Patents by Inventor Brett M. Wingeier
Brett M. Wingeier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230414959Abstract: Described herein are methods and systems for treatment of neurological conditions using aTBS. One variation includes a method for treating anxiety disorders, including generating a personalized accelerated theta burst stimulation (aTBS) target, placing a TMS device relative to the patient's brain such that the focus of the magnetic field is over the aTBS target, applying TMS to the aTBS target according to an aTBS protocol to the brain using the TMS device to alleviate one or more symptoms of the anxiety disorder. Methods and systems for concurrently treating two or more disorders, e.g., depression and an anxiety disorder, are also described.Type: ApplicationFiled: March 3, 2023Publication date: December 28, 2023Inventors: Shan H. SIDDIQI, Adi MARON-KATZ, Armani PORTER, Brandon S. BENTZLEY, Brett M. WINGEIER
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Publication number: 20220296903Abstract: Described herein are systems and methods for the automated prediction of relapse of a neurological or psychiatric disorder. The systems and methods may generally use patient data such as patient characteristics, treatment history, clinical history, biometric data, and/or neuroimaging data as inputs to a predictive model. Additionally, the systems and methods may be integrated with a treatment system so that neurostimulation may be automatically delivered when triggered by the predictive model. Systems and methods configured to propose a personalized treatment schedule for maintaining the effects of neurostimulation therapy are also described herein.Type: ApplicationFiled: March 21, 2022Publication date: September 22, 2022Inventors: Adi MARON-KATZ, Brandon S. BENTZLEY, Brett M. WINGEIER
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Publication number: 20210298654Abstract: Systems and methods rely on feedback from an active medical device or devices (e.g., neurostimulator coupled to sensing and stimulation elements such as electrodes) to assess the effectiveness of a patient's drug regimen. Such reliance may include analyzing characteristics in physiological data acquired by the medical device(s), for example, in the form of responses evoked from the patient by electrical stimulation waveforms. Systems and methods further involved adjusting one or more parameters according to which a combination therapy consisting of at least a drug regimen and an electrical stimulation therapy are delivered to a patient, in an effort to optimize the therapeutic effect of the combination. The adjustments may be automatically by one or more implanted or external hosts working together or alone, and/or with the input of a physician.Type: ApplicationFiled: June 14, 2021Publication date: September 30, 2021Inventors: Tara L. Crowder, Brett M. Wingeier, Martha J. Morrell, Felice Sun, Thomas Tcheng
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Patent number: 11064926Abstract: Systems and methods rely on feedback from an active medical device or devices (e.g., neurostimulator coupled to sensing and stimulation elements such as electrodes) to assess the effectiveness of a patient's drug regimen. Such reliance may include analyzing characteristics in physiological data acquired by the medical device(s), for example, in the form of responses evoked from the patient by electrical stimulation waveforms. Systems and methods further involved adjusting one or more parameters according to which a combination therapy consisting of at least a drug regimen and an electrical stimulation therapy are delivered to a patient, in an effort to optimize the therapeutic effect of the combination. The adjustments may be automatically by one or more implanted or external hosts working together or alone, and/or with the input of a physician.Type: GrantFiled: November 17, 2017Date of Patent: July 20, 2021Assignee: NeuroPace, Inc.Inventors: Tara L. Crowder, Brett M. Wingeier, Martha J. Morrell, Felice Sun, Thomas Tcheng
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Publication number: 20180085015Abstract: Systems and methods rely on feedback from an active medical device or devices (e.g., neurostimulator coupled to sensing and stimulation elements such as electrodes) to assess the effectiveness of a patient's drug regimen. Such reliance may include analyzing characteristics in physiological data acquired by the medical device(s), for example, in the form of responses evoked from the patient by electrical stimulation waveforms. Systems and methods further involved adjusting one or more parameters according to which a combination therapy consisting of at least a drug regimen and an electrical stimulation therapy are delivered to a patient, in an effort to optimize the therapeutic effect of the combination. The adjustments may be automatically by one or more implanted or external hosts working together or alone, and/or with the input of a physician.Type: ApplicationFiled: November 17, 2017Publication date: March 29, 2018Inventors: Tara L. Crowder, Brett M. Wingeier, Martha J. Morrell, Felice Sun, Thomas Tcheng
