Patents Assigned to SoluBest Ltd.
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Patent number: 9254268Abstract: Compositions are provided comprising a lipophilic active compound, e.g., a human or veterinary drug or a nutraceutical, interwoven with a polymeric matrix formed by two or more polymers, wherein one of the polymers is an amphiphilic polymer and the other polymer is either an amphiphilic polymer with a different hydrophobic-hydrophilic balance or a hydrophilic polymer, and the active lipophilic compound has modified physicochemical properties. The composition forms colloidal nanodispersion upon contact with aqueous media.Type: GrantFiled: September 25, 2008Date of Patent: February 9, 2016Assignee: SOLUBEST LTD.Inventors: Galia Temtsin Krayz, Maryana Averbuch, Ilya Zelkind, Larisa Gitis
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Publication number: 20090098200Abstract: Compositions are provided comprising a lipophilic active compound, e.g., a human or veterinary drug or a nutraceutical, interwoven with a polymeric matrix formed by two or more polymers, wherein one of the polymers is an amphiphilic polymer and the other polymer is either an amphiphilic polymer with a different hydrophobic-hydrophilic balance or a hydrophilic polymer, and the active lipophilic compound has modified physicochemical properties. The composition forms colloidal nanodispersion upon contact with aqueous media.Type: ApplicationFiled: September 25, 2008Publication date: April 16, 2009Applicant: SOLUBEST LTD.Inventors: Galia Temtsin Krayz, Maryana Averbuch, Ilya Zelkind, Larisa Gitis
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Publication number: 20060228419Abstract: The invention provides a solvent-free process for the preparation of a hydrophilic dispersion comprising nanoparticles of an hydrophilic inclusion complex consisting essentially of nanosized particles of an active compound and an amphiphilic polymer which wraps said active compound such that non-valent bonds are formed between said compound and said polymer in said inclusion complex, comprising: (i) preparation of an aqueous solution of the amphiphilic polymer; and (ii) bringing the active compound and the polymer aqueous solution into interaction under conditions suitable for the formation of said hydrophilic dispersion. The process can be applied to small organic compounds as well as to macromolecules, and provides stable hydrophilic dispersions.Type: ApplicationFiled: April 7, 2005Publication date: October 12, 2006Applicant: SoluBest Ltd.Inventors: Rina Goldshtein, Larisa Gitis, Vladimir Mikunis, Galina Ratner, Boris Tulbovich, Ilya Zelkind, Vadim Goldshtein
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Patent number: 7081450Abstract: This invention provides a soluble nano-sized particles formed of a core (water-insoluble lipophilic compound or hydrophilic compound) and an amphiphilic polymer and which demonstrated improved solubility and/or stability. The lipophilic compound within the soluble nano-sized soluble (“solu-nanoparticles”) may consist of pharmaceutical compounds, food additives, cosmetics, agricultural products and veterinary products. The invention also provides novel methods for preparing the nano-sized soluble particles, as well as a novel chemical reactor for manufacturing an inclusion complex comprising the nano-sized soluble particles.Type: GrantFiled: September 26, 2002Date of Patent: July 25, 2006Assignee: Solubest Ltd.Inventor: Rina Goldshtein
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Publication number: 20050249786Abstract: The present invention provides a hydrophilic inclusion complex consisting essentially of nanosized particles of an active compound in amorphous form and an amphiphilic polymer which wraps the active compound such that non-valent bonds are formed between the active compound and the amphiphilic polymer. The invention further provides hydrophilic dispersions comprising said inclusion complexes, particularly of pharmaceutical drugs, and stable pharmaceutical compositions comprising said dispersions of the pharmaceutical drugs in amorphous form.Type: ApplicationFiled: April 7, 2005Publication date: November 10, 2005Applicant: SoluBest Ltd.Inventors: Rina Goldshtein, Irene Jaffe, Boris Tulbovich
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Publication number: 20050233003Abstract: The invention provides a hydrophilic inclusion complex consisting essentially of nanosized particles of salicylic acid wrapped in an amphiphilic polymer, wherein said amphiphilic polymer is selected from the group consisting of polyacrylic acid, polyacrylamide and copolymers thereof, polymethacrylamide and copolymers thereof, and polylysine, and said amphiphilic polymer is modified by reaction with urea or a derivative thereof, nicotinamide or guanidine. Further provided are hydrophilic dispersions comprising nanoparticles of said inclusion complexes and pharmaceutical and cosmetic compositions comprising said dispersions.Type: ApplicationFiled: April 7, 2005Publication date: October 20, 2005Applicant: SoluBest Ltd.Inventors: Rina Goldshtein, Vadim Goldshtein, Vladimir Mikunis, Larisa Gitis
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Publication number: 20050226934Abstract: The present invention provides a hydrophilic inclusion complex consisting essentially of nanosized particles of a non-crystalline active compound wrapped by an amphiphilic polymer consisting of a homopolymer of acrylic acid or methacrylic acid or a copolymer of acrylic acid or methacrylic acid, or both, with one or more comonomers. The invention further provides hydrophilic dispersions comprising nanoparticles of said inclusion complexes and stable compositions comprising them.Type: ApplicationFiled: April 7, 2005Publication date: October 13, 2005Applicant: SoluBest Ltd.Inventors: Rina Goldshtein, Olga Sklyarsky, Ilya Zelkind, Michael Kopylov, Boris Tulbovich, Vadim Goldshtein
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Publication number: 20050227911Abstract: The present invention provides hydrophilic dispersions comprising nanoparticles of inclusion complexes consisting essentially of nanosized particles of a macromolecule wrapped in an amphiphilic polymer such that non-valent bonds are formed between the macromolecule and the amphiphilic polymer. The macromolecules may be a naturally-occurring, synthetic or recombinant polypeptide, protein, polysaccharide or polynucleotide, and the amphiphilic polymer is a polysaccharide or a modified polysaccharide such as starch, chitosan or an alginate.Type: ApplicationFiled: April 7, 2005Publication date: October 13, 2005Applicant: SoluBest Ltd.Inventors: Rina Goldshtein, Galina Ratner, Larisa Gitis, Boris Tulbovich
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Publication number: 20050191359Abstract: Hydrophilic dispersions of stable nano-sized particles are provided comprising: (a) a water-insoluble or water-soluble active compound, wherein said active compound is selected from the group consisting of a macrolide antibiotic, donepezil hydrochloride, an azole compound and a taxane; and (b) an amphiphilic polymer which wraps said active compound in a non-crystalline manner to form a nano-sized molecular entity in which no valent bonds are formed.Type: ApplicationFiled: September 29, 2004Publication date: September 1, 2005Applicant: SoluBest Ltd.Inventors: Rina Goldshtein, Roman Kamburg, Galina Ratner, Michael Kopylov, Ilya Zelkind, Vadim Goldshtein, Olga Skylarsky, Boris Tulbovich, Erwin Stern
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Patent number: 6878693Abstract: This invention provides a soluble inclusion complex formed of a water-insoluble lipophilic compound and an amphiphilic polymer and which demonstrated improved solubility and stability. The lipophilic compound within the inclusion complex may consist of pharmaceutical compounds, food additives, cosmetics, agricultural products and veterinary products. The invention also provides novel methods for preparing the inclusion complex, as well as a novel chemical reactor for forming the inclusion complex.Type: GrantFiled: September 28, 2001Date of Patent: April 12, 2005Assignee: SoluBest Ltd.Inventor: Rina Goldshtein