Abstract: Provided are methods of treating cardiac infarction by using an injectable material to influence cardiac structure and remodeling after infarction. Also provided are kits that comprise an injectable material to influence cardiac structure.

Abstract: The present invention concerns a compound of formula wherein R represents a hydrogen atom or a C1-2 alkyl or alkoxyl group; each R1, R2 or R3 represents a hydrogen atom or a methyl or ethyl group; and X represents a CHO, COOR4 or CN group, R4 being a methyl or ethyl group; and at least one of said R, R1 or R2 represents a group containing at least one carbon atom; and it use as perfuming ingredient, for instance to impart odor notes of the floral and/or anis type.

Abstract: siRNA-conjugated liposomes and micelles, methods of making such conjugates, and methods of using such conjugates, such as for the delivery of siRNA to cells to reduce expression of target polypeptides in such cells, are described.

Abstract: The present invention relates to a solid pharmaceutical cation-exchange resin composition allowing the preparation of a stable resin suspension in an aqueous vehicle and the resin being easily resuspended in the case of sediment formation. Said composition comprises hydroxypropyl methylcellulose and pregelatinized starch as functional excipients. The invention also relates to a solid form for oral administration comprising the composition, to the use thereof for the preparation of oral solid forms, and to said composition for use in the treatment of hyperkalaemia.

Abstract: The present invention provides an oral composition comprising hydroxyapatite, potassium nitrate, and calcium monohydrogen phosphate, wherein the composition has an increased ability to occlude dentinal tubules of a tooth and has an excellent inhibitory effect on hypersensitivity.

Abstract: The present invention provides a novel boron carrier compound that can be used for boron neutron capture therapy for cancer, and that can realize improvement in the efficiency of a Drug Delivery System (DDS) and an increase in the boron concentration in a tumor. The present invention provides a boron cluster-modified PEG lipid derivative represented by Formula (I): wherein, m and n are each independently an integer of 1-4, q is an integer of 1-280, and R1 and R2 are each independently a hydrocarbon group with a carbon number of 8-22, and a molecular assembly containing the same.

Abstract: A method of moisturizing while decolonizing mammalian tissue, comprising applying a multi-valent cationic antiseptic composition to the tissue, and applying a moisturizer composition to at least a portion of the same tissue is provided. An oral care kit comprising a composition comprising the multi-valent cationic antiseptic and the moisturizer composition, and a method of moisturizing oral tissue of a patient requiring intubation using the moisturizer composition and an endotracheal tube coated or impregnated with a cationic antiseptic are also provided.

Abstract: Pharmaceutical compositions and single unit dosage forms of apremilast, i.e., (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, or a pharmaceutically acceptable stereoisomer, prodrug, salt, solvate, hydrate, or clathrate, are provided herein. Also provided are methods of treating, managing, or preventing various disorders, such as diseases or disorders ameliorated by the inhibition of TNF-? production in mammals.

Abstract: Disclosed are a method for producing an aripiprazole suspension, wherein the aripiprazole has a mean particle size of 1 to 10 ?m, the method comprising the steps of: (a) combining bulk aripiprazole and a vehicle to form a primary suspension; (b) subjecting the primary suspension to first pulverization using e.g., a high shear pulverizing machine, a dispersion machine that applies shear force to a material to be processed, a colloid mill, an ultrasonic dispersion machine, or a high-pressure jet type emulsifying dispersion machine to form a secondary suspension; and (c) subjecting the secondary suspension to second pulverization using e.g., a high-pressure jet type emulsifying dispersion machine to form a sterile final suspension; and a method for producing a freeze-dried formulation from the aripiprazole suspension.

Abstract: The present invention relates to a liposome composition comprising 0.001 to 5% by weight of conjugate of lysophophatidylcholine and chlorin e6, 1 to 10% by weight of sucrose laurate, 0.1 to 5% by weight of sodium stearoyl glutamate, 1 to 10% by weight of PEG-5 rapeseed sterol, 1 to 20% by weight of medium-chain triglyceride, 1 to 10% by weight of vegetable oil, 0.1 to 5% by weight of sodium deoxycholate, 3 to 10% by weight of glycerin and the balance of water, and a skin care composition comprising the same. The liposome composition of the present invention is very effective in the treatment of acne.

