Patents by Inventor Chi-Dean Liang
Chi-Dean Liang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6506876Abstract: The present invention provides compounds of the formula Ar1—Q—Ar2—Y—R—Z and pharmaceutically acceptable salts thereof wherein Ar1 and Ar2 are optionally substituted aryl moieties, Z is an optionally substituted nitrogen-containing moiety which may be an acyclic, cyclic or bicyclic amine or an optionally substituted monocyclic or bicyclic nitrogen-containing heteroaromatic moiety; Q is a linking group capable of linking two aryl groups; R is an alkylene moiety; Y is a linking moiety capable of linking an aryl group to an alkylene moiety and wherein Z is bonded to R through a nitrogen atom. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of inflammatory diseases which are mediated by LTB4 production, such as psoriasis, ulcerative colitis, IBD and asthma.Type: GrantFiled: October 11, 1994Date of Patent: January 14, 2003Assignee: G.D. Searle & Co.Inventors: Nizal Samuel Chandrakumar, Barbara Baosheng Chen, Michael Clare, Bipinchandra Nanubhai Desai, Stevan Wakefield Djuric, Stephen Hermann Docter, Alan Frank Gasiecki, Richard Arthur Haack, Chi-Dean Liang, Julie Marion Miyashiro, Thomas Dale Penning, Mark Andrew Russell, Stella Siu-tzyy Yu
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Patent number: 6451852Abstract: A class of substituted phenylacetonitrile-alkylaminoalkyl-ortho-substituted aryl compounds having immunosuppressive properties is described. Compounds of this class would be useful in reducing recipient rejection of transplanted organs and for treatment of autoimmune or inflammatory diseases.Type: GrantFiled: January 22, 2001Date of Patent: September 17, 2002Assignee: G. D. Searle & Co.Inventors: Chi-Dean Liang, John P. McKearn, John M. Farah, Jr., Richard A. Mueller
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Publication number: 20010016602Abstract: A class of substituted phenylacetonitrile-alkylaminoalkyl-ortho-substituted aryl compounds having immunosuppressive properties is described. Compounds of this class would be useful in reducing recipient rejection of transplanted organs and for treatment of autoimmune or inflammatory diseases.Type: ApplicationFiled: January 22, 2001Publication date: August 23, 2001Applicant: G.D. Searle & Co.,Inventors: Chi-Dean Liang, John P. McKearn, John M. Farah, Richard A. Mueller
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Patent number: 6162823Abstract: The present invention provides compounds having the of the formula I: ##STR1## and pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment of inflammatory diseases which are mediated by LTB.sub.4 production, such as psoriasis, ulcerative colitis, IBD, and asthma.Type: GrantFiled: March 12, 1997Date of Patent: December 19, 2000Assignee: G.D. Searle & Co.Inventors: Thomas Dale Penning, Stella Siu-tzyy Yu, James Malecha, Chi-Dean Liang, Mark Andrew Russell
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Patent number: 5723492Abstract: The present invention provides compounds of the formula Ar.sup.1 --Q--Ar.sup.2 --Y--R--Z and pharmaceutically acceptable salts thereof wherein Ar.sup.1 and Ar.sup.2 are optionally substituted aryl moieties, Z is an optionally substituted nitrogen-containing moiety which may be an acyclic, cyclic or bicyclic amine or an optionally substituted monocyclic or bicyclic nitrogen-containing heteroaromatic moiety; Q is a linking group capable of linking two aryl groups; R is an alkylene moiety; Y is a linking moiety capable of linking an aryl group to an alkylene moiety and wherein Z is bonded to R through a nitrogen atom. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of inflammatory diseases which are mediated by LTB.sub.4 production, such as psoriasis, ulcerative colitis, IBD and asthma.Type: GrantFiled: June 6, 1995Date of Patent: March 3, 1998Assignee: G.D. Searle & Co.Inventors: Nizal Samuel Chandrakumar, Barbara Baosheng Chen, Michael Clare, Bipinchandra Nanubhai Desai, Stevan Wakefield Djuric, Stephen Hermann Docter, Alan Frank Gasiecki, Richard Arthur Haack, Chi-Dean Liang, Julie Marion Miyashiro, Thomas Dale Penning, Mark Andrew Russell, Stella Siu-tzyy Yu
