Patents Assigned to Supernus Pharmaceuticals, Inc.
  • SUSTAINED-RELEASE FORMULATIONS OF TOPIRAMATE
    Publication number: 20170266121
    Abstract: Pharmaceutical compositions of topiramate for once-a-day oral administration are provided. The formulations comprise a sustained-release component and an optional immediate-release component, the compositions of which can be selectively adjusted, respectively, to release the active ingredient along a pre-determined release profile. Method of treating or preventing pathological disorders in mammalian subjects comprising the administration of the novel formulations disclosed herein is also provided.
    Type: Application
    Filed: March 30, 2017
    Publication date: September 21, 2017
    Applicant: Supernus Pharmaceuticals, Inc.
    Inventors: Likan LIANG, Hua WANG, Padmanabh P. BHATT, Michael L. VIEIRA
  • FORMULATIONS OF VILOXAZINE
    Publication number: 20170258801
    Abstract: Modified release formulations of viloxazine and methods of administering the same are disclosed. High-drug load formulations of viloxazine are further disclosed.
    Type: Application
    Filed: May 25, 2017
    Publication date: September 14, 2017
    Applicant: Supernus Pharmaceuticals, Inc.
    Inventors: Michael L. VIEIRA, Austin B. HUANG, Padmanabh P. BHATT
  • Topiramate compositions and methods of enhancing its bioavailability
    Patent number: 9744137
    Abstract: The present invention is directed to pharmaceutical compositions that allow for once-daily or alternate day dosage forms of topiramate. The proposed delayed/extended release single dosage form is equivalent to the immediate-release multiple dose daily regimen, and upon administration, provides steady state blood levels of topiramate. Formulations with increased bioavailability and improved pharmacokinetics are disclosed. A once-a-day administration of topiramate is advantageous over the multiple dose regimen both in terms of patient compliance and reduced adverse events, thus providing better treatment of the conditions for which the topiramate is indicated.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: August 29, 2017
    Assignee: Supernus Pharmaceuticals, Inc.
    Inventors: Avinash Nangia, Daya D. Verma, Jules Jacob
  • Formulations of viloxazine
    Patent number: 9662338
    Abstract: Modified release formulations of viloxazine and methods of administering the same are disclosed. High-drug load formulations of viloxazine are further disclosed.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: May 30, 2017
    Assignee: Supernus Pharmaceuticals, Inc.
    Inventors: Michael L. Vieira, Austin B. Huang, Padmanabh P. Bhatt
  • METHODS OF PRODUCING MOLINDONE AND ITS SALTS
    Publication number: 20170101377
    Abstract: The present invention is directed towards novel methods of synthesis of molindone, synthesis of the intermediates of molindone, and high-purity compositions of molindone. In particular, the invention relates to the methods of synthesis of molindone through the Mannich reaction.
    Type: Application
    Filed: November 30, 2016
    Publication date: April 13, 2017
    Applicant: Supernus Pharmaceuticals, Inc.
    Inventors: Martin HANBAUER, Zarghun NAZIR, Peter HILDEBRAND, Attilia FIGINI, Likan LIANG, Tiziano FUMAGALLI
  • Formulations of viloxazine
    Patent number: 9603853
    Abstract: Modified release formulations of viloxazine and methods of administering the same are disclosed. High-drug load formulations of viloxazine are further disclosed.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: March 28, 2017
    Assignee: Supernus Pharmaceuticals, Inc.
    Inventors: Michael L. Vieira, Austin B. Huang, Padmanabh P. Bhatt
  • MODIFIED RELEASE PREPARATIONS CONTAINING OXCARBAZEPINE AND DERIVATIVES THEREOF
    Publication number: 20170056411
    Abstract: Controlled-release preparations of oxcarbazepine and derivatives thereof for once-a-day administration are disclosed. The inventive compositions comprise solubility- and/or release enhancing agents to provide tailored drug release profiles, preferably sigmoidal release profiles. Methods of treatment comprising the inventive compositions are also disclosed.
    Type: Application
    Filed: May 27, 2016
    Publication date: March 2, 2017
    Applicant: Supernus Pharmaceuticals, Inc.
    Inventors: Padmanabh P. BHATT, Argaw KIDANE, Kevin EDWARDS
  • Osmotic drug delivery system
    Patent number: 9566245
    Abstract: An oral osmotic pharmaceutical delivery system comprises a highly water-soluble drug exhibiting an erratic or an incomplete release profile when formulated in an elementary osmotic pump delivery system and at least one release enhancing agent.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: February 14, 2017
    Assignee: Supernus Pharmaceuticals, Inc.
    Inventors: Argaw Kidane, Padmanabh P Bhatt
  • Methods of producing molindone and its salts
    Patent number: 9562011
    Abstract: The present invention is directed towards novel methods of synthesis of molindone, synthesis of the intermediates of molindone, and high-purity compositions of molindone. In particular, the invention relates to the methods of synthesis of molindone through the Mannich reaction.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: February 7, 2017
    Assignee: Supernus Pharmaceuticals, Inc.
    Inventors: Martin Hanbauer, Zarghun Nazir, Peter Hildebrand, Attilia Figini, Likan Liang, Tiziano Fumagalli
  • Sustained-release formulations of topiramate
    Patent number: 9555004
    Abstract: Pharmaceutical compositions of topiramate for once-a-day oral administration are provided. The formulations comprise a sustained-release component and an optional immediate-release component, the compositions of which can be selectively adjusted, respectively, to release the active ingredient along a pre-determined release profile. Method of treating or preventing pathological disorders in mammalian subjects comprising the administration of the novel formulations disclosed herein is also provided.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: January 31, 2017
    Assignee: Supernus Pharmaceuticals, Inc.
