Abstract: A micronutrient composition shown as Mix 1 comprises Rosemary extract at 1 mg-6,000 mg, Fenugreek extract 1 mg-50,000 mg and Fenugreek seed powder at 2 mg-8,000 mg, Cassia nomane seed extract powder 1 mg to 1,000 mg and dry extract 1 mg-300 mg, 3?3-di indolylmethylene 1 mg-800 mg, Zinc 0.1 mg-1,000 mg, Phosphatidylserine 1 mg-1,500 mg, Vitamin D 20 IU-10,000 IU, Vitamin C 10 mg-50,000 mg, Niacin 1 mg-3,000 mg, Theanine 0.1 mg-10,000 mg, Aspartic acid 10 mg-10,000 mg, Arginine 10 mg-50,000 mg and Dehydroepiandrosterone (DHEA) 1 mg-500 mg and Mix A comprising of all the ingredients of Mix 1 but does not contain DHEA and both are used improve men's health.

Abstract: The present invention pertains to the use of the calcium-sensing receptor (CaSR)-activating nutrients (designated as “CaSR-based nutrients”) for the prevention and/or treatment of diarrheal diseases and inflammation in the gastrointestinal tract. In one embodiment, the current invention is formulated for oral administration. The anti-diarrheal composition of the present invention is useful for treating diarrheal and gastrointestinal inflammatory conditions in infants and young children.

Abstract: The invention relates to three-part makeup remover compositions comprising (a) a water part; (b) an oil part; and (c) a silicone-in-water emulsion part.

Abstract: Various embodiments of the invention relate to compositions comprising vitamins, minerals and trace elements, antioxidants, amino acids, probiotics, and other components and methods for using such compositions to treat or prevent diseases associated with oxidative stress, including cardiovascular disease.

Abstract: A hair conditioner composition containing an aqueous carrier, from about 2.5 wt % to about 6.7 wt % of a behenamidopropyl dimethylamine, from about 3 wt % to about 8 wt % of a fatty alcohol; and less than 1.5 wt % of a salt. The molar ratio of behenamidopropyl dimethylamine to fatty alcohol can be from about 7:50 to about 4:5. The conditioner composition can have a uniform gel network. The composition can have d-spacing of less than 32 nm, as measured according to the d-spacing (L?-basal spacing) of Lamella Gel Network Test Method.

Abstract: A topical composition and method of treating chronic pain are provided. The topical composition contains cannabidiol (CBD) and plant extract and is well suited to treat chronic pain while also avoiding the negative side effects caused by commonly used anti-inflammatory and pain-treating compounds. When the topical composition is applied to the skin at the locus of pain and allowed sufficient time to absorb, the pain is reduced or even eliminated. The topical compositions also show therapeutic effect on mucosal tissue and internal tissues of humans or animals.

Abstract: Embodiments of the invention provide multi-stage biodegradable drug delivery platforms and methods for the subcutaneous delivery of therapeutic agents (TA). Embodiments of the platform may be configured to subcutaneously deliver a first dose of a first TA which is absorbed into the body and/or blood stream (BBS) to produce a first therapeutic effect for a first selectable time period (STP), and subsequently after a second STP, deliver a second dose of a second TA which is absorbed into the BBS to produce a second therapeutic effect for a third STP. An embodiment of the platform may comprise a body having a tissue-penetrating end, a primary cavity having a first TA dose and a shell having a secondary cavity having a second TA dose. The first TA dose is released after the first STP and the second TA dose is released after the second STP by biodegradation of the shell.

Abstract: A personal cleansing soap bar composition is provided, comprising: a soap; an aqueous ethylene acrylic acid copolymer dispersion; a silicone copolymer emulsion with an internal phase viscosity at 25° C. of ?100×106 mm2/sec; wherein the personal cleansing soap bar is a solid.

Abstract: An ethyl 2-[9-(6-fluoro-2-hydroxyquinolin-3-yl)-1,8-dioxo-3,4,9,10-tetrahydroacridine-10-yl]-acetate compound, its synthesis, and its use as an antimicrobial agent.