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Patent number: 5719306Abstract: The present invention provides compounds of the formula Ar.sup.1 --Q--Ar.sup.2 --Y--R--Z and pharmaceutically acceptable salts thereof wherein Ar.sup.1 and Ar.sup.2 are optionally substituted aryl moieties, Z is an optionally substituted nitrogen-containing moiety which may be an acyclic, cyclic or bicyclic amine or an optionally substituted monocyclic or bicyclic nitrogen-containing heteroaromatic moiety; Q is a linking group capable of linking two aryl groups; R is an alkylene moiety; Y is a linking moiety capable of linking an aryl group to an alkylene moiety and wherein Z is bonded to R through a nitrogen atom. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of inflammatory diseases which are mediated by LTB.sub.4 production, such as psoriasis, ulcerative colitis, IBD and asthma.Type: GrantFiled: June 6, 1995Date of Patent: February 17, 1998Assignee: G.D. Searle & Co.Inventors: Nizal Samuel Chandrakumar, Barbara Baosheng Chen, Michael Clare, Bipinchandra Nanubhai Desai, Stevan Wakefield Djuric, Stephen Hermann Docter, Alan Frank Gasiecki, Richard Arthur Haack, Chi-Dean Liang, Julie Marion Miyashiro, Thomas Dale Penning, Mark Andrew Russell, Stella Siu-tzyy Yu
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Patent number: 5585492Abstract: The present invention provides compounds of the formula Ar.sup.1 --Q--Ar.sup.2 --Y--R--Z and pharmaceutically acceptable salts thereof wherein Ar.sup.1 and Ar.sup.2 are optionally substituted aryl moieties, Z is an optionally substituted nitrogen-containing moiety which may be an acyclic, cyclic or bicyclic amine or an optionally substituted monocyclic or bicyclic nitrogen-containing heteroaromatic moiety; Q is a linking group capable of linking two aryl groups; R is an alkylene moiety; Y is a linking moiety capable of linking an aryl group to an alkylene moiety and wherein Z is bonded to R through a nitrogen atom. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of inflammatory diseases which are mediated by LTB.sub.4 production, such as psoriasis, ulcerative colitis, IBD and asthma.Type: GrantFiled: October 11, 1994Date of Patent: December 17, 1996Assignee: G. D. Searle & Co.Inventors: Nizal S. Chandrakumar, Barbara B. Chen, Michael Clare, Bipinchandra N. Desai, Stevan W. Djuric, Stephen H. Docter, Alan F. Gasiecki, Richard A. Haack, Chi-Dean Liang, Julie M. Miyashiro, Thomas D. Penning, Mark A,. Russell, Stella S. Yu
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Patent number: 5486539Abstract: A class of substituted phenylacetonitrile-alkylaminoalkyl-ortho-substituted aryl compounds having immunosuppressive properties is described. Compounds of this class would be useful in reducing recipient rejection of transplanted organs and for treatment of autoimmune or inflammatory diseases. Compounds of particular interest are of the formula ##STR1## wherein m is one or two; wherein n is a number selected from one to five, inclusive; wherein R.sup.1 is selected from hydrido, alkyl, hydroxyalkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkenyl and alkynyl; wherein R.sup.6 is selected from loweralkyl; wherein each of R.sup.8, R.sup.9, R.sup.10 and R.sup.12 through R.sup.16 is independently selected from hydrido, hydroxy, alkyl, hydroxyalkyl, alkoxy, alkenyl, alkynyl, alkylcarbonyl, alkoxycarbonyl, alkylcarbonylalkenyl, alkylaminocarbonyl and alkoxyalkyl; with the proviso that at least one of R.sup.12 and R.sup.Type: GrantFiled: March 1, 1994Date of Patent: January 23, 1996Assignee: G. D. Searle & Co.Inventors: Chi-Dean Liang, John P. McKearn, John M. Farah, Jr., Richard A. Mueller
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Patent number: 5162569Abstract: A class of substituted phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds having immunosuppressive properties is described. Compounds of this class would be useful in reducing recipient rejection of transplanted organs and for treatment of autoimmune or inflammatory diseases. Compounds of particular interest are of the formula ##STR1## wherein m is one or two; wherein n is a number selected from one to five, inclusive; wherein R.sup.1 is selected from hydrido, alkyl, hydroxyalkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkenyl and alkynyl; wherein R.sup.6 is selected from loweralkyl; wherein each of R.sup.8, R.sup.9, R.sup.10 and R.sup.12 through R.sup.16 is independently selected from hydrido, hydroxy, alkyl, hydroxyalkyl, alkoxy, alkenyl, alkynyl, alkylcarbonyl, alkoxycarbonyl, alkylcarbonylalkenyl, alkylaminocarbonyl and alkoxyalkyl; with the proviso that at least one of R.sup.12 and R.sup.Type: GrantFiled: December 12, 1990Date of Patent: November 10, 1992Assignee: G. D. Searle & Co.Inventors: Chi-Dean Liang, John P. McKearn, John M. Farah, Jr., Richard A. Mueller
