Patents Examined by Ruth Davis
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Patent number: 11985979Abstract: The invention relates to methods for controlling mycotoxin production in field populations of heterothallic and homothallic filamentous fungi through application of biocontrol compositions comprising selected strains of the heterothallic and homothallic filamentous fungi, the selected strains having a lineage of low mycotoxin production or no mycotoxin production and having opposite mating types (heterothallic) or both mating types (homothallic) (e.g., MAT1-1, MATT-2).Type: GrantFiled: April 29, 2019Date of Patent: May 21, 2024Assignee: NORTH CAROLINA STATE UNIVERSITYInventor: Ignazio Carbone
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Patent number: 11976268Abstract: The present invention relates generally to growth of bacteria. More specifically the invention relates to a method for oxidative environment adaptation of anaerobic microorganisms and their use in developing new probiotics. In particular, the present invention provides a method for adaptation of anaerobic microorganisms and selection of more oxygen tolerant anaerobic microorganisms, said method comprising the steps of culturing said microorganisms with a stepwise dual induction of oxidative stress via applied voltage and oxygen diffusion, and a stepwise change of anti-oxidant/oxidized counterpart concentration ratio to adjust the redox state. New strains are also provided.Type: GrantFiled: November 18, 2020Date of Patent: May 7, 2024Assignee: BIOGAIA ABInventors: Muhammad-Tanweer Khan, Fredrik Backhed
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Patent number: 11974976Abstract: The invention relates to animal feeds and feed premixes containing synergistically effective amounts of betaine hydrochloride and a phytase.Type: GrantFiled: June 23, 2021Date of Patent: May 7, 2024Assignee: Rural Chemical Industries (AUST) PTY LTDInventors: Aaron Joell Cowieson, Peter Henry Selle, Brett Ruth
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Patent number: 11977060Abstract: The present disclosure features methods of detecting crop damage in an algal culture. Such methods include detecting one or more carotenoids as a volatile organic compound in a sample obtained from a headspace of the algal culture.Type: GrantFiled: December 17, 2020Date of Patent: May 7, 2024Assignees: National Technology & Engineering Solutions of Sandia, LLC, Lawrence Livermore National Security, LLCInventors: Carolyn Laura Fisher, Todd Lane, Kristen Leigh Reese, Matthias Frank
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Patent number: 11968982Abstract: Disclosed is a method for controlling corn rootworm damage to corn comprising the step of applying to a corn seed from 103 to 106 colony forming units of one of Beauveria bassiana strain ARSEF 2579 (BF503), Metarhizium pingshaence strain ARSEF 5197 (BF517) or mixtures thereof. Another aspect of the present disclosure comprises further combining either BF503 or BF517 with the fungi Trichoderma afroharzianum strain K2 (ATCC PTA-9708) plus Trichoderma atroviride strain K4 (ATCC PTA 9707) and applying it to corn seeds. Another aspect of the present disclosure comprises applying at least one of the BF503 or BF517 to a field planted with corn, with the fungi applied into the seed zone. In another aspect of the present disclosure the same field is further treated with both Trichoderma afroharzianum strain K2 (ATCC PTA-9708) plus Trichoderma atroviride strain K4 (ATCC PTA 9707) into the seed zone.Type: GrantFiled: November 2, 2021Date of Patent: April 30, 2024Assignee: Agrauxine Corp.Inventor: Molly Cadle-Davidson
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Patent number: 11964004Abstract: The present disclosure provides is a short in vivo half-life and in vivo unstable recombinant microplasmin, wherein the recombinant microplasmin can be a mutant type and wild type and is expressed in a bacteria host, can be purified, or can be refolded and purified in case expressed as an insoluble inclusion body, producing an active thrombolytic agent. The present disclosure also provides the pharmaceutical composition comprising the recombinant microplasmin and method of treating thromboembolism related diseases including the administration of the pharmaceutical composition.Type: GrantFiled: March 30, 2022Date of Patent: April 23, 2024Assignee: SHENZHEN BAY LABORATORYInventor: Xinli Henry Lin
