Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.

Abstract: An external data retrieval apparatus receives a low resolution version of a physiological signal from an active implantable medical device and determines if the physiological signal represents a clinically significant event. The apparatus provides an indication of such determination to the implantable medical device. If the physiological signal does represent a clinically significant event, the apparatus receives a full download of the physiological signal from the implantable device.

Abstract: A method of assessing electrical activity of a brain includes, for each of a plurality of electrical-activity records of the brain, applying a machine-learned ESC model to the record to classify the record as one of a seizure record or a non-seizure record, wherein each of record is sensed by a corresponding one of a plurality of sensing channels of an implanted medical device; for each seizure record in a set of seizure records, applying the machine-learned ESC model to the seizure record to classify the seizure record as one of a local-seizure record or a spread-seizure record, wherein the seizure record comprises a first seizure record captured by a first sensing channel and a second seizure record captured by a second sensing channel; and for each spread-seizure record in a set of spread-seizure records, applying a machine-learned SSC model to the spread-seizure record to classify the spread-seizure record as a type of seizure spread pattern.

Abstract: A lead fixation device for securing a first portion of a lead relative to a hole formed through a skull includes a skull attachment member having an upper surface and a lower surface and a bore extending through and between the upper surface and the lower surface. The lead fixation device also includes a lead compression mechanism integral with the skull attachment member and aligned with the bore of the skull attachment member. The lead compression mechanism defines a passageway through the lead fixation device, which passageway is characterized by a diameter that is defined by the lead compression mechanism. The lead compression mechanism is configured to transition the diameter from a first size to a second size greater than the first size upon insertion of an implant tool through the passageway, and from the second size to the first size upon removal of the implant tool from the passageway.

Abstract: A system for monitoring financial threats includes: at least one central processing unit and system memory that causes the system to: receive information about a threat associated with a financial services device; identify a type of the threat; identify a location associated with the threat; and notify one or more customers associated with the financial services device based upon the type or the location of the threat.

Abstract: A lead fixation device for securing a first portion of a lead relative to a hole formed through a skull includes a skull attachment member having an upper surface and a lower surface and a bore extending through and between the upper surface and the lower surface. The lead fixation device also includes a lead compression mechanism integral with the skull attachment member and aligned with the bore of the skull attachment member. The lead compression mechanism defines a passageway through the lead fixation device, which passageway is characterized by a diameter that is defined by the lead compression mechanism. The lead compression mechanism is configured to transition the diameter from a first size to a second size greater than the first size upon insertion of an implant tool through the passageway, and from the second size to the first size upon removal of the implant tool from the passageway.

Abstract: An implanted neurostimulation system is configured to sense episodes of electrographic events and determine durations of episodes. Durations of electrographic events sensed by the implanted neurostimulation system are mapped with seizure probability biomarkers derived from records of the electrographic events to create a mapping function. A seizure probability biomarker that has a value desired for the operation of the implanted neurostimulation system is selected. The duration mapped to the selected seizure probability biomarker is identified and programmed into a control module of the implanted neurostimulation system as a programmed parameter that triggers the operation by the implanted neurostimulation system. The process may be repeated for other operations of the implanted neurostimulation system.

Abstract: A method implemented on an augmented reality electronic device includes establishing a wireless connection with an automated teller machine (ATM). The AR electronic device is used to authenticate a user of the AR electronic device at the ATM. An initiation is permitted of a financial transaction through user interface functionality for the ATM that is displayed on the AR electronic device. Financial information for the financial transaction is displayed on a display screen of the AR electronic device, instead of displaying the financial information at the ATM.

Abstract: A method implemented on an augmented reality electronic device includes establishing a wireless connection with an automated teller machine (ATM). The AR electronic device is used to authenticate a user of the AR electronic device at the ATM. An initiation is permitted of a financial transaction through user interface functionality for the ATM that is displayed on the AR electronic device. Financial information for the financial transaction is displayed on a display screen of the AR electronic device, instead of displaying the financial information at the ATM.

Abstract: An external data retrieval apparatus receives a low resolution version of a physiological signal from an active implantable medical device and determines if the physiological signal represents a clinically significant event. The apparatus provides an indication of such determination to the implantable medical device. If the physiological signal does represent a clinically significant event, the apparatus receives a full download of the physiological signal from the implantable device.

Abstract: An external data retrieval apparatus receives a low resolution version of a physiological signal from an active implantable medical device and determines if the physiological signal represents a clinically significant event. The apparatus provides an indication of such determination to the implantable medical device. If the physiological signal does represent a clinically significant event, the apparatus receives a full download of the physiological signal from the implantable device.

