Patents by Inventor David A. Betebenner

David A. Betebenner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-infective agents
    Publication number: 20050107364
    Abstract: Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
    Type: Application
    Filed: August 24, 2004
    Publication date: May 19, 2005
    Inventors: Douglas Hutchinson, John Bellettini, David Betebenner, Richard Bishop, Thomas Borchardt, Todd Bosse, Russell Cink, Charles Flentge, Bradley Gates, Brian Green, Mira Hinman, Peggy Huang, Larry Klein, Allan Krueger, Daniel Larson, M. Leanna, Dachun Liu, Darold Madigan, Keith McDaniel, John Randolph, Todd Rockway, Teresa Rosenberg, Kent Stewart, Vincent Stoll, Rolf Wagner, Ming Yeung
  • Anti-infective agents
    Publication number: 20050075331
    Abstract: The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.
    Type: Application
    Filed: October 6, 2003
    Publication date: April 7, 2005
    Inventors: John Pratt, David Betebenner, Pamela Donner, Brian Green, Dale Kempf, Keith McDaniel, Clarence Maring, Vincent Stoll, Rong Zhang
  • Anti-infective agents
    Publication number: 20040167123
    Abstract: The present invention provides an HCV polymerase inhibiting compound having the formula (I) 1
    Type: Application
    Filed: October 31, 2003
    Publication date: August 26, 2004
    Inventors: John K. Pratt, David A. Betebenner, Pamela L. Donner, Brian E. Green, Dale J. Kempf, Keith F. McDaniel, Clarence J. Maring, Vincent S. Stoll, Rong Zhang
  • Anti-infective agents
    Publication number: 20040162285
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: July 23, 2003
    Publication date: August 19, 2004
    Inventors: John K. Pratt, David A. Betebenner, Pamela L. Donner, Brian E. Green, Dale J. Kempf, Keith F. McDaniel, Clarence J. Maring, Vincent S. Stoll, Rong Zhang
  • Anti-infective agents
    Publication number: 20040097492
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: November 1, 2002
    Publication date: May 20, 2004
    Inventors: John K. Pratt, David A. Betebenner, Pamela L. Donner, Brian E. Green, Dale J. Kempf, Keith F. McDaniel, Clarence J. Maring, Vincent S. Stoll, Rong Zhang
  • Anti-infective agents
    Publication number: 20040087577
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: April 10, 2003
    Publication date: May 6, 2004
    Inventors: John K. Pratt, David A. Betebenner, Pemela L. Donner, Brian E. Green, Dale J. Kempf, Keith F. McDaniel, Clarence J. Maring, Vincent S. Stoll, Rong Zhang
  • Retroviral protease inhibiting compounds
    Publication number: 20030100755
    Abstract: A compound of the formula: 1
    Type: Application
    Filed: October 25, 2002
    Publication date: May 29, 2003
    Inventors: Hing Leung Sham, Daniel W. Norbeck, Xiaoqi Chen, David A. Betebenner, Dale J. Kempf, Thomas R. Herrin, Gondi N. Kumar, Stephen L. Condon, Arthur J. Cooper, Daniel A. Dickman, Steven M. Hannick, Lawrence Kolaczkowski, Patricia A. Oliver, Daniel J. Plata, Peter J. Stengel, Eric J. Stoner, Jieh-Heh J. Tien, Jih-Hua Liu, Ketan M. Patel
  • Retroviral protease inhibiting compounds
    Patent number: 6472529
    Abstract: A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: October 29, 2002
    Assignee: Abbott Laboratories
    Inventors: Hing Leung Sham, Daniel W. Norbeck, Xiaoqi Chen, David A. Betebenner, Dale J. Kempf, Thomas R. Herrin, Gondi N. Kumar, Stephen L. Condon, Arthur J. Cooper, Daniel A. Dickman, Steven M. Hannick, Lawrence Kolaczkowski, Patricia A. Oliver, Daniel J. Plata, Peter J. Stengel, Eric J. Stoner, Jieh-Heh J. Tien, Jih-Hua Liu, Ketan M. Patel
  • Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
    Patent number: 6395767
    Abstract: Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula where x is 0 or 1 and y is 0 or 1 (provided that x=1 when y=0 and x=0 when y=1); n is 0 or 1; X is H or CN; and wherein R1, R2, R3 and R4 are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, and other diseases as set out herein, employing such DP 4 inhibitor *or a combination of such DP 4 inhibitor and one or more of another antidiabetic agent such as metformin, glyburide, troglitazone, pioglitazone, rosiglitazone and/or insulin and/or one or more of a hypolipidemic agent and/or anti-obesity agent and/or other therapeutic agent.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: May 28, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jeffrey A. Robl, Richard B. Sulsky, David J. Augeri, David R. Magnin, Lawrence G. Hamann, David A. Betebenner
  • Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
    Publication number: 20020019411