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Patent number: 11957754Abstract: Some aspects of this disclosure provide clinical media that support viability, re-plating efficiency, and repopulation capacity of cells and tissues during storage for up to 48 hours or longer. The clinical media provided herein are also useful for clinical irrigation. Cell or tissue preparations comprising a cell population or tissue and a clinical medium as provided herein are also provided, as are methods for generating such preparations. Methods for using the clinical media and cell and tissue preparations provided herein, for example, for administering an effective amount of cells or tissue to a subject in need thereof, are also disclosed.Type: GrantFiled: March 23, 2021Date of Patent: April 16, 2024Assignee: Astellas Institute for Regenerative MedicineInventors: Roger Gay, Judson Ratliff, Romma E. Southwick
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Patent number: 11931387Abstract: The present disclosure provides methods, systems, compositions, and kits to address the need for microbiome-related treatment of health conditions and disease. The present disclosure provides for treatment of metabolic conditions using microbial compositions.Type: GrantFiled: July 22, 2020Date of Patent: March 19, 2024Assignee: Pendulum Therapeutics, Inc.Inventors: Colleen Cutcliffe, John S. Eid, James H. Bullard, Marcus F. Schicklberger
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Patent number: 11926816Abstract: The disclosure provides a culture plate comprising medium which supports microbial growth and comprises a dextrin comprising four or more glucose units linked by ?(1?4) glycosidic bonds as a sole carbon source. The culture plate comprises a first zone inoculated with a sta? S. cerevisiae strain which produces a pigment upon sugar fermentation, and a second zone adjacent to the first zone and which is not inoculated with a microbe. The disclosure further provides a method of using the culture plate to characterize microbial diastatic activity.Type: GrantFiled: January 19, 2021Date of Patent: March 12, 2024Assignee: OMEGA YEAST LABS, LLCInventors: Lance Shaner, Laura Burns
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Patent number: 11891620Abstract: Platelet lysate compositions and cell culture media compositions for maintaining and/or growing mammalian cells, such as mammalian endothelial cells (ECs) and mammalian endothelial progenitor cells (EPCs), in particular human ECs (huECs) and human EPCs (huEPCs), such as primary huECs and primary huEPCs, are provided. The cell culture media compositions contain a basal medium, a platelet lysate and, optionally, one or more exogenously added growth factors. Also provided are methods for making and using such cell culture media compositions to grow and/or maintain ECs and EPCs, including huECs and huEPCs, as well as cell culture vessels, dishes, plates, and/or flasks pretreated with the cell culture media compositions.Type: GrantFiled: May 14, 2015Date of Patent: February 6, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventors: Allan B. Dietz, Gaylord Knutson
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Patent number: 11877578Abstract: A composition for biologically controlling phytopathogenic fungi that pertains to the agricultural biotechnology area, more particularly a composition of bacteria and fungi with different complementary mechanisms of action in the mitigation of phytopathogenic fungi in crops. The composition is a formulation containing Bacillus amyloliquefaciens and Trichoderma harzianum mixed with additives and excipients. Micro-organism Clonostachys rosea can also be added.Type: GrantFiled: September 6, 2018Date of Patent: January 23, 2024Assignee: AGRIVALLE BRASIL INDÚSTRIA E COMÉRCIO DE PRODUTOS AGRÍCOLAS LTDA.Inventors: Eduardo Roberto de Almeida Bernardo, Tiago Domingues Zucchi
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Patent number: 11879122Abstract: A method of producing natto includes inoculating a mutant strain of Bacillus subtilis var. natto onto steamed or boiled soybeans, and fermenting the soybeans inoculated with the mutant strain by maintaining a temperature of the soybeans at 40° C. to 53° C. The number of the mutant strain spores after fermenting the soybeans is 5×105 or less spores per gram of the fermented soybeans. A single colony of the mutant strain cultured in a selective solid medium supplemented with biotin at a gas phase temperature of 49° C. for 48 hours has a region having a hue of yellow (Y), a value of 9 or more, and a chroma of 2 or less, as defined by the Munsell Color System, and a surface area of the region is 20% or less of the total surface area of the single colony.Type: GrantFiled: August 28, 2019Date of Patent: January 23, 2024Assignee: Mizkan Holdings Co., Ltd.Inventor: Atsushi Ishikawa
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Patent number: 11871767Abstract: The disclosure relates to isolated microorganisms—including novel strains of the microorganisms—microbial ensembles, and compositions comprising the same. Furthermore, the disclosure teaches methods of utilizing the described microorganisms, microbial compositions, and compositions comprising the same, in methods for modulating the agricultural production of ruminants. In particular aspects, the disclosure provides methods of increasing feed efficiency, and methods of decreasing acidosis.Type: GrantFiled: June 22, 2021Date of Patent: January 16, 2024Assignee: Native Microbials, Inc.Inventors: Mallory Embree, Cameron Martino, Norman Pitt, Jordan Embree, Corey Dodge
