Abstract: Disclosed are a composition and a method for freeze-drying which allow excellent stability, safety, and efficacy to be exhibited at the time of freeze-drying and reconstituting a composition for anionic drug delivery.
Type:
Application
Filed:
November 15, 2018
Publication date:
March 18, 2021
Applicant:
SAMYANG BIOPHARMACEUTICALS CORPORATION
Inventors:
Ji Hye CHOI, Ji Yeon SON, So Jin LEE, Bo Mi KIM, Hye Yeong NAM
Abstract: Disclosed is a method capable of selectively synthesizing cationic lipids by controlling the introduction rate of a fatty acid group with respect to an oligoalkyleneamine by the change of reaction conditions.
Type:
Grant
Filed:
December 29, 2016
Date of Patent:
October 6, 2020
Assignee:
SAMYANG BIOPHARMACEUTICALS CORPORATION
Inventors:
Sungwon Choi, Hye Yeong Nam, Min-Hyo Seo
Abstract: The present invention relates to a polymer nanoparticle freeze-dried product, and a preparation method therefor, the polymer nanoparticle freeze-dried product being obtainable by treating, through a freeze-drying process comprising an annealing step, a polymer nanoparticle aqueous solution comprising an amphiphilic block copolymer, a polylactic acid derivative having a carboxyl terminal group, and a freeze-drying adjuvant, wherein the polymer nanoparticle freeze-dried product is reconstituted within five minutes upon reconstitution by means of an aqueous solvent under atmospheric pressure.
Type:
Grant
Filed:
December 28, 2015
Date of Patent:
September 8, 2020
Assignee:
SAMYANG BIOPHARMACEUTICALS CORPORATION
Inventors:
Sa Won Lee, Gyeong Hae Kim, Min Hyo Seo
Abstract: The present invention relates to an emulsion composition for chemoembolization comprising a nanoparticle comprising a drug and a biocompatible polymer, a water-soluble contrast agent and a water-insoluble contrast agent, and a water-insoluble drug as well as an aqueous drug can be administered in a form of stable emulsion, and drugs are slowly released, thereby enhancing the effect of chemoembolization.
Abstract: Disclosed are an oral solid dosage form composition comprising an active ingredient and a solubilizing carrier wherein a foaming ingredient is used to improve disintegration, dispersion or dissolution, and a preparation method therefor.
Type:
Application
Filed:
October 30, 2018
Publication date:
August 20, 2020
Applicant:
SAMYANG BIOPHARMACEUTICALS CORPORATION
Inventors:
Sang Yeob PARK, Hye Jung LIM, Jae Young LEE, Min Hyo SEO, Sa Won LEE
Abstract: A method for analyzing related substances in a pharmaceutical composition containing an amphiphilic block copolymer comprising a hydrophilic block and a hydrophobic block as a polymeric drug carrier, related substances identified thereby, and a method for evaluating a pharmaceutical composition by using the same are provided. Preferably, the method comprises evaluating a polymeric micelle pharmaceutical composition, which comprises an amphiphilic block copolymer comprising a hydrophilic block (A) and a hydrophobic block (B), and paclitaxel or docetaxel as a poorly water-soluble drug, by using a compound represented by Chemical Formula 1, wherein the hydrophilic block (A) comprises one or more selected from the group consisting of polyethylene glycol or derivatives thereof, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylamide and combinations thereof; and the hydrophobic block (B) is polylactide.
Type:
Grant
Filed:
July 28, 2016
Date of Patent:
August 11, 2020
Assignee:
SAMYANG BIOPHARMACEUTICALS CORPORATION
Inventors:
Hye Rim Kim, Ji Yeong Kim, Bum Chan Min, Min Hyo Seo, Ho Joon Choi
Abstract: A pharmaceutical composition containing a specific related compound within a specified limit and a method for preparing the same are provided.
Type:
Application
Filed:
April 24, 2020
Publication date:
August 6, 2020
Applicant:
SAMYANG BIOPHARMACEUTICALS CORPORATION
Inventors:
Bong Oh KIM, Bum Chan MIN, Ji Yeong KIM, Hye Rim KIM, Min Hyo SEO, Sa Won LEE, Yil Woong YI, Joong Woong CHO, In Ja CHOI
Abstract: Provided are: a method for preparing biodegradable polymer microparticles and, particularly, porous microparticles of a biodegradable polymer; and biodegradable polymer microparticles prepared thereby, particularly, porous microparticles of a biodegradable polymer.
Type:
Application
Filed:
July 25, 2018
Publication date:
July 2, 2020
Applicant:
SAMYANG BIOPHARMACEUTICALS CORPORATION
Inventors:
Jin Su KIM, Wang Soo SHIN, Na Jeong PARK
Abstract: Disclosed are: a composition having improved water solubility and bioavailability, containing sorafenib and a polymethacrylate copolymer; and a preparation method therefor.
