Patents by Inventor Denis Forster
Denis Forster has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7445641Abstract: The present invention relates to biomaterials modified with non-proteinaceous catalysts for the dismutation of superoxide, and processes for making such materials. This modification may be by covalent conjugation, copolymerization, or admixture of the non-proteinaceous catalysts with the biomaterial. The resulting modified biomaterials exhibit a marked decrease in inflammatory response and subsequent degradation when placed in contact with vertebrate biological systems.Type: GrantFiled: May 26, 2000Date of Patent: November 4, 2008Assignee: Pharmacia CorporationInventors: Richard Ornberg, Kishore Udipi, Denis Forster, Dennis Riley, Bruce Thurmond, Susan Henke, Kerry Brethauer
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Publication number: 20060089710Abstract: This invention provides modified biopolymers comprising biopolymers attached to at least one non-proteinaceous catalyst capable of dismutating superoxide in the biological system or precursor ligand thereof. The invention further provides pharmaceutical compositions comprising the modified biopolymer and therapeutic methods comprising administering the modified biopolymer to a subject in need thereof.Type: ApplicationFiled: September 15, 2005Publication date: April 27, 2006Inventors: Richard Ornberg, Kishore Udipi, Denis Forster, Dennis Riley, Kenneth Thurmond, Susan Henke, Kerry Brethauer, Saikat Joardar
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Patent number: 7004976Abstract: This invention provides modified biopolymers comprising biopolymers attached to at least one non-proteinaceous catalyst capable of dismutating superoxide in the biological system or precursor ligand thereof. The invention further provides pharmaceutical compositions comprising the modified biopolymer and therapeutic methods comprising administering the modified biopolymer to a subject in need thereof.Type: GrantFiled: November 5, 2003Date of Patent: February 28, 2006Assignee: Pharmacia CorporationInventors: Richard L. Ornberg, Kishore Udipi, Denis Forster, Dennis P. Riley, Kenneth B. Thurmond, Susan Henke, Kerry Brethaur, Saikat Joardar
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Patent number: 6818450Abstract: The present invention is directed to an analytical method for measuring the concentration of an N-(phosphonomethyl)iminodiacetic acid (“NPMIDA”) substrate, an N-(phosphonomethyl)glycine product, formaldehyde, formic acid, N-methyl-N-(phosphonomethyl)glycine (“NMG”), N-methyl-aminomethylphosphonic acid (MAMPA) or aminomethylphosphonic acid (“AMPA”)) in an aqueous mixture thereof, using infrared spectroscopy. The present invention is also directed to a process for oxidizing an N-(phosphonomethyl)iminodiacetic acid substrate to form a N-(phosphonomethyl)glycine product, and as part of the process, measuring the concentration of at least one reactant, product or byproduct of the oxidation reaction using the analytical method of the present invention and controlling the oxidation process in response to the measurement taken.Type: GrantFiled: May 17, 2002Date of Patent: November 16, 2004Assignee: Monsanto Technology LLCInventors: David R. Eaton, Walter Gavlick, Gary Klopf, Arnold Hershman, Denis Forster
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Publication number: 20040116332Abstract: This invention provides modified biopolymers comprising biopolymers attached to at least one non-proteinaceous catalyst capable of dismutating superoxide in the biological system or precursor ligand thereof. The invention further provides pharmaceutical compositions comprising the modified biopolymer and therapeutic methods comprising administering the modified biopolymer to a subject in need thereof.Type: ApplicationFiled: November 5, 2003Publication date: June 17, 2004Inventors: Richard L. Ornberg, Kishore Udipi, Denis Forster, Dennis P. Riley, Kenneth B. Thurmond, Susan Henke, Kerry Brethauer, Saikat Joardar
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Publication number: 20040110722Abstract: The present invention relates to hyaluronic acid polymers modified with non-proteinaceous catalysts for the dismutation of superoxide, and processes for making such materials. The invention further provides pharmaceutical compositions comprising the modified biopolymer and therapeutic methods comprising administering the modified biopolymer to a subject in need thereof.Type: ApplicationFiled: November 5, 2003Publication date: June 10, 2004Inventors: Richard L. Ornberg, Kishore Udipi, Denis Forster, Dennis P. Riley, Kenneth B. Thurmond, Susan Henke, Kerry Brethauer, Saikat Joardar
