Patents by Inventor Chiaki Hidai

Chiaki Hidai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9738884
    Abstract: The present invention provides a therapeutic agent for epithelial and endothelial injury, and in particular, for epithelial and endothelial microinjury, and the like. The therapeutic agent according to the present invention comprises, for example, a peptide of the following (a), (b), etc., a derivative thereof, or their salt: (a) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS: 10, 4, 12 and 6; or (b) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS: 16, 18, 20 and 22.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: August 22, 2017
    Assignee: NIHON UNIVERSITY
    Inventors: Chiaki Hidai, Hisataka Kitano, Atsushi Mamiya
  • Patent number: 9371523
    Abstract: The present invention provides a cell migration regulator capable of promoting or inhibiting cell migration, a method for regulating cell migration, and a pharmaceutical composition comprising such a regulator, etc. The cell migration regulator of the present invention comprises a peptide, a derivative thereof, or a salt of the peptide or the derivative, wherein the peptide comprises the full-length blood coagulation factor IX, a segment derived from the full-length blood coagulation factor IX by removal of the trypsin domain, the light chain of blood coagulation factor IX, or the EGF1 domain of blood coagulation factor IX, or the EGF3 domain of the endothelial cell locus-1 protein.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: June 21, 2016
    Assignee: NIHON UNIVERSITY
    Inventors: Chiaki Hidai, Hisataka Kitano, Atsushi Mamiya
  • Publication number: 20150175995
    Abstract: The present invention provides a therapeutic agent for epithelial and endothelial injury, and in particular, for epithelial and endothelial microinjury, and the like. The therapeutic agent according to the present invention comprises, for example, a peptide of the following (a), (b), etc., a derivative thereof, or their salt: (a) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS: 10, 4, 12 and 6; or (b) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS: 16, 18, 20 and 22.
    Type: Application
    Filed: April 30, 2013
    Publication date: June 25, 2015
    Applicant: NIHON UNIVERSITY
    Inventors: Chiaki Hidai, Hisataka Kitano, Atsushi Mamiya
  • Publication number: 20130330319
    Abstract: The present invention provides a cell migration regulator capable of promoting or inhibiting cell migration, a method for regulating cell migration, and a pharmaceutical composition comprising such a regulator, etc. The cell migration regulator of the present invention comprises a peptide, a derivative thereof, or a salt of the peptide or the derivative, wherein the peptide comprises the full-length blood coagulation factor IX, a segment derived from the full-length blood coagulation factor IX by removal of the trypsin domain, the light chain of blood coagulation factor IX, or the EGF1 domain of blood coagulation factor IX, or the EGF3 domain of the endothelial cell locus-1 protein.
    Type: Application
    Filed: December 12, 2011
    Publication date: December 12, 2013
    Applicant: NIHON UNIVERSITY
    Inventors: Chiaki Hidai, Hisataka Kitano, Atsushi Mamiya
  • Publication number: 20120245099
    Abstract: The present invention provides an apoptosis-inducing agent capable of inducing apoptosis in various cells including tumor cells and other cells in a simple manner, etc. The apoptosis-inducing agent of the present invention comprises a peptide shown in (a) or (b) below, a derivative thereof, or a salt of the peptide or the derivative: (a) a peptide which comprises an amino acid sequence represented by the formula: C—X-D-X—X—X—X—Y—X—C—X—C (SEQ ID NO: 1)(I); or (b) a peptide which comprises an amino acid sequence with deletion, substitution or addition of one or several amino acids in the amino acid sequence represented by formula (I) and which has apoptosis-inducing activity.
    Type: Application
    Filed: August 25, 2010
    Publication date: September 27, 2012
    Applicant: NIHON UNIVERSITY
    Inventors: Chiaki Hidai, Hisataka Kitano
  • Patent number: 8017334
    Abstract: A method for testing dysgeusia, which is characterized in that it comprises amplifying at least a portion of a gene encoding a taste receptor belonging to the THTR family and a gene encoding a taste receptor belonging to the T2R family collected from a sample derived from the oral cavity; a primer used for the above amplification; and a kit used for the above test.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: September 13, 2011
    Assignee: Nihon University
    Inventors: Kyoichi Takao, Chiaki Hidai, Fumihiko Koike, Tetsuya Takao, Hinako Suga
  • Publication number: 20100087005
    Abstract: The present invention provides a means for introducing a gene of interest into a host cell with a higher degree of efficiency regardless of the gene transfer method employed and the type of the host cell. The auxiliary reagent for gene transfer of the present invention is characterized in that it comprises a peptide comprising a specific amino acid sequence represented by formula (I), a mutant or derivative thereof, or a salt of the peptide, the mutant or the derivative.
    Type: Application
    Filed: October 10, 2007
    Publication date: April 8, 2010
    Inventors: Chiaki Hidai, Hisataka Kitano
  • Patent number: 7517655
    Abstract: The present invention provides the following partial fragment (a) or (b) of developmentally regulated endothelial cell locus-1 (Del-1) protein: (a) a protein consisting of the amino acid sequence as shown in SEQ ID NO: 6, 8, 10, 12, 18 or 24; or (b) a protein which consists of the amino acid sequence as shown in SEQ ID NO: 6, 8, 10, 12, 18 or 24 having deletion, substitution or addition of one or several amino acids, and has deposition activity onto extracellular matrix.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: April 14, 2009
    Assignee: Nihon University
    Inventor: Chiaki Hidai
  • Publication number: 20080145842
    Abstract: A method for testing dysgeusia, which is characterized in that it comprises amplifying at least a portion of a gene encoding a taste receptor belonging to the THTR family and a gene encoding a taste receptor belonging to the T2R family collected from a sample derived from the oral cavity; a primer used for the above amplification; and a kit used for the above test.
    Type: Application
    Filed: June 28, 2005
    Publication date: June 19, 2008
    Inventors: Kyoichi Takao, Chiaki Hidai, Fumihiko Koike, Tetsuya Takao, Hinako Suga
  • Publication number: 20060199184
    Abstract: The present invention provides the following partial fragment (a) or (b) of developmentally regulated endothelial cell locus-I (Del-1) protein: (a) a protein consisting of the amino acid sequence as shown in SEQ ID NO: 6, 8, 10, 12, 18 or 24; or (b) a protein which consists of the amino acid sequence as shown in SEQ ID NO: 6, 8, 10, 12, 18 or 24 having deletion, substitution or addition of one or several amino acids, and has deposition activity onto extracellular matrix.
    Type: Application
    Filed: June 30, 2004
    Publication date: September 7, 2006
    Applicant: NIHON UNIVERSITY
    Inventor: Chiaki Hidai