Abstract: The present invention is related to a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of poly(ADP-ribose)polymerase (PARP). The definitions of the variables are provided herein.
Type:
Grant
Filed:
June 9, 2021
Date of Patent:
May 28, 2024
Assignee:
Mitobridge, Inc.
Inventors:
Taisuke Takahashi, Arthur Kluge, Bharat Lagu, Nan Ji
Abstract: Methods of inhibiting endosomal trafficking of PD-L1, inducing PD-L1 secretion via exosomes, decreasing PD-L1 level at a surface of a cancer or tumor cell, and treating a cancer or tumor through promoting T cell immune response in a subject suffering from a cancer or tumor, includes the step of administering a compound of Formula I to various cells. Also, a composition to treat a cancer or a tumor, includes a compound of Formula I and an anti-PD-1 antibody.
Type:
Grant
Filed:
March 21, 2022
Date of Patent:
May 21, 2024
Assignees:
City University of Hong Kong, 6J Biotechnology (Hong Kong) Limited
Inventors:
Jianbo Yue, Qingru Zhang, Zuodong Ye, Wang Peng
Abstract: In various embodiments, the present disclosure provides methods reducing the risk of heart failure in a subject on statin therapy by administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of eicosapentaenoic acid ethyl ester or a derivative thereof.
Abstract: A gold(III) complex of formula (I) or formula (II) wherein R1 and R2 are each independently a hydrogen, an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted arylalkyl, or an optionally substituted aryl; R3 and R4 are each independently a hydrogen, an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted arylalkyl, an optionally substituted aryl, an optionally substituted heterocyclyl, an optionally substituted alkoxy, a hydroxyl, a halo, a nitro, a cyano, a N-monosubstituted amino group, or a N,N-disubstituted amino group; and X is Cl, Br, or I. A pharmaceutical composition containing the gold(III) complex of formula (I) or (II), and a method of treating cancer are included.
Type:
Grant
Filed:
May 26, 2022
Date of Patent:
May 14, 2024
Assignee:
KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS
Inventors:
Anvarhusein A. Isab, Adam Ahmed Abdullah Sulaiman
Abstract: In some embodiments, a mass spectrometry tag may comprise a linker region, a mass balance region, and a reporter region. The mass spectrometry tag may be configured to fragment in a mass spectrometer via an energy dependent process to produce multiple reporter molecules. For example, the reporter region of the tag may be configured to produce at least two reporter molecules via fragmentation. In some embodiments, one or more regions of the tag may comprise at least one heavy isotope. In some such embodiments, the ability to fragment into multiple reporter molecules as well as the placement and/or number of heavy isotope(s) allows the mass spectrometry tag to be distinguished from other similar mass spectrometry tags. In some such embodiments, the ability to distinguish between tags having the same or substantially similar total mass to charge ratio and reporter region mass may allow the system to have a greater multiplexing capacity than conventional systems.
Type:
Grant
Filed:
July 28, 2021
Date of Patent:
May 14, 2024
Assignees:
President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
Inventors:
Craig Braun, Wilhelm Haas, Steven P. Gygi, Gregory H. Bird, Loren D. Walensky, Martin Helmut Wuhr, Brian K. Erickson
Abstract: The present invention provides a combination and method for treating a Temozolomide (TMZ)-resistant cancer patient, which comprises a combination of TMZ and an isoform-selective HDAC8 inhibitor, such as BMX at an effective relative ratio to overcome TMZ resistance by enhancing TMZ-mediated cytotoxic effect by downregulating the ?-catenin/c-Myc/SOX2 signaling pathway and upregulating WT-p53 mediated MGMT inhibition.
Abstract: The present invention provides novel compounds that are modulators of RORgamma. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the modulation of RORgamma has therapeutic effects, for instance in autoimmune diseases, autoimmune-related diseases, inflammatory diseases, metabolic diseases, fibrotic diseases, or cholestatic diseases.
Abstract: There is provided a novel halogenated zinc phthalocyanine pigment for a color filter, which can form a green color filter having excellent contrast and high luminance. A halogenated zinc phthalocyanine pigment for a color filter shows, in a Raman spectrum, a peak intensity of 3.0% or more at 716±2.2 cm?1 when a peak intensity at 650±10 cm?1 is regarded as 100%.