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Publication number: 20020197725Abstract: The present invention is directed to an analytical method for measuring the concentration of an N-(phosphonomethyl)iminodiacetic acid (“NPMIDA”) substrate, an N-(phosphonomethyl)glycine product, formaldehyde, formic acid, N-methyl-N-(phosphonomethyl)glycine (“NMG”), N-methyl-aminomethylphosphonic acid (MAMPA) or aminomethylphosphonic acid (“AMPA”)) in an aqueous mixture thereof, using infrared spectroscopy. The present invention is also directed to a process for oxidizing an N-(phosphonomethyl)iminodiacetic acid substrate to form a N-(phosphonomethyl)glycine product, and as part of the process, measuring the concentration of at least one reactant, product or byproduct of the oxidation reaction using the analytical method of the present invention and controlling the oxidation process in response to the measurement taken.Type: ApplicationFiled: May 17, 2002Publication date: December 26, 2002Applicant: Monsanto Technology LLCInventors: David R. Eaton, Walter Gavlick, Gary Klopf, Arnold Hershman, Denis Forster
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Patent number: 6491903Abstract: Provided are methods of inhibiting bile acid uptake from the gastrointestinal system and reducing blood serum cholesterol by administering to a mammal, such as a human, an effective amount of particles comprising amphiphilic copolymers, having a crosslinked shell domain and an interior core domain.Type: GrantFiled: June 27, 1997Date of Patent: December 10, 2002Assignee: Washington UniversityInventors: Denis Forster, Gary S. Jacob, James M. Warner
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Patent number: 6471955Abstract: This invention provides a method of preparing a polymeric delivery system for active ingredients having enhanced site specific release performance characteristics. The delivery system is formed either by attaching the active ingredient to a linker through an acid-sensitive covalent bond, then forming a covalent bond between the linker and a portion of the subunits of a crosslinked polystyrene polymer, or by attaching a linker to a portion of the subunits of a crosslinked polystyrene polymer, then attaching the active ingredient to the polymer-linker combination through an acid-sensitive covalent bond. The invention also provides a delivery system comprising an active ingredient covalently bonded through an acid-sensitive covalent bond to a linker, which is in turn covalently bonded to a portion of subunits of a crosslinked polystyrene polymer.Type: GrantFiled: March 30, 1998Date of Patent: October 29, 2002Assignee: Pharmacia CorporationInventors: Samuel J. Tremont, Denis Forster, Ricky L. Fenton, Yinong Ma
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Patent number: 5294675Abstract: Functionalized polymers manifesting exceptional stress-strain properties are prepared from polyols having terminal and nonterminal hydroxyl groups.Type: GrantFiled: April 12, 1993Date of Patent: March 15, 1994Assignee: Monsanto CompanyInventors: Denis Forster, Samuel J. Tremont, Martin P. McGrath, Erik D. Sall
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Patent number: 5232989Abstract: Functionalized polymers manifesting exceptional stress-strain properties are prepared from polyols having terminal and nonterminal hydroxyl groups.Type: GrantFiled: March 4, 1991Date of Patent: August 3, 1993Assignee: Monsanto CompanyInventors: Denis Forster, Samuel J. Tremont, Martin P. McGrath, Erik D. Sall
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Patent number: 4598162Abstract: Novel, liquid mixtures of isomeric aldehydes and alcohols are described in the C.sub.11 -C.sub.16 carbon range, the compounds being characterized by a main carbon branched at the position and moderate additional branching in most isomers; the aldehyde mixtures are prepared by an economic route from olefins involving oxo and aldol reaction with the reaction conducted in such a way as to give a high percentage of aldolable product, and preferably with a base catalyzed aldol reaction conducted under conditions to make high conversions attainable. The aldehyde mixtures can be hydrogenated to alcohols and converted to novel ethoxylates or sulfate compositions suitable for use as biodegradable detergents; or hydrogenated and oxidized to novel carboxylic acid compositions also suitable for detergent use.Type: GrantFiled: November 4, 1983Date of Patent: July 1, 1986Assignee: Monsanto CompanyInventors: Denis Forster, George F. Schaefer, George E. Barker
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Patent number: 4518809Abstract: A novel, liquid mixture of C.sub.14 isomeric alcohols is described which is suitable for use in forming effective and biodegradable detergents, the alcohols being characterized by a 5-carbon branch at the 2-position and moderate additional branching in most isomers; the alcohols are prepared by a novel economic route from propylene dimer, involving oxo, aldol and hydrogenation reactions with the oxo reaction conducted in such a way as to give a high percentage of aldolable product and preferably with a base-catalyzed aldol reaction conducted under particular conditions to make high conversions attainable.Type: GrantFiled: June 1, 1983Date of Patent: May 21, 1985Assignee: Monsanto CompanyInventors: Denis Forster, George F. Schaefer
