Patents by Inventor Chrystal M. PAULOS

Chrystal M. PAULOS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Activated CD26-high immune cells and CD26-negative immune cells and uses thereof
    Patent number: 11963980
    Abstract: Provided herein are methods for the production of activated CD26high T cells by co-stimulation with inducible coactivator (ICOS). Further provided are methods for treatment of cancer by administration of the of activated CD26high T cells as an adoptive T cell therapy.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: April 23, 2024
    Assignee: MUSC Foundation for Research Development
    Inventors: Chrystal M. Paulos, Michelle H. Nelson, Stefanie R. Bailey
  • MODIFIED T CELLS AND USES THEREOF
    Publication number: 20200283728
    Abstract: Provided herein are methods for the production of enhanced ICOS-stimulated Th17 cells by co-stimulation with inducible coactivator (ICOS) and an inhibitor of POK/Akt signaling and/or an inhibitor of Wnt/?-catenin signaling. Further provided are methods for treatment of cancer by administration of the enhanced ICOS-stimulated Th17 cells as an adoptive T cell therapy.
    Type: Application
    Filed: January 25, 2018
    Publication date: September 10, 2020
    Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
    Inventors: Chrystal M. PAULOS, Kinga MAJCHRZAK, Jacob S. BOWERS
  • ACTIVATED CD26-HIGH IMMUNE CELLS AND CD26-NEGATIVE IMMUNE CELLS AND USES THEREOF
    Publication number: 20190247431
    Abstract: Provided herein are methods for the production of activated CD26high T cells by co-stimulation with inducible coactivator (ICOS). Further provided are methods for treatment of cancer by administration of the of activated CD26high T cells as an adoptive T cell therapy.
    Type: Application
    Filed: April 25, 2017
    Publication date: August 15, 2019
    Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
    Inventors: Chrystal M. PAULOS, Michelle H. NELSON, Stefanie R. BAILEY