Abstract: Systems, methods, and software described herein manage the deployment of applications across multiple provisioning layers. In managing the applications, a management service may monitor resource usage by the applications that are executing in a first provisioning layer, wherein the first provisioning layer comprises physical nodes such as airborne or spaceborne nodes. While monitoring the resource usage, the management service may determine when the resource usage by the applications satisfies migration criteria and, when the applications satisfy the migration criteria, select one or more of the applications to be offloaded to another provisioning layer. Once selected, the management service may initiate deployment of the one or more applications in the other provisioning layer.

Abstract: Systems, methods, and software described herein provide enhancements for the deployment of applications in an airborne and spaceborne system. In one implementation, when an application is to be deployed to the system, the system identifies a subset of physical nodes with sensor data associated with the application. Once identified, the system determines accessibility data for the physical nodes of the system to access the sensor data associated with the application and deploys the application to at least one physical node based on the accessibility data.

Abstract: Systems, methods, and software described herein provide enhancements for the deployment of applications in an airborne and spaceborne system. In one implementation, when an application is to be deployed to the system, the system identifies a subset of physical nodes with sensor data associated with the application. Once identified, the system determines accessibility data for the physical nodes of the system to access the sensor data associated with the application and deploys the application to at least one physical node based on the accessibility data.

Abstract: Systems, methods, and software described herein provide enhancements for the deployment and management of resources across spaceborne, airborne, and ground-based physical nodes to perform user tasks and applications. In one implementation, physical nodes of a system collect sensor data from physical sensors. Once collected, the physical nodes apportion the sensor data among logical sensors associated with the physical sensors and provides data streams to data requestors as originating from the logical sensors.

Abstract: Systems, methods, and software described herein provide enhancements for the deployment and management of converged resources across satellites, aircraft, and ground-based nodes to perform user tasks and applications. In one implementation, a system includes a first physical node that monitors sensor data to determine when the sensor data qualifies for an operation triggering event. Once the sensor data qualifies for the operation triggering event, the first physical node may generate and communicate a notification to a second physical node to initiate a new operation to support the triggering event.

Abstract: Systems, methods, and software described herein provide enhancements for managing data storage in a spaceborne or airborne platform. In one implementation, an airborne device in an airborne platform may identify a request to store a data object in a storage pool provided by a plurality of airborne devices. The airborne device will further identify at least one airborne device for storing the data object from the plurality of airborne devices, and communicate the data object to the at least one airborne device.

Abstract: Systems, methods, and software described herein provide enhancements for deploying applications in spaceborne and airborne devices. In one example, a satellite device includes one or more sensor systems, a communication interface, and a virtualized execution system. The virtualized execution system is configured to receive state information via the communication interface from at least a peer device related to execution of one or more software payloads by the peer device, and execute one or more virtual nodes based at least on the state information to employ the one or more sensor systems and establish imaging data.

Abstract: Systems, methods, and software described herein provide enhancements for the deployment and management of converged resources across satellites, aircraft, and ground-based nodes to perform user tasks and applications. In one implementation, a method includes identifying a request for a logical node and identifying physical requirements of the logical node. The method further includes selecting physical nodes from a plurality of physical nodes to support the physical requirements of the logical node and distributing configuration data to the physical nodes to implement the logical node.

Abstract: Systems, methods, and software described herein provide enhancements for spaceborne and airborne computing platforms. In one example, an airborne computing platform includes a plurality of airborne devices, with one or more of the airborne devices comprising specialized roles defined by at least one among software elements and hardware elements targeted to the specialized roles. Individual ones of the airborne devices are configured to identify tasks to be serviced using one or more of the specialized roles, determine one or more target devices to handle the tasks based at least in part on attributes of the target devices, and transfer at least task instructions for delivery to the target devices for performing the tasks.

Abstract: Systems, methods, and software described herein provide enhancements for spaceborne and airborne computing platforms. In one example, an airborne computing platform includes a plurality of airborne devices, with one or more of the airborne devices comprising specialized roles defined by at least one among software elements and hardware elements targeted to the specialized roles. Individual ones of the airborne devices are configured to identify tasks to be serviced using one or more of the specialized roles, determine one or more target devices to handle the tasks based at least in part on attributes of the target devices, and transfer at least task instructions for delivery to the target devices for performing the tasks.

Abstract: The present invention is directed to compounds of generic formula (I): or pharmaceutically acceptable salts thereof that are believed to be useful as an A2A-receptor antagonist. The invention is further directed to methods of treating a patient (preferably a human) for diseases or disorders in which the A2A-receptor is involved. The invention further involves use of the compounds as an A2A-receptor antagonist and/or inhibitor for the preparation of a medicament for the treatment and/or prevention of diseases associated with inhibiting the receptor, which includes central nervous system disorders such as Parkinson's disease. The invention is also directed to pharmaceutical compositions which include an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, and the use of the compounds and pharmaceutical compositions of the invention in the treatment of such diseases.

Abstract: Disclosed are compounds of Formula G1: where “RG3”. “Rd1” to “Rd4”, “n”, “m”, “p”, “W”, “X”, “Y”, and “Z” are defined herein, which compounds are antagonists of A2A receptor. Disclosed herein also are uses of the compounds described herein as antagonists of the A2A receptor in the potential treatment or prevention of neurological disorders and diseases in which A2A receptors are involved. Disclosed herein also are pharmaceutical compositions comprising these compounds and uses of these pharmaceutical compositions.

Abstract: This invention relates to indoline compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variables are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.

Abstract: Disclosed are compounds of Formula G1: where “RG3”. “Rd1” to “Rd4”, “n”, “m”, “p”, “W”, “X”, “Y”, and “Z” are defined herein, which compounds are antagonists of A2A receptor. Disclosed herein also are uses of the compounds described herein as antagonists of the A2A receptor in the potential treatment or prevention of neurological disorders and diseases in which A2A receptors are involved. Disclosed herein also are pharmaceutical compositions comprising these compounds and uses of these pharmaceutical compositions.

Abstract: This invention relates to indo line compounds of the structural formula I, or their pharmaceutically acceptable salts, wherein the variables are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.

Abstract: This invention relates to indoline compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variables are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.

Abstract: The present invention is directed to 2,2-difluorodioxolo compounds that are antagonists of A2A receptor. The present invention is also directed to uses of the 2,2-difluorodioxolo compounds described herein in the potential treatment or prevention of neurological disorders and diseases in which A2A receptor are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds and to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which A2A receptors are involved.

Abstract: Disclosed are compounds of Formula G1 (structurally represented): where “RG3” “Rd1” to “Rd4”, “n”, “m”, “p”, “W”, “X”, “Y”, and “Z” are defined herein which compounds are antagonists of A2A receptor. Disclosed herein also are uses of the compounds described herein as antagonists of the A2a receptor in the potential treatment or prevention of neurological disorders and diseases in which A2A receptors are involved. Disclosed herein also are pharmaceutical compositions comprising these compounds and uses of these pharmaceutical compositions.

Abstract: A compound having the structure: useful for treating hypertension, Pulmonary Arterial Hypertension (PAH), congestive heart failure, conditions resulting from excessive water retention, cardiovascular disease, diabetes, oxidative stress, endothelial dysfunction, cirrhosis, pre-eclampsia, osteoporosis or nephropathy.

Abstract: This invention relates to indo line compounds of the structural formula I, or their pharmaceutically acceptable salts, wherein the variables are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.