Abstract: A thread lift cannula has a plurality of therapeutic liquid discharge ports to enable the discharge of a therapeutic liquid into the surrounding tissue. The therapeutic liquid may be injected into the thread lift cannula conduit by a syringe and the thread therein may be bioresorbable and absorb the therapeutic liquid. The therapeutic liquid may include a medicament to reduce swelling or to treat pain, or a biologic that aids in collagen creation, formation, or restructuring. The plurality of therapeutic liquid discharge ports may vary in size along the length of the cannula. A distal discharge port may be larger than a proximal discharge port to enable a more uniform delivery of therapeutic liquid along the cannula. A therapeutic liquid discharge port may be configured at a port angle, offset from orthogonally through the wall of the cannula, to prevent blockage of the outlet opening of the discharge port.

Abstract: An example method for displaying renovation options for a structure includes: receiving homeowner financial information; receiving a selection of a renovation option; receiving pricing information of the renovation option; generating a financial impact analysis based on the homeowner financial information and the pricing information; displaying a renovation view on an augmented reality device, the renovation view displaying the structure with a representation of the renovation option depicted thereon; and displaying a financial impact analysis view showing the financial impact analysis, including a renovation budget amount.

Abstract: A system for monitoring financial threats includes: at least one central processing unit and system memory that causes the system to: receive information about a threat associated with a financial services device; identify a type of the threat; identify a location associated with the threat; and notify one or more customers associated with the financial services device based upon the type or the location of the threat.

Abstract: A lead fixation device for securing a first portion of a lead relative to a hole formed through a skull includes a skull attachment member having an upper surface and a lower surface and a bore extending through and between the upper surface and the lower surface. The lead fixation device also includes a lead compression mechanism integral with the skull attachment member and aligned with the bore of the skull attachment member. The lead compression mechanism defines a passageway through the lead fixation device, which passageway is characterized by a diameter that is defined by the lead compression mechanism. The lead compression mechanism is configured to transition the diameter from a first size to a second size greater than the first size upon insertion of an implant tool through the passageway, and from the second size to the first size upon removal of the implant tool from the passageway.

Abstract: Apparatus for controlling dust exhausted from a container. A lid fits over the opening of a container, such as a feed mixer, that receives a stream of ingredients that carries and/or produces dust. The lid includes a pair of wedge-shaped end sections. The proximal ends of the end sections define a lid through-opening, which is sized to receive ingredients poured into the container. Each of the end sections have a cavity with an open bottom that is contiguous with the inside of the container. Inside the cavity is at least one baffle that extends down toward the container. The baffles are configured to redirect particles entrained in the air pushed inside the container. In one embodiment, at least two of the sides of the lid opening are lined with brushes.

Abstract: A lead fixation accessory configured to be positioned over a skull hole and to transition between an opened state and a closed state during a lead implant procedure protects against lead migration by providing a mechanism for securing the lead in place at the skull hole while a stylet is removed from the lead. The lead fixation accessory remains in place after the implant procedure to provide chronic lead stability. A lead stabilization tool configured to access and grip a lead through a slotted cannula during the lead implant procedure also protects against lead migration by providing a mechanism for securing the lead in place at a point where the lead exits the skull hole while the slotted cannula is removed from the skull hole and peeled away from the lead.

Abstract: A rotating platform has a peripheral wall to form a catch basin. A donut shaped wrapper housing can hold perhaps 50-100 cigarette wrappers facing inbound with a closed end projecting out an outer wall exit hole into the catch basin. Tobacco or any work material is dropped onto the center of the rotating platform which may be motor driven. Centripetal forces urge the work material into the wrappers. Empty wrapper channel feed the excess material into the catch basin. A lid prevents loss of work material.

Abstract: An external data retrieval apparatus receives a low resolution version of a physiological signal from an active implantable medical device and determines if the physiological signal represents a clinically significant event. The apparatus provides an indication of such determination to the implantable medical device. If the physiological signal does represent a clinically significant event, the apparatus receives a full download of the physiological signal from the implantable device.

Abstract: A lead fixation accessory configured to be positioned over a skull hole and to transition between an opened state and a closed state during a lead implant procedure protects against lead migration by providing a mechanism for securing the lead in place at the skull hole while a stylet is removed from the lead. The lead fixation accessory remains in place after the implant procedure to provide chronic lead stability. A lead stabilization tool configured to access and grip a lead through a slotted cannula during the lead implant procedure also protects against lead migration by providing a mechanism for securing the lead in place at a point where the lead exits the skull hole while the slotted cannula is removed from the skull hole and peeled away from the lead.