Abstract: An improved method for the manufacture of transdermal drug delivery devices comprising liquid dispersions of a liquid in an aqueous or nonaqueous matrix is disclosed. More particularly, the invention relates to preventing the formation of a crystalline structure in such liquid dispersions by annealing films and laminates in-line immediately following film formation and/or lamination during the manufacture of these devices.
Abstract: A topical sustained release delivery system for delivery of antifungal agents to the finger or toenails achieving high penetration through the nails by combining the antifingal agent with a keratolytic agent and a humectant. The pharmaceutical sustained release topical preparation is provided in a varnish or spray form for treating the nail and surrounding tissues, where the active ingredient is an antifungal agent, a keratolytic agent, or preferably a combination of an antifuingal and a keratolytic agent. The composition may further comprise an antibacterial, an antiviral, an antipsoriatic agents, or combinations thereof.
Type:
Grant
Filed:
March 27, 2000
Date of Patent:
July 11, 2006
Assignee:
Taro Pharmaceutical Industries Limited
Inventors:
Michael Friedman, Daniella Licht, Rachel Cohen, Avraham Yacobi
Abstract: Improved extrusion-processed daily ration animal feeds are provided which include minor amounts of actives to ensure that an animal consuming the feed receives quantities of the actives sufficient to establish and maintain substantially constant concentrations of the actives in the animal's bloodstream. The feeds may be produced by extrusion with addition of minor quantities of one or more actives so as to uniformly distribute the actives throughout the extruded product.
Type:
Grant
Filed:
October 5, 2001
Date of Patent:
May 30, 2006
Assignee:
Rubicon Scientific LLC
Inventors:
Gordon R. Huber, David R. Jones, John C. Kuenzi, Kevin D. Kuenzi, Francisco A. Cabrera
Abstract: An antifungal composition for the treatment of fungal infections in, around and under human nails, the composition comprising an aqueous solution of a wetting agent such as alcohol and a source of fluoride ions sufficient to establish a pH ranging from about 2.8 to about 3.5 in the composition. A preferred source of fluoride ions is stannous fluoride or stannous fluoride in an amount sufficient to saturate the solution. According to the method of the invention, one or more drops of the subject solution are topically applied to the infected nail and surrounding cuticular area periodically until the infection abates.
Abstract: Sheet cosmetics including a single-layered aqueous gel sheet having no supporting layer wherein the sheet of 1 mm in thickness has a light transmittance of 70% or more. These sheet cosmetics have high adhesion force to the skin, transparent appearance presenting no sense of incongruity and achieve excellent moistening and cooling effects on the skin.
Abstract: A polymer-based preparation in film form for biphasic release of substances present therein to liquid surroundings, is characterized in that the preparation comprises at least two polymer matrix layers which differ in terms of their construction from polymers, with release taking place rapidly from one of the layers, and release taking place slowly from at least one other layer.
Abstract: The present invention relates to a compressed, chewable tablet containing at least one active ingredient, a water-disintegratable, compressible carbohydrate and a binder. These components are dry blended and compressed into convex-shaped tablet having a hardness of about 2 to about 11 kp/cm2 and friability less than 1%.
Type:
Grant
Filed:
August 22, 2002
Date of Patent:
April 18, 2006
Inventors:
Ronni L. Robinson, James R. Damon, James R. Mossop, Michael D. Palmer
Abstract: The invention herein provides for an oral pharmaceutical composition adapted for use in capsular dosage forms comprising acetaminophen and a lactate salt alone or in combination with an acetate salt. Compositions of the invention exhibit improved solubility characteristics of the active ingredient per given fill volume, thereby permitting the use of smaller capsule sizes to deliver a given effective dose of the active ingredient. Compositions of the invention also exhibit improved clarity per concentration of active ingredient. The invention also provides for a capsular dosage form containing the composition.
Abstract: The present invention addresses the problem of excessive discoloration in hydroquinone compositions of a neutral pH. Antioxidants in the hydroquinone phase and inorganic or amino acyl cationic salts of acidic ascorbyl esters, preferably sodium metabisulfite and magnesium ascorbyl phosphate respectively, are effective in stabilizing such hydroquinone compositions, which are used in treatment of pigmentation disorders. Protected retinoid may be added to these compositions for additional skin benefit effects.
Type:
Grant
Filed:
July 10, 2003
Date of Patent:
April 11, 2006
Assignee:
Medicis Pharmaceutical Corporation
Inventors:
Mitchell Wortzman, Philip J. Gordon, Eugene H. Gans, Bhiku G. Patel
Abstract: The present invention is directed to microdispersions and pharmaceutical compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less than about 40° C., as determined by differential scanning calorimetry, and a synthetic, bioabsorbable, biocompatible polymeric wax comprising the reaction product of a polybasic acid or derivative thereof, a fatty acid and a polyol, the polymeric wax having a melting point less than about 70° C., as determined by differential scanning calorimetry.
