Patents by Inventor Alfred W. Alberts

Alfred W. Alberts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for enhancing the lowering of plasma-cholesterol levels
    Patent number: 5376383
    Abstract: The instant invention is directed to a method for enhancing the lowering of plasma cholesterol level in a subject in need thereof which comprises the time-controlled administration of a nontoxic therapeutically effective amount of an HMG-CoA reductase inhibitor to said subject which surprisingly affords an equivalent or improved reduction of plasma cholesterol levels while significantly reducing the amount of HMG-CoA reductase inhibitor circulating in the bloodstream of the subject as compared to the same parameters when the oral administration of a conventional rapid release dosage form is utilized.
    Type: Grant
    Filed: February 1, 1993
    Date of Patent: December 27, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Alfred W. Alberts, Edward M. Scolnick, Arnold J. Repta
  • Squalene synthetase inhibitors
    Patent number: 5135935
    Abstract: Compounds of structural formula (I): ##STR1## are squalene synthestase inhibitors useful in inhibiting the biosynthesis of cholesterol in the treatment of hypercholesterolemia and related disorders.
    Type: Grant
    Filed: May 17, 1991
    Date of Patent: August 4, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Alfred W. Alberts, Gregory D. Berger, James D. Bergstrom
  • Method for enhancing the lowering of plasma cholesterol levels
    Patent number: 4997658
    Abstract: The instant invention is directed to a method for enhancing the lowering of plasma cholesterol level in a subject in need thereof which comprises the time-controlled administration of a nontoxic therapeutically effective amount of an HMG-CoA reductase inhibitor to said subject which surprisingly affords an equivalent or improved reduction of plasma cholesterol levels while significantly reducing the amount of HMG-CoA reductase inhibitor circulating in the bloodstream of the subject as compared to the same parameters when the oral administration of a conventional rapid release dosage form is utilized.
    Type: Grant
    Filed: November 21, 1988
    Date of Patent: March 5, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Alfred W. Alberts, Edward M. Scolnick, Arnold J. Repta
  • Treatment of diabetic ketoacidosis
    Patent number: 4873260
    Abstract: There is disclosed the use of .beta.-lactone alkylene carboxylic acids and derivatives thereof, which are known compounds, for the use of treating diabetic ketoacidosis. The compounds are administered orally or parenterally and compositions containing the .beta.-lactone alkylene carboxylic acid compounds as the active ingredient are also disclosed.
    Type: Grant
    Filed: June 27, 1988
    Date of Patent: October 10, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Alfred W. Alberts, Michael D. Greenspan
  • Hypocholesteremic fermentation products
    Patent number: 4342767
    Abstract: Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise compounds which have structures: ##STR1## Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.
    Type: Grant
    Filed: June 16, 1980
    Date of Patent: August 3, 1982
    Assignee: Merck & Co., Inc.
    Inventors: George Albers-Schonberg, Richard L. Monaghan, Alfred W. Alberts, Carl H. Hoffman
  • Hypocholesteremic fermentation products and process of preparation
    Patent number: 4294926
    Abstract: Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise a compound designated MSD803 which has the lactone structure: ##STR1## as well as its free hydroxy acid form. Together with salts and esters of the free acid form, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.
    Type: Grant
    Filed: January 23, 1980
    Date of Patent: October 13, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Richard L. Monaghan, Alfred W. Alberts, Carl H. Hoffman, George Albers-Schonberg
  • Hypocholesteremic fermentation products and process of preparation
    Patent number: 4231938
    Abstract: Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise a compound designated MSD803 which has the lactone structure: ##STR1## as well as its free hydroxy acid form. Together with salts and esters of the free acid form, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.
    Type: Grant
    Filed: June 15, 1979
    Date of Patent: November 4, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Richard L. Monaghan, Alfred W. Alberts, Carl H. Hoffman, George Albers-Schonberg