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Patent number: 9314182Abstract: A system and method for detecting and predicting neurological events with an implantable device uses a relatively low-power central processing unit in connection with signal processing circuitry to identify features (including half waves) and calculate window-based characteristics (including line lengths and areas under the curve of the waveform) in one or more electrographic signals received from a patient's brain. The features and window-based characteristics are employed within the framework of a programmable finite state machine to identify patterns and sequences in and across the electrographic signals, facilitating early and reliable detection and prediction of complex spatiotemporal neurological events in real time, and enabling responsive action by the implantable device.Type: GrantFiled: November 16, 2012Date of Patent: April 19, 2016Assignee: NeuroPace, Inc.Inventors: Brett M. Wingeier, Thomas K. Tcheng
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Patent number: 9186082Abstract: A system and method for detecting and predicting neurological events with an implantable device uses a relatively low-power central processing unit in connection with signal processing circuitry to identify features (including half waves) and calculate window-based characteristics (including line lengths and areas under the curve of the waveform) in one or more electrographic signals received from a patient's brain. The features and window-based characteristics are employed within the framework of a programmable finite state machine to identify patterns and sequences in and across the electrographic signals, facilitating early and reliable detection and prediction of complex spatiotemporal neurological events in real time, and enabling responsive action by the implantable device.Type: GrantFiled: June 7, 2007Date of Patent: November 17, 2015Assignee: NeuroPace, Inc.Inventors: Brett M. Wingeier, Thomas K. Tcheng
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Patent number: 8771194Abstract: A system including an implantable neurostimulator device capable of modulating cerebral blood flow to treat epilepsy and other neurological disorders. In one embodiment, the system is capable of modulating cerebral blood flow (also referred to as cerebral perfusion) in response to measurements and other observed conditions. Perfusion may be increased or decreased by systems and methods according to the invention as clinically required.Type: GrantFiled: December 13, 2012Date of Patent: July 8, 2014Assignee: NeuroPace, Inc.Inventors: Michael S. John, Benjamin D. Pless, Brett M. Wingeier
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Publication number: 20130172774Abstract: Systems and methods rely on feedback from an active medical device or devices (e.g., neurostimulator coupled to sensing and stimulation elements such as electrodes) to assess the effectiveness of a patient's drug regimen. Such reliance may include analyzing characteristics in physiological data acquired by the medical device(s), for example, in the form of responses evoked from the patient by electrical stimulation waveforms. Systems and methods further involved adjusting one or more parameters according to which a combination therapy consisting of at least a drug regimen and an electrical stimulation therapy are delivered to a patient, in an effort to optimize the therapeutic effect of the combination. The adjustments may be automatically by one or more implanted or external hosts working together or alone, and/or with the input of a physician.Type: ApplicationFiled: June 30, 2012Publication date: July 4, 2013Applicant: NEUROPACE, INC.Inventors: Tara L. Crowder, Brett M. Wingeier, Martha J. Morrell, Felice Sun, Thomas Tcheng
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Patent number: 8423156Abstract: Medical electrical lead systems and related methods are described. The lead systems may be configured to be at least partially implanted in neural tissue of a subject, such as a brain of a subject. Some variations of the lead systems may comprise a lead body, an electrode connected to the lead body, and a bioactive agent. The electrode and/or lead body may comprise a substrate, and the bioactive agent may be supported by the substrate (e.g., by a substantial portion of the area of the substrate). Methods described herein may comprise contacting the substrate of a lead body and/or an electrode of a medical electrical lead system with at least one bioactive agent, where the lead body and the electrode are connected to each other.Type: GrantFiled: February 9, 2012Date of Patent: April 16, 2013Assignee: NeuroPace, Inc.Inventors: C. Lance Boling, Daniel Chao, Martha J. Morrell, Benjamin D. Pless, Thomas K. Tcheng, Brett M. Wingeier