Abstract: A simple cellulose sulphate based microencapsulation technology has been applied to encapsulate bacterial or other microbial cells, which produce and release digestive enzymes and thereby provides an acid resistant shelter for these microbial cells. Surprisingly, the resulting spheres were found to provide sufficient protection for encapsulated cells from treatment with aqueous acidic solutions. Thereby the cellulose sulphate microencapsulated cells, such as probiotics are now enabled to survive passage, for example, through the stomach after consumption by a human or animal with a higher survival rate than those not within a microcapsule. After passing the stomach these cells are delivering products produced by them, e.g. enzymes or other nutrition factors. This technology therefore proves to be very useful in providing digestive or otherwise beneficial enzymes and/or of living microbial cells, into the lower gastrointestinal tract, where they could confer their health benefit to the host.

Abstract: The present disclosure provides use of fructose in preparing a drug for treating a cerebral ischemic stroke, and relates to the technical field of biomedicine. In the present disclosure, an ischemic injury cell model and an ischemic injury animal model are established, and fructose treatment is conducted on the injury models; and it is found that the fructose can regulate energy metabolism and redox metabolism of neurons, and reduce an ischemic injury of model cells and model animals. Specifically, the present disclosure includes: reducing a neuronal mortality after the ischemic injury, reducing an area of cerebral infarction in animals with the ischemic injury, and improving neurobehavioral characteristics of the animals.

Abstract: Disclosed in the present specification is a liquid lipid composite composition comprising ceramide, cholesterol, a C10-30 unsaturated fatty acid having three or fewer double bonds, and natural oil or wax containing a C10-60 fatty acid ester or C10-60 fatty acid ester at a weight ratio of 1:0.03-3:2.5-12:0.3-6. The liquid lipid composite composition comprises a high content of ceramide and is present in a liquid state during storage at normal temperature, and thus can be easily applied as a formulation of a hair cosmetic composition. The liquid lipid composite composition, when used to treat hair, has excellent hair condition improving effects, such as improving the softness of the hair, enhancing the elasticity and strength of the hair, and increasing the shininess of the hair.

Abstract: A hair conditioner composition containing an aqueous carrier, a cationic surfactant, a high melting point fatty compound and an effective preservation system. The conditioner composition comprises a gel network. The preservation system contains sodium benzoate and a second composition selected from the group consisting of glycol, glyceryl ester, and combinations thereof.

Abstract: The disclosure is directed to compositions and methods of treating or preventing headaches, including migraines. The compositions comprise a nitrate anion source, an elemental metal (uncharged), and an acid. The compositions are preferably administered orally. In some aspects, the product of a reaction of the nitrate anion source, the elemental metal (uncharged), and the acid are administered to the subject via inhalation.

Abstract: Described herein are rinse-off hair conditioner compositions with high deposition properties for cationically coated microcapsules. The compositions contain limited amounts of quaternary ammonium salts that are replaced by at least one non-quaternized conditioning ingredient to provide a high deposition of microcapsules onto a surface.

Abstract: The present disclosure relates to a vaginal system that prevents pregnancy comprised of segesterone acetate and ethinyl estradiol and is configured for thirteen 28-day product-use cycles.

Abstract: The present specification discloses compositions comprising one or more silicon dioxide-based particles comprising, consisting essentially of or consisting of one or more active agents and methods and uses for the disclosed compositions. A composition disclosed herein can be incorporated into a body wash, an after-shower body lotion, a shampoo, a conditioner, a soap, a gel, a hand sanitizer, a cream, a spray, a mousse, a lotion, an ointment, a powder, a stick, an injectable, an ingestable, a make-up product, a lip balm, a hair spray product, an arachnid/insect repellent, a cosmetic product, or a medicinal product.

Abstract: Certain liquid personal care cleaning compositions containing: linalool, a linalool isomer, or combinations thereof; and hinokitiol exhibit effective antibacterial properties.

Abstract: Disclosed herein is a self-supporting, dissolvable, film containing dexmedetomidine or a pharmaceutically acceptable salt thereof. The film is administered orally to treat various conditions, particularly agitation, by transmucosal delivery of the active agent.

Abstract: [Problem] If lidocaine is composed of non-aqueous patch, the adhesive power of the preparation tends to get lower, as the composition amount of lidocaine is higher. It is popular to solve lidocaine in dissolving agent in order to compose lidocaine in patch and release effective amount into skin. However, if the amount of dissolving agent gets higher, the adhesive power gets extremely lower, so that an long-time attachment is difficult. [Solution] A non-aqueous patch comprising lidocaine and/or its reactant, and a dissolving agent which are contained in a base of plaster, the plaster being hold by a support, of which strength of 50% stretched to longitudinal direction is less than 2000 g/50 mm and of biaxially-oriented stretch cloth.