Patents by Inventor Ahmed Abdel-Magid

Ahmed Abdel-Magid has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel anticonvulsant derivative salts
    Publication number: 20030176362
    Abstract: The invention relates to novel pharmaceutically acceptable salts of anticonvulsant derivatives, processes for preparation of and pharmaceutical compositions containing said salts, useful in the treatment of epilepsy.
    Type: Application
    Filed: January 3, 2003
    Publication date: September 18, 2003
    Inventors: Ahmed Abdel-Magid, Cynthia Maryanoff
  • Novel anticonvulsant derivative salts
    Publication number: 20030069190
    Abstract: The invention relates to novel pharmaceutically acceptable salts of anticonvulsant derivatives, processes for preparation of and pharmaceutical compositions containing said salts, useful in the treatment of epilepsy.
    Type: Application
    Filed: July 3, 2002
    Publication date: April 10, 2003
    Inventors: Ahmed Abdel-Magid, Cynthia Maryanoff
  • Process for the preparation of tetrasubstituted imidazole derivatives and novel crystalline structures thereof
    Publication number: 20030045723
    Abstract: The present invention relates to a process for preparing tetrasubstituted imidazole derivatives of the general formula (I) 1
    Type: Application
    Filed: February 22, 2002
    Publication date: March 6, 2003
    Inventors: Hua Zhong, Silke Dubberke, Stefan Muller, Armin Rossler, Thomas W. Schultz, Daniel J. Korey, Thomas Otten, Donald G. Walker, Ahmed Abdel-Magid
  • Liquid phase process for the preparation of GNRH peptides
    Patent number: 6235876
    Abstract: A liquid phase process for preparing GnRH peptide analogs of the formula: G-AA1-(A)D-Phe-AA3-AA4-(R2-AA5-AA6-AA7-AA8-Pro-AA10-NH2   Formula 1 which comprises: (a) reacting a peptide of the formula: T-(R2)AA5-AA6-X  where T is (P2) AA4 orP2 and X is AA7-OH or is —OH, with a peptide of the formula: X′-AA8-Pro-AA10-NH2  or acid-addition salt form thereof, where X′ is AA7 when X is absent and X′ is absent when X is AA7-OH;  in a liquid reaction medium in the presence of a peptide coupling reagent and a strong organic amine base to obtain a product of the formula: T-(R2)AA5-AA6-AA7-AA8-Pro-AA10-NH2 (b) removing the P2 protecting group at the N-terminus, and (c) reacting the product of step (b) or an acid addition salt thereof, with a peptide of the formula: G-AA1-(R1)D-Phe-AA3-T′  or acid-addition salt form thereof, where T′ is AA4-OH when T is absent and is absent when T is P2-AA4, in a liquid reaction medium to obtain a GnRH pepti
    Type: Grant
    Filed: July 8, 1999
    Date of Patent: May 22, 2001
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: David C. Palmer, Ahmed Abdel-Magid, Urs P. Eggmann, Bruce Harris, Kirk L. Sorgi
  • Liquid phase process for the preparation of GnRH peptides
    Patent number: 5977302
    Abstract: A liquid phase process for preparing GnRH peptide analogs of the formula:G-AA.sub.1 -(A)D-Phe-AA.sub.3 -AA.sub.4 -(R.sub.2)-AA.sub.5 -AA.sub.6 AA.sub.7 -AA.sub.8 -Pro-AA.sub.10 -NH.sub.2Formula 1which comprises:(a) reacting a peptide of the formula:T-(R.sub.2)AA.sub.5 -AA.sub.6 -Xwhere T is (P.sub.2)AA4 orP.sub.2 and X is AA.sub.7 --OH or is --OH, with a peptide of the formula:X'-AA.sub.8 -Pro-AA.sub.10 -NH.sub.2or acid-addition salt form thereof, where X' is AA.sub.7 when X is absent and X' selected from P-Ala, Gly, GABA, the D- and L- isomers of Ala, amino isobutyric acid, 6-amino-hexanoic acid, Ser, Thr, His, Tyr, Asn, and Gln' is absent when X is AA.sub.7 --OH;in a liquid reaction medium in the presence of a peptide coupling reagent and a strong organic amine base to obtain a product of the formula:T-(R.sub.2)AA.sub.5 -AA.sub.6 -AA.sub.7 -AA.sub.8 -Pro-AA.sub.10 -NH.sub.2(b) removing the P.sub.
    Type: Grant
    Filed: November 18, 1998
    Date of Patent: November 2, 1999
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: David C. Palmer, Ahmed Abdel-Magid, Michael S. Breslav, Urs P. Eggmann, Bruce Harris, Mark L. Haslego, Kirk L. Sorgi