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Patent number: 5132311Abstract: Cyanoguanidines which have activity as Class III antiarrhythmic agents, acting by prolonging cardiac action potential repolarization. The invention further provides for compositions incorporating the compounds and methods of their use, as well as providing for pharmaceutically acceptable salts of the compounds.Type: GrantFiled: July 30, 1991Date of Patent: July 21, 1992Assignee: G. D. Searle & Co.Inventor: Chi-Dean Liang
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Patent number: 4681970Abstract: The invention relates to compounds of the formula: ##STR1## which are useful cardiovascular agents.Type: GrantFiled: March 21, 1986Date of Patent: July 21, 1987Assignee: G. D. Searle & Co.Inventor: Chi-Dean Liang
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Patent number: 4650874Abstract: The invention relates to compounds of the formula: ##STR1## which are useful cardiovascular agents.Type: GrantFiled: November 26, 1984Date of Patent: March 17, 1987Assignee: G. D. Searle & Co.Inventors: Kurt J. Rorig, Chi-Dean Liang, Robert W. Hamilton
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Patent number: 4628095Abstract: The invention relates to compounds of the formula: ##STR1## which are useful cardiovascular agents.Type: GrantFiled: June 5, 1985Date of Patent: December 9, 1986Assignee: G. D. Searle & Co.Inventors: Kurt J. Rorig, Stevan W. Djuric, Kerry W. Fowler, Chi-Dean Liang
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Patent number: 4600710Abstract: .beta.-Adrenergic receptor site activation by novel pyridinemethanol derivatives and pharmaceutical compositions and methods of use thereof are described.Type: GrantFiled: March 14, 1985Date of Patent: July 15, 1986Assignee: G. D. Searle & Co.Inventors: Chi-Dean Liang, Gerald M. Walsh
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Patent number: 4593042Abstract: The invention relates to compounds of the formula: ##STR1## which are useful cardiovascular agents.Type: GrantFiled: October 18, 1985Date of Patent: June 3, 1986Assignee: G. D. Searle & Co.Inventor: Chi-Dean Liang
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Patent number: 4499289Abstract: The invention relates to octahydronapthalenes which are useful in antiatherosclerotic agents.Type: GrantFiled: November 7, 1983Date of Patent: February 12, 1985Assignee: G. D. Searle & Co.Inventors: John S. Baran, Chi-Dean Liang
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Patent number: 4404144Abstract: This invention relates to .beta.-Alkyl-.beta.-Hydroxy Glutaric acid .differential. ester derivatives which are useful as anti-hyperlipoproteinemia agents.Type: GrantFiled: December 7, 1981Date of Patent: September 13, 1983Assignee: G. D. Searle & Co.Inventor: Chi-Dean Liang
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Patent number: 4264517Abstract: Alkylphenyl 5Z,8Z,11Z,14Z,17Z-eicosapentaenoates having platelet aggregation inhibiting and antisecretory activity and methods of preparation thereof are disclosed.Type: GrantFiled: October 26, 1979Date of Patent: April 28, 1981Assignee: G.D. Searle & Co.Inventor: Chi-Dean Liang
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Patent number: 4181670Abstract: Preparation and use of platelet aggregation inhibiting and antisecretory phenyl 5Z,8Z,11Z,14Z-eicosatetraenoate and congeners are disclosed.Type: GrantFiled: December 11, 1978Date of Patent: January 1, 1980Assignee: G. D. Searle & Co.Inventor: Chi-Dean Liang
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Patent number: 3972907Abstract: 2,2-Dialkylated arachidonic acid and esters are prepared from the alkyl esters of arachidonic acid by treatment with the appropriate alkyl iodide. The compounds so produced are useful as pharmacological agents in view of their ability to inhibit lipogenesis.Type: GrantFiled: March 24, 1975Date of Patent: August 3, 1976Assignee: G. D. Searle & Co.Inventors: John S. Baran, Chi-Dean Liang