Patents by Inventor Andrew K. Shiau

Andrew K. Shiau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTICANCER COMPOUNDS
    Publication number: 20230025178
    Abstract: Disclosed are compounds of formula (I): and pharmaceutically acceptable salts thereof. The compounds of the invention are BDII-selective inhibitors of BET proteins, and have therapeutic potential for treating cancer, acute kidney disease, and viral infections, among other diseases.
    Type: Application
    Filed: June 8, 2022
    Publication date: January 26, 2023
    Inventors: Andrew K. Shiau, Mehmet Kahraman, Michael J. Bishop
  • Bicyclic heteroaryl inhibitors of PDE4
    Patent number: 9078887
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: July 14, 2015
    Assignees: Kalypsys, Inc., Alcon Laboratories, Inc.
    Inventors: Steven P. Govek, Andrew K. Shiau, Stewart A. Noble, David J. Thomas
  • BICYCLIC HETEROARYL INHIBITORS OF PDE4
    Publication number: 20130178498
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Application
    Filed: June 28, 2012
    Publication date: July 11, 2013
    Applicant: KALYPSYS, INC.
    Inventors: Steven Govek, Andrew K. Shiau, Stewart A. Noble, David J. Thomas
  • BICYCLIC HETEROARYL INHIBITORS OF PDE4
    Publication number: 20130116279
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Application
    Filed: November 7, 2011
    Publication date: May 9, 2013
    Applicant: KALYPSYS, INC.
    Inventors: Steven P. Govek, Andrew K. Shiau, Stewart A. Noble, David J. Thomas
  • BICYCLIC HETEROARYL INHIBITORS OF PDE4
    Publication number: 20130045975
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Application
    Filed: February 10, 2012
    Publication date: February 21, 2013
    Applicant: KALYPSYS, INC.
    Inventors: Steven P. Govek, Clay Beauregard, Daniel A. Gamache, Mark R. Hellberg, Stewart A. Noble, Andrew K. Shiau, David J. Thomas, John M. Yanni
  • Bicyclic heteroaryl inhibitors of PDE4
    Patent number: 8258154
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: September 4, 2012
    Assignee: Kalypsys Inc.
    Inventors: Steven Govek, Andrew K. Shiau, Stewart A. Noble, David J. Thomas
  • Heteroarylalkoxy-substituted quinolone inhibitors of PDE4
    Patent number: 8138205
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: March 20, 2012
    Assignee: Kalypsys, Inc.
    Inventors: Steven P. Govek, Clay Beauregard, Daniel A. Gamache, Mark R. Hellberg, Stewart A. Noble, Andrew K. Shiau, David J. Thomas, John M. Yanni
  • Bicyclic heteroaryl inhibitors of PDE4
    Patent number: 8080563
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PD E4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: December 20, 2011
    Assignee: Kalypsys
    Inventors: Steven P. Govek, Andrew K. Shiau, Stewart A. Noble, David J. Thomas
  • Sulfonyl-substituted bicyclic compounds as modulators of PPAR
    Patent number: 7915253
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: March 29, 2011
    Assignee: Kalypsys, Inc
    Inventors: Stewart A. Noble, Guy Oshiro, James W. Malecha, Cunxiang Zhao, Carmen K. Robinson, Sergio G. Duron, Michael Sertic, Andrew K. Lindstrom, Andrew K. Shiau, Christopher D. Bayne, Mehmet Kahraman, Boliang Lou, Steve P. Govek
  • Sulfonyl-substituted bicyclic compounds as modulators of PPAR
    Patent number: 7834004
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: November 16, 2010
    Assignee: Kalypsys, Inc
    Inventors: Stewart A. Noble, Guy Oshiro, James W. Malecha, Cunxiang Zhao, Carmen Robinson, Sergio G. Duron, Michael Sertic, Andrew K. Lindstrom, Andrew K. Shiau, Christopher D Bayne, Mehmet Kahraman, Boliang Lou, Steven P. Govek
  • Bicyclic heteroaryl inhibitors of PDE4
    Patent number: 7745646
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: June 29, 2010
    Assignee: Kalypsys, Inc.
