Abstract: The new galenic formulation of paracetamol is comprised of a base mixture of paracetamol and citric acid in a proportion of 85:15 to 90:10 w/w among other pharmaceutically acceptable components, in an exsiccation state corresponding to a water activity of less than 0.6 and it is in the form of a powder, granulate or tablet. The process comprises obtaining said exsiccated base mixture up to a water activity of less than 0.6 in order to obtain a powder, that can be granulated in order to obtain a granulate dispersible and soluble in water, whose granulate can also be compressed in order to obtain a tablet dispersible and soluble in water. Said new formulation is useful in human and veterinary medicine.
Type:
Grant
Filed:
July 3, 2002
Date of Patent:
September 16, 2003
Assignee:
Laboratorios Belmac, S.A.
Inventors:
Luis Carvajal MartÃn, Juan Carlos Asensio Asensio, Francisco Javier Sevilla Tirado
Abstract: Compositions comprising a peptide and polylactic-glycolic acid (PLGA) wherein the distribution of the size of the particles of the peptide in the PLGA results highly heterogeneous, suitable to the preparation of subcutaneous implants having a release time at least equal to 6 months.
Type:
Grant
Filed:
June 1, 2001
Date of Patent:
September 16, 2003
Assignee:
Mediolanum Farmaceutici S.p.A.
Inventors:
Alain Maquin, Patrice Mauriac, Pierre Marion
Abstract: An encapsulation system comprising: a core formed wholly or in part of at least one organic active principle; an inorganic shell formed wholly or in part of aluminum hydroxycarbonate; and wherein cohesion of the system is achieved by means of at least one nonionic surfactant comprising at least one hydrophobic segment and at least one hydrophilic segment. Also, a process for the preparation of an encapsulation system having an organic core, composed wholly or in part of at least one organic active principle, and an inorganic shell composed wholly or in part of a basic aluminum carbonate, includes: the in situ precipitation in an aqueous medium of basic aluminum carbonate, at a pH of less than 5, with stirring, in the presence of at least one nonionic surfactant, having at least one hydrophobic segment and at least one hydrophilic segment, and at least one organic active principle, the recovery of the aqueous dispersion thus formed.
Abstract: Antibacterial compositions having enhanced antibacterial effectiveness are disclosed. The antibacterial compositions contain an antibacterial agent, an alkamine oxide, a nonionic and/or cationic cosurfactant, an optional polymeric thickener, and water.
Type:
Grant
Filed:
March 27, 2001
Date of Patent:
September 9, 2003
Assignee:
The Dial Corporation
Inventors:
Timothy J. Taylor, Priscilla S. Fox, E. Phil Seitz, Michael D. Slayton
Abstract: A reshapable hair styling composition comprising, in a cosmetic vehicle appropriate for hair, at least one dispersion comprising at least one polyurethane in a water and/or solvent medium, said at least one polyurethane being obtained by reacting:
(a) an isocyanate terminated polyurethane prepolymer being obtained by reacting: (i) at least one polyactive hydrogen compound insoluble in the medium of the dispersion, wherein said polyactive hydrogen compound is chosen from alkyl, aryl, and aralkyl structures optionally substituted in and/or on the structure by N, O, and/or S groups; (ii) at least one polyisocyanate, and (iii) at least one polyactive hydrogen compound soluble in the medium of the dispersion,
(b) at least one polyfunctional chain extender; and
(c) at least one chain terminator.
Abstract: The invention relates to a sterile ophthalmic drop preparation, especially a gel preparation, which comprises a two-phase carrier liquid or gel basis comprising a liquid aqueous and a liquid hydrophobic phase.
Abstract: The present invention is directed to a method for treating the symptoms associated with fibromyalgia and related conditions by administering flupirtine.
Abstract: Methods and compositions are provided comprising ingestibles and a thermochromic composition which is informative as to the temperature history of the ingestible, either prior or contemporaneous with use. Various solid or liquid ingestible compositions are provided for determining storage temperature, temperature of the user, temperature of the ingestible, particularly comestibles, and the like. Of particular interest are polydiacetylene polymers which may be formulated to provide compositions having transition temperature over a broad temperature range.
Abstract: Customized implants for use in reconstructive bone surgeries where anatomical accuracy and bone adaptation are important, such as plastic and craniomaxillofacial reconstructions. This implant comprises a porous surface layer and a tough inner core of interpenetrating phase composite. The porous surface layer enhances the biocompatibility, tissue ingrowth, and implant stability. The tough inner core improves the mechanical properties of the implant with a high fracture toughness and a low modulus. The anatomical accuracy of the implants will minimize the intra-operative manipulation required to maintain a stable host bone-implant interface.
Abstract: A pack cosmetic which characteristically comprises dextrin. The present invention can provide an unprecedented superior pack cosmetic which gives high tension, adhesion, and a stretched feeling during use, is easy to remove, and can leave a superior moist feeling after removal. It can also provide a pack cosmetic which has a superior keratotic plug removal effect as well.