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Publication number: 20130073003Abstract: In some embodiments, the power generator for converting mechanical energy to electrical energy may include a compressible element adapted and configured to be placed in an environment having a variable compressive force such as varying ambient pressures. The compressible element may be compressed by a force applied by the variable pressure to the compressible element. The power generator may further include a transducer that may be coupled to the compressible element and that may convert mechanical energy from the compression of the compressible element to electrical energy. In some embodiments, the power generator may be adapted to be an implantable power generator for converting mechanical energy from a patient to electrical energy, such that the compressible element adapted and configured to be placed between two adjacent tissue layers of the patient and to be compressed by a force applied from the two adjacent tissue layers to the compressible element.Type: ApplicationFiled: November 12, 2012Publication date: March 21, 2013Inventors: Benjamin David Pless, Carl Lance Boling, Barbara Gibb, Adolf van der Heide, Brett M. Wingeier
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Patent number: 8311632Abstract: In some embodiments, the power generator for converting mechanical energy to electrical energy is described may include a compressible element adapted and configured to be placed in an environment having a variable compressive force such as varying ambient pressures. The compressible element may be compressed by a force applied by the variable pressure to the compressible element. The power generator may further include a transducer that may be coupled to the compressible element and that may convert mechanical energy from the compression of the compressible element to electrical energy. In some embodiments, the power generator may be adapted to be an implantable power generator for converting mechanical energy from a patient to electrical energy, such that the compressible element adapted and configured to be placed between two adjacent tissue layers of the patient and to be compressed by a force applied from the two adjacent tissue layers to the compressible element.Type: GrantFiled: February 25, 2009Date of Patent: November 13, 2012Assignee: Autonomic Technologies, Inc.Inventors: Benjamin David Pless, Carl Lance Boling, Barbara Gibb, Adolf van der Heide, Brett M. Wingeier
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Publication number: 20120232628Abstract: Medical electrical lead systems and related methods are described. The lead systems may be configured to be at least partially implanted in neural tissue of a subject, such as a brain of a subject. Some variations of the lead systems may comprise a lead body, an electrode connected to the lead body, and a bioactive agent. The electrode and/or lead body may comprise a substrate, and the bioactive agent may be supported by the substrate (e.g., by a substantial portion of the area of the substrate). Methods described herein may comprise contacting the substrate of a lead body and/or an electrode of a medical electrical lead system with at least one bioactive agent, where the lead body and the electrode are connected to each other.Type: ApplicationFiled: February 9, 2012Publication date: September 13, 2012Applicant: NeuroPace, Inc.Inventors: C. Lance Boling, Daniel Chao, Martha J. Morrell, Benjamin D. Pless, Thomas K. Tcheng, Brett M. Wingeier
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Patent number: 8190270Abstract: Medical electrical lead systems and related methods are described. The medical electrical lead systems may be configured to be at least partially implanted in a body of a subject. Some variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and a lumen extending at least partially therebetween, at least one electrode in the proximity of the distal end of the lead body, and a reservoir in fluid communication with the lumen, where the reservoir is located at a position removed from the distal end of the lead body. Certain variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and first and second lumens extending at least partially therebetween, and at least one electrode in the proximity of the distal end of the lead body.Type: GrantFiled: January 10, 2012Date of Patent: May 29, 2012Assignee: NeuroPace, Inc.Inventors: Brett M. Wingeier, Martha Morrell, Carl Lance Boling
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Publication number: 20120109253Abstract: Medical electrical lead systems and related methods are described. The medical electrical lead systems may be configured to be at least partially implanted in a body of a subject. Some variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and a lumen extending at least partially therebetween, at least one electrode in the proximity of the distal end of the lead body, and a reservoir in fluid communication with the lumen, where the reservoir is located at a position removed from the distal end of the lead body. Certain variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and first and second lumens extending at least partially therebetween, and at least one electrode in the proximity of the distal end of the lead body.Type: ApplicationFiled: January 10, 2012Publication date: May 3, 2012Applicant: NEUROPACE, INC.Inventors: Brett M. Wingeier, Martha Morrell, C. Lance Boling
