Patents Assigned to Transform Pharmaceuticals, Inc.
-
Publication number: 20080319068Abstract: A polymer of aspirin is provided by the present invention. Methods of making and using the same are also provided.Type: ApplicationFiled: April 25, 2006Publication date: December 25, 2008Applicants: Transform Pharmaceuticals, Inc., University of South FloridaInventors: Orn Almarsson, Jennifer McMahon, Vishweshwar Peddy, Matthew Peterson, Michael J. Zaworotko
-
Patent number: 7449307Abstract: The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving surface configured for holding a sample thereon for in situ experimentation. The sample receiving surface preferably has at least one sharp edge at the junction between a sidewall coupling the sample receiving surface to the substrate surface. The sample receiving surface is preferably a circle, oval, square, rectangle, triangle, pentagon, hexagon, or octagon shape that is sized to hold a predetermined volume of the sample. A method of using the above described assay plate is also provided. Once a raised pad extending from a substrate is formed, a sample is deposited on the raised pad. Experiments are subsequently performed using the sample on the raised pad.Type: GrantFiled: October 27, 2003Date of Patent: November 11, 2008Assignee: Transform Pharmaceuticals, Inc.Inventors: Michael Cima, Wendy Pryce Lewis, Javier Gonzalez-Zugasti, J. Richard Gyory, Anthony V. Lemmo, Julie Monagle
-
Patent number: 7449342Abstract: The invention relates to methods and apparatuses for manipulating small amounts of solids. Specific embodiments of the invention are particularly suited for the automated transfer of small amounts of solids. In one embodiment, a uniform powder bed is lightly compressed into plugs of powder and dispensed. In another embodiment, the solid is placed in a liquid carrier to form a slurry, dispensed, and the liquid component is subsequently removed. In yet another embodiment, solids are manipulated using adhesive surfaces.Type: GrantFiled: November 3, 2003Date of Patent: November 11, 2008Assignee: Transform Pharmaceuticals, Inc.Inventors: Nathan Kane, Michael Cima, Javier Gonzalez-Zugasti, Jeanie Cherng, Anthony Lemmo, J. Richard Gyory
-
Patent number: 7446107Abstract: The invention provides novel soluble conazole crystalline forms (e.g. itraconazole, posaconazole and saperconazole) that include salts, co-crystals and related solvates useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, and processes for making, these conazole crystalline forms. Methods of using such compositions for the treatment or prevention of systemic and local fungal, yeast, and dermatophyte infections are also provided.Type: GrantFiled: August 26, 2004Date of Patent: November 4, 2008Assignee: Transform Pharmaceuticals, Inc.Inventors: Julius Remenar, Michael MacPhee, Matthew Peterson, Sherry Morissette, Orn Almarsson
-
Publication number: 20080200474Abstract: Disclosed herein are novel salts of flunarizine with improved properties. Also described herein are novel pharmaceutical compositions comprising such flunarizine salts, methods of making, and related methods of treatment.Type: ApplicationFiled: January 17, 2008Publication date: August 21, 2008Applicant: TRANSFORM PHARMACEUTICALS, INC.Inventors: Matthew Peterson, Julius Remenar, Carlos Sanrame
-
Publication number: 20080194860Abstract: The present invention relates to a novel crystal of the Active Pharmaceutical Ingredient (API) (S)-(+)-2-(2-chlorophenyl)-2-hydroxy-ethyl carbamate, methods for the preparation of this crystal, pharmaceutical compositions comprising this crystal, and methods of treating a patient with this crystal.Type: ApplicationFiled: October 5, 2007Publication date: August 14, 2008Applicant: TRANSFORM PHARMACEUTICALS, INC.Inventor: Michael Tauber
-
Patent number: 7408632Abstract: The present invention provides methods for the determination of miscibility of a mixture of two or more liquids. Measurements of the local deviation of a pattern characteristic or of the variation in light intensity are employed in such determinations.Type: GrantFiled: February 17, 2005Date of Patent: August 5, 2008Assignee: TransForm Pharmaceuticals, Inc.Inventor: Christopher B. Moore
-
Publication number: 20080182293Abstract: The present invention relates to computer-controlled high-throughput systems, computer-program products, and methods of use to prepare a large number of component combinations, at varying concentrations and identities, at the same time, and high-throughput methods to test tissue barrier transfer, such as transdermal transfer, of components in each combination. The methods of the present invention allow determination of the effects of inactive components, such as solvents, excipients, enhancers, adhesives and additives, on tissue barrier transfer of active components, such as pharmaceuticals. The invention thus encompasses the use of computer-controlled high-throughput systems, computer-program products, and methods of high-throughput testing of pharmaceutical compositions or formulations in order to determine the overall optimal composition or formulation for improved tissue transport, such as transdermal transport.Type: ApplicationFiled: August 24, 2006Publication date: July 31, 2008Applicant: Transform Pharmaceuticals, Inc.Inventors: Anthony V. Lemmo, Javier P. Gonzalez-Zugasti, Michael J. Cima, Douglas A. Levinson, Alasdair Y. Johnson, Orn Almarsson, Hongming Chen, Christopher McNulty