Abstract: A method of treating or preventing tinea corporis, commonly known as ringworm of the skin, includes applying a polymerizable monomer adhesive composition to an area of skin afflicted with or susceptible to tinea corporis, optionally with at least one of an additional anti-fungal agent or a skin care additive, and allowing the polymerizable monomer composition to polymerize to form a polymer film over the area of skin.
Type:
Grant
Filed:
July 5, 2001
Date of Patent:
August 5, 2003
Assignee:
Closure Medical Corporation
Inventors:
Daniel L. Hedgpeth, William S. C. Nicholson, Upvan Narang, Anthony Sherbondy, Gabriel N. Szabo
Abstract: The present invention provides a porous structure of fibrin or fibrinogen material. The structure in its substantially dry form, having a compression strain of less than 8%, and a creep modulus higher than 1.5×106 Pa. The compression strain and creep modulus being measured for a sample having a diameter of 5 mm on which a compression of 2500 milli Newtons is exerted with a compression ramp of 500 milli Newtons per minute, after a compression release step following an initial compression of 2500 milli Newtons with a compression ramp of 500 milli Newtons per minute. After hydration, the structure has a porosity wherein at least 50% by volume of the total porosity is formed by channels with an open cross section of more than 500 &mgr;m2.
Abstract: A composition comprising cyclodextrin and an &agr;-hydroxy acid complexed by the cyclodextrin. A pharmaceutical preparation comprising a cyclodextrin-&agr;-hydroxy acid complex and a pharmaceutically acceptable adjuvant. A combination of a cyclodextrin/&agr;-hydroxy acid complex and an applicator having an applicator head with alternating grooves and ridges disposed on the applicator head. A method of treating a skin area comprising applying a cyclodextrin/&agr;-hydroxy acid complex to the skin area in a pharmaceutically effective amount.
Abstract: The present invention provides a method for preparing a spray-dried, compressible granular formulation for preparing pharmaceutical tablets in which essentially water-insoluble, acidic, amphoteric, and basic pharmaceutically active agents are converted to more water-soluble salts which are granulated with hydrolyzed cellulose, drug-containing slurries, the resulting granulations, capsules containing granulations, and pharmaceutical tablets compressed from such granules. In these formulations there is employed from 1% to 85% by weight of the pharmaceutically active agent and its salt form, from 5% to 99% of hydrolyzed cellulose, based on the dry weight of the granulation, and optionally, conventional granulation and/or tableting additives such as surfactants, disintegrants, and antiadherents/flow aids. Said tablets have significantly increased dissolution of the pharmaceutically active agent at the pH of the gastrointestinal tract in comparison with the unconverted free pharmaceutically active agent.
Type:
Grant
Filed:
September 26, 2000
Date of Patent:
July 22, 2003
Assignee:
R.P. Scherer Technologies, Inc.
Inventors:
David F. Erkoboni, Ronald S. Vladyka, Jr., Christopher A. Sweriduk, Andrew J. Favara
Abstract: The present invention includes a method for treating periodontal disease. The method comprises delivering to a pocket of a tooth with periodontal disease, a viscous, reddish-brown solution comprising sulfuric acid and sulphonated phenolic compounds. The method also comprises retaining the reddish-brown solution in the pocket for t time ranging from about 5 seconds to about 60 seconds.
Abstract: The present invention is to provide a sustained-release preparation which comprises a compound having angiotensin II antagonistic activity, its pro-drug or their salt, and a biodegradable polymer, and if necessary, a polyvalent metal, and which is highly stable and active and shows angiotensin II antagonistic activity while maintaining circadian rhythm of blood pressure for a long time.
Abstract: A powdered, dispersible composition having stable dispersibility over time is provided. The composition exhibits a characteristic glass transition temperature (Tg) and a recommended storage temperature (Ts), wherein the difference between Tg and Ts is at least about 10° C. (i.e. Tg−Ts is greater than 10° C.). The composition comprises a mixture of a pharmaceutically-acceptable glassy matrix and at least one pharmacologically active material within the glassy matrix. It may be further mixed with a powdered, pharmaceutically-acceptable carrier. It is particularly valuable in unit dosage form having a moisture barrier, in combination with appropriate labelling instructions.
Type:
Grant
Filed:
June 11, 2001
Date of Patent:
July 8, 2003
Assignee:
Nektar Therapeutics
Inventors:
Linda C. Foster, Mei-chang Kuo, Shelia R. Billingsley
Abstract: The invention relates to the prophylactic and therapeutic treatment of subjects for the purpose of inhibiting vaso-occlusive events, including embolism, by administering agents which reduce the number of circulating platelets to below normal levels. Methods and pharmaceutical preparations comprising such agents are provided.
Abstract: The present invention is a system and method capable of increasing glucose oxidation in an affected area and therefore providing more energy for treating wounds, promoting healing and avoiding amputations in both diabetic and non-diabetic patients. The current invention is the treating of wounds, promoting healing and avoiding lower extremity amputations using insulin pulses to a patient utilizing Chronic Intermittent Intravenous Insulin Therapy to achieve an increase in glucose oxidation in tissues surrounding an affected area, therefore treating wounds, promoting healing and avoiding amputations in both diabetic and non-diabetic patients.