    Abstract: Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula 1
    Type: Application
    Filed: February 16, 2001
    Publication date: February 14, 2002
    Inventors: Jeffrey A. Robl, Richard B. Sulsky, David J. Augeri, David R. Magnin, Lawrence G. Hamann, David A. Betebenner
  • Retroviral protease inhibiting compounds
    Publication number: 20020004503
    Abstract: A compound of the formula: 1
    Type: Application
    Filed: April 18, 2001
    Publication date: January 10, 2002
    Inventors: Hing Leung Sham, Daniel W. Norbeck, Xiaoqi Chen, David A. Betebenner, Dale J. Kempf, Thomas R. Herrin, Gondi N. Kumar, Stephen L. Condon, Arthur J. Cooper, Daniel A. Dickman, Steven M. Hannick, Lawrence Kolaczkowski, Patricia A. Oliver, Daniel J. Plata, Peter J. Stengel, Eric J. Stoner, Jieh-Heh J. Tien, Jih-Hua Liu, Ketan M. Patel
  • Retroviral protease inhibiting compounds
    Patent number: 6313296
    Abstract: A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
    Type: Grant
    Filed: February 23, 2000
    Date of Patent: November 6, 2001
    Assignee: Abbott Laboratories
    Inventors: Hing Leung Sham, Daniel W. Norbeck, Xiaoqi Chen, David A. Betebenner, Dale J. Kempf, Thomas R. Herrin, Gondi N. Kumar, Stephen L. Condon, Arthur J. Cooper, Daniel A. Dickman, Steven M. Hannick, Lawrence Kolaczkowski, Patricia A. Oliver, Daniel J. Plata, Peter J. Stengel, Eric J. Stoner, Jieh-Heh J. Tien, Jih-Hua Liu, Ketan M. Patel
  • Inhibitors of matrix metalloproteinases
    Patent number: 6288261
    Abstract: Compounds having the formula and pharmaceutically acceptable salts and prodrugs thereof are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
    Type: Grant
    Filed: December 14, 1999
    Date of Patent: September 11, 2001
    Assignee: Abbott Laboratories
    Inventors: David J. Augeri, David A. Betebenner, Richard Craig, Steven K. Davidsen, Stephen W. Fesik, Jamie R. Giesler-Stacey, Yan Guo, Philip J. Hajduk, Michael R. Michaelides, David G. Nettesheim
  • Retroviral protease inhibiting compounds
    Patent number: 6284767
    Abstract: A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
    Type: Grant
    Filed: December 8, 1998
    Date of Patent: September 4, 2001
    Assignee: Abbott Laboratories
    Inventors: Hing Leung Sham, Daniel W. Norbeck, Dale J. Kempf, Xiaoqi Chen, David A. Betebenner, Thomas R. Herrin, Gondi N. Kumar, John M. Lipari, Laman Alani, Soumojeet Ghosh, Rong R. Gao, Dilip Kaul
  • Retroviral protease inhibiting compounds
    Patent number: 5914332
    Abstract: A compound of the formula: ##STR1## is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
    Type: Grant
    Filed: November 21, 1996
    Date of Patent: June 22, 1999
    Assignee: Abbott Laboratories
    Inventors: Hing Leung Sham, Daniel W. Norbeck, Xiaoqi Chen, David A. Betebenner
  • 3-methoxy-4-hydroxyphenylglycol fluorescence polarization immunoassay and conjugates
    Patent number: 5372949
    Abstract: The present invention is directed to a fluorescence polarization immunoassay for determining the 3-methoxy-4-hydroxyphenylglycol content in body fluids, to the various components needed for preparing and carrying out such an assay, and to methods of making these components. Specifically, tracers, immunogens and antibodies are disclosed, as well as methods for preparing them. The assay is conducted by measuring the degree of polarization of plane polarized light that has been passed through a sample containing antiserum and tracer.
    Type: Grant
    Filed: September 3, 1992
    Date of Patent: December 13, 1994
    Assignee: Abbott Laboratories
    Inventors: Christine H. Zeitvogel, Maciej B. Adamczyk, David A. Betebenner, Kenward S. Vaughan
  • 3-methoxy-4-hydroxyphenylglycol fluorescence polarization immunoassay
    Patent number: 5145791
    Abstract: The present invention is directed to a fluoroescence polarization immunoassay for determining the 3-methoxy-4-hydroxyphenylglycol content in body fluids, to the various components needed for preparing and carrying out such an assay, and to methods of making these components. Specifically, tracers, immunogens and antibodies are disclosed, as well as methods for preparing them. The assay is conducted by measuring the degree of polarization of plane polarized light that has been passed through a sample containing antiserum and tracer.
    Type: Grant
    Filed: September 30, 1991
    Date of Patent: September 8, 1992
    Assignee: Abbott Laboratories
    Inventors: Christine H. Zeitvogel, Maciej B. Adamczyk, David A. Betebenner, Kenward S. Vaughan