-
Publication number: 20080091026Abstract: The present invention relates to a novel crystal of the Active Pharmaceutical Ingredient (API) N-[[(5S)-3 -[4-(2,6-dihydro-2-methylpyrrolo[3,4-c]pyrazol-5(4H)-yl)-3-fluorophenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide, methods for the preparation of this crystal, pharmaceutical compositions comprising this crystal, and methods of treating a patient with this crystal.Type: ApplicationFiled: October 10, 2007Publication date: April 17, 2008Applicant: TRANSFORM PHARMACEUTICALS, INC.Inventors: Renato Chiarella, Matthew Peterson, Lisa Scoppettuolo
-
Novel Saperconazole Crystalline Forms and Related Processes, Pharmaceutical Compositions and Methods
Publication number: 20070293674Abstract: The invention provides novel soluble conazole crystalline forms (e.g., cisitraconazole, saperconazole) that include salts, co-crystals and polymorphs useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, and processes for making, these conazole crystalline forms. Methods of using such compositions for the treatment or prevention of systemic and local fungal, yeast, and dermatophyte infections are also provided.Type: ApplicationFiled: April 21, 2005Publication date: December 20, 2007Applicant: TRANSFORM PHARMACEUTICALS, INC.Inventors: Lisa Scoppettuolo, Matthew Peterson, Orn Almarsson, Julius Remenar -
Publication number: 20070171361Abstract: The present invention provides multifocal lenses containing at least four zones of different refractive power. The zones are positioned such that the wearer is able to use the inferior-most portion of the lens to more clearly, as compared to conventional multifocal lenses, view objects at distances more than 45 cm from the eye.Type: ApplicationFiled: May 13, 2004Publication date: July 26, 2007Applicant: TransForm Pharmaceuticals, IncInventors: Amitava Gupta, Benjamin Wooley, Shyamy Sastry, Edgar Menezes
-
Publication number: 20070117851Abstract: The present invention relates to liquid compositions of nimodipine and administration of said compositions. New stable liquid compositions of nimodipine can be used to treat conditions such as, but not limited to, aneurysms, subarachnoid hemorrhage, vasospastic angina, Prenzmetal's angina, stable angina, acute myocardial infarction, myocardial arrest, arrhythmia, systemic hypertension, pulmonary hypertension, congestive heart failure, and hypertrophic cardiomyopathy.Type: ApplicationFiled: October 12, 2006Publication date: May 24, 2007Applicant: TRANSFORM PHARMACEUTICALS, INC.Inventors: Julius Remenar, Zhong Zhang
-
Patent number: 7205413Abstract: Novel solvates and crystal polymorphs of Ritonavir are disclosed, as well as methods of making them. Specific solvates of the compound include a formamide solvate and a partially desolvated solvate. Also disclosed are methods of making previously known forms of Ritonavir. Methods of using the novel forms of Ritonavir for the treatment of diseases, such as HIV-infection, are disclosed, as are pharmaceutical compositions and unit dosage forms comprising the novel forms of Ritonavir.Type: GrantFiled: May 1, 2003Date of Patent: April 17, 2007Assignee: TransForm Pharmaceuticals, Inc.Inventors: Sherry L. Morissette, Orn Almarsson, Stephen Soukasene
-
Patent number: 7186863Abstract: An acid salt of sertraline, wherein the acid is citric acid, fumaric acid, malic acid, maleic acid, malonic acid, phosphoric acid, succinic acid, sulfuric acid, L-tartaric acid, HBr, acetic acid, benzoic acid, benzenesulfonic acid, ethanesulfonic acid, lactic acid, methanesulfonic acid or toluenesulfonic acid. Similarly, a solvate of sertraline HCl, wherein the solvent is methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, t-butanol, acetic acid, ethyl acetate, or propylene glycol.Type: GrantFiled: May 21, 2004Date of Patent: March 6, 2007Assignee: TransForm Pharmaceuticals, Inc.Inventors: Julius Remenar, Michael MacPhee, Matthew Lynn Peterson, Mark Tawa
-
Patent number: 7172859Abstract: The present invention relates to high-throughput systems and methods to prepare a large number of component combinations, at varying concentrations and identities, at the same time, and high-throughput methods to test tissue barrier transfer, such as transdermal transfer, of components in each combination. The methods of the present invention allow determination of the effects of inactive components, such as solvents, excipients, enhancers, adhesives and additives, on tissue barrier transfer of active components, such as pharmaceuticals. The invention thus encompasses the high-throughput testing of pharmaceutical compositions or formulations in order to determine the overall optimal composition or formulation for improved tissue transport, such as transdermal transport.Type: GrantFiled: February 20, 2003Date of Patent: February 6, 2007Assignee: Transform Pharmaceuticals, Inc.Inventors: Michael J. Cima, Hongming Chen, J. Richard Gyory
