Abstract: Compounds of the formula: ##STR1## in which X.sub.1, X.sub.2 and X.sub.3, which are identical or different each represent hydrogen, halogen, methyl, or methoxy, n represents an integer from 1 to 10, and R represents hydroxyl, OM, NH.sub.2, NH(CH.sub.2).sub.3 --COH, --NH(CH.sub.2).sub.3 --COOM, (where M represents an alkali metal atom), NH(CH.sub.2).sub.3 --COOC.sub.2 H.sub.5, NH-cycloalkyl, NH-phenyl, NH-benzyl (where the benzyl radical is unsubstituted or substituted by halogen or trifluoromethyl), NH-alkyl, N(alkyl).sub.2 and N-(alkyl)-(benzyl), the aforesaid alkyls being straight or branched and having from 1 to 4 carbon atoms and the aforesaid cycloalkyls having from 3 to 6 carbon atoms, except that when X.sub.1 and X.sub.3 are both hydrogen, n is 1 and R is OH, X.sub.2 is not chlorine in the 5-position are useful in the treatment of epilepsy by oral or parenteral administration.

Abstract: The invention provides novel phenylacetic acid derivatives of the formula: ##STR1## in which X and Y are the same or different and each represents halogen and R represents hydroxyl, alkoxy of 1 to 4 carbon atoms, a radical of formula R.sub.1 --NH--C.sub.n H.sub.2n --O--, in which n is an integer from 1 to 4 and R.sub.1 is hydrogen or an alkanoyl radical R.sub.2 CO--, in which R.sub.2 is alkyl of 1 to 4 carbon atoms, a radical of formula R.sub.4 NH--, in which R.sub.4 is hydrogen or --C.sub.m H.sub.2m OH, where m is an integer from 1 to 3, or a radical of formula: ##STR2## --OC.sub.m H.sub.2m --COOR.sub.2 or --O(CH.sub.2).sub.p --Z radical, where n, m and R.sub.2 have the meanings given above, p is 0 or 1, and Z is a saturated or unsaturated ring with 6 ring atoms, one of which can be nitrogen, and which can carry from 1 to 3 methyl radicals, and the addition salts which such a derivative which contains a salifiable basic group forms with pharmaceutically acceptable acids and a process for their preparation.

Abstract: The invention provides a new piperazine derivative, 1-(4-fluoro-3-trifluoromethylthio-phenyl)-piperazine of the formula ##STR1## and its pharmaceutically acceptable acid addition salts, which is useful as a medicament in human and veterinary therapy because of its anorexia-inducing effect.

Abstract: Compounds particularly useful in view of their anorexigenic and anxiolytic properties are provided which are the N'-alcoxycarbonylalkyl, N'-cyanoalkyl and N'-carboxyalkyl derivatives of N-meta-trifluoromethylphenylpiperazine.

Abstract: The invention provides novel 2-methoxy-benzamide derivatives of the formula: ##STR1## in which n is 1 or 2; R.sub.1 represents a cycloalkyl-alkyl radical of formula:(CH.sub.2).sub.m -CH-A- ,a phenylalkyl radical of formula ##STR2## (in which m is an integer from 2 to 5, A is a linear or branched alkylene chain of 1 to 4 carbon atoms, and R.sub.4 is hydrogen, halogen, especially fluorine or chlorine, trifluoromethyl, or alkyl or alkoxy of 1 to 3 carbon atoms), CNCH.sub.2 -CH.sub.2 -, CH.tbd.C-CH.sub.2 -, ##STR3## R.sub.2 is either chlorine, SO.sub.2 R.sub.5 (in which R.sub.5 is alkyl of 1 to 4 carbon atoms), or SO.sub.2 NR.sub.6 R.sub.7 (in which, R.sub.6 and R.sub.7, which are identical or different, represent, independently of one another, hydrogen or alkyl of 1 to 4 carbon atoms); and R.sub.

Abstract: The invention provides a new method for treating sickle-cell anemia, by administering to an affected patient the vincamine salt of 6,7-dihydroxycoumarin-4-methylsulphonic acid.

Abstract: The compounds of the formula: ##STR1## in which R.sub.1 is chlorine, CF.sub.3, or -SCF.sub.3 and R.sub.2 is phenyl or phenyl substituted by one or two Cl, CH.sub.3, CF.sub.3, OCF.sub.3 or SCF.sub.3 radicals, the phenyl being substituted when R.sub.1 is chlorine, and their salts, having interesting analgesic and anti-inflammatory properties.

Abstract: The invention provides compounds of formula ##STR1## wherein A and B are hydrogen and R is hydrogen or cycloalkyl, or A and B together form an additional bond and R is cycloalkyl or cycloalkyl-alkyl. Useful in treating pathological disturbancies involving an anoxia factor.

Abstract: Compounds of the formula: ##STR1## in which R represents a group of the formula: ##STR2## in which n represents an integer of 1 to 5 and R.sub.1 and R.sub.2, which may be the same or different, each represents a hydrogen atom or a linear or branched, saturated or unsaturated aliphatic hydrocarbon group containing 1 to 5 carbon atoms, or R.sub.1 and R.sub.2, together with the nitrogen atom to which they are attached, form a heterocyclic ring having 5 to 7 ring members, which heterocyclic ring optionally contains a second hetero-atom and/or one or more substituent groups, and their pharmaceutically acception acid addition salts, which compounds and salts are particularly suitable for use as analgesics.

Abstract: The invention provides vincaminic acid esters of formula ##SPC1##Wherein R.sub.1 is hydrogen or hydroxy, R.sub.2 is hydrogen or R.sub.1 and R.sub.2 form an additional bond between the two carbon atoms to which they are attached, and R.sub.3, R.sub.4 and R.sub.5 are hydrogen or methyl, and their salts. The esters are useful in treatment of cardiac-circulatory, cerebal-vascular or respiratory insufficiency.

Abstract: Compounds of the general formula ##SPC1##Wherein R.sub.1 is H or OH and R.sub.2 is H or R.sub.1 and R.sub.2 together represent an additional double bond between the two carbon atoms to which they are attached and m and n are integers of 1 to 5 and 2 to 7 respectively; and pharmaceutically acceptable acid addition salts thereof. The compounds are useful for the treatment of vascular disorders in mammals.

Abstract: Trifluoromethylthiophenylethylamine derivatives, made from the corresponding acid chlorides by successive reduction, condensation with nitroethane, reduction, and condensation with an amide, possess anorexigenic properties, unaccompanied by central stimulant activity or cardiovascular effects.

Abstract: In accordance with the present invention there are provided N-(m-trifluoromethylthio-phenyl)-piperazine and its salts. These compounds are intermediates for synthesis.

Abstract: The invention provides compound of formula ##SPC1##Wherein R.sub.1 is alkyl or substituted or unsubstituted phenyl or 3-pyridyl, and R.sub.2 is hydrogen, halogen, alkoxy or trifluoromethyl, methoxy or methylthio. The compounds are useful as analgesic agents.

Abstract: The compounds of the formula: ##SPC1##In which R.sub.1 is chlorine, CF.sub.3, or --SCF.sub.3 and R.sub.2 is phenyl or phenyl substituted by one or two Cl, CH.sub.3, CF.sub.3, OCF.sub.3 or SCF.sub.3 radicals, the phenyl being substituted when R.sub.1 is chlorine, and their salts, have interesting analgesic and anti-inflammatory properties.