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Patent number: 8160720Abstract: Medical electrical lead systems and related methods are described. The medical electrical lead systems may be configured to be at least partially implanted in a body of a subject. Some variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and a lumen extending at least partially therebetween, at least one electrode in the proximity of the distal end of the lead body, and a reservoir in fluid communication with the lumen, where the reservoir is located at a position removed from the distal end of the lead body. Certain variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and first and second lumens extending at least partially therebetween, and at least one electrode in the proximity of the distal end of the lead body.Type: GrantFiled: September 13, 2010Date of Patent: April 17, 2012Assignee: NeuroPace, Inc.Inventors: Brett M. Wingeier, Martha Morrell, Carl Lance Boling
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Publication number: 20110004282Abstract: Medical electrical lead systems and related methods are described. The lead systems may be configured to be at least partially implanted in neural tissue of a subject, such as a brain of a subject. Some variations of the lead systems may comprise a lead body, an electrode connected to the lead body, and a bioactive agent. The electrode and/or lead body may comprise a substrate, and the bioactive agent may be supported by the substrate (e.g., by a substantial portion of the area of the substrate). Examples of bioactive agents that may be used in the lead system include bioactive agents that promote neural adhesion and living cells that have been biologically manipulated, engineered cells, and cells of a particular phenotype and/or adapted to induce a desired neural or glial response.Type: ApplicationFiled: August 30, 2010Publication date: January 6, 2011Applicant: NEUROPACE, INC.Inventors: C. Lance Boling, Daniel Chao, Martha J. Morrell, Benjamin D. Pless, Thomas K. Tcheng, Brett M. Wingeier
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Publication number: 20100331762Abstract: Medical electrical lead systems and related methods are described. The medical electrical lead systems may be configured to be at least partially implanted in a body of a subject. Some variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and a lumen extending at least partially therebetween, at least one electrode in the proximity of the distal end of the lead body, and a reservoir in fluid communication with the lumen, where the reservoir is located at a position removed from the distal end of the lead body. Certain variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and first and second lumens extending at least partially therebetween, and at least one electrode in the proximity of the distal end of the lead body.Type: ApplicationFiled: September 13, 2010Publication date: December 30, 2010Applicant: NeuroPace, Inc.Inventors: Brett M. Wingeier, Martha J. Morrell, C. Lance Boling
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Publication number: 20100305664Abstract: An implantable medical device is provided for the treatment of a variety of disorders. The implantable medical device can be a neurostimulator having a stimulation lead and electrode(s) configured to be implanted on or near neural tissue in communication with the adrenal gland. Application of an electrical waveform to the neural tissue can cause the adrenal gland to release catecholamines to treat hypoglycemia. In other embodiments, chemical, magnetic, optical, or mechanical neuromodulation can be used.Type: ApplicationFiled: June 1, 2010Publication date: December 2, 2010Inventors: Brett M. Wingeier, Benjamin David Pless, Anthony V. Caparso, Margaret McLaughlin
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Patent number: 7844345Abstract: Medical electrical lead systems and related methods are described. The lead systems may be configured to be at least partially implanted in neural tissue of a subject, such as a brain of a subject. Some variations of the lead systems may comprise a lead body, an electrode connected to the lead body, and a bioactive agent. The electrode and/or lead body may comprise a substrate, and the bioactive agent may be supported by the substrate (e.g., by a substantial portion of the area of the substrate). Examples of bioactive agents that may be used in the lead system include antiproliferative agents, bactericidal agents, bacteriostatic agents, antiepileptic agents, and/or antifungal agents. Methods described herein may comprise coating a lead body and/or an electrode of a medical electrical lead system with at least one bioactive agent, where the lead body and the electrode are connected to each other.Type: GrantFiled: February 8, 2007Date of Patent: November 30, 2010Assignee: NeuroPace, Inc.Inventors: C. Lance Boling, Daniel Chao, Martha J. Morrell, Benjamin D. Pless, Thomas K. Tcheng, Brett M. Wingeier