagnosed to suffer from pancreas cancer. Contemplated are, furthermore, diagnostic devices and kits for carrying out said methods.Type: ApplicationFiled: June 26, 2023Publication date: February 1, 2024Applicants: Deutsches Krebsforschungszentrum, Queen Mary University of LondonInventors: Christoph SCHRÖDER, Jörg HOHEISEL, Tatjana CRNOGORAC-JURCEVIC
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Publication number: 20240025955Abstract: The present invention relates to novel polypeptides, which are derived from a human agrin or a variant of a human agrin. The invention also concerns uses of the polypeptides and compositions comprising the polypeptides.Type: ApplicationFiled: August 17, 2021Publication date: January 25, 2024Applicant: QUEEN MARY UNIVERSITY OF LONDONInventors: Francesco DELL'ACCIO, Suzanne Elizabeth RUANE
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Patent number: 11730755Abstract: The present invention relates to anti-ROR2 inhibitors and uses thereof in treating and/or preventing cartilage loss.Type: GrantFiled: November 16, 2018Date of Patent: August 22, 2023Assignee: Queen Mary University of LondonInventors: Francesco Dell'Accio, Anne-Sophie Thorup
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Patent number: 11726090Abstract: The present invention pertains to the field of cancer diagnosis. Specifically, it relates to a method for diagnosing pancreas cancer in a subject comprising the steps of determining in a sample of a subject suspected to suffer from pancreas cancer the amount of at least one biomarker selected from the biomarkers shown in Table 1 and comparing the said amount of the at least one biomarker with a reference, whereby pancreas cancer is to be diagnosed. The present invention also contemplates a method for identifying whether a subject is in need of a pancreas cancer therapy comprising the steps of the aforementioned methods and the further step of identifying a subject in need of a pancreas cancer therapy if said subject is to be diagnosed to suffer from pancreas cancer. Contemplated are, furthermore, diagnostic devices and kits for carrying out said methods.Type: GrantFiled: December 21, 2016Date of Patent: August 15, 2023Assignees: DEUTSCHES KREBSFORSCHUNGSZENTRUM, QUEEN MARY UNIVERSITY OF LONDONInventors: Christoph Schröder, Jörg Hoheisel, Tatjana Crnogorac-Jurcevic
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Patent number: 11721317Abstract: Disclosed herein is a sound synthesis system for generating a user defined synthesised sound effect, the system comprising: a receiver of user defined inputs for defining a sound effect; a generator of control parameters in dependence on the received user defined inputs; a plurality of sound effect objects, wherein each sound effect object is arranged to generate a different class of sound and each sound effect object comprises a sound synthesis model arranged to generate a sound in dependence on one or more of the control parameters; a plurality of audio effect objects, wherein each audio effect object is arranged to receive a sound from one or more sound effect objects and/or one or more other audio effect objects, process the received sound in dependence on one or more of the control parameters and output the processed sound; a scene creation function arranged to receive sound output from one or more sound effect objects and/or audio effect objects and to generate a synthesised sound effect in dependence oType: GrantFiled: November 29, 2018Date of Patent: August 8, 2023Assignee: QUEEN MARY UNIVERSITY OF LONDONInventors: Joshua Reiss, Thomas Vassallo, Adan Benito, Parham Bahadoran
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Patent number: 11690841Abstract: The present invention relates to glycolysis-activating agents. The present invention also relates to the treatment or prevention of diseases or medical conditions, in particular immune-related diseases or medical conditions. In particular, the present invention also relates to agents for use in the treatment or prevention of a disease or medical condition, which treatment or prevention is mediated via the trafficking of endogenous regulatory T cells (Tregs).Type: GrantFiled: September 13, 2018Date of Patent: July 4, 2023Assignee: Queen Mary University of LondonInventor: Federica Maria Marelli-Berg