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Patent number: 4426542Abstract: A preparation of a plasticizer alcohol, consisting of predominantly 2-propylheptanol, from linear butenes is described in which oxo product of the butenes is aldoled to condense n-pentaldehyde therein with very little cross-aldolization followed by hydrogenation to obtain the 2-propylheptanol with very small 2-propyl-4-methyl hexanol content. The alcohol product as phthalate ester has excellent plasticizer properties. Also processes are described for converting other olefins to alcohols by oxo, aldol and hydrogenation reactions, with particular attention to converting hexenes obtained by propylene dimerization to C.sub.14 alcohols suitable for preparation of detergents.Type: GrantFiled: June 11, 1981Date of Patent: January 17, 1984Assignee: Monsanto CompanyInventors: George E. Barker, Denis Forster
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Patent number: 4190729Abstract: In the cobalt carbonyl-catalyzed carbonylation of methanol to ethanol, acetaldehyde and methyl acetate, a tertiary phosphine oxide is utilized as a stabilizer. Product is distilled from the reaction mixture and the cobalt-containing residue solution is recycled.Type: GrantFiled: September 19, 1977Date of Patent: February 26, 1980Assignee: Monsanto CompanyInventor: Denis Forster
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Patent number: 4087463Abstract: Hydrogenolysis of hydrobenzoins [1,2-bis(aryl)ethane-1,2-diols] in the presence of a catalyst comprising cobalt carbonyl yields 1,2-bis(aryl)ethanes. The process is particularly directed to the production of 1,2-bis(4-hydroxyphenyl)ethane from 4,4-dihydroxyhydrobenzoin [1,2-bis(4-hydroxyphenyl)ethane-1,2-diol].Type: GrantFiled: December 22, 1976Date of Patent: May 2, 1978Assignee: Monsanto CompanyInventors: Denis Forster, George F. Schaefer
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Patent number: 4029748Abstract: The complexes [Ir(CO).sub.3 I], [HIr(CO).sub.3 I.sub.2 ], [HIr(CO).sub.2 I.sub.2 (H.sub.2 O)], [RIr(CO).sub.2 I.sub.2 ], [(RCO)Ir(CO).sub.2 I.sub.2 ] where R is an alkyl radical, are described. Processes for preparing the aforesaid complexes are described and in addition a new process for preparation of [Ir(CO).sub.3 I.sub.3 ] is described.Type: GrantFiled: July 29, 1974Date of Patent: June 14, 1977Assignee: Monsanto CompanyInventors: Denis Forster, Arnold Hershman, Donald E. Morris
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Patent number: 4000170Abstract: The present invention relates to an improved process for the preparation of carboxylic acids, specifically by the reaction of ethylenically unsaturated compounds with carbon monoxide and water, in the presence of catalyst compositions essentially comprising iridium compounds and complexes, together with an iodide promoter, the improvement being the provision of at least 50 percent by weight of the iridium in the reaction solution in a highly catalytically active form as a species having infrared absorption bands at 2098 cm.sup.-.sup.1 (vs), 2155 cm.sup.-.sup.1 (w), 2180 cm.sup.-.sup.1 (vw, br). By monitoring the infrared absorption spectra of reacting solutions and following the magnitude of the 2098 cm.sup.-.sup.1 band the operating conditions are adjusted so that this band is present in 50 percent or more concentration relative to the infrared absorption spectral bands of the other iridium species in solution.Type: GrantFiled: July 29, 1974Date of Patent: December 28, 1976Assignee: Monsanto CompanyInventors: Denis Forster, Arnold Hershman, Donald E. Morris
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Patent number: 3989751Abstract: The present invention relates to an improved process for the preparation of organic carboxylic acid anhydrides, specifically by the reaction of ethylenically unsaturated compounds having 2 to 30 carbon atoms with carbon monoxide and carboxylic acids or substances which yield carboxylic acids under reaction conditions at a temperature of 50.degree. C to 300.degree. C and a partial pressure of carbon monoxide of from 1 to 200 atm. in the presence of a catalyst composition essentially comprised of1. a cobalt or nickel compound, and2. an iodide component subject to the conditions that the atomic ratio of iodide to cobalt or nickel is from 1:1 to 300:1,3. a catalyst preserver or regenerator component selected from the group consisting of hydrogen or a compound capable of giving rise to hydrogen under the reaction conditions. The process is particularly suited to the production of propionic anhydride.Type: GrantFiled: December 12, 1974Date of Patent: November 2, 1976Assignee: Monsanto CompanyInventors: Denis Forster, Arnold Hershman
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Patent number: 3944604Abstract: The present invention relates to an improved process for the preparation of propionic acid, specifically by the reaction of ethylene with carbon monoxide and water at mild pressure, in the presence of catalyst compositions essentially comprising critical proportions of cobalt compounds with an iodide promoter.Type: GrantFiled: August 21, 1973Date of Patent: March 16, 1976Assignee: Monsanto CompanyInventors: Arnold Hershman, Denis Forster