Patents by Inventor Daniel Mufson
Daniel Mufson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11065400Abstract: Inhalation delivery of aerosols containing small particles is described. Specifically, it relates to a device that forms drug containing aerosols for use in inhalation therapy. In a device aspect of the present disclosure, a device for delivering drug containing aerosols for inhalation therapy is provided. The device includes a housing and an airway that has a gas/vapor mixing airway. The airway further includes a subassembly, which has a metallic substrate coated on its surface with a composition comprising a drug.Type: GrantFiled: June 26, 2017Date of Patent: July 20, 2021Assignee: ALEXZA PHARMACEUTICALS, INC.Inventors: Craig C. Hodges, Peter M. Lloyd, Daniel Mufson, Daniel D. Rogers, Martin J. Wensley
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Publication number: 20170281884Abstract: The present disclosure relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a device that forms drug containing aerosols for use in inhalation therapy. In a device aspect of the present disclosure, a device for delivering drug containing aerosols for inhalation therapy is provided. The device includes a housing and an airway that has a gas/vapor mixing airway. The airway further includes a subassembly, which has a metallic substrate coated on its surface with a composition comprising a drug.Type: ApplicationFiled: June 26, 2017Publication date: October 5, 2017Inventors: Craig C. Hodges, Peter M. Lloyd, Daniel Mufson, Daniel D. Rogers, Martin J. Wensley
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Patent number: 9687487Abstract: Inhalation delivery of aerosols containing small particles from a device that forms drug containing aerosols for use in inhalation therapy. A device for delivering drug containing aerosols for inhalation therapy is provided. The device includes a housing and an airway that has a gas/vapor mixing airway. The airway further includes a subassembly, which has a metallic substrate coated on its surface with a composition comprising a drug.Type: GrantFiled: November 13, 2013Date of Patent: June 27, 2017Assignee: Alexza Pharmaceuticals, Inc.Inventors: Craig C. Hodges, Peter M. Lloyd, Daniel Mufson, Daniel D. Rogers, Martin J. Wensley
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Patent number: 9636254Abstract: Methods, system and apparatus for relieving pressure in an organ such as, but not limited to, the eye are disclosed. The method includes implanting a bioabsorbable channel into the selected area of the organ using a delivery apparatus.Type: GrantFiled: November 17, 2009Date of Patent: May 2, 2017Assignee: AqueSys, Inc.Inventors: Dao-Yi Yu, Cory Anderson, Roelof Trip, Ying Yang, Hoang Van Nguyen, Surag Mantri, Er-Ning Su, Stephen Cringle, James McCrea, Daniel Mufson, Colin Tan
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Patent number: 9439907Abstract: The present application relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. The method involves: (a) heating a substrate coated with a composition of a drug to form a vapor, wherein the coated composition is in the form of a film less than 10? thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another aspect, a method of forming an aerosol for use in inhalation therapy is provided, wherein the method involves: (a) heating a substrate coated with a composition of a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.Type: GrantFiled: November 11, 2013Date of Patent: September 13, 2016Assignee: ALEXZA PHARMACEUTICAL, INC.Inventors: Ron L. Hale, Craig C. Hodges, Peter M. Lloyd, Daniel Mufson, Daniel D. Rogers, Soonho Song, Martin J. Wensley, Daniel J. Myers, Jeffrey A. McKinney, Reynaldo J. Quintana, Joshua D. Rabinowitz
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Patent number: 9308208Abstract: A method and device are provided to generate an aerosol having a desired particle sizes, i.e., from molecular to about 10 microns, which can be used to effectively deliver a physiologically active compound to organs and tissues such as the lung, eye, mucosa and skin. The aerosol is formed through vaporization of the compound while mixing the resulting vapor with a gas, in a ratio, to form the desired particle size when a stable concentration of particles in the gas is reached.Type: GrantFiled: July 30, 2010Date of Patent: April 12, 2016Assignee: ALEXZA PHARMACEUTICALS, INC.Inventors: Martin J. Wensley, Daniel Mufson, Craig C. Hodges, Peter M. Lloyd, Daniel D. Rogers
