Patents Examined by Celeste A Roney
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Patent number: 11992557Abstract: Pharmaceutical compositions comprising at least one lipid-based particle encapsulating a proteolytic enzyme and a pharmaceutically acceptable carrier, wherein the proteolytic enzyme comprises at least 75% proteolytically active enzyme are provided. Methods of using same and producing same are also provided.Type: GrantFiled: January 23, 2019Date of Patent: May 28, 2024Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITEDInventors: Avi Schroeder, Assaf Zinger
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Patent number: 11992553Abstract: A method of preparing spray dried particles for inhalation comprising providing: (i) an aqueous liquid composition including the alginate oligomer and an aqueous liquid composition including an anti-adherent compound, or (ii) an aqueous liquid composition including the alginate oligomer and an anti-adherent compound; providing an organic liquid composition including a phospholipid; combining a volume of the organic liquid composition with a volume of the aqueous liquid composition, wherein the total volume of the organic liquid composition is smaller than the total volume of the aqueous liquid composition with which it is combined, and wherein the total volume of aqueous liquid composition and said total volume of organic liquid composition are sufficient to provide a combination; homogenizing the combination to form an organic-in-aqueous liquid emulsion for spray drying; and spray drying the organic-in-aqueous liquid emulsion to form the spray dried particles for inhalation.Type: GrantFiled: August 20, 2021Date of Patent: May 28, 2024Assignee: AlgiPharma ASInventors: Bildad Nyambura, Anand Bakle, Arne Dessen
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Patent number: 11980636Abstract: The invention relates to compositions and methods for treating patients with hematological proliferative disorders with CPX-351, a liposomal composition of daunorubicin and cytarabine, and venetoclax.Type: GrantFiled: November 18, 2021Date of Patent: May 14, 2024Assignee: Jazz Pharmaceuticals Ireland LimitedInventor: Stefan Faderl
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Patent number: 11969477Abstract: Disclosed is the use of a gold cluster or a gold cluster-containing substance in the preparation of a drug for preventing and/or treating glaucoma.Type: GrantFiled: June 28, 2022Date of Patent: April 30, 2024Assignee: Shenzhen Profound-View Pharma Tech Co., LtdInventor: Taolei Sun
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Patent number: 11964026Abstract: Disclosed are particles for delivering cytokinese, such as IL-12, for the treatment of cancer. The particles comprise cytokines non-covalently bound to liposomes, where the liposomes are coated with polyelectrolytes.Type: GrantFiled: August 22, 2022Date of Patent: April 23, 2024Assignee: Massachusetts Institute of TechnologyInventors: Antonio Eric Barberio, Santiago Correa Echavarria, Mariane Bandeira Melo, Talar Tokatlian, Erik Christopher Dreaden, Paula T. Hammond, Darrell J. Irvine
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Patent number: 11957653Abstract: The present invention is directed to compositions comprising N-Acetyl Methyl GABA, methods of preparing N-Acetyl Methyl GABA and compositions including N-Acetyl Methyl GABA, and methods of using N-Acetyl Methyl GABA for instance to improve sleep and control anxiety.Type: GrantFiled: April 30, 2021Date of Patent: April 16, 2024Assignee: MBI DistributingInventor: Ned L. Jensen
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Patent number: 11957705Abstract: Provided herein are methods for the prevention and treatment of cardiovascular diseases and disorders in a subject diagnosed as having suffered a cerebrovascular injury by administering agents that contain or induce the expression of microRNA-126.Type: GrantFiled: February 24, 2023Date of Patent: April 16, 2024Assignee: Henry Ford Health SystemInventors: Jieli Chen, Michael Chopp
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Patent number: 11957782Abstract: A tooth paste composition comprising black cumin oil (Nigella sativa) and fluoride-doped bioactive glass, zinc oxide, and/or titanium oxide is disclosed.Type: GrantFiled: June 16, 2023Date of Patent: April 16, 2024Assignee: Imam Abdulrahman Bin Faisal UniversityInventor: Abdul Samad Khan
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Patent number: 11958827Abstract: A 9-(2-hydroxyquinoline-3-yl)-10-[3-(dimethylamino)propyl]-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione compound, its synthesis, and its use as an antimicrobial agent.Type: GrantFiled: November 7, 2023Date of Patent: April 16, 2024Assignee: KING FAISAL UNIVERSITYInventors: Hany Mohamed Abd El-Lateef Ahmed, Mai Mostafa Khalaf Ali, Antar Ahmed Abdelhamid Ahmed
