Patents Assigned to The University of Kentucky Research Foundation
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Patent number: 11986464Abstract: Methods of treating or reducing risk of aneurysm, reducing cardiovascular risk, reducing serum cholesterol, reducing serum triglycerides, and/or reducing atherosclerotic plague in a subject involve administering to the subject an effective amount of a 5HT3R antagonist.Type: GrantFiled: May 2, 2022Date of Patent: May 21, 2024Assignee: University of Kentucky Research FoundationInventors: Lisa Cassis, Sean Thatcher, Yasir Alsiraj, Mark Ensor, Eric Blalock
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Patent number: 11984046Abstract: A surgical skills training model has an elongated body including muscle, fascia, subcutaneous tissue, connective tissue and skin mimicking layers. The fascia and connective tissue layer are made from a material having a stretch direction that is aligned with a longitudinal axis of the muscle layer and the body of the model.Type: GrantFiled: August 17, 2020Date of Patent: May 14, 2024Assignee: University of Kentucky Research FoundationInventors: Samuel G. Powdrill, DeShana Collett
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Patent number: 11980687Abstract: A composition and method for treating a subject following myocardial infarction are provided. The composition includes a non-PEGylated liposome. The method includes administering a non-PEGylated liposome to a subject in need thereof following myocardial infarction.Type: GrantFiled: April 18, 2023Date of Patent: May 14, 2024Assignee: University of Kentucky Research FoundationInventors: Vincent J. Venditto, Ahmed Abdel-Latif, Ahmed Al-Darraji, Dave Feola, John C. Gensel
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Patent number: 11976092Abstract: Disclosed herein are high Tm RNA nanostructures that can be composed of one or more modules or motifs to build RNA nanostructures with or without layers. The RNA nanostructures can have a core domain and three or more double-stranded arms and formulations thereof to conjugate high copy numbers of therapeutics, pH responsive or enzyme cleavable drug cargo. Also described herein is a design strategy for generation of synthetic RNA oligonucleotides that can self assemble into highly thermostable RNA structures. Also described herein are uses of the RNA nanostructures described herein.Type: GrantFiled: November 12, 2018Date of Patent: May 7, 2024Assignees: Ohio State Innovation Foundation, University of Kentucky Research FoundationInventors: Peixuan Guo, Mario Vieweger, Xin Li, Sijin Guo, Hongran Yin, Xijun Piao, Yi Shu, Dan Shu, Mehdi Rajabi
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Patent number: 11964028Abstract: The presently-disclosed subject matter relates to an artificial RNA nanostructure and method of use thereof. In particular, the presently-disclosed subject matter relates to RNA nanoparticles and RNA dendrimers, and methods of disease diagnosis and treatments using the RNA nanostructure and RNA dendrimers.Type: GrantFiled: November 9, 2020Date of Patent: April 23, 2024Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATIONInventors: Peixuan Guo, Hui Li, Wei Luo
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Patent number: 11964172Abstract: A quality assurance device for a medical accelerator includes a housing having an inner radioluminescent layer adapted to provide a visual indication when contacted with invisible radiation generated by the medical accelerator. In addition, the quality assurance device includes one or more cameras located within the housing and adapted to image the inner radioluminescent layer of the housing including the visual indication.Type: GrantFiled: December 12, 2019Date of Patent: April 23, 2024Assignee: University of Kentucky Research FoundationInventors: Janelle A. Molloy, Dennis A. Cheek, Quan Chen
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Patent number: 11938443Abstract: A hybrid post-combustion carbon dioxide capture system for capturing carbon dioxide from a flue gas includes a compressor adapted to produce a compressed flue gas stream, a membrane-based carbon dioxide separation unit configured to receive a first portion of the compressed flue gas stream from the compressor, and an aqueous-based carbon dioxide capture unit configured to receive a second portion of the compressed flue gas stream from the compressor whereby the compressed flue gas stream is processed in parallel by the membrane-based carbon dioxide separation unit and the aqueous-based carbon dioxide capture unit.Type: GrantFiled: February 12, 2021Date of Patent: March 26, 2024Assignee: University of Kentucky Research FoundationInventor: Kunlei Liu
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Patent number: 11932557Abstract: Methods for detecting and extracting plastic contaminants within a water sample, which involve introducing the water sample to a hydrophobic deep eutectic solvent, are provided.Type: GrantFiled: June 29, 2021Date of Patent: March 19, 2024Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATIONInventors: Jian Shi, Wenqi Li, Jameson Hunter, Yuxuan Zhang, Qing Shao