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Publication number: 20150157635Abstract: The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided.Type: ApplicationFiled: February 17, 2015Publication date: June 11, 2015Inventors: Ron L. Hale, Craig C. Hodges, Peter M. Lloyd, Daniel Mufson, Daniel D. Rogers, Soonho Song, Martin J. Wensley, Daniel J. Myers, Jeffrey A. McKinney, Reynaldo J. Quintana, Joshua D. Rabinowitz
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Patent number: 8955512Abstract: The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. The method involves: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10? thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another aspect, a method of forming an aerosol for use in inhalation therapy is provided, wherein the method comprises: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.Type: GrantFiled: March 27, 2013Date of Patent: February 17, 2015Assignee: Alexza Pharmaceuticals, Inc.Inventors: Ron L. Hale, Craig C. Hodges, Peter M. Lloyd, Daniel Mufson, Daniel D. Rogers, Soonho Song, Martin J. Wensley, Daniel J. Myers, Jeffrey A. McKinney, Reynaldo J. Quintana, Joshua D. Rabinowitz
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Publication number: 20140060532Abstract: The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a device that forms drug containing aerosols for use in inhalation therapy. In a device aspect of the present invention, a device for delivering drug containing aerosols for inhalation therapy is provided. The device includes a housing and an airway that has a gas/vapor mixing airway. The airway further includes a subassembly, which has a metallic substrate coated on its surface with a composition comprising a drug.Type: ApplicationFiled: November 13, 2013Publication date: March 6, 2014Applicant: Alexza Pharmaceuticals, Inc.Inventors: Craig C. Hodges, Peter M. Lloyd, Daniel Mufson, Daniel D. Rogers, Martin J. Wensley
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Publication number: 20140066618Abstract: The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. The method involves: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10 ?thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another aspect, a method of forming an aerosol for use in inhalation therapy is provided, wherein the method comprises: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.Type: ApplicationFiled: November 11, 2013Publication date: March 6, 2014Inventors: Ron L. Hale, Craig C. Hodges, Peter M. Lloyd, Daniel Mufson, Daniel D. Rogers, Soonho Song, Martin J. Wensley, Daniel J. Myers, Jeffrey A. McKinney, Reynaldo J. Quintana, Joshua D. Rabinowitz
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Publication number: 20130276779Abstract: The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. The method involves: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10? thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another aspect, a method of forming an aerosol for use in inhalation therapy is provided, wherein the method comprises: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.Type: ApplicationFiled: March 27, 2013Publication date: October 24, 2013Inventors: Ron L. Hale, Craig C. Hodges, Peter M. Lloyd, Daniel Mufson, Daniel D. Rogers, Soonho Song, Martin J. Wensley, Daniel J. Myers, Jeffrey A. McKinney, Reynaldo J. Quintana, Joshua D. Rabinowitz
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Publication number: 20120197175Abstract: The invention generally relates to shunts in which at least a portion of the body includes a drug.Type: ApplicationFiled: December 8, 2011Publication date: August 2, 2012Applicant: AQUESYS, INC.Inventors: Christopher Horvath, Ronald D. Bache, Laszlo O. Romoda, Dao-Yi Yu, Cory Anderson, Roelof Trip, Ying Yang, Hoang Van Nguyen, Surag Mantri, Er-Ning Su, Stephen Cringle, James McCrea, Daniel Mufson, Colin Tan, Richard L. Lindstrom
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Patent number: 8074644Abstract: The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10? thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.Type: GrantFiled: May 22, 2009Date of Patent: December 13, 2011Assignee: Alexza Pharmaceuticals, Inc.Inventors: Ron L. Hale, Craig C. Hodges, Peter M. Lloyd, Daniel Mufson, Daniel D. Rogers, Soonho Song, Martin J. Wensley, Daniel J. Myers, Jeffrey A. McKinney, Reynaldo J. Quintana, Joshua D. Rabinowitz
