Patents by Inventor Billie M. York, Jr.

Billie M. York, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
    Patent number: 5153211
    Abstract: Disclosed are substituted or unsubstituted planar tricyclic fluorene or nuclear analogs thereof, spiro-coupled to a five-membered ring containing a secondary amide, and the pharmaceutically acceptable salts thereof. These compounds are useful, inter alia in the treatment of diabetes. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when indicated for, inter alia, long term, prophylactic treatment of the diabetes syndrome. A particularly preferred class of compounds comprise difluoro-dialkoxy substituted spiro-(9H-fluorene-9,4'-imidazolidine)-2',5-diones.
    Type: Grant
    Filed: August 27, 1991
    Date of Patent: October 6, 1992
    Assignee: Alcon Laboratories, Inc.
    Inventor: Billie M. York, Jr.
  • Spiro-tricyclicaromatic succinimide derivatives
    Patent number: 5070100
    Abstract: Disclosed are substituted or unsubstituted planar tricyclic fluorene or nuclear analogs thereof, spiro-coupled to a five-membered ring containing a secondary amide, and the pharmaceutically acceptable salts thereof. These compounds are useful, inter alia in the treatment of diabetes. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when indicated for, inter alia, long term, prophylactic treatment of the diabetes syndrome. A particularly preferred class of compounds comprise difluoro-dialkoxy substituted spiro-(9H-fluorene-9,4'-imidazolidine)-2,40 ,5-diones.
    Type: Grant
    Filed: September 5, 1989
    Date of Patent: December 3, 1991
    Assignee: Alcon Laboratories, Inc.
    Inventor: Billie M. York, Jr.
  • Spiro-tricyclicaromatic succinimide derivatives
    Patent number: 4864028
    Abstract: Disclosed are substituted or unsubstituted planar tricyclic fluorene or nuclear analogs thereof, spiro-coupled to a five-membered ring containing a secondary amide, and the pharmaceutically acceptable salts thereof. These compounds are useful, inter alia, in the treatment of diabetes. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when indicated for, inter alia, long term, prophylactic treatment of the diabetes syndrome.
    Type: Grant
    Filed: September 9, 1987
    Date of Patent: September 5, 1989
    Assignee: Alcon Laboratories, Inc.
    Inventor: Billie M. York, Jr.
  • High energy ionizing protective 2,3-diamino-1,4-butanedithiol; 4,5-diamino-1,2-dithiane; and N-acyl and N-alkyl derivatives thereof, compositions and method of use therefor
    Patent number: 4755528
    Abstract: Disclosed are 2,3-diamino-1,4-butanedithiol; 4,5-diamino-1,2-dithiane; and their N-acyl and N-alkyl derivatives. Also disclosed are processes for preparing the disclosed compounds; pharmaceutical compositions comprising such compounds; and a method of treatment comprising administering such compounds and compositions when an antihypertensive effect or radioprotective effect is indicated.
    Type: Grant
    Filed: April 17, 1987
    Date of Patent: July 5, 1988
    Assignee: Alcon Laboratories, Inc.
    Inventors: Mark T. DuPriest, Billie M. York, Jr.
  • Ophthalmic wound healing with aldose reductase inhibitors
    Patent number: 4717725
    Abstract: Method of promoting healing of ocular wounds comprising the topical application of an aldose reductase inhibitor; compositions comprising such inhibitors are also disclosed.
    Type: Grant
    Filed: January 7, 1986
    Date of Patent: January 5, 1988
    Assignee: Alcon Laboratories, Inc.
    Inventor: Billie M. York, Jr.
  • Method for treating hypertension with 2,3-diamino-1,4-butanedithiol; 4,5-diamino-1,2-dithiane; and N-acyl and N-alkyl derivatives thereof
    Patent number: 4659733
    Abstract: Disclosed are 2,3-diamino-1,4-butanedithiol; 4,5-diamino-1,2-dithiane; and their N-acyl and N-alkyl derivatives. Also disclosed are processes for preparing the disclosed compounds; pharmaceutical compositions comprising such compounds; and a method of treatment comprising administering such compounds and compositions when an antihypertensive effect or radioprotective effect is indicated.
    Type: Grant
    Filed: December 6, 1984
    Date of Patent: April 21, 1987
    Assignee: Alcon Laboratories, Inc.
    Inventors: Mark T. DuPriest, Billie M. York, Jr.
  • 3-chloro-4-(4,5-dihydro-1H-imidazo-2-yl)-amino-5-alkylbenzoic acids, esters, salts, compositions and methods
    Patent number: 4644007
    Abstract: 3-chloro-4-(4,5-dihydro-1H-imidazao-2-yl)-amino-5-alkylbenzoic acid, its pharmaceutically acceptable metal salts and esters are useful in treating glaucoma by virtue of the effect in lowering intraocular pressure when administered systemically or topically to the eye. Also disclosed are processes for preparing the compounds, pharmaceutical compositions comprising the disclosed compounds; and methods of treatment comprising administering said compositions when a lowering of intraocular pressure is indicated.
    Type: Grant
    Filed: July 15, 1985
    Date of Patent: February 17, 1987
    Assignee: Alcon Laboratories, Inc.
    Inventor: Billie M. York, Jr.
  • Aldose reductase inhibitors useful in glaucoma therapy
    Patent number: 4609663
    Abstract: Method of treating glaucoma comprising the topical or systemic application of an aldose reductase inhibitor; compositions comprising such inhibitors are also disclosed.