    Inventors: Steven Govek, Andrew K. Shiau, Stewart A. Noble, David J. Thomas
  • ARYL-SUBSTITUTED HETEROCYCLIC PDE4 INHIBITORS AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20100105729
    Abstract: Disclosed herein are potent and selective aryl-substituted heterocyclic compounds, useful as inhibitors of phosphodiesterase 4 (PDE4), compositions comprising the same, and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of PDE4 activity are also provided, as well as methods for the treatment of inflammatory diseases and other diseases in which PDE4 or one of its isoforms may play a role.
    Type: Application
    Filed: September 20, 2007
    Publication date: April 29, 2010
    Applicant: KALYPSYS, INC.
    Inventors: Steven P. Govek, Guy Oshiro, Stewart A. Noble, James W. Malecha, Andrew K. Shiau
  • BICYCLIC HETEROARYL INHIBITORS OF PDE4
    Publication number: 20100081646
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Application
    Filed: August 19, 2009
    Publication date: April 1, 2010
    Applicant: KALYPSYS, INC.
    Inventors: Steven P. Govek, Clay Beauregard, Daniel A. Gamache, Mark R. Hellberg, Stewart A. Noble, Andrew K. Shiau, David J. Thomas, John M. Yanni
  • BICYCLIC HETEROARYL INHIBITORS OF PDE4
    Publication number: 20100022586
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PD E4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Application
    Filed: July 6, 2007
    Publication date: January 28, 2010
    Applicant: KALYPSYS, INC.
    Inventors: Steven P. Govek, Andrew K. Shiau, Stewart A. Noble, David J. Thomas
  • BICYCLIC HETEROARYL INHIBITORS OF PDE4
    Publication number: 20090291950
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PD E4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Application
    Filed: July 6, 2007
    Publication date: November 26, 2009
    Applicant: KALYPSYS, INC.
    Inventors: Steven P. Govek, Andrew K. Shiau, Stewart A. Noble, David J. Thomas
  • HETEROCYCLIC INHIBITORS OF PDE4
    Publication number: 20090275586
    Abstract: The present invention is directed to potent and selective heterocyclic compounds, useful as inhibitors of phosphodiesterase 4 (PDE4), compositions comprising the same, and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of PDE4 activity are also provided, as well as methods for the treatment of inflammatory diseases and other diseases in which PDE4 or one of its isoforms may play a role.
    Type: Application
    Filed: September 20, 2007
    Publication date: November 5, 2009
    Applicant: KALYPSYS, INC.
    Inventors: Steven P. Govek, Guy Oshiro, Stewart A. Noble, James W. Malecha, Andrew K. Shiau
  • SULFONYL-SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF PPAR
    Publication number: 20090264417
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Application
    Filed: September 4, 2008
    Publication date: October 22, 2009
    Applicant: KALYPSYS, INC.
    Inventors: Stewart A. Noble, Guy Oshiro, James W. Malecha, Cunxiang Zhao, Carmen Robinson, Sergio G. Duron, Michael Sertic, Andrew K. Lindstrom, Andrew K. Shiau, Christopher D. Bayne, Mehmet Kahraman, Boliang Lou, Steven P. Govek
  • SULFONYL-SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF PPAR
    Publication number: 20090227599
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Application
    Filed: March 3, 2009
    Publication date: September 10, 2009
    Applicant: KALYPSYS, INC.
    Inventors: Stewart A. Noble, Guy Oshiro, James W. Malecha, Cunxiang Zhao, Sergio G. Duron, Andrew K. Lindstrom, Andrew K. Shiau, Boliang Lou, Steven P. Govek, David J. Thomas
  • Sulfonyl-substituted bicyclic compounds as modulators of PPAR
    Patent number: 7494999
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: February 24, 2009
    Assignee: Kalypsys, Inc
    Inventors: Stewart A. Noble, Guy Oshiro, James W. Malecha, Cunxiang Zhao, Carmen Robinson, Sergio G. Duron, Michael Sertic, Andrew K. Lindstrom, Andrew K. Shiau, Christopher D. Bayne, Mehmet Kahraman, Boliang Lou, Steven P. Govek
  • SULFONYL-SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF PPAR
    Publication number: 20090029971
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Application
    Filed: September 4, 2008
    Publication date: January 29, 2009
    Applicant: KALYPSYS, INC.
    Inventors: Stewart A. Noble, Guy Oshiro, James W. Malecha, Cunxiang Zhao, Carmen Robinson, Sergio G. Duron, Michael Sertic, Andrew K. Lindstrom, Andrew K. Shiau, Christopher D. Bayne, Mehmet Kahraman, Boliang Lou, Steve P. Govek