Patents by Inventor David Jose Simon Laine

David Jose Simon Laine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-CXCR2 ANTIBODIES AND USES THEREOF
    Publication number: 20220348671
    Abstract: Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.
    Type: Application
    Filed: April 12, 2022
    Publication date: November 3, 2022
    Inventors: Doris Shim Siew Chen, Lynn Dorothy Poulton, Adam Clarke, David Jose Simon Laine, Matthew Pollard, Bridget Ann Cooksey, Anthony Doyle, Jason William Gill
  • Anti-CXCR2 antibodies and uses thereof
    Patent number: 11332534
    Abstract: Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: May 17, 2022
    Assignee: Cephalon, Inc.
    Inventors: Doris Shim Siew Chen, Lynn Dorothy Poulton, Adam Clarke, David Jose Simon Laine, Matthew Pollard, Bridget Ann Cooksey, Anthony Doyle, Jason William Gill
  • ANTIBODIES THAT SPECIFICALLY BIND TO HUMAN IL-15 AND USES THEREOF
    Publication number: 20220127352
    Abstract: Recombinant antibodies that specifically bind to IL-15 as well as a complex of IL-15 and the IL-15 Receptor-alpha are provided. The antibodies inhibit immune cell proliferation, and are capable of use in the treatment of any autoimmune or inflammatory disease or condition where IL-15 is dysregulated, including Celiac disease.
    Type: Application
    Filed: January 5, 2022
    Publication date: April 28, 2022
    Inventors: David Jose Simon LAINE, Matthew POLLARD, Anthony Gerard DOYLE, Lynn Dorothy POULTON, Adam William CLARKE
  • Antibodies that specifically bind to human IL-15 and uses thereof
    Patent number: 11267883
    Abstract: Recombinant antibodies that specifically bind to IL-15 as well as a complex of IL-15 and the IL-15 Receptor-alpha are provided. The antibodies inhibit immune cell proliferation, and are capable of use in the treatment of any autoimmune or inflammatory disease or condition where IL-15 is dysregulated, including Celiac disease.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: March 8, 2022
    Assignee: Cephalon, Inc.
    Inventors: David Jose Simon Laine, Matthew Pollard, Anthony Gerard Doyle, Lynn Dorothy Poulton, Adam William Clarke
  • Anti-IL-5 Antibodies
    Publication number: 20210355205
    Abstract: Disclosed herein are fully human antibody molecules that immunospecifically bind to human IL-5. The antibody molecules can bind to human IL-5 with an equilibrium affinity constant (KD) of at least about 40 pM as determined by surface plasmon resonance.
    Type: Application
    Filed: July 26, 2021
    Publication date: November 18, 2021
    Inventors: Mark Terence Liddament, Anthony Doyle, Adam Clarke, David Jose Simon Laine, Bridget Ann Cooksey
  • Anti-IL-5 antibodies
    Patent number: 11111292
    Abstract: Disclosed herein are fully human antibody molecules that immunospecifically bind to human IL-5. The antibody molecules can bind to human IL-5 with an equilibrium affinity constant (KD) of at least about 40 pM as determined by surface plasmon resonance.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: September 7, 2021
    Assignee: CEPHALON, INC.
    Inventors: Mark Terence Liddament, Anthony Doyle, Adam Clarke, David Jose Simon Laine, Bridget Ann Cooksey
  • ANTIBODIES THAT SPECIFICALLY BIND TO HUMAN IL-15 AND USES THEREOF
    Publication number: 20200270339
    Abstract: Recombinant antibodies that specifically bind to IL-15 as well as a complex of IL-15 and the IL-15 Receptor-alpha are provided. The antibodies inhibit immune cell proliferation, and are capable of use in the treatment of any autoimmune or inflammatory disease or condition where IL-15 is dysregulated, including Celiac disease.
    Type: Application
    Filed: December 21, 2017
    Publication date: August 27, 2020
    Inventors: David Jose Simon LAINE, Matthew POLLARD, Anthony Gerard DOYLE, Lynn Dorothy POULTON, Adam William CLARKE
  • ANTI-CXCR2 ANTIBODIES AND USES THEREOF
    Publication number: 20200040089
    Abstract: Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.
    Type: Application
    Filed: July 31, 2019
    Publication date: February 6, 2020
    Inventors: Doris Shim Siew Chen, Lynn Dorothy Poulton, Adam Clarke, David Jose Simon Laine, Matthew Pollard, Bridget Ann Cooksey, Anthony Doyle, Jason William Gill
  • Anti-IL-5 Antibodies
    Publication number: 20180186873
    Abstract: Disclosed herein are fully human antibody molecules that immunospecifically bind to human IL-5. The antibody molecules can bind to human IL-5 with an equilibrium affinity constant (KD) of at least about 40 pM as determined by surface plasmon resonance.
    Type: Application
    Filed: December 20, 2017
    Publication date: July 5, 2018
    Inventors: Mark Terence Liddament, Anthony Doyle, Adam Clarke, David Jose Simon Laine, Bridget Ann Cooksey