    Type: Grant
    Filed: September 11, 1984
    Date of Patent: September 2, 1986
    Assignee: Alcon Laboratories, Inc.
    Inventor: Billie M. York, Jr.
  • Aldose reductase inhibitors useful in ophthalmic wound healing
    Patent number: 4600717
    Abstract: Method of promoting healing of ocular wounds comprising the topical application of an aldose reductase inhibitor; compositions comprising such inhibitors are also disclosed.
    Type: Grant
    Filed: April 11, 1984
    Date of Patent: July 15, 1986
    Assignee: Alcon Laboratories, Inc.
    Inventor: Billie M. York, Jr.
  • Control of ocular bleeding using clonidine derivatives
    Patent number: 4587257
    Abstract: A method of controlling anterior segment ocular bleeding is described. The method utilizes various clonidine derivatives (e.g., p-aminoclonidine) as the hemostatic agent.
    Type: Grant
    Filed: December 14, 1984
    Date of Patent: May 6, 1986
    Assignee: Alcon Laboratories, Inc.
    Inventors: Louis M. DeSantis, Joseph M. deFaller, Billie M. York, Jr.
  • Treatment of diabetic complications with certain spiro-imidazolidine-diones
    Patent number: 4540700
    Abstract: Inhibition of aldose reductase activity with tetracyclic spiro-hydantoins, new tetracyclic spirohydantoin derivatives useful in the treatment of complications arising from diabetes mellitus, and a process for preparing spiro-imidazolidine-diones by reacting a mono- or di-fluorofluorene with an excess of oxygen and a tetralkyl- or arylalkyl-trialkyl-ammonium hydroxide are disclosed.
    Type: Grant
    Filed: February 7, 1984
    Date of Patent: September 10, 1985
    Assignee: Alcon Laboratories, Inc.
    Inventor: Billie M. York, Jr.
  • Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
    Patent number: 4537892
    Abstract: Disclosed are substituted or unsubstituted planar tricyclic fluorene or nuclear analogs thereof, spiro-coupled to a five-membered ring containing a secondary amide, and the pharmaceutically acceptable salts thereof. These compounds are useful, inter alia, in the treatment of diabetes. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when indicated for, inter alia, long term, prophylactic treatment of the diabetes syndrome.
    Type: Grant
    Filed: September 14, 1983
    Date of Patent: August 27, 1985
    Assignee: Alcon Laboratories, Inc.
    Inventor: Billie M. York, Jr.
  • Method for lowering intraocular pressure using phenylimino-imidazoles
    Patent number: 4517199
    Abstract: 2-(Trisubstituted phenylimino)-imidazole compounds also known as 2-(trisubstituted anilino)-1,3 diazacyclopentene-(2) compounds are used to lower intraocular pressure.
    Type: Grant
    Filed: August 3, 1983
    Date of Patent: May 14, 1985
    Assignee: Alcon Laboratories, Inc.
    Inventor: Billie M. York, Jr.
  • Method of lowering intraocular pressure using phenylimino-imidazoles
    Patent number: 4515800
    Abstract: A method is provided of treating glaucoma in a patient which comprises administering, preferably as eye drops, an effective amount of the compound ##STR1## which is preferably in the form of its hydrochloride. The compound is administered preferably in the form of a sterile pharmacologically acceptable solution which contains from 0.1 to 5, and more preferably 0.1 to 2.0, percent by weight of said compound. The patient preferably obtains the anti-glaucoma agent in the form of a kit which comprises the sterile pharmacologically acceptable solution and an eyedropper for dispensing said sterile pharmacologically acceptable solution to the affected eyes of a patient suffering from glaucoma.
    Type: Grant
    Filed: August 3, 1983
    Date of Patent: May 7, 1985
    Inventors: Icilio Cavero, Salomon Z. Langer, Billie M. York, Jr.
  • Treatment of diabetic complications with hydantoins
    Patent number: 4464385
    Abstract: 6-Methythio and 6-methylsulfinyl spiro-chroman-imidazolidine diones useful in the treatment of complications arising from diabetes mellitus.
    Type: Grant
    Filed: April 15, 1982
    Date of Patent: August 7, 1984
    Assignee: Alcon Laboratories, Inc.
    Inventor: Billie M. York, Jr.
  • 2-(Trisubstituted phenylimino)-imidazolines
    Patent number: 4461904
    Abstract: 2-Trisubstituted Phenylimino-imidazolines also known as 2-(trisubstituted anilino)-1,3 diazacyclopentene-(2) compounds and their use for lowering intraocular pressure are disclosed.
    Type: Grant
    Filed: November 20, 1981
    Date of Patent: July 24, 1984
    Assignee: Alcon Laboratories, Inc.
    Inventor: Billie M. York, Jr.
  • Spiro-(fluoren-9,4'-imidazolidine)-2',5'-diones
    Patent number: 4438272
    Abstract: Tetracyclic spiro-hydantoin derivatives useful in the treatment of complications arising from diabetes mellitus.
    Type: Grant
    Filed: April 15, 1982
    Date of Patent: March 20, 1984
    Assignee: Alcon Laboratories, Inc.
    Inventor: Billie M. York, Jr.
  • Method of inhibiting aldose reductase activity
    Patent number: 4436745
    Abstract: Inhibition of aldose reductase activity with tetracyclic spiro-hydantoins.
    Type: Grant
    Filed: April 15, 1982
    Date of Patent: March 13, 1984
    Assignee: Alcon Laboratories, Inc.
    Inventor: Billie M. York, Jr.