Type:
Application
Filed:
April 30, 2018
Publication date:
March 12, 2020
Applicant:
SAMYANG BIOPHARMACEUTICALS CORPORATION
Inventors:
Sang Yeob PARK, Hye Jung LIM, Sa Won LEE, Min Hyo SEO
Abstract: The present disclosure relates to an oral tablet composition comprising lenalidomide and a method for preparing the same. More particularly, the present disclosure relates to a tablet-type composition and a method for preparing the same wherein the composition exhibits physicochemical equivalence with lenalidomide preparations of hard capsules, has the same pharmacological, therapeutic effect in non-clinical studies and bioequivalence studies, and also has improved ease of taking, handling, safety and the like.
Type:
Application
Filed:
September 11, 2017
Publication date:
February 6, 2020
Applicant:
SAMYANG BIOPHARMACEUTICALS CORPORATION
Inventors:
Sang Yeob PARK, Hye Jung LIM, Sa Won LEE, Min Hyo SEO
Abstract: Disclosed are a pharmaceutical composition containing plasmid DNA, characterized by that it comprises plasmid DNA as active ingredients; a peptide comprising a nuclear localization signal (NLS) sequence or RGD peptide sequence; a cationic compound; and an amphiphilic copolymer, and the plasmid DNA binds to a peptide to form a complex with the cationic compound and the complex is entrapped in the nanoparticle structure of the amphiphilic block copolymer, and a preparation method thereof.
Type:
Application
Filed:
September 8, 2017
Publication date:
October 31, 2019
Applicant:
SAMYANG BIOPHARMACEUTICALS CORPORATION
Inventors:
Joung-Woo CHOI, Sang Hoon KIM, Hye Yeong NAM
Abstract: The present invention relates to an amphiphilic block copolymer composition which provides enhanced stability to a micelle formed by an amphiphilic block copolymer in an aqueous phase.
Abstract: Provided are a composition containing an unstable drug against oxidation like pemetrexed with improved stability and a preparation method thereof, by removing oxygen during the preparation. The method is readily applicable for manufacturing by freezing and degassing in a sealed chamber, and can provide formulations with significantly increased stability for the unstable drug against oxidation.
Type:
Grant
Filed:
May 27, 2016
Date of Patent:
October 29, 2019
Assignee:
SAMYANG BIOPHARMACEUTICALS CORPORATION
Inventors:
Joong-Woong Cho, Gyeong-Hae Kim, Min-Hyo Seo, Sa-Won Lee
Abstract: The present disclosure relates to a process for obtaining an ultrapure polymer by simply and effectively removing unreacted residual monomer in polymer, which is generated during production of a biodegradable polymer such as polylactic acid or derivatives thereof.
Type:
Application
Filed:
July 6, 2017
Publication date:
September 5, 2019
Applicant:
SAMYANG BIOPHARMACEUTICALS CORPORATION
Inventors:
Na Young LEE, Young Joo KOH, Guw Dong YEO
Abstract: Disclosed is a method capable of selectively synthesizing cationic lipids by controlling the introduction rate of a fatty acid group with respect to an oligoalkyleneamine by the change of reaction conditions.
Type:
Grant
Filed:
December 29, 2016
Date of Patent:
July 23, 2019
Assignee:
SAMYANG BIOPHARMACEUTICALS CORPORATION
Inventors:
Sungwon Choi, Hye Yeong Nam, Min-Hyo Seo
Abstract: Provided are a composition containing an unstable drug against oxidation like pemetrexed with improved stability and a preparation method thereof, by removing oxygen during the preparation without use of an antioxidant. The method is readily applicable for manufacturing by freezing and degassing in a sealed chamber, and can provide formulations with significantly increased stability for the unstable drug against oxidation.
Type:
Grant
Filed:
December 26, 2014
Date of Patent:
May 28, 2019
Assignee:
SAMYANG BIOPHARMACEUTICALS CORPORATION
Inventors:
Joong-Woong Cho, Gyeong-Hae Kim, Min-Hyo Seo, Sa-Won Lee
Abstract: Disclosed are an anionic drug-containing polymeric micelle particle comprising: an anionic drug as an active ingredient; a cationic lipid; and an amphiphilic block copolymer, wherein the anionic drug forms a complex with the cationic lipid, and the complex is entrapped in the micelle structure of the amphiphilic block copolymer, and a method for preparing the same. The particle may increase stability of the anionic drug in blood or in a body fluid, and it may enable intracellular delivery to improve efficacy of anionic drugs.
Type:
Grant
Filed:
April 25, 2016
Date of Patent:
May 21, 2019
Assignee:
SAMYANG BIOPHARMACEUTICALS CORPORATION
Inventors:
Se-Ho Kim, Ji-Yeon Son, Muhn-Ho La, Sung-Won Choi, Min-Hyo Seo
Abstract: Disclosed is a mucoadhesive pharmaceutical composition comprising a poly-ionic complex of chitosan and a polyacrylic acid polymer. As an oral formulation, the composition has the extended retention time in the gastrointestinal tract by its mucoadhesive and swelling properties, which is useful as sustained release formulations, retentive formulations of active ingredients with limited absorption regions, and active ingredients with pH dependent solubility.