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Patent number: 11932897Abstract: A method of making curcuminoids in a mammalian cell. The method of making a curcuminoid in a mammalian cell includes expressing one or more enzymes in the mammalian cell, the enzymes being selected from the group consisting of tyrosine ammonia lyase (TAL), 4-coumaroyl-CoA ligase (4CL1), curcuminoid synthase (CUS), diketide-CoA synthase (DCS), curcumin synthase (CURS1), 4-coumarate 3-hydroxylase (C3H), caffeoyl-CoA 3-O-methyltransferase (CCoAMT), and acetyl-CoA carboxylase (ACC). The expressing of the one or more enzymes converts a starting material, such as tyrosine or ferulic acid, to the curcuminoid. Also provided herein are therapeutic uses for the curcuminoid made in a mammalian cell.Type: GrantFiled: December 18, 2019Date of Patent: March 19, 2024Assignee: University of Kentucky Research FoundationInventors: Logan W. Warriner, Daniel W. Pack
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Patent number: 11920039Abstract: Derivatized malachite green leuco dyes for use in radio-chromic systems are described. The dyes have the following structure: in which Ar is a substituted phenyl or thiophene ring in which at least one substitution of the Ar ring is not ortho to the bond between the ring and the linking carbon, and in which R1, R2, R3, and R4 are independently selected from methyl, alkyl, or alkyl halide. The systems include the dyes in conjunction with an activator, e.g., a halogenated activator, and a carrier, e.g., a fluid carrier or an encapsulating polymeric matrix.Type: GrantFiled: January 29, 2020Date of Patent: March 5, 2024Assignees: Battelle Savannah River Alliance, LLC, University of Kentucky Research FoundationInventors: Aaron L. Washington, II, John T. Bobbitt, III, John E. Anthony, Brent Peters, James C. Nicholson
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Patent number: 11890490Abstract: A quality assurance device for a medical accelerator includes a housing having an inner radioluminescent layer adapted to provide a visual indication when contacted with invisible radiation generated by the medical accelerator. In addition, the quality assurance device includes one or more passive optical components within the housing adapted to deliver an image of the inner radioluminescent layer of the housing including the visual indication to one or more cameras located outside of the housing.Type: GrantFiled: December 12, 2019Date of Patent: February 6, 2024Assignee: University of Kentucky Research FoundationInventors: Janelle A. Molloy, Dennis A. Cheek, Quan Chen
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Patent number: 11883409Abstract: Therapeutic uses P2X7 inhibition and inhibition of IRAK1 and/or IRAK4, methods protecting a cell, and screening methods for identifying inhibitors are described herein.Type: GrantFiled: January 10, 2020Date of Patent: January 30, 2024Assignee: University of Kentucky Research FoundationInventor: Jayakrishna Ambati
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Patent number: 11857914Abstract: An apparatus for removing an acid gas from a feed gas stream includes an absorber and an electrochemical regenerator. The absorber is adapted for separating the acid gas from the feed gas feed stream using a lean carbon capture solvent. The electrochemical regenerator is connected to the absorber and adapted for (a) regenerating the carbon capture solvent and (b) generating hydrogen gas. A method for removing acid gas from a feed gas stream includes steps of separating, delivering, releasing, generating and returning.Type: GrantFiled: November 18, 2021Date of Patent: January 2, 2024Assignee: University of Kentucky Research FoundationInventors: Ayokunle Omosebi, Xin Gao, Reynolds Frimpong, Kunlei Liu
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Patent number: 11851391Abstract: An antifungal composition and a method of treating a systemic fungal infection are provided herein. The antifungal composition includes a diaryl bishydrazone. The method includes administering a therapeutically effective amount of the diaryl bishydrazone to a subject in need thereof.Type: GrantFiled: July 17, 2019Date of Patent: December 26, 2023Assignee: University of Kentucky Research FoundationInventors: Sylvie Garneau-Tsodikova, David S. Watt, Nishad Thamban Chandrika
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Patent number: 11833185Abstract: Therapeutic peptides of the following sequence are disclosed: Xaa1-Xaa2-Xaa3-Xaa4-Xaa5, and optionally further comprising Xaa6, wherein Xaa represents an amino acid; Xaa3 is proline; and subscripts represent the positions of each amino acid in the peptide sequence starting from the amino terminus of said peptide extending to the C-terminus. A therapeutic peptide optionally includes a linker that cyclizes the peptide. Also described are methods of treating a neurodegenerative disorder and/or injury in a human subject in need of such treatment by administering to the subject a therapeutically effective amount of a therapeutic peptide as disclosed herein.Type: GrantFiled: February 11, 2020Date of Patent: December 5, 2023Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATIONInventors: Luke H. Bradley, Don M. Gash, Greg A. Gerhardt, Raymond T. Bartus, Sr.