Type:
Grant
Filed:
June 25, 2002
Date of Patent:
April 11, 2006
Inventors:
Aruna Nathan, Joel Rosenblatt, Steven C. Arnold
Abstract: The present invention includes a cosmetic film. The film includes butylphthalimide isopropylphthalimide, one or more primary film forming polymers and one or more secondary film forming resins.
Type:
Grant
Filed:
November 6, 2002
Date of Patent:
March 14, 2006
Assignee:
Coty, Inc.
Inventors:
Steven W. Amato, Wayne M. Hoyte, Alexander Naranjo, Shirish Patel, Salvatore Barone
Abstract: A composite is disclosed having a controlled rate of dissolution. The composite includes (a) a first region that includes a first composition that includes calcium sulfate, the first region exhibiting a first rate of dissolution; and (b) a second region that includes a second composition that includes calcium sulfate, the second region exhibiting a second rate of dissolution, the first rate of dissolution being different from the second rate of dissolution.
Type:
Grant
Filed:
February 5, 2004
Date of Patent:
February 14, 2006
Assignee:
Wright Medical Technology, Inc.
Inventors:
Warren Oliver Haggard, Michael Earl Kaufman, Jack Eldon Parr, Linda Morris
Abstract: The present invention addresses the problem of excessive discoloration in hydroquinone compositions of a neutral pH. Antioxidants in the hydroquinone phase and inorganic or amino acyl cationic salts of acidic ascorbyl esters, preferably sodium metabisulfite and magnesium ascorbyl phosphate respectively, are effective in stabilizing such hydroquinone compositions, which are used in treatment of pigmentation disorders. Protected retinoid may be added to these compositions for additional skin benefit effects.
Type:
Grant
Filed:
July 10, 2003
Date of Patent:
February 14, 2006
Assignee:
Medicis Pharmaceutical Corporation
Inventors:
Mitchell S. Wortzman, Philip J. Gordon, Eugene H. Gans, Bhiku G. Patel
Abstract: The present invention is directed to ion triggerable, water-dispersible cationic polymers. The present invention is also directed to a method of making ion triggerable, water-dispersible cationic polymers and their applicability as binder compositions. The present invention is further directed to fiber-containing fabrics and webs comprising ion triggerable, water-dispersible binder compositions and their applicability in water-dispersible personal care products, such as wet wipes.
Type:
Grant
Filed:
September 20, 2002
Date of Patent:
February 7, 2006
Assignee:
Kimberly-Clark Worldwide, Inc.
Inventors:
Kelly D. Branham, W. Clayton Bunyard, Frederick J. Lang, Kevin Possell, Walter T. Schultz, Kim G. Schick
Abstract: A composition and method for treating soft nails, particularly soft fingernails, the composition including bisphosphonate, preferably alendronate sodium, in a vehicle effective for topical administration.
Type:
Grant
Filed:
September 4, 2002
Date of Patent:
January 17, 2006
Inventors:
E. William Rosenberg, Robert B. Skinner, Jr.
Abstract: An alcohol-free antibacterial wipe comprising a flexible fabric coated with a polymeric latex binder, and an aqueous antibacterial solution wherein the aqueous antibacterial solution is comprised of an effective amount of a cationic antibacterial agent and sufficient amount of a surfactant.
Type:
Grant
Filed:
August 4, 2000
Date of Patent:
January 17, 2006
Assignee:
Johnson & Johnson Consumer Companies, Inc.
Inventors:
Joseph T. Roberts, Carol A. Duden-Antenna, Shaw Kong Chang, Walter J. Hines, Joseph Librizzi
Abstract: New cosmetic compositions are disclosed that are effective both as moisturizers and skin sloughing agents. The compositions contain neutralized weak organic acids that when applied over time to the skin in appropriate formulations will gradually increase in acidity to pH 5.5 or less, for example about pH 4.5, without causing skin irritation while exhibiting increasing activity in skin renewal effects.
Abstract: The invention provides a liquid cosmetic suitable for application to the lips which comprises about 60% to about 80% of an alcoholic solvent; about 2% to about 20% of a vinyl acetate copolymer; about 0.10% to about 5% of a non-toxic glycol; about 0.09% to about 10% of cyclomethicone and aluminum magnesium hydroxide stearate; about 1% to about 7% decamethyl cyclopentasiloxane and trimethylsilicate; and about 0.01% to about 5% of a dye or pigment.
Abstract: The present invention relates to a nail-care composition. It is an object of the present invention to provide a solvent-based nail-care composition which can be easily applied to nails, provides a film (coating film) on the nail with excellent strength and gloss, and generates a coating film that is difficult to peel off over time and free from loss of gloss. The means used to meet the objective is a nail-care composition comprising (a) nitrocellulose, (b) neopentyl glycol trimellitate adipate polyester resin, (c) one, two, or more members selected from the group consisting of alkyl methacrylate-alkyl acrylate copolymers, sucrose benzoate, and a polymer compound having a glass transition temperature of 50-80° C., and (d) a solvent. The present invention provides a solvent-based nail-care composition which is easy to apply, excellent in the strength of film(coating film) on the nail and gloss, difficult to peel off over a period of time, and free from the loss of gloss.