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Patent number: 11866691Abstract: The present invention provides an improved method of utilizing agricultural waste and fungal mycelium in order to create mycelium-based biocomposite materials capable of serving in structural, load-bearing capacities. The dramatic reduction in the embodied carbon of a part grown with the method of the present invention over prior art creates benefit for the use of mycelium-based biocomposites in a new, regenerative economy. The present invention creates parts of superior strength over prior art using far less embodied carbon in the process of manufacture.Type: GrantFiled: June 10, 2021Date of Patent: January 9, 2024Assignee: okom wrks labs, PBCInventor: Joshua Aaron English
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Patent number: 11859170Abstract: Animal feed or animal feed additives comprising one or more polypeptides having lysozyme activity. Polypeptides having lysozyme activity, polynucleotides encoding the polypeptides nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: GrantFiled: May 11, 2018Date of Patent: January 2, 2024Assignee: Novozymes A/SInventors: Ye Liu, Ming Li, Kirk Matthew Schnorr, Peter Bjarke Olsen
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Patent number: 11845971Abstract: Methods for producing methane from algae, and particularly methods for producing methane from brown algae. The present methods can use a biomass of brown algae such as Hormophysa cuneiformis subjected to bacterial treatment to produce methane. The bacteria can comprise Aeromonas sobria and Staphylococcus haemolyticus. The brown algae and bacteria can all be obtained from the Arabian Gulf.Type: GrantFiled: May 4, 2023Date of Patent: December 19, 2023Assignee: KING FAISAL UNIVERSITYInventor: Nermin Adel El Semary
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Patent number: 11820974Abstract: A pomegranate molasses medium for culturing microbes includes a mixture of pomegranate molasses, soil extract, and water. The pomegranate molasses medium for culturing microbes may optionally include at least one of potassium dihydrogen phosphate and iron ammonium EDTA. At least one beneficial microbe may be cultured on the pomegranate molasses medium. The at least one beneficial microbe may include, e.g., Cyanothece and/or beneficial fungus.Type: GrantFiled: August 31, 2022Date of Patent: November 21, 2023Assignee: KING FAISAL UNIVERSITYInventor: Nermin Adel Hussein El Semary
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Patent number: 11812751Abstract: The biocontrol agent for use against soil and air-borne pathogens includes a mixture of isolates from at least three Trichoderma species, including Trichoderma harzianum, Trichoderma longibrachiatum, and Trichoderma asperellum. The mixture of Trichoderma isolates may be effective in controlling plant pathogens. The biocontrol agent for use against soil and air-borne fungal pathogens may be formulated as a wettable powder. The biocontrol agent may be used in the treatment or prevention of infection of date palms with Thielaviopsis punctulata. In a further embodiment, the biocontrol agent may be used in the treatment or prevention of infection of cucumbers with Rhizoctonia solanii.Type: GrantFiled: October 3, 2022Date of Patent: November 14, 2023Assignee: KING FAISAL UNIVERSITYInventors: Khalid A. Alhudaib, Sherif Mohamed El-Ganainy, Muhammad Naeem Sattar, Mustafa Ibrahim Al-Maghaslah
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Patent number: 11814617Abstract: The present invention relates to methods of producing ensiled plant materials using the anaerobic bacterium Megasphaera elsdenii and ensiled plant materials thereof.Type: GrantFiled: October 19, 2018Date of Patent: November 14, 2023Assignees: Kansas State University Research Foundation, Axiota U.S., Inc.Inventors: James Scott Drouillard, Kevin Alan Miller, Celine Caroline Aperce, Taylor Marie Horne, Tara Jo Ellerman, Gina Rae Herren
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Patent number: 11771722Abstract: Methods of inhibiting or reducing tumor metabolism and growth are disclosed. A composition containing oxygen scavenging membrane fragments and anaerobe bacteria is injected into a tumor to interfere with tumor growth and metabolism, leading to tumor necrosis. The composition may also contain a cryoprotectant, which permits the composition to be stored at sub-zero temperatures without freezing.Type: GrantFiled: July 27, 2020Date of Patent: October 3, 2023Assignee: Oxyrase, Inc.Inventor: James C. Copeland