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Patent number: 11827718Abstract: Provided herein are antibodies, or antigen-binding portions thereof, which specifically bind to pathologic forms of calcineurin. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and methods for use of these antibodies.Type: GrantFiled: May 19, 2021Date of Patent: November 28, 2023Assignee: University of Kentucky Research FoundationInventors: Susan D. Kraner, Rodney P Guttmann, Christopher M. Norris, Jenna Leigh Gollihue
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Patent number: 11819799Abstract: An acid gas absorber includes a co-current flue gas-lean solution section and a packed counter-current flue gas-liquid phase section useful in a method of capturing an acid gas from flue gas in a more efficient and cost effective manner.Type: GrantFiled: February 1, 2021Date of Patent: November 21, 2023Assignee: University of Kentucky Research FoundationInventors: Kunlei Liu, Heather Nikolic
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Patent number: 11821054Abstract: A method for recovering valuable elements from pre-combustion coal-based materials includes the steps of grinding the materials to a predetermined size, roasting the ground materials at a temperature of 600° C.-700° C. for a predetermined residence time needed for mineral decomposition, submerging the roasted, ground materials in a solution of lixiviant, filtering the lixiviant solution to separate residual solids from a pregnant leach solution including the valuable elements and recovering and concentrating the valuable elements from the pregnant leach solution.Type: GrantFiled: March 27, 2020Date of Patent: November 21, 2023Assignee: University of Kentucky Research FoundationInventors: Rick Honaker, Wencai Zhang
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Patent number: 11813118Abstract: This application concerns a loupe-based wearable device that is enhanced by a mounted visualization aid on the housing body of at least one of the loupe eyepieces, the aid providing a dual light source, a beam splitter, and a camera directed in the same optical path as a user's eyesight such that both visible light and fluorescent dye exciting light can be directed at a site of operation to enhance real time visualization of tissue resection.Type: GrantFiled: July 10, 2018Date of Patent: November 14, 2023Assignee: University of Kentucky Research FoundationInventors: Guoqiang Yu, Thomas A. Pittman, Chong Huang, Nick McGregor
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Patent number: 11807859Abstract: Compositions and methods for reducing the level of nornicotine and N?-nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for cytochrome P450s that are involved in the metabolic conversion of nicotine to nornicotine in these plants. Expression cassettes, vectors, plants, and plant parts thereof comprising inhibitory sequences that target expression or function of the disclosed cytochrome P450 polypeptides are also provided. Methods for the use of these novel sequences to inhibit expression or function of cytochrome P450 polypeptides involved in this metabolic conversion are also provided. The methods find use in the production of tobacco products that have reduced levels of nornicotine and its carcinogenic metabolite, NNN, and thus reduced carcinogenic potential for individuals consuming these tobacco products or exposed to secondary smoke derived from these products.Type: GrantFiled: March 1, 2022Date of Patent: November 7, 2023Assignees: North Carolina State University, University of Kentucky Research FoundationInventors: Ralph E. Dewey, Balazs Siminszky, Steven W. Bowen, Lily Gavilano