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Patent number: 11944694Abstract: Oral care compositions and/or unit-dose oral care compositions comprising a high level of surfactant. Oral care compositions and/or unit-dose oral care compositions with a high foaming efficiency. Oral care compositions and/or unit-dose oral care compositions with one or more web forming materials, one or more surfactants, and a sugar alcohol.Type: GrantFiled: September 1, 2020Date of Patent: April 2, 2024Assignee: The Procter & Gamble CompanyInventors: Jeanette Marie Swartz, Arif Ali Baig, Gregory Charles Gordon, Min Mao, Melissa Cherie Payne, Holly Balasubramanian Rauckhorst, Paul Albert Sagel, Paul Dennis Trokhan, Brian Patrick Croll, Dinah Achola Nyangiro
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Patent number: 11938220Abstract: Provided is an anesthetic composition for locally administering a local anesthetic agent to a subject in need thereof. The anesthetic composition has a lipid based complex prepared by hydrating a lipid cake containing a local anesthetic agent and a lipid mixture with an aqueous buffer solution at a pH higher than 5.5. Also provided is a method to prepare an anesthetic composition using a simpler and more robust for large-scale manufacture and for providing a high molar ratio of local anesthetic agent to phospholipid content as compared to the prior art. This anesthetic composition has a prolonged duration of efficacy adapted to drug delivery.Type: GrantFiled: March 30, 2019Date of Patent: March 26, 2024Assignees: Taiwan Liposome Co., Ltd, TLC Biopharmaceuticals, Inc.Inventors: Keelung Hong, Yun-Long Tseng, Chun-Yen Lai, Wan-Ni Yu, Hao-Wen Kao, Yi-Yu Lin
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Patent number: 11931457Abstract: The present invention refers to a set for the production of a ready-to-use chemo-therapeutic composition for intraperitoneal administration as an aerosol, wherein the set comprises an aqueous concentrate containing at least cisplatin in a first predetermined concentration and doxorubicin in a second predetermined concentration with a predetermined ratio of the first and the second concentration and having a pH value in the range from 3.0 to 7.0. The set further comprises a physiological aqueous carrier solution, which is for optional dilution of the concentrate depending on target concentrations of cisplatin and doxorubicin in the chemo-therapeutic composition to be applied. Further, the invention refers to a method for providing of a ready-for-use chemotherapeutic composition for intraperitoneal administration as an aerosol by using of a set, to a chemotherapeutic composition for intraperitoneal administration as an aerosol, and a use of the chemotherapeutic composition.Type: GrantFiled: June 24, 2019Date of Patent: March 19, 2024Assignee: CAPNOPHARM GMBHInventors: Alexander Hetzel, Janek Kibat, Ranjita Sahoo, Mona Kibat
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Patent number: 11931459Abstract: In some embodiments provided herein is a method of treating pain, the method comprising administering to the subject a pharmaceutical composition comprising: a) a multivesicular liposome comprising: at least one amphipathic lipid, and at least one neutral lipid; and b) an aqueous phase comprising bupivacaine phosphate, wherein the aqueous phase is encapsulated within the multivesicular liposome.Type: GrantFiled: March 17, 2022Date of Patent: March 19, 2024Assignee: Pacira Pharmaceuticals, Inc.Inventor: Roy Winston
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Patent number: 11931364Abstract: Pharmaceutical compositions and methods of treatment or prevention of diseases and conditions associated with or characterized by at least one of xerostomia and periodontal disease by modulation of the nitric oxide synthase pathway are provided, as are animal models and drug screening methods. Such modulation may be achieved by the administration of tetrahydrobiopterin (BH4) or its prodrugs and/or salts. Treating and preventing xerostomia can have the downstream effect of also preventing periodontitis, dental caries, parotid gland enlargement, inflammation and fissuring of the lips (chelitis), inflammation or ulcers of the tongue and buccal mucosa, oral candidiasis, salivary gland infection (sialadenitis), halitosis, and cracking and fissuring of oral mucosa.Type: GrantFiled: September 19, 2022Date of Patent: March 19, 2024Assignee: Meharry Medical CollegeInventors: Janet H. Southerland, Pandu R. Gangula