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Publication number: 20230197043Abstract: A computer-implemented method of processing audio data, the method comprising receiving input audio data (x) comprising a time-series of amplitude values; transforming the input audio data (x) into an input frequency band decomposition (X1) of the input audio data (x); transforming the input frequency band decomposition (X1) into a first latent representation (Z); processing the first latent representation (Z) by a first deep neural network to obtain a second latent representation (Z{circumflex over (?)}, Z1{circumflex over (?)}); transforming the second latent representation (Z{circumflex over (?)}, Z1{circumflex over (?)}) to obtain a discrete approximation (X3{circumflex over (?)}); element-wise multiplying the discrete approximation (X3{circumflex over (?)}) and a residual feature map (R, X5{circumflex over (?)}) to obtain a modified feature map, wherein the residual feature map (R, X5{circumflex over (?)}) is derived from the input frequency band decomposition (X1); processing a pre-shaped frequency bandType: ApplicationFiled: May 12, 2020Publication date: June 22, 2023Applicant: QUEEN MARY UNIVERSITY OF LONDONInventors: Marco Antonio MARTINEZ RAMIREZ, Joshua Daniel REISS, Emmanouil BENETOS
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Patent number: 11578035Abstract: The present invention provides a crystalline salt of chlorhexidine chloride having a spherical morphology under Scanning Electron Microscopy (SEM) comprising a chloride anion and a cation selected from the group consisting of calcium, sodium, potassium, magnesium, zinc, strontium or iron, processes for the preparation of the salt, compositions, pharmaceutical compositions and uses thereof in medicine. Also provided are crystalline forms of the salt and fibres comprising the same.Type: GrantFiled: March 27, 2020Date of Patent: February 14, 2023Assignee: Queen Mary University of LondonInventors: Michael Cattel, Gleb Sukhorukov, Saroash Shahid, Dong Luo
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Patent number: 11542622Abstract: EL The present invention provides a system for electrodepositing a plurality of electrolytes onto a substrate in a single deposition chamber to form an article, in which the system comprises a removable substrate; a deposition chamber containing the substrate in which the chamber has an inlet and an outlet and in which the chamber comprises at least one anode with connection to a source of electrical current; a plurality of electrolyte reservoirs for an electrolyte solution connected to the deposition chamber through the inlet; and a rinse medium reservoir connected to the deposition chamber through the inlet. Also provided is a system comprising a cradle to form an article, methods using the systems of the invention, and composite materials and devices prepared by the methods of the invention.Type: GrantFiled: July 17, 2018Date of Patent: January 3, 2023Assignees: Queen Mary University of London, Morganic Solutions Ltd.Inventors: Andrew John Bushby, Ross Morgan
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Patent number: 11531036Abstract: A method, device, computer program and related immunoassay are disclosed for assessing the efficacy of a statin selected from, for example, selected from RvT1 (7,13,20-trihydroxy-8,10,14,16Z,18-docosapentaenoic acid), RvT2 (7,12,13-trihydroxy-8,10,14,16Z,19Z-docosapentaenoic acid), RvT3 (7,8,13-trihydroxy-9,11,14,16Z,19Z-docosapentaenoic acid) and RvT4 (7,13-dihydroxy-8,10,14,16Z,19Z-docosapentaenoic acid), for use in the treatment of an inflammatory condition in an individual patient, which comprises measuring the levels of at least one 13-series resolvin in biological samples obtained from the patient before and after administration of the statin, wherein an increase in the level of the resolvin after administration of the statin is indicative of efficacy of the statin. Also disclosed is a method of storing a biological sample to preserve lipid mediators in the sample comprising placing the sample in an organic solvent and storing the sample at a temperature of ??75° C.Type: GrantFiled: April 26, 2018Date of Patent: December 20, 2022Assignee: Queen Mary University of LondonInventors: Jesmond Dalli, Romain Alexandre Colas, Patricia Regina Soares De Souza, Mary Elizabeth Walker