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Publication number: 20110240022Abstract: The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a device that forms drug containing aerosols for use in inhalation therapy. In a device aspect of the present invention, a device for delivering drug containing aerosols for inhalation therapy is provided. The device includes a housing and an airway that has a gas/vapor mixing airway. The airway further includes a subassembly, which has a metallic substrate coated on its surface with a composition comprising a drug.Type: ApplicationFiled: April 1, 2011Publication date: October 6, 2011Applicant: ALEXZA PHARMACEUTICALS, INC.Inventors: Craig C. Hodges, Peter M. Lloyd, Daniel Mufson, Daniel D. Rogers, Martin J. Wensley
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Publication number: 20110240013Abstract: The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming a vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10? thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.Type: ApplicationFiled: April 1, 2011Publication date: October 6, 2011Applicant: ALEXZA PHARMACEUTICALS, INC.Inventors: Ron L. Hale, Craig C. Hodges, Peter M. Lloyd, Daniel Mufson, Daniel D. Rogers, Soonho Song, Martin J. Wensley, Daniel J. Myers, Jeffrey A. McKinney, Reynaldo J. Quintana, Joshua D. Rabinowitz
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Publication number: 20110118745Abstract: Methods, systems and apparatus for relieving pressure in an organ such as, but not limited to, the eye are disclosed. The method includes implanting a bioabsorbable, channel into the selected area of the organ using a delivery apparatus.Type: ApplicationFiled: December 9, 2010Publication date: May 19, 2011Applicant: AQUESYS, INC.Inventors: DAO-YI YU, Cory Anderson, Roelof Trip, Ying Yang, Hoang Van Nguyen, Surag Mantri, Er-Ning Su, Stephen Cringle, James McCrea, Daniel Mufson, Colin Tan
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Patent number: 7942147Abstract: The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a device that forms drug containing aerosols for use in inhalation therapy. In a device aspect of the present invention, a device for delivering drug containing aerosols for inhalation therapy is provided. The device includes a housing and an airway that has a gas/vapor mixing airway. The airway further includes a subassembly, which has a metallic substrate coated on its surface with a composition comprising a drug.Type: GrantFiled: May 13, 2002Date of Patent: May 17, 2011Assignee: Alexza Pharmaceuticals, Inc.Inventors: Craig C. Hodges, Peter M. Lloyd, Daniel Mufson, Daniel D. Rogers, Martin J. Wensley
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Publication number: 20100294268Abstract: A method and device are provided to generate an aerosol having a desired particle sizes, i.e., from molecular to about 10 microns, which can be used to effectively deliver a physiologically active compound to organs and tissues such as the lung, eye, mucosa and skin. The aerosol is formed through vaporization of the compound while mixing the resulting vapor with a gas, in a ratio, to form the desired particle size when a stable concentration of particles in the gas is reached.Type: ApplicationFiled: July 30, 2010Publication date: November 25, 2010Applicant: ALEXZA PHARMACEUTICALS, INC.Inventors: Martin J. WENSLEY, Daniel MUFSON, Craig C. HODGES, Peter M. LLOYD, Daniel D. ROGERS
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Patent number: 7766013Abstract: A method and device are provided to generate an aerosol having a desired particle sizes, i.e., from molecular to about 10 microns, which can be used to effectively deliver a physiologically active compound to organs and tissues such as the lung, eye, mucosa and skin. The aerosol is formed through vaporization of the compound while mixing the resulting vapor with a gas, in a ratio, to form the desired particle size when a stable concentration of particles in the gas is reached.Type: GrantFiled: October 26, 2001Date of Patent: August 3, 2010Assignee: Alexza Pharmaceuticals, Inc.Inventors: Martin J. Wensley, Daniel Mufson, Craig C. Hodges, Peter M. Lloyd, Daniel D. Rogers
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Publication number: 20100121248Abstract: Methods, system and apparatus for relieving pressure in an organ such as, but not limited to, the eye are disclosed. The method includes implanting a bioabsorbable channel into the selected area of the organ using a delivery apparatus.Type: ApplicationFiled: November 17, 2009Publication date: May 13, 2010Applicant: AqueSys, Inc.Inventors: Dao-Yi Yu, Cory Anderson, Roelof Trip, Ying Yang, Hoang Van Nguyen, Surag Mantri, Er-Ning Su, Stephen Cringle, James McCrea, Daniel Mufson, Colin Tan