    Inventors: Likan Liang, Hua Wang, Padmanabh P. Bhatt, Michael L. Vieira
  • Sustained-release formulations of topiramate
    Patent number: 9549940
    Abstract: Pharmaceutical compositions of topiramate for once-a-day oral administration are provided. The formulations comprise a sustained-release component and an optional immediate-release component, the compositions of which can be selectively adjusted, respectively, to release the active ingredient along a pre-determined release profile. Method of treating or preventing pathological disorders in mammalian subjects comprising the administration of the novel formulations disclosed herein is also provided.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: January 24, 2017
    Assignee: Supernus Pharmaceuticals, Inc.
    Inventors: Likan Liang, Hua Wang, Padmanabh P. Bhatt, Michael L. Vieira
  • SUSTAINED-RELEASE FORMULATIONS OF TOPIRAMATE
    Publication number: 20160375048
    Abstract: Pharmaceutical compositions of topiramate for once-a-day oral administration are provided. The formulations comprise a sustained-release component and an optional immediate-release component, the compositions of which can be selectively adjusted, respectively, to release the active ingredient along a pre-determined release profile. Method of treating or preventing pathological disorders in mammalian subjects comprising the administration of the novel formulations disclosed herein is also provided.
    Type: Application
    Filed: September 8, 2016
    Publication date: December 29, 2016
    Applicant: Supernus Pharmaceuticals, Inc.
    Inventors: Likan LIANG, Hua WANG, Padmanabh P. BHATT, Michael L. VIEIRA
  • SUSTAINED-RELEASE FORMULATIONS OF TOPIRAMATE
    Publication number: 20160375047
    Abstract: Pharmaceutical compositions of topiramate for once-a-day oral administration are provided. The formulations comprise a sustained-release component and an optional immediate-release component, the compositions of which can be selectively adjusted, respectively, to release the active ingredient along a pre-determined release profile. Method of treating or preventing pathological disorders in mammalian subjects comprising the administration of the novel formulations disclosed herein is also provided.
    Type: Application
    Filed: September 8, 2016
    Publication date: December 29, 2016
    Applicant: Supernus Pharmaceuticals, Inc.
    Inventors: Likan LIANG, Hua WANG, Padmanabh P. BHATT, Michael L. VIEIRA
  • METHODS FOR PRODUCING VILOXAZINE SALTS AND NOVEL POLYMORPHS THEREOF
    Publication number: 20160304475
    Abstract: Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HCl while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.
    Type: Application
    Filed: June 24, 2016
    Publication date: October 20, 2016
    Applicant: Supernus Pharmaceuticals, Inc.
    Inventors: Likan LIANG, Padmanabh P. BHATT, David DAIN, Jean-Philippe TAQUET, Aleksandr PECHENOV, Alexei TCHESNOKOV, Reynold MARIAUX
  • FORMULATIONS OF VILOXAZINE
    Publication number: 20160279136
    Abstract: Modified release formulations of viloxazine and methods of administering the same are disclosed. High-drug load formulations of viloxazine are further disclosed.
    Type: Application
    Filed: June 3, 2016
    Publication date: September 29, 2016
    Applicant: Supernus Pharmaceuticals, Inc.
    Inventors: Michael L. VIEIRA, Austin B. HUANG, Padmanabh P. BHATT
  • OSMOTIC DRUG DELIVERY SYSTEM
    Publication number: 20160263042
    Abstract: An oral osmotic pharmaceutical delivery system comprises a highly water-soluble drug exhibiting an erratic or an incomplete release profile when formulated in an elementary osmotic pump delivery system and at least one release enhancing agent.
    Type: Application
    Filed: May 24, 2016
    Publication date: September 15, 2016
    Applicant: Supernus Pharmaceuticals, Inc.
    Inventors: Argaw Kidane, Padmanabh P Bhatt
  • FORMULATIONS OF VILOXAZINE
    Publication number: 20160256465
    Abstract: Modified release formulations of viloxazine and methods of administering the same are disclosed. High-drug load formulations of viloxazine are further disclosed.
    Type: Application
    Filed: May 18, 2016
    Publication date: September 8, 2016
    Applicant: Supernus Pharmaceuticals, Inc.
    Inventors: Michael L. VIEIRA, Austin B. HUANG, Padmanabh P. BHATT
  • Viloxazine compositions
    Patent number: 9434703
    Abstract: Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HCl while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: September 6, 2016
    Assignee: Supernus Pharmaceuticals, Inc.
    Inventors: Likan Liang, Padmanabh P. Bhatt, David Dain, Jean-Philippe Taquet, Aleksandr Pechenov, Alexei Tchesnokov, Reynold Mariaux
  • Methods for producing viloxazine salts and novel polymorphs thereof
    Patent number: 9403783
    Abstract: Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HCl while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: August 2, 2016
    Assignee: Supernus Pharmaceuticals, Inc.
    Inventors: Likan Liang, Padmanabh P. Bhatt, David Dain, Jean-Philippe Taquet, Aleksandr Pechenov, Alexei Tchesnokov, Reynold Mariaux
  • Osmotic drug delivery system
    Patent number: 9393203
    Abstract: An oral osmotic pharmaceutical delivery system comprises a highly water-soluble drug exhibiting an erratic or an incomplete release profile when formulated in an elementary osmotic pump delivery system and at least one release enhancing agent.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: July 19, 2016
    Assignee: Supernus Pharmaceuticals, Inc.
    Inventors: Argaw Kidane, Padmanabh P Bhatt