Abstract: A novel class of inhibitors of protein kinates that are useful in the treatment of cell proliferative diseases and conditions, and especially those characterised by over-expression of CDK4, CDK6 and/or cyclin D, including certain cancers of lung, breast, brain, central nervous system, colorectal cancer and leukaemias.
Abstract: In various implementations, berberine metabolites, such as dihydroberberine and/or tetrahydroberberine, may be administered to manage blood glucose levels, increase ketone levels (e.g., blood concentration of ketones), and/or for therapeutic purposes in humans. The administration of a pharmaceutically effective amount of berberine metabolites, such as dihydroberberine, may reduce fasting blood glucose levels, improve glucose tolerance, and/or improve blood ketone response. In some implementations, berberine metabolites may be administered with one or more other compounds.
Type:
Grant
Filed:
June 7, 2021
Date of Patent:
April 30, 2024
Assignee:
AXCESS GLOBAL SCIENCES, LLC
Inventors:
Ryan Lowery, Jacob Wilson, Terry LaCore
Abstract: The present invention relates to a pharmaceutical composition that provides long-term stability of a hydrolytically labile antipsychotic agent.
Type:
Grant
Filed:
August 10, 2021
Date of Patent:
April 30, 2024
Assignee:
ALKERMES PHARMA IRELAND LIMITED
Inventors:
Jason M. Perry, Daniel R. Deaver, Magali B. Hickey, Julius F. Remenar, Jennifer Vandiver, Michael J. Palmieri, Jr., Zhengzheng Pan
Abstract: Disclosed herein are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.
Type:
Grant
Filed:
June 2, 2022
Date of Patent:
April 23, 2024
Assignees:
The University of Chicago, J. Craig Venter Institute, Inc., The University of Sheffield, Institute for Systems Biology, The University of Leeds, The University of Strathclyde, The Government of the United States
Inventors:
Rima McLeod, Martin McPhillie, Colin W. G. Fishwick, Hernan Alejandro Lorenzi, Kai Wang, Taek-Kyun Kim, Yong Zhou, Leroy E. Hood, Ying Zhou, Kamal El Bissati, Mark Hickman, QiGui Li, Craig Roberts
Abstract: A camsylate salt of D(+)-10-camphorsulfonic acid and a triazolopyrazine derivative of formula (1), pharmaceutical compositions thereof, methods of making the salt, and therapeutic use thereof:
Type:
Grant
Filed:
June 27, 2022
Date of Patent:
April 23, 2024
Inventors:
Jun Young Choi, Kyung-eui Park, Na Young Kim
Abstract: The present technology relates to methods for treating, preventing, and/or ameliorating kinase mutation-associated neurodegenerative diseases, including BRAFV600E-associated neurodegenerative diseases, in a subject in need thereof. In particular aspects, the present technology relates to the use of BRAF, MEK, and/or CSF-1R inhibitors to treat, prevent, and/or ameliorate kinase mutation-associated neurodegenerative diseases, including BRAFV600E-associated neurodegenerative diseases.
Abstract: A gold(III) complex of formula (I) or formula (II) wherein R1 and R2 are each independently a hydrogen, an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted arylalkyl, or an optionally substituted aryl; R3 and R4 are each independently a hydrogen, an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted arylalkyl, an optionally substituted aryl, an optionally substituted heterocyclyl, an optionally substituted alkoxy, a hydroxyl, a halo, a nitro, a cyano, a N-monosubstituted amino group, or a N,N-disubstituted amino group; and X is Cl, Br, or I. A pharmaceutical composition containing the gold(III) complex of formula (I) or (II), and a method of treating cancer are included.
Type:
Grant
Filed:
May 26, 2022
Date of Patent:
April 16, 2024
Assignee:
KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS
Inventors:
Anvarhusein A. Isab, Adam Ahmed Abdullah Sulaiman
Abstract: An electronically weakly coupled 4,4?-divinylazobenzene-bridged diruthenium complex bearing two Ru(CO)Cl(PiPr3)2 moieties, its synthesis, and its use as a catalyst in organic processes.
Abstract: An application of ellagic acid and a metabolic derivative urolithin compound thereof in preparation of an immunomodulatory medicine is provided. Classical animal models of autoimmunity and immunoregulation, such as experimental autoimmune encephalomyelitis, neuromyelitis optica mouse model, ulcerative colitis, and skin transplantation, are used as examples to conduct experiments from various aspects and perspectives, such as neurological function scores, histopathological changes of lesions, inflammatory factor expression, and pro-inflammatory cell numbers.