Abstract: Oral care compositions comprising one or more active agents and hydroxypropyl cellulose, and that are liquid at or below room temperature and which form a two-phase cloudy system at body temperature. In certain embodiments the active agent is a mineralizing agent, an anti-caries agent, an anti-inflammatory agent, an antibacterial agent, an antifungal agent, an anti-malodour agent or a mixture thereof.

Abstract: A chewing gum tablet including at least two cohered chewing gum modules, the tableted chewing gum being formed by compression of chewing gum granules, at least one of the chewing gum modules including gum base granules, the gum base granules including an elastomer system, the chewing gum tablet including an elastomer system in an amount of at least 10% by weight of the tablet. A compressed chewing gum tablet has been obtained featuring extremely impressing abilities of incorporating well-defined amounts of chewing gum ingredients combined with acceptable rheological properties of the compete tablet.

Abstract: This invention details a method for providing thermal protection to human hair by applying an aerosolized polymer system to the hair before heat treatment. It has been found that acrylate polymers provide good protection from the damaging affects of curling irons and straightening irons and afford improvements in the look and feel of the treated hair.

Abstract: The present invention relates to liquid application for skin rejuvenation created from specific amino acids, lipids, nucleic acids and vitamins. This collection of molecules delivers precisely the factors necessary to a specific site requiring healing; a direct intervention system to most expeditiously remodel skin with building blocks. This delivery is a transdermal topical delivery and healing is via specific molecules that engender a false autocoid reaction rapidly followed by an incremental healing-anti-inflammatory response augmented by very specific GRAS ingredients in the invention and also recruited from the body to this needy site. Energy is brought to site by transdermally delivered protons and enhanced by the local vascular flow initiated by transdermal molecules. This delivery system bypasses digestion and dilution. Key is a lipophilic carrier with nuclear and mitochondrial ligands that rapidly penetrate and permeate all membranes and truncates the inflammatory site quickly manifesting curation.

Abstract: The invention provides oral care compositions comprising isobutyl magnolol and propylene glycol monolaurate, together with methods of making and using the same. Also described is a method of enhancing the solubility of isobutyl magnolol in an oral care composition comprising effective amount of propylene glycol monolaurate. The composition is for use in the treatment of caries, gingivitis, periodontitis, tooth yellowing and halitosis.

Abstract: The present invention relates to pharmaceutical compositions of lurasidone or salts thereof. In particular, the invention relates to pharmaceutical compositions of lurasidone or salts thereof with one or more water-insoluble pharmaceutical excipients. The invention also relates to processes for the preparation of such compositions and use thereof for treatment of schizophrenia, bipolar disorders or senile dementia.

Abstract: The present invention relates to a pharmaceutical composition of oligopeptides, preferably cyclic oligopeptides, said composition further comprising one or more lipophilic and/or amphiphilic compounds, in the presence or absence of water as the main ingredients, the use of the lipophilic and/or amphiphilic compounds for making pharmaceutical compositions of said oligopeptides, and methods of making said pharmaceutical composition.

Abstract: The present invention relates to a chewing gum composition comprising 0.01 to 15% by weight a cannabinoid or a derivative thereof, based on the total weight of the chewing gum composition, and to chewing gums and blistering packages comprising said chewing gums.

Abstract: A dental care product comprising carbonate-substituted fluoro-hydroxyapatite particles having the formula: Ca(10-z-y-m)ZnxSryMm(PO4)(6-z)(CO3)z(OH)2-wFw wherein M is selected from the group comprising Mg, Se, K and mixtures thereof; x is a number comprised between 0 and 0.02; y is a number comprised between 0.0010 and 0.015; m is a number between 0 and 0.5; z is a number comprised between 0.0010 and 0.010 and w is a number comprised between 0.000002 and 0.0001; wherein said fluoro-hydroxyapatite particles have a crystallinity degree CD comprised between 50 and 85%.

Abstract: A chewing gum composition with high pH-release includes an insoluble gum base matrix and a soluble bulk portion, wherein the gum base matrix and the bulk portion is mixed and extruded to form a final chewing gum core, and wherein the gum base matrix is buffered before mixing with the bulk portion. Furthermore, a method of producing a chewing gum core, wherein a gum base matrix and a bulk portion is mixed and extruded to form a final chewing gum core, and wherein the gum base matrix is buffered before mixing with the bulk portion, and the gum base matrix includes a first amount of buffer from 2 to 20 percent by weight of the gum base matrix before mixing with the bulk portion.