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Patent number: 11925608Abstract: The disclosure herein relates to the innovative epinephrine formulations in aqueous solution of medicinal products that enhance the physicochemical stabilities of epinephrine and extend the product shelf life. In some instances, the formulations comprise epinephrine or a salt thereof, a complexing agent, and a “non-sulfite” antioxidant. The epinephrine formulations substantially demonstrated the superior physicochemical stabilities to conventional sulfite formulation of commercial medications currently available. In some instances, sulfite-free formulations further provide further benefit (e.g., safety benefits) to sulfite-sensitive patients. The compositions, methods for preparing the formulations, and methods of using the same (e.g., in the treatment of anaphylaxis) are also provided.Type: GrantFiled: September 26, 2018Date of Patent: March 12, 2024Assignee: YS PHARMTECHInventor: Yosyong Surakitbanharn
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Patent number: 11904051Abstract: A liposome vesicle comprising a membrane consisting of 1,3-diheptadecanamidopropan-2-yl(2-(trimethylammonio)ethyl)phosphate surrounding a volume comprising a pharmaceutical drug or contrast agent. The vesicle is mechanosensitive at body temperature and at physiologically or pathophysiologically relevant shear stress.Type: GrantFiled: January 31, 2019Date of Patent: February 20, 2024Assignees: Universität Basel, Universität FreiburgInventors: Bert Müller, Andreas Zumbühl, Thomas Pfohl, Dennis Müller, Frederik Neuhaus, Radu Tanasescu, Till Saxer, Marzia Buscema, Sofiya Matviykiv, Gabriela Gerganova
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Patent number: 11896488Abstract: Scaffolds for use in bone tissue engineering include a skeleton and a host component. Methods of preparation of scaffolds include identification of biodegradation properties for the skeleton and the host component. The skeleton is constructed to form a three-dimensional shape. The skeleton is constructed of a first material and has a first rate of biodegradation. The host component fills the three-dimensional shape formed by the skeleton. The host component is constructed of a second material and has a second rate of biodegradation. The first rate of biodegradation is slower than the second rate of biodegradation.Type: GrantFiled: April 26, 2021Date of Patent: February 13, 2024Assignee: Marquette UniversityInventors: Lobat Tayebi, Morteza Rasoulianboroujeni
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Patent number: 11890376Abstract: The present disclosure relates to a pharmaceutical composition comprising an inhalable immunosuppressive macrocyclic active ingredient for use in the prevention or treatment of a pulmonary disease or condition in a subject, wherein the pharmaceutical composition is administered to the subject by inhalation in form of an aerosol, and wherein the aerosol is generated by nebulization of the pharmaceutical composition using a nebulizer (100), the nebulizer comprising: a) an aerosol generator (101) comprising: —a fluid reservoir (103) for holding the pharmaceutical composition or an interface configured to connect a fluid reservoir, and a vibratable membrane (110) having a plurality of apertures, the apertures being adapted to produce an aerosol comprising droplets having a mass median aerodynamic diameter (MMAD) of up to about 4.0 gm as measured with a 0.Type: GrantFiled: July 15, 2022Date of Patent: February 6, 2024Assignee: Breath Therapeutics, GmbHInventor: Oliver Denk
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Patent number: 11883368Abstract: Leave-on oral care compositions comprising a hyaluronic acid, and a gum-strengthening polyol are provided for promoting Gum Health of a user.Type: GrantFiled: June 12, 2020Date of Patent: January 30, 2024Assignee: The Procter & Gamble CompanyInventors: Ross Strand, Yang Su, Yunming Shi, Xiaoxiao Li, Guannan Wang
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Patent number: 11872312Abstract: Methods for the treatment of stroke, such as stroke of undetermined origin, by administration of xenon (Xe)-loaded liposome compositions are provided. In some aspects, Xe is encapsulated in echogenic liposomes and release of Xe can be enhanced by application of ultrasound stimulation. Compositions for use in treating stroke, such as liposomes loaded with Xe or Xe in combination with H2 or H2S, are also provided.Type: GrantFiled: April 13, 2021Date of Patent: January 16, 2024Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMSInventors: Shao-Ling Huang, Melvin E. Klegerman, Yong-Jian Geng, Hyunggun Kim, David D. McPherson