-
Publication number: 20070026078Abstract: A pharmaceutical composition comprising a co-crystal of an API and a co-crystal former; wherein the API has at least one functional group selected from ether, thioether, alcohol, thiol, aldehyde, ketone, thioketone, nitrate ester, phosphate ester, thiophosphate ester, ester, thioester, sulfate ester, carboxylic acid, phosphonic acid, phosphinic acid, sulfonic acid, amide, primary amine, secondary amine, ammonia, tertiary amine, sp2 amine, thiocyanate, cyanamide, oxime, nitrile diazo, organohalide, nitro, s-heterocyclic ring, thiophene, n-heterocyclic ring, pyrrole, o-heterocyclic ring, furan, epoxide, peroxide, hydroxamic acid, imidazole, pyridine and the co-crystal former has at least one functional group selected from amine, amide, pyridine, imidazole, indole, pyrrolidine, carbonyl, carboxyl, hydroxyl, phenol, sulfone, sulfonyl, mercapto and methyl thio, such that the API and co-crystal former are capable of co-crystallizing from a solution phase under crystallization conditions.Type: ApplicationFiled: September 11, 2003Publication date: February 1, 2007Applicants: TransForm Pharmaceuticals, Inc., University of South Florida, The Regents of the University of MichiganInventors: Orn Almarsson, Magali Bourghol Hickey, Matthew Peterson, Michael Zaworotko, Brian Moulton, Nair Rodriguez-Hornedo
-
Publication number: 20070020662Abstract: The present invention relates to computer-controlled automated high-throughput systems and/or computer-program products to design, prepare, process, and analyze a large number of samples having experimental formulations each containing a compound of interest formulated with differing component combinations and varying concentrations and component identities. The computer-controlled methods of the present invention allow determination of the effects of additional or inactive components, such as excipients, carriers, enhancers, adhesives, additives, and the like, on the compound of interest, such as pharmaceuticals. The invention thus encompasses the computer systems, computer methods, and computer-program products for computer-controlled automated high-throughput testing of pharmaceutical compositions or formulations in order to determine the overall optimal composition or formulation for an intended use or purpose.Type: ApplicationFiled: August 24, 2006Publication date: January 25, 2007Applicant: Transform Pharmaceuticals, Inc.Inventors: Michael Cima, Douglas Levinson, Donovan Chin, Christopher McNulty, Christopher Moore, Anthony Lemmo, Javier Gonzalez-Zugasti, Alasdair Johnson, Hongming Chen, Orn Almarsson
-
Publication number: 20070021929Abstract: Computer-controlled automated high-throughput systems can be used to design, prepare, process, screen, and analyze a large number of samples in removable sample vials each containing a compound of interest formulated with differing component combinations and varying concentrations. The computer-controlled methods of the present invention allow for a determination of the effects of additional or inactive components, such as excipients, carriers, enhancers, adhesives, additives, and the like, on the compound of interest, such as a pharmaceutical. The invention thus encompasses the computer systems, computer methods, and computer-program products for computer-controlled automated high-throughput testing of experimental formulations in order to identify experimental formulations that can be further processed. Identified experimental formulations from multiple arrays can be removed and re-arrayed together to form a new array for further processing.Type: ApplicationFiled: August 24, 2006Publication date: January 25, 2007Applicant: Transform Pharmaceuticals, Inc.Inventors: Anthony Lemmo, Javier Gonzalez-Zugasti, Michael Cima, Douglas Levinson, Alasdair Johnson, Orn Almarsson, Hongming Chen, Christopher McNulty
-
Publication number: 20070015841Abstract: The invention relates to pharmaceutical compositions comprising propylene glycol solvates of APIs.Type: ApplicationFiled: December 29, 2003Publication date: January 18, 2007Applicant: TransForm Pharmaceuticals, Inc.Inventors: Mark Tawa, Orn Almarsson, Julius Remenar
-
Publication number: 20060287392Abstract: The present invention comprises an organic acid salt of gabapentin, wherein the organic acid is tartaric acid, ethanedisulfonic acid, or maleic acid. Methods for modulating the solubility and dose response of gabapentin are discussed. Methods of making organic acid salts of gabapentin are also discussed.Type: ApplicationFiled: August 2, 2006Publication date: December 21, 2006Applicant: TRANSFORM PHARMACEUTICALS, INC.Inventors: Matthew Peterson, Mark Oliveira