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Publication number: 20220325317Abstract: The present invention relates to novel methods for generating a population of double-stranded polynucleotide molecules from a sample containing at least one polynucleotide.Type: ApplicationFiled: August 12, 2020Publication date: October 13, 2022Applicant: QUEEN MARY UNIVERSITY OF LONDONInventors: Gabriella Ficz, Emily Saunderson
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Patent number: 11415573Abstract: The present invention relates to the detection or diagnosis of infection or inflammation in a patient. In particular, the invention provides methods that allow the detection of markers in a sample from a patient or subject, such as a blood sample, which will indicate whether the patient or subject has an infection or has an inflammatory response.Type: GrantFiled: July 8, 2015Date of Patent: August 16, 2022Assignee: QUEEN MARY UNIVERSITY OF LONDONInventor: Gareth Ackland
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BIODEGRADABLE MULTILAYER NANOCAPSULES FOR THE DELIVERY OF BIOLOGICALLY ACTIVE AGENTS IN TARGET CELLS
Publication number: 20220233462Abstract: The present invention relates to a biodegradable multilayer nanocapsule for the delivery of at least one biologically active agent into at least one target cell consisting of at least two layers of at least two biodegradable polymers which are laid one onto the other and whereby the biologically active agent is layered onto a layer of a biodegradable polymer and covered with a further layer of a biodegradable polymer, whereby one biologically active agent is a nucleic acid.Type: ApplicationFiled: January 13, 2022Publication date: July 28, 2022Applicants: Albert-Ludwigs-Universitaet Freiburg, Queen Mary University of LondonInventors: Gleb SUKHORUKOV, Irina NAZARENKO, Yana TARAKANCHIKOVA, Toni CATHOMEN, Tatjana CORNU, Valentina PENNUCCI, Jamal ALZUBI -
Publication number: 20220221600Abstract: A radiation detector comprising a transistor, e.g. a FET, formed of one or more organic semiconductor materials having a neutron sensitizer element dispersed therein. The sensitizer element is one or more elements selected from the group consisting of boron, cadmium, lithium and gadolinium. The semiconductor device comprises a diode, a transistor (e.g. a Field Effect Transistor) or a non-rectifying, symmetric, semiconductor device. The organic semiconductor materials comprise a donor organic semiconductor material and an acceptor organic semiconductor material or a combination of organic and inorganic donor- acceptor materials.Type: ApplicationFiled: April 9, 2020Publication date: July 14, 2022Applicant: QUEEN MARY UNIVERSITY OF LONDONInventors: Theo KREOUZIS, Cozmin TIMIS, William GILLIN, Adrian BEVAN, Xiaoqi LIU
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Publication number: 20220220559Abstract: A method of prognosing a course of disease progression and/or survival time in a subject diagnosed with ALS or FTD is disclosed. The method comprising: (a) detecting a level of miR-181 in a biological sample of the subject; and (b) determining the disease progression and/or survival time based on the level of the miR-181, wherein: (i) when the level of miR-181 is higher than that in a control sample, it is indicative of a rapid disease progression and/or poor survival; or (ii) when the level of miR-181 is about the same or lower than that in the control sample, it is indicative of a slow disease progression and/or good survival. Methods of prognosing a stage of disease in a subject diagnosed with ALS or FTD are also disclosed.Type: ApplicationFiled: May 13, 2020Publication date: July 14, 2022Applicants: Yeda Research And Development Co. Ltd., Queen Mary University London, UCL Business LtdInventors: Eran HORNSTEIN, Iddo MAGEN, Andrea MALASPINA, Pietro FRATTA
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Patent number: 11351209Abstract: The present invention provides a composition comprising a phosphatidylinositol 3-kinase (PI3K) inhibitor and a modified virus for separate, subsequent or simultaneous use in the treatment of cancer, wherein the modified virus is for intravenous administration.Type: GrantFiled: January 11, 2017Date of Patent: June 7, 2022Assignee: Queen Mary University of LondonInventors: Yaohe Wang, Mark